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学者姓名：徐会有
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Abstract ：
研究三七内生真菌Nigrospora sp.的化学成分及其生物活性。应用硅胶柱色谱、高效液相色谱等多种色谱分离技术，从该菌株土豆液体发酵产物的乙酸乙酯提取物中分离得到3个聚酮类化合物，根据NMR、HR-ESI-MS、ECD等方法确定其结构，分别鉴定为(R)-2-methyl-4-(2-oxobutyl) cyclopent-2-en-1-one (1)、multiplolide A(2)、8-O-acetylmultiplolide(3)。其中，化合物1是一个新的环戊烯酮类衍生物，化合物2和3是十元大环内酯类衍生物，均为首次从Nigrospora sp.分离得到。抗菌活性实验结果表明，化合物1对大肠杆菌(Escherichia coli)具有微弱的抗菌活性，最小抑菌浓度为64μg/mL。
Keyword ：
Nigrospora sp. Nigrospora sp. 内生真菌 内生真菌 抗菌活性 抗菌活性 聚酮 聚酮
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| GB/T 7714 | 陈浩阳 , 张继宇 , 徐孟飞 et al. 三七内生真菌Nigrospora sp.中一个新的聚酮化合物 [J]. | 天然产物研究与开发 , 2025 , 37 (06) : 1051-1054 . |
| MLA | 陈浩阳 et al. "三七内生真菌Nigrospora sp.中一个新的聚酮化合物" . | 天然产物研究与开发 37 . 06 (2025) : 1051-1054 . |
| APA | 陈浩阳 , 张继宇 , 徐孟飞 , 付硕硕 , 徐会有 , 倪林 . 三七内生真菌Nigrospora sp.中一个新的聚酮化合物 . | 天然产物研究与开发 , 2025 , 37 (06) , 1051-1054 . |
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本发明公开了药物提取技术领域的一种福建柏叶提取物的制备方法及其应用，包括以下步骤：1)取收集的新鲜福建柏叶，经50‑60℃烘干后粉碎，过20目‑50目筛，得干燥的粉末；2)步骤1)所得粉末1000g，加入体积浓度为55‑95％乙醇溶液14500mL，提取温度为70‑90℃并回流提取40‑80min；3)将步骤2)所得物在超声功率为300‑500W条件下提取0.5‑3H，然后过滤，收集提取液，减压浓缩，得福建柏叶浸膏；4)将步骤3)所得福建柏叶浸膏与等量硅藻土拌样后用乙酸乙酯萃取，收集该部分萃取液，减压浓缩回收溶剂，得福建柏叶提取物；福建柏叶制备所得的提取物在体外有显著的抑制α‑葡萄糖苷酶活性。
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| GB/T 7714 | 黄维 , 李欣瑜 , 龚维勇 et al. 一种福建柏叶提取物的制备方法及其应用 : CN202510084192.7[P]. | 2025-01-20 . |
| MLA | 黄维 et al. "一种福建柏叶提取物的制备方法及其应用" : CN202510084192.7. | 2025-01-20 . |
| APA | 黄维 , 李欣瑜 , 龚维勇 , 李渊顺 , 徐会有 , 倪林 . 一种福建柏叶提取物的制备方法及其应用 : CN202510084192.7. | 2025-01-20 . |
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【目的】研究独蒜兰假鳞茎乙醇提取物对植物病原真菌的抑菌作用，为植物源杀菌剂的开发提供依据。【方法】采用菌丝生长速率法，研究独蒜兰假鳞茎乙醇提取物对15种植物病原菌的抑制活性;以西瓜尖孢镰刀菌作为供试菌，进一步研究该提取物对病原真菌的菌丝干重、细胞膜、过氧化氢酶(CAT)、过氧化物酶(POD)和超氧化物歧化酶(SOD)等的影响。【结果】独蒜兰假鳞茎提取物对辣椒疫霉病菌、西瓜尖孢镰刀菌、番茄灰霉病菌和非洲隐地疫霉菌的抑菌效果明显，其EC50值分别为0.849、0.782、0.813和1.161 mg·mL~(-1);经独蒜兰提取物处理后的西瓜尖孢镰刀菌菌丝干重随着药剂浓度的增加而减少;细胞膜丙二醛含量和相对电导率增加;菌丝体细胞内CAT、POD和SOD 3种保护酶活性增加。【结论】独蒜兰假鳞茎提取物对植物病原真菌具有较好的抑菌活性，其抑菌作用可能与其干扰菌丝生长、使菌丝细胞膜正常功能受损等有关。
Keyword ：
抑菌活性 抑菌活性 提取物 提取物 植物病原菌 植物病原菌 独蒜兰 独蒜兰
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| GB/T 7714 | 傅佳蕊 , 刘世林 , 牛泽岳 et al. 独蒜兰提取物对植物病原真菌的抑菌活性 [J]. | 生物安全学报(中英文) , 2024 , 33 (01) : 77-82 . |
| MLA | 傅佳蕊 et al. "独蒜兰提取物对植物病原真菌的抑菌活性" . | 生物安全学报(中英文) 33 . 01 (2024) : 77-82 . |
| APA | 傅佳蕊 , 刘世林 , 牛泽岳 , 郑丽鋆 , 徐会有 , 倪林 . 独蒜兰提取物对植物病原真菌的抑菌活性 . | 生物安全学报(中英文) , 2024 , 33 (01) , 77-82 . |
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The bioactive compounds of the pseudobulbs of Pleione bulbocodioides were isolated, purified, and identified using modern spectroscopic techniques, which identified seven butanedioic acid compounds. Compounds 1-3, 5, and 6 were isolated for the first time from Pleione bulbocodioides. The antifungal activity of the seven compounds was evaluated through cytotoxic activity assays, revealing that compound 4, militarine, exhibited moderate inhibitory activity against Phoma herbarum, with an effective concentration (EC50) of 68.575 mu g/mL. We get further deep insight into the antifungal mechanism of militarine against Phoma herbarum through electron microscopy, transcriptomics, and changes in physiological and biochemical indicators. Transcriptomic sequencing revealed 216 significantly upregulated differentially expressed genes and 277 significantly downregulated differentially expressed genes. