Query：
学者姓名：陈启建
Refining：
Year
Type
Indexed by
Source
Complex
Co-Author
Language
Clean All
Abstract ：
The infection and resistance of pathogenic fungi pose a significant threat to food crop safety, highlighting the urgent need for new green antifungal agents. Fusarium acid (FA) with its simple and novel structure correlates with the principles of green pesticides and has demonstrated substantial broad-spectrum antifungal activity. In a previous study, several promising lead compounds were identified. This study focused on further optimizing lead compound A1. Its inhibitory effect was evaluated against six different pathogenic fungi and several new promising compounds were identified. Notably, the anti-Magnaporthe oryzae (M. oryzae) activity of compound B4 was significantly enhanced with an EC50 value of 910 ng/mL. Rice safety tests indicated that B4 not only exhibited no adverse effect on rice growth and chlorophyll synthesis but also induced plant immunity by increasing the levels of polyphenol oxidase (PPO), peroxidase (POD), and superoxide dismutase (SOD), and soluble sugars. Further investigations into the antifungal mechanism of B4 indicated that it enhanced the permeability and damage of the mycelial membrane, thereby leading to electrolyte leakage and the loss of essential cellular substances. Subsequently, B4 induced the production of reactive oxygen species (ROS) in M. oryzae cell, including center dot OH, center dot O2 -, and 1O2, while promoting increased levels of malondialdehyde (MDA) and SOD enzyme activity. Rice infection tests indicated that B4 effectively inhibited M. oryzae conidia activity and inhibited melanin production. These findings indicated that FA derivatives hold significant potential as a new strategy for M. oryzae disease management and offer valuable insights for the control of plant fungal diseases.
Keyword ：
3D-QSAR 3D-QSAR fungicidal activity fungicidal activity fusaric acid derivatives fusaric acid derivatives safety index safety index
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Huang, Bin Bin , Gao, Ming Wei , Wang, Xi Guang et al. From Spear to Shield: A Novel Antifungal Drug that Safely Enhances Rice Immune Defenses [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (13) : 7547-7561 . |
| MLA | Huang, Bin Bin et al. "From Spear to Shield: A Novel Antifungal Drug that Safely Enhances Rice Immune Defenses" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73 . 13 (2025) : 7547-7561 . |
| APA | Huang, Bin Bin , Gao, Ming Wei , Wang, Xi Guang , Huang, Xin Yi , Li, Guo , Song, Li Yan et al. From Spear to Shield: A Novel Antifungal Drug that Safely Enhances Rice Immune Defenses . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (13) , 7547-7561 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Rice stripe disease caused by the rice stripe virus (RSV), which infects many Poaceae species in nature, is one of the most devastating plant viruses in rice that causes enormous losses in production. Ailanthone is one of the typical C20 quassinoids synthesized by the secondary metabolism of Ailanthus altissima, which has been proven to be a biologically active natural product with promising prospects and great potential for use as a lead structure for pesticide development. Based on the achievement of the systemic infection and replication of RSV in Nicotiana benthamiana plants and rice protoplasts, the antiviral properties of Ailanthone were investigated by determining its effects on viral-coding RNA gene expression using reverse transcription polymerase chain reaction, and Western blot analysis. Ailanthone exhibited a dose-dependent inhibitory effect on RSV NSvc3 expression in the assay in both virus-infected tobacco plants and rice protoplasts. Further efforts revealed a potent inhibitory effect of Ailanthone on the expression of seven RSV protein-encoding genes, among which NS3, NSvc3, NS4, and NSvc4 are the most affected genes. These facts promoted an extended and greater depth of understanding of the antiviral nature of Ailanthone against plant viruses, in addition to the limited knowledge of its anti-tobacco mosaic virus properties. Moreover, the leaf disc method introduced and developed in the study for the detection of the antiviral activity of Ailanthone facilitates an available and convenient screening method for anti-RSV natural products or synthetic chemicals.
