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学者姓名：魏太云
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Abstract ：
Insect melanization triggered by the conversion of prophenoloxidase to active phenoloxidase via serine proteases (SPs) is an important immediate immune response. However, how phytoplasmas evade this immune response to promote their propagation in insect vectors remains unknown. Here, we demonstrate that infection of leafhopper vectors with rice orange leaf phytoplasma (ROLP) activates the mild melanization response in hemolymph. ROLP-encoded effector protein SRP1 is highly expressed in leafhopper hemolymph, where it competitively binds to SP2, thereby inhibiting SP2-mediated cleavage of prophenoloxidase into active phenoloxidase. Consequently, microinjection of SRP1 effectively suppresses the melanization response and enhances ROLP propagation. The histidine residue at position 23 of SRP1 is essential for SRP1-SP2 interaction, and the mutation of this position abolishes its ability to inhibit such SP2-meidated cleavage, ultimately promoting melanization response and inhibiting ROLP propagation. Our findings provide insights into how phytoplasmas antagonize insect melanization response to facilitate their persistent transmission.
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| GB/T 7714 | Zhang, Xiao-Feng , Li, Zhanpeng , Qiu, Jiaxin et al. A phytoplasma effector suppresses insect melanization immune response to promote pathogen persistent transmission [J]. | SCIENCE ADVANCES , 2025 , 11 (5) . |
| MLA | Zhang, Xiao-Feng et al. "A phytoplasma effector suppresses insect melanization immune response to promote pathogen persistent transmission" . | SCIENCE ADVANCES 11 . 5 (2025) . |
| APA | Zhang, Xiao-Feng , Li, Zhanpeng , Qiu, Jiaxin , Zhang, Ruonan , Jiang, Zhoumian , Wang, Tengfei et al. A phytoplasma effector suppresses insect melanization immune response to promote pathogen persistent transmission . | SCIENCE ADVANCES , 2025 , 11 (5) . |
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本发明属于植物病害防治技术领域，具体涉及一种柑橘木虱源的抗菌肽DcAMP2的制备和应用。所述抗菌肽DcAMP2的氨基酸序列为SEQ ID NO.1，编码所述抗菌肽DcAMP2的基因的核苷酸序列为SEQ ID NO.2。本发明采用原核表达质粒构建包含编码抗菌肽DcAMP2的基因的重组质粒，实现了抗菌肽DcAMP2的原核表达，方法简单易行。原核表达获得的抗菌肽DcAMP2在纯化后对柑橘黄龙病菌近缘细菌费氏中华根瘤菌具有明显的抑菌效果，可显著降低带有柑橘黄龙病菌的甜橙树中的柑橘黄龙病菌滴度。
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| GB/T 7714 | 魏太云 , 李猷 , 陈倩 et al. 一种柑橘木虱源的抗菌肽DcAMP2的制备和应用 : CN202510699670.5[P]. | 2025-05-28 . |
| MLA | 魏太云 et al. "一种柑橘木虱源的抗菌肽DcAMP2的制备和应用" : CN202510699670.5. | 2025-05-28 . |
| APA | 魏太云 , 李猷 , 陈倩 , 宾羽 , 杜宇 . 一种柑橘木虱源的抗菌肽DcAMP2的制备和应用 : CN202510699670.5. | 2025-05-28 . |
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本发明公开了一种抗病毒肽及其防治水稻病毒病的应用。本发明打破了从土壤微生物寻找抗病毒肽的传统思路，创新性地从动物生物体内寻找可能的抗病毒肽；经一系列前期研究，最终确定了8条抗病毒肽序列，经验证，本发明提供的天然来源的抗病毒肽均对水稻病毒病有显著的防治作用，为水稻病毒病的防治提供了一种新的农药，对环境无害，效果非常明显。
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| GB/T 7714 | 魏太云 , 杜宇 , 李猷 et al. 抗病毒肽及其防治水稻病毒病的应用 : CN202510341064.6[P]. | 2025-03-21 . |
| MLA | 魏太云 et al. "抗病毒肽及其防治水稻病毒病的应用" : CN202510341064.6. | 2025-03-21 . |
| APA | 魏太云 , 杜宇 , 李猷 , 宾羽 , 陈倩 . 抗病毒肽及其防治水稻病毒病的应用 : CN202510341064.6. | 2025-03-21 . |
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Insects transmit diverse arthropod-borne viruses. However, it remains largely unknown whether insect innate immune pathways regulate the expression of antiviral factors to mediate the degradation of viral capsids. Here, we discover that transcription factor Dorsal in leafhopper Toll immune pathway binds to the promoter of vertebrate homolog myxovirus resistance-like (MxL) protein to activate its transcription. MxL associates with two different viral particles, promoting ubiquitinated degradation of viral capsids via E3 ubiquitin ligase SIAH1. Notably, MxL forms biomolecular condensates to recruit capsid protein P8 of a destructive rice reovirus and SIAH1. The disordered N-terminal region of MxL is essential for condensate formation. The Arg residue at position 159 of MxL is essential for MxL-P8 interaction and P8 recruitment into condensates. Viral nonstructural protein Pns11 interacts with Dorsal, effectively blocking its nuclear translocation and attenuating antiviral MxL1 expression. Our finding represents the first evidence that MxLs in invertebrates possess broad-spectrum antiviral functions.