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that differentially expressed genes were involved in pathways related to secondary metabolism, biosynthesis, membrane components, nitrogen metabolism, and ATP -binding cassette (ABC) transporter, suggesting that militarine may inhibit the normal growth of hyphae through these pathways.
Keyword ：
antifungal mechanism antifungal mechanism chemical composition chemical composition Phoma herbarum Phoma herbarum Pleione bulbocodioides Pleione bulbocodioides
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| GB/T 7714 | Liu, Shilin , Fu, Jiarui , Fu, Yuping et al. Butanedioic Acid Benzyl Ester Glycosides from Pleione bulbocodioides (Franch.) Rolfe: Promising Fungicide Against Phoma herbarum [J]. | RECORDS OF NATURAL PRODUCTS , 2024 , 18 (4) : 419-435 . |
| MLA | Liu, Shilin et al. "Butanedioic Acid Benzyl Ester Glycosides from Pleione bulbocodioides (Franch.) Rolfe: Promising Fungicide Against Phoma herbarum" . | RECORDS OF NATURAL PRODUCTS 18 . 4 (2024) : 419-435 . |
| APA | Liu, Shilin , Fu, Jiarui , Fu, Yuping , Chen, Yuanan , Zhen, Lijun , Xu, Huiyou et al. Butanedioic Acid Benzyl Ester Glycosides from Pleione bulbocodioides (Franch.) Rolfe: Promising Fungicide Against Phoma herbarum . | RECORDS OF NATURAL PRODUCTS , 2024 , 18 (4) , 419-435 . |
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There are seven species in the genus Nageia, a member of the Podocarpaceae family; five are found in China. They are primarily found in eastern and southern Asia, close to the equator at the 30th parallel north and south, and in coastal mountainous areas and islands in the western Pacific. These herbs are extremely valuable for medicinal purposes. The three species of Nageia that are the subject of most current research on their chemical composition and pharmacological properties are N. nagi, N. fleuryi, and N. wallichiana. There are currently 232 known chemical components, which include steroids, flavonoids, sesquiterpenoids, and diterpenoids. Of these, 86 diterpenoid dilactones comprise most of the chemical components, and only plants of the Nageia genus contain C -ring decarbonized diterpenoid dilactones. These plants exhibit promising pharmacological activities such as anti-tumor, antioxidant, antibacterial, and anti-inflammatory properties. For the first time, an in-depth and systematic evaluation of the chemical constituents and pharmacological properties of plants in the Nageia genus is presented in the this article. This theoretical framework will help in the future investigation and development of medicinal resources and active ingredients within the genus.