Keyword ：
ailanthone ailanthone coat protein coat protein in vivo antiviral in vivo antiviral movement protein movement protein quassinoid quassinoid rice stripe virus rice stripe virus
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Tan, Qingwei , Zhu, Jianxuan , Ju, Yuanyuan et al. Antiviral Activity of Ailanthone from Ailanthus altissima on the Rice Stripe Virus [J]. | VIRUSES-BASEL , 2024 , 16 (1) . |
| MLA | Tan, Qingwei et al. "Antiviral Activity of Ailanthone from Ailanthus altissima on the Rice Stripe Virus" . | VIRUSES-BASEL 16 . 1 (2024) . |
| APA | Tan, Qingwei , Zhu, Jianxuan , Ju, Yuanyuan , Chi, Xinlin , Cao, Tangdan , Zheng, Luping et al. Antiviral Activity of Ailanthone from Ailanthus altissima on the Rice Stripe Virus . | VIRUSES-BASEL , 2024 , 16 (1) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
In research related to fungicides, the development of compounds from natural products with high antifungal activity has attracted considerable attention. Fusaric acid (FA), an alkaloid isolated from the metabolites of Fusarium oxysporum, is an important precursor for developing pharmacologically active herbicides. In our previous work, we reported that FA has a wide range of inhibitory activities against 14 plant pathogenic fungi. In particular, it exhibited excellent antifugal effects on Colletotrichum higginsianum (EC50 = 31.7 mu g/mL). Herein, to explore the practical application in the agricultural field, the design and synthesis of three series of FA derivatives and their inhibitory activities against plant pathogenic fungi were examined. Results demonstrated that the optimized FA derivatives had excellent inhibitory activities against C.higginsianum, Helminthosporium (Harpophora maydis), and Pyricularia grisea. In particular, the inhibitory activities were considerably improved when the 5-butyl groups of FA were substituted. The EC50 of C. higginsianum and P. grisea was only 1.2 and 12.0 mu g/mL when 5-butylalkyl groups were substituted with 5-([1,1 '-biphenyl]-4-yl) and 5-phenyl, respectively. Moreover, the safety index of target compounds, which was obtained from the treatment index of medicines, on rice seeds was evaluated. Finally, 16 leading compounds (H4, H22-H24, H27, H29, H30-H34, H37, H45, H50, H52, and H53) were obtained; they had considerable potential for additional modification and optimization as agricultural fungicides. Moreover, three-dimensional quantitative structure-activity relationship models were developed for obtaining a systematic structure-activity relationship profile to explore the possibility of more potent FA derivatives as novel fungicides.
Keyword ：
3D-QSAR 3D-QSAR fungicidal activity fungicidal activity fusaric acid derivatives fusaric acid derivatives safety index safety index
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Huang, Bin Bin , Gao, Ming Wei , Li, Guo et al. Design, Synthesis, Structure-Activity Relationship, and Three-Dimensional Quantitative Structure-Activity Relationship of Fusarium Acid Derivatives and Analogues as Potential Fungicides [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2023 , 71 (47) : 18566-18577 . |
| MLA | Huang, Bin Bin et al. "Design, Synthesis, Structure-Activity Relationship, and Three-Dimensional Quantitative Structure-Activity Relationship of Fusarium Acid Derivatives and Analogues as Potential Fungicides" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71 . 47 (2023) : 18566-18577 . |
| APA | Huang, Bin Bin , Gao, Ming Wei , Li, Guo , Ouyang, Ming-An , Chen, Qi-Jian . Design, Synthesis, Structure-Activity Relationship, and Three-Dimensional Quantitative Structure-Activity Relationship of Fusarium Acid Derivatives and Analogues as Potential Fungicides . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2023 , 71 (47) , 18566-18577 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Phytochemistry investigations on Ailanthus altissima (Mill.) Swingle, a Simaroubaceae plant that is recognized as a traditional herbal medicine, have afforded various natural products, among which C-20 quassinoid is the most attractive for their significant and diverse pharmacological and biological activities. Our continuous study has led to the isolation of two novel quassinoid glycosides, named chuglycosides J and K, together with fourteen known lignans from the samara of A. altissima. The new structures were elucidated based on comprehensive spectra data analysis. All of the compounds were evaluated for their anti-tobacco mosaic virus activity, among which chuglycosides J and K exhibited inhibitory effects against the virus multiplication with half maximal inhibitory concentration (IC50) values of 56.21 +/- 1.86 and 137.74 +/- 3.57 mu M, respectively.
Keyword ：
Ailanthus altissima (Mill Ailanthus altissima (Mill lignanoid lignanoid quassinoid quassinoid Simaroubaceae Simaroubaceae ) Swingle ) Swingle tobacco mosaic virus tobacco mosaic virus
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Tan, Qing-Wei , Ni, Jian-Cheng , Shi, Jian-Ting et al. Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of Ailanthus altissima [J]. | MOLECULES , 2020 , 25 (23) . |
| MLA | Tan, Qing-Wei et al. "Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of Ailanthus altissima" . | MOLECULES 25 . 23 (2020) . |
| APA | Tan, Qing-Wei , Ni, Jian-Cheng , Shi, Jian-Ting , Zhu, Jian-Xuan , Chen, Qi-Jian . Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of Ailanthus altissima . | MOLECULES , 2020 , 25 (23) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
A new phenolic derivative, 4-hydroxyphenol-1-O-[6-O-(E)-feruloyl-beta-d-glucopyranosyl]-(1 -> 6)-beta-d-glucopyranoside (1), and a new terpenylated coumarin, named altissimacoumarin H (2) were identified from the fruit of Ailanthus altissima (Mill.) Swingle (Simaroubaceae), together with ten known compounds (3-12), including two coumarins and eight phenylpropanoids. Their structures were determined on the basis of chemical method and spectroscopic data. Antiviral effect against Tobacco mosaic virus (TMV) of all the compounds obtained were evaluated using leaf-disc method. [GRAPHICS] .