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| GB/T 7714 | Du, Yu , Li, You , Xiao, Yuqing et al. Insect antiviral Mx-like protein forms biomolecular condensates to promote viral capsid ubiquitinated degradation [J]. | CELL REPORTS , 2025 , 44 (8) . |
| MLA | Du, Yu et al. "Insect antiviral Mx-like protein forms biomolecular condensates to promote viral capsid ubiquitinated degradation" . | CELL REPORTS 44 . 8 (2025) . |
| APA | Du, Yu , Li, You , Xiao, Yuqing , Jia, Dongsheng , Wei, Taiyun . Insect antiviral Mx-like protein forms biomolecular condensates to promote viral capsid ubiquitinated degradation . | CELL REPORTS , 2025 , 44 (8) . |
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唾液蛋白是刺吸式口器介体昆虫唾液的重要成分，在昆虫取食过程中调控寄主植物的防御反应、自身取食的顺利进行和病毒的有效传播。本文围绕昆虫唾液蛋白与植物防御反应的“攻-守”关系，阐述唾液蛋白作为激发子触发植物防御反应，以及作为效应子抑制植物防御反应的作用机制，论述了唾液激发子和效应子对介体昆虫取食和传播病毒的影响。介体昆虫唾液蛋白作为介导病毒传播的跨界信号，将成为制定病害调控策略的重要靶标。昆虫唾液蛋白的研究也将为开拓植物病毒病有效防控的新技术提供重要的理论基础。
Keyword ：
介体昆虫 介体昆虫 唾液蛋白 唾液蛋白 昆虫取食 昆虫取食 植物病毒 植物病毒 植物防御 植物防御
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| GB/T 7714 | 张洪祥 , 陈倩 , 魏太云 . 介体昆虫利用唾液蛋白调控植物防御促进自身取食和病毒传播的研究进展 [J]. | 生命科学 , 2025 , 37 (05) : 514-521 . |
| MLA | 张洪祥 et al. "介体昆虫利用唾液蛋白调控植物防御促进自身取食和病毒传播的研究进展" . | 生命科学 37 . 05 (2025) : 514-521 . |
| APA | 张洪祥 , 陈倩 , 魏太云 . 介体昆虫利用唾液蛋白调控植物防御促进自身取食和病毒传播的研究进展 . | 生命科学 , 2025 , 37 (05) , 514-521 . |
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Huanglongbing (HLB), one of the most destructive diseases of citrus, is caused by the fastidious Gram-negative alpha-proteobacteria bacterium Candidatus Liberibacter asiaticus (CLas) and vectored by the Asian citrus psyllid (ACP), Diaphorina citri. Currently, there are no highly effective management strategies for HLB. This review focuses on specific aspects of HLB research, including the global distribution of Candidatus Liberibacter species in citrus, HLB status in major citrus-producing countries and plant-pathogen interactions. The elucidation of virulence effectors used by CLas is explored, focusing on the molecular mechanisms that enable the pathogen to manipulate the host plant, and the insect vector ACP to evade their immune systems. Biotechnological approaches and possible management methods for minimizing HLB and ACP risks are reviewed. This review provides a summary of the CLas Sec-delivered effectors, CLas flagellar genes, tight adherence pilus, transcriptional regulators and facilitates the development of integrated and sustainable solutions to safeguard citrus cultivation. (c) 2025 Society of Chemical Industry.