Keyword ：
antioxidants antioxidants antitumor antitumor bacteriostatic bacteriostatic diterpenoids diterpenoids Nageia Nageia nagilactones nagilactones
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| GB/T 7714 | Zou, Lijun , Chen, Xiao , Zhang, Jialin et al. Chemical Constituents and Pharmacological Activities of the Genus Nageia [J]. | RECORDS OF NATURAL PRODUCTS , 2024 , 18 (3) : 302-323 . |
| MLA | Zou, Lijun et al. "Chemical Constituents and Pharmacological Activities of the Genus Nageia" . | RECORDS OF NATURAL PRODUCTS 18 . 3 (2024) : 302-323 . |
| APA | Zou, Lijun , Chen, Xiao , Zhang, Jialin , Sun, Qi , Fu, Shuoshuo , Yang, Sha et al. Chemical Constituents and Pharmacological Activities of the Genus Nageia . | RECORDS OF NATURAL PRODUCTS , 2024 , 18 (3) , 302-323 . |
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【目的】优化山苍子精油提取工艺，探究精油抑菌活性，为山苍子精油的加工及应用提供参考数据。【方法】通过响应面法优化山苍子精油提取过程中NaCl体积分数、液料比、蒸馏时间的工艺条件。采用生长速率法探究山苍子精油对瓜果腐霉菌的抑制作用，通过测定精油对菌丝干重、丙二醛含量、还原糖含量、过氧化氢酶、过氧化物酶和超氧化物歧化酶等保护酶活性的影响，探讨了其抑制植物病原真菌的生理生化作用。【结果】确定了最佳工艺条件：NaCl体积分数为2.39%，液料比[V(mL)∶m(g)]为4.8∶1，蒸馏时间4.94 h。在该条件下，精油得率可达4.43%。山苍子精油对瓜果腐霉具有较好抑制效果，EC50值为224.4μg·mL~(-1)。瓜果腐霉菌经山苍子精油处理后，菌丝干重减少，细胞膜通透性增加，菌体内还原糖含量减少，保护酶含量增多。【结论】经响应面优化后的工艺稳定可行，与其他的各类提取方法相比成本低消耗低与得率高。山苍子精油可以通过抑制菌丝生长、破坏细胞膜结构以及降低菌丝体保护酶活性等发挥抑菌活性。
Keyword ：
EC50 EC50 响应面 响应面 山苍子 山苍子 抑菌活性 抑菌活性 瓜果腐霉 瓜果腐霉 生理生化 生理生化
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| GB/T 7714 | 伍楷文 , 阮学瑞 , 孙玮玮 et al. 山苍子精油提取工艺优化及抑菌活性 [J]. | 福建农业学报 , 2023 , 38 (08) : 966-975 . |
| MLA | 伍楷文 et al. "山苍子精油提取工艺优化及抑菌活性" . | 福建农业学报 38 . 08 (2023) : 966-975 . |
| APA | 伍楷文 , 阮学瑞 , 孙玮玮 , 贝加炎 , 潘镇泽 , 徐会有 et al. 山苍子精油提取工艺优化及抑菌活性 . | 福建农业学报 , 2023 , 38 (08) , 966-975 . |
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Litsea cubeba, a deciduous shrub belonging to the Lauraceae family, has a variety of medicinal properties, and its fruit, leaves, roots, and bark are used for treating conditions such as spleen-stomach deficiency, dysphagia, and unidentified tumors. The main chemical components of Litsea cubeba are alkaloids, flavonoids, lignans, terpenes, and their glycosides, with aporphine alkaloids being the most characteristic. Recent studies have demonstrated that Litsea cubeba has a wide variety of pharmacological activities, including antitumor, antioxidant, antimicrobial, anti-inflammatory, and hypoglycemic effects. This article summarizes the chemical composition and pharmacological activities of Litsea cubeba and explores their mechanisms of action, providing a reference for the development and utilization of the Litsea cubeba chemical components.
Keyword ：
biological activity biological activity chemical composition chemical composition Lauraceae Lauraceae Litsea cubeba Litsea cubeba
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| GB/T 7714 | Zhang, Yuqi , Pan, Zhenze , Wu, Kaiwen et al. Research Progress on the Chemical Constituents and Pharmacological Activity of Litsea cubeba (Lour) Pers [J]. | RECORDS OF NATURAL PRODUCTS , 2023 . |
| MLA | Zhang, Yuqi et al. "Research Progress on the Chemical Constituents and Pharmacological Activity of Litsea cubeba (Lour) Pers" . | RECORDS OF NATURAL PRODUCTS (2023) . |
| APA | Zhang, Yuqi , Pan, Zhenze , Wu, Kaiwen , Yan, Ganming , Xu, Huiyou , Gong, Qianfeng et al. Research Progress on the Chemical Constituents and Pharmacological Activity of Litsea cubeba (Lour) Pers . | RECORDS OF NATURAL PRODUCTS , 2023 . |
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On the basis of the structure of natural product lansiumamide B (1), a total of 27 novel cis-enamide compounds were designed and synthesized via Intermediate Derivatization Method. Their chemical structures were characterized by 1H and 13C nuclear magnetic resonance and high-resolution mass spectrometry. The in vitro antifungal activities against Sclerotinia sclerotiorum, Thanatephorus cucumeris and Botrytis cinerea were evaluated by the mycelium linear growth rate method. Most of the compounds showed some activity against each of the fungi at 25 or 50 mu g/mL. The relationship between structure and antifungal activity was also discussed, which showed the cinnamic double bond was critical to maintain the antifungal activity. Notably, among the title compounds, 3e and 3h could inhibit mycelia growth of Botrytis cinerea by approximately 50% (EC50) at 39.17 and 41.25 mu g/mL respectively, which showed better antifungal activity than lansiumamide B (1) with more concise chemical structure. The present study pointed out the correct direction for the development and optimization of lansiumamide B derivatives as potential inhibitors of pathogenic fungi.