Keyword ：
Ailanthus altissima Ailanthus altissima coumarin coumarin phenylpropanoid phenylpropanoid Simaroubaceae Simaroubaceae Tobacco mosaic virus (TMV) Tobacco mosaic virus (TMV)
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Ni, Jian-Cheng , Shi, Jian-Ting , Tan, Qing-Wei et al. Two new compounds from the fruit of Ailanthus altissima [J]. | NATURAL PRODUCT RESEARCH , 2019 , 33 (1) : 101-107 . |
| MLA | Ni, Jian-Cheng et al. "Two new compounds from the fruit of Ailanthus altissima" . | NATURAL PRODUCT RESEARCH 33 . 1 (2019) : 101-107 . |
| APA | Ni, Jian-Cheng , Shi, Jian-Ting , Tan, Qing-Wei , Chen, Qi-Jian . Two new compounds from the fruit of Ailanthus altissima . | NATURAL PRODUCT RESEARCH , 2019 , 33 (1) , 101-107 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
为了研究红豆树茎枝抑菌活性成分,采用色谱法分离纯化得到16个黄酮类化合物,通过理化性质及波谱技术分别鉴定为圆荚草双糖苷(1)、5,7-二羟基-4'-甲氧基异黄酮-7-O-β-D-葡萄糖苷(2)、4',8-二甲氧基-7-O-β-D-葡萄糖基异黄酮(3)、芒柄花苷(4)、异樱黄素-7-O-β-D-葡萄糖苷(5)、芦丁(6)、山奈酚-3-O-β-D-芸香糖苷(7)、4'-甲氧基异黄酮-7-O-β-D-木糖(1→6)-O-β-D-吡喃葡萄糖苷(8)、4'-甲氧基异黄酮-7-O-β-D-芹糖(1→6)-O-β-D-吡喃葡萄糖苷(9)、染料木素(10)、异樱黄素(11)、2',4',5,7-四羟基异黄酮(12)、大豆素(13)、柚皮素(14)、二氢染料木素(15)、去甲基化美迪紫檀素(16)。其中化合物1～16为首次从红豆树植物中分离得到;化合物1、3、4、6～9、12、15、16首次从红豆属中分离得到;化合物2,5和14对禾谷镰刀菌、西瓜尖镰孢菌、茄病镰刀菌的菌丝生长显示出了中等强度的抑制作用。
Keyword ：
异黄酮 异黄酮 抑菌 抑菌 红豆属 红豆属 红豆树 红豆树 黄酮 黄酮
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 邱亚铁 , 石妍 , 徐会有 et al. 红豆树茎枝中黄酮类成分及其抑菌活性研究 [J]. | 天然产物研究与开发 , 2018 , 30 (12) : 2056-2062 . |
| MLA | 邱亚铁 et al. "红豆树茎枝中黄酮类成分及其抑菌活性研究" . | 天然产物研究与开发 30 . 12 (2018) : 2056-2062 . |
| APA | 邱亚铁 , 石妍 , 徐会有 , 倪林 , 陈启建 , 何碧珠 et al. 红豆树茎枝中黄酮类成分及其抑菌活性研究 . | 天然产物研究与开发 , 2018 , 30 (12) , 2056-2062 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
A new Erythrina alkaloid glycoside, named erythraline-11 beta-O-glucopyranoside, was isolated from the seeds of Erythrina crista-galli L., together with five known Erythrina alkaloids and an indole alkaloid. The structure of the new alkaloid glycoside was elucidated by spectroscopic methods, and all of the compounds were evaluated for their antiviral activity against tobacco mosaic virus.