Keyword ：
biotechnological approaches biotechnological approaches CLas CLas Diaphorina citri Diaphorina citri host-pathogen interactions host-pathogen interactions management methods management methods virulence effectors virulence effectors
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| GB/T 7714 | Younas, Muhammad , Zheng, Zheng , Atiq, Muhammad et al. Insights into the Huanglongbing pandemic focusing on transmission biology, virulence factors and multifaceted management strategies [J]. | PEST MANAGEMENT SCIENCE , 2025 , 81 (10) : 6076-6094 . |
| MLA | Younas, Muhammad et al. "Insights into the Huanglongbing pandemic focusing on transmission biology, virulence factors and multifaceted management strategies" . | PEST MANAGEMENT SCIENCE 81 . 10 (2025) : 6076-6094 . |
| APA | Younas, Muhammad , Zheng, Zheng , Atiq, Muhammad , Wei, Taiyun , Li, You . Insights into the Huanglongbing pandemic focusing on transmission biology, virulence factors and multifaceted management strategies . | PEST MANAGEMENT SCIENCE , 2025 , 81 (10) , 6076-6094 . |
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由水稻矮缩病毒(Rice dwarf virus, RDV)引起的水稻矮缩病是危害水稻安全生产的主要病毒病害，建立RDV的监测技术体系对于水稻矮缩病的田间早期预警与防控具有重要意义。本研究通过反转录PCR(Reverse transcription-PCR, RT-PCR)从RDV感染的水稻病株中扩增1 056 bp的P9基因片段，并将其在大肠杆菌(Escherichia coli)BL21(DE3)中表达。以纯化的P9蛋白为抗原免疫新西兰雄兔，制备P9多克隆抗血清。酶联免疫吸附测定(Enzyme-linked immunosorbent assay, ELISA)结果显示该抗血清效价为1:32 000。蛋白质印迹(Western blotting)结果表明经抗原亲和纯化获得的多克隆抗体可特异性识别RDV感染的水稻病株及带毒介体黑尾叶蝉中的RDV P9蛋白。进一步将该多克隆抗体应用于间接ELISA和斑点ELISA(dot-ELISA)分析，并结合RT-PCR对采集自福建省莆田市仙游县的田间样品，包括水稻、稗草及3种昆虫介体(黑尾叶蝉、电光叶蝉、褐飞虱)共223份样本进行检测。结果显示：相对于RDV,水稻和稗草的感病率分别为29.03%和19.05%,黑尾叶蝉、电光叶蝉和褐飞虱的带毒率分别为12.28%、2.56%和0。本研究成功制备了高效价、高特异性的RDV P9多克隆抗体，基于此建立的血清学检测方法不仅提升了水稻矮缩病诊断的可靠性，更为后续P9蛋白功能研究及RDV检测提供了技术支撑。
Keyword ：
多克隆抗体 多克隆抗体 次要外壳蛋白P9 次要外壳蛋白P9 水稻矮缩病毒(RDV) 水稻矮缩病毒(RDV)
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| GB/T 7714 | 李晶 , 张雅婷 , 林泽芬 et al. 水稻矮缩病毒次要外壳蛋白P9多克隆抗体的制备和应用 [J]. | 植物病理学报 , 2025 , 55 (04) : 991-1000 . |
| MLA | 李晶 et al. "水稻矮缩病毒次要外壳蛋白P9多克隆抗体的制备和应用" . | 植物病理学报 55 . 04 (2025) : 991-1000 . |
| APA | 李晶 , 张雅婷 , 林泽芬 , 魏太云 , 陈倩 . 水稻矮缩病毒次要外壳蛋白P9多克隆抗体的制备和应用 . | 植物病理学报 , 2025 , 55 (04) , 991-1000 . |
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Insect Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a crucial role in antiviral defense, yet how arboviruses activate this pathway remains unclear. Here, we reveal that outer capsid protein of a double-stranded RNA (dsRNA) arbovirus (rice gall dwarf virus, RGDV) directly binds the Dome receptor's extracellular domain, triggering receptor dimerization and JAK/STAT activation. Structural and mutational analyses pinpoint cysteine 743 in Dome as essential for viral recognition, establishing Dome as the first identified viral pattern recognition receptor (PRR) in insects capable of initiating JAK/ STAT signaling, a pathway previously thought to be exclusively cytokine dependent. Furthermore, we identify viperin as a transcriptional factor STAT-regulated antiviral effector with broad-spectrum activity against multiple rice viruses. Intriguingly, RGDV's nonstructural protein Pns11 competitively binds STAT, blocking its phosphorylation by JAK and nuclear translocation, thereby suppressing viperin expression. These findings elucidate how leafhopper Dome functions as a viral PRR and how arboviruses antagonize Dome-JAK-STAT signaling to promote persistent viral infection.