Keyword ：
Antifungal Antifungal cis-enamide cis-enamide Lansiumamide B Lansiumamide B Structure activity relationship Structure activity relationship Synthesis Synthesis
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| GB/T 7714 | Xu, Huiyou , Sun, Yuyao , Li, Hongzuo et al. Design, synthesis and antifungal activities of novel cis-enamides via intermediate derivatization method [J]. | ADVANCED AGROCHEM , 2023 , 2 (1) : 97-103 . |
| MLA | Xu, Huiyou et al. "Design, synthesis and antifungal activities of novel cis-enamides via intermediate derivatization method" . | ADVANCED AGROCHEM 2 . 1 (2023) : 97-103 . |
| APA | Xu, Huiyou , Sun, Yuyao , Li, Hongzuo , Lai, Yunrong , Zhao, Tongchao , Meng, Yufei et al. Design, synthesis and antifungal activities of novel cis-enamides via intermediate derivatization method . | ADVANCED AGROCHEM , 2023 , 2 (1) , 97-103 . |
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本发明公开的一种从大花独蒜兰中提取纯化的联苄类化合物及用途，属于天然产物提取技术领域。包括化合物1和化合物2，其中化合物1为大花独蒜兰甲素，5, 3'‑二羟基‑2‑(3, 4‑二羟基苄基)‑3‑甲氧基‑联苄，化合物2为大花独蒜兰乙素，5, 3'‑二羟基‑2‑(p‑羟基苄基)‑4'‑甲氧基‑联苄。通过体外抗氧化活性试验表明大花独蒜兰联苄类化合物对DPPH自由基有显著的清除能力，与阳性对照药维生素C相当，表现出良好的抗氧化活性。
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| GB/T 7714 | 倪林 , 傅佳蕊 , 颜武华 et al. 一种从大花独蒜兰中提取纯化的联苄类化合物及用途 : CN202210416799.7[P]. | 2022-04-20 . |
| MLA | 倪林 et al. "一种从大花独蒜兰中提取纯化的联苄类化合物及用途" : CN202210416799.7. | 2022-04-20 . |
| APA | 倪林 , 傅佳蕊 , 颜武华 , 李威 , 徐会有 . 一种从大花独蒜兰中提取纯化的联苄类化合物及用途 : CN202210416799.7. | 2022-04-20 . |
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A new alkaloid, hositisine E (1) and nine known compounds (2-10) were isolated from the seeds of Ormosia hosiei Hemsl. et Wils. Compound 1 was identified on the basis of a combination of UV, IR, NMR, CD and HRESIMS data. The structures of the known compounds were determined as isoprunetin (2), biochanin A (3), ononin (4), 4',8-dimethoxy-7-O-beta-D-glucopyranosylisoflavone (5), sphaerobioside (6), ambocin(7), rutin (8), kaempferol-3-rutinoside (9) and narcissin (10). In the anti-inflammatory activity assay, compounds 1 3,7 displayed inhibitory effects against lipopolysaccharide-induced interleukin-6release in RAW264.7 macrophages, exhibiting IC50 values of 19.4 - 58.9 mu M.
Keyword ：
anti-inflammatory anti-inflammatory cytisine-like alkaloid cytisine-like alkaloid flavonoid flavonoid hositisine hositisine IL-6 IL-6 Ormosia hosiei Ormosia hosiei
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| GB/T 7714 | Zheng, Lijun , Zhang, Linjing , Huang, Jianyong et al. A New Alkaloid from Ormosia hosiei Hemsl. et Wils [J]. | RECORDS OF NATURAL PRODUCTS , 2022 , 16 (6) : 579-584 . |
| MLA | Zheng, Lijun et al. "A New Alkaloid from Ormosia hosiei Hemsl. et Wils" . | RECORDS OF NATURAL PRODUCTS 16 . 6 (2022) : 579-584 . |
| APA | Zheng, Lijun , Zhang, Linjing , Huang, Jianyong , Zhang, Xiaoqin , Huang, Mingqing , Xu, Huiyou et al. A New Alkaloid from Ormosia hosiei Hemsl. et Wils . | RECORDS OF NATURAL PRODUCTS , 2022 , 16 (6) , 579-584 . |
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