Keyword ：
antiviral activity antiviral activity Erythrina crista-galli Erythrina crista-galli Erythrinan alkaloid Erythrinan alkaloid fabaceae fabaceae tobacco mosaic virus tobacco mosaic virus
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Tan, Qing-Wei , Ni, Jian-Cheng , Fang, Pei-Hua et al. A New Erythrinan Alkaloid Glycoside from the Seeds of Erythrina crista-galli [J]. | MOLECULES , 2017 , 22 (9) . |
| MLA | Tan, Qing-Wei et al. "A New Erythrinan Alkaloid Glycoside from the Seeds of Erythrina crista-galli" . | MOLECULES 22 . 9 (2017) . |
| APA | Tan, Qing-Wei , Ni, Jian-Cheng , Fang, Pei-Hua , Chen, Qi-Jian . A New Erythrinan Alkaloid Glycoside from the Seeds of Erythrina crista-galli . | MOLECULES , 2017 , 22 (9) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Four novel compoundstwo phenylpropionamides, one piperidine, and one phenolic derivativeswere isolated and identified from the fruit of a medicinal plant, Ailanthus altissima (Mill.) Swingle (Simaroubaceae), together with one known phenylpropionamide, 13 known phenols, and 10 flavonoids. The structures of the new compounds were elucidated as 2-hydroxy-N-[(2-O--d-glucopyranosyl)phenyl]propionamide (1), 2-hydroxy-N-[(2-O--d-glucopyranosyl-(16)--d-glucopyranosyl)phenyl]propionamide (2), 2-carboxyl-piperidine-4-acetic acid methyl ester (4), and 4-hydroxyphenyl-1-O-[6-(hydrogen-3-hydroxy-3-methylpentanedioate)]--d-glucopyranoside (5) based on spectroscopic analysis. All the isolated compounds were evaluated for their inhibitory activity against Tobacco mosaic virus (TMV) using the leaf-disc method. Among the compounds isolated, arbutin (6), -d-glucopyranosyl-(16)-arbutin (7), 4-methoxyphenylacetic acid (10), and corilagin (18) showed moderate inhibition against TMV with IC50 values of 0.49, 0.51, 0.27, and 0.45 mM, respectively.
Keyword ：
Ailanthus altissima Ailanthus altissima flavonoid flavonoid phenols phenols phenylpropionamide phenylpropionamide piperidine piperidine Simaroubaceae Simaroubaceae Tobacco mosaic virus (TMV) Tobacco mosaic virus (TMV)
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Ni, Jian-Cheng , Shi, Jian-Ting , Tan, Qing-Wei et al. Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima [J]. | MOLECULES , 2017 , 22 (12) . |
| MLA | Ni, Jian-Cheng et al. "Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima" . | MOLECULES 22 . 12 (2017) . |
| APA | Ni, Jian-Cheng , Shi, Jian-Ting , Tan, Qing-Wei , Chen, Qi-Jian . Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima . | MOLECULES , 2017 , 22 (12) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
The fermentation and isolation of metabolites produced by an endophytic fungus, which was identified as Phomopsis sp. FJBR-11, based on phylogenetic analysis, led to the identification of six compounds, including dothiorelones A-C, and H, and cytosporones C and U. Among these compounds, cytosporone U exhibited potent inhibitory activity against Tobacco mosaic virus (TMV). Moreover, the crude and a purified exopolysaccharide were proved to possess strong inhibitory effects against the virus infection.
Keyword ：
cytosporone cytosporone dothiorelone dothiorelone Phomopsis Phomopsis Tobacco mosaic virus Tobacco mosaic virus
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Tan, Qing-Wei , Fang, Pei-Hua , Ni, Jian-Cheng et al. Metabolites Produced by an Endophytic Phomopsis sp and Their Anti-TMV Activity [J]. | MOLECULES , 2017 , 22 (12) . |
| MLA | Tan, Qing-Wei et al. "Metabolites Produced by an Endophytic Phomopsis sp and Their Anti-TMV Activity" . | MOLECULES 22 . 12 (2017) . |
| APA | Tan, Qing-Wei , Fang, Pei-Hua , Ni, Jian-Cheng , Gao, Fangluan , Chen, Qi-Jian . Metabolites Produced by an Endophytic Phomopsis sp and Their Anti-TMV Activity . | MOLECULES , 2017 , 22 (12) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
本发明涉及一株代谢产物对病毒具有抑制作用的真菌菌株及其应用，该菌株为链格孢(Altemaria altemata)FJA14，已于2015年06月05日在中国微生物菌种保藏管理委员会普通微生物中心登记保藏，保藏编号为CGMCC No. 10902。菌株FJA14可用于制备病毒病防治制剂。本发明的菌株FJA14来源于植物内生菌，制备的活性化学成分具有抗病毒活性高、对环境无污染等特点，因此，从FJA14发酵液中分离提取抗病毒活性物质，并将其研制成天然抗病毒剂，具有广阔的应用前景。
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 陈启建 , 谭庆伟 , 杨波 . 一株产抗病毒活性物质的真菌菌株及其应用 : CN201610071084.7[P]. | 2016-02-02 . |
| MLA | 陈启建 et al. "一株产抗病毒活性物质的真菌菌株及其应用" : CN201610071084.7. | 2016-02-02 . |
| APA | 陈启建 , 谭庆伟 , 杨波 . 一株产抗病毒活性物质的真菌菌株及其应用 : CN201610071084.7. | 2016-02-02 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