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| GB/T 7714 | Chen, Siyu , Tang, Yupeng , Zhang, Chunyu et al. Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression [J]. | CELL REPORTS , 2025 , 44 (8) . |
| MLA | Chen, Siyu et al. "Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression" . | CELL REPORTS 44 . 8 (2025) . |
| APA | Chen, Siyu , Tang, Yupeng , Zhang, Chunyu , Li, You , Jia, Dongsheng , Wei, Taiyun . Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression . | CELL REPORTS , 2025 , 44 (8) . |
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Janus kinase/signal transducer and activator of transcription (JAK/STAT) immune response traditionally requires cytokine binding to receptors for activation; however, it remains unclear whether cytokine receptors function as direct pattern recognition receptors (PRRs) that recognise viral envelopes. In this study, we demonstrate that cytokine receptor Domeless (Dome) in leafhopper Recilia dorsalis directly recognises glycoprotein (G) of an important rice rhabdovirus. This binding induces Dome dimerisation, which initiates JAK/STAT pathway and leads to STAT-dependent expression of antiviral immune effector in R. dorsalis (RdIE1). RdIE1 suppresses viral replication by inhibiting the RNA-binding activity of viral large polymerase (L). Dome residue T659 is essential for G recognition and L residues E774 and D775 are required for RdIE1 target. Notably, virus-encoded phosphoprotein competitively inhibits the phosphorylation of STAT by casein kinase II (CK2 beta), thereby abrogating STAT-dependent transactivation of target genes. Our findings redefine Dome as a viral sensor and reveal a biphasic strategy that balances antiviral immunity with persistent viral infection in insect vectors.
Keyword ：
antiviral immune effector antiviral immune effector JAK/STAT pathway JAK/STAT pathway pathogens pathogens persistent viral infection persistent viral infection rhabdovirus rhabdovirus signalling signalling
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| GB/T 7714 | Yu, Tingting , Li, You , Xu, Mengjia et al. Rhabdovirus Glycoprotein Triggers Janus Kinase/Signal Transducer and Activator of Transcription Antiviral Immunity via Direct Recognition by Insect Dome Receptor [J]. | PLANT CELL AND ENVIRONMENT , 2025 , 49 (1) : 94-110 . |
| MLA | Yu, Tingting et al. "Rhabdovirus Glycoprotein Triggers Janus Kinase/Signal Transducer and Activator of Transcription Antiviral Immunity via Direct Recognition by Insect Dome Receptor" . | PLANT CELL AND ENVIRONMENT 49 . 1 (2025) : 94-110 . |
| APA | Yu, Tingting , Li, You , Xu, Mengjia , Wan, Zhihao , Jia, Dongsheng , Wei, Taiyun . Rhabdovirus Glycoprotein Triggers Janus Kinase/Signal Transducer and Activator of Transcription Antiviral Immunity via Direct Recognition by Insect Dome Receptor . | PLANT CELL AND ENVIRONMENT , 2025 , 49 (1) , 94-110 . |
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本实用新型涉及一种适合稻叶蝉和稻飞虱的圆筒形饲养管，包括上端具有管口的圆筒形饲养管本体，所述饲养管本体的上端管口覆盖有用以封口的防虫网，所述饲养管本体的周侧壁设有一对相对立分布的、便利于水稻叶片贯穿的通孔，饲养管本体的下部连接有用于插设在土里的支撑架；所述通孔内设置有封堵件。本实用新型通过在饲养管侧壁设置以利于水稻叶片贯穿的通孔，并借助插设在土里的支撑架对饲养管进行支撑，整体结构简单，使用时占用空间小，便于操作人员观察昆虫的饲养情况，对水稻的生长不会产生显著的影响。
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| GB/T 7714 | 陈倩 , 魏太云 . 一种适合稻叶蝉和稻飞虱的圆筒形饲养管 : CN202421200068.X[P]. | 2024-05-29 . |
| MLA | 陈倩 et al. "一种适合稻叶蝉和稻飞虱的圆筒形饲养管" : CN202421200068.X. | 2024-05-29 . |
| APA | 陈倩 , 魏太云 . 一种适合稻叶蝉和稻飞虱的圆筒形饲养管 : CN202421200068.X. | 2024-05-29 . |
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