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学者姓名：王惠
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Abstract ：
High-throughput sequencing was used to identify and characterize a novel marafivirus from the weed Leptochloa chinensis, which was tentatively named "Leptochloa chinensis marafivirus" (LcMV). The complete genome of the virus consists of 6,178 base pairs, and its nucleotide sequence is 73.82% identical to that of Sorghum almum marafivirus, which is a member of the genus Marafivirus within the family Tymoviridae. The LcMV genome contains a relatively large open reading frame (ORF) encoding a single polyprotein (220.6 kDa) with five functional domains (methyltransferase, papain-like protease, helicase, RNA-dependent RNA polymerase, and coat proteins), which is a characteristic of members of this genus. Furthermore, a 16-nucleotide conserved marafibox sequence was identified at nucleotide positions 5341-5356. The coat protein of LcMV is 68.02% identical to that of Sorghum almum marafivirus. Phylogenetic analysis based on nucleotide and polyprotein sequences showed that LcMV is closely related to members of the genus Marafivirus. Our findings support the classification of LcMV as a member of a new species within this genus. This is the first report of a marafivirus infecting Leptochloa chinensis, a very important weed of rice.
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| GB/T 7714 | Muqmirah, Guangming , Xiao, Guangming , Jie, Pengpeng et al. Sequence analysis and genome organization of a new marafivirus from Leptochloa chinensis [J]. | ARCHIVES OF VIROLOGY , 2025 , 170 (2) . |
| MLA | Muqmirah, Guangming et al. "Sequence analysis and genome organization of a new marafivirus from Leptochloa chinensis" . | ARCHIVES OF VIROLOGY 170 . 2 (2025) . |
| APA | Muqmirah, Guangming , Xiao, Guangming , Jie, Pengpeng , Xu, Zhongtian , Wei, Taiyun , Wang, Hui . Sequence analysis and genome organization of a new marafivirus from Leptochloa chinensis . | ARCHIVES OF VIROLOGY , 2025 , 170 (2) . |
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Autophagy plays a crucial role in virus-host interactions, as viral components and particles can be degraded by the host's autophagic machinery. Additionally, some viruses can hijack autophagy for their own benefit. However, the mechanisms underlying the transcriptional regulation of autophagy by arboviruses in insect vectors remain largely unexplored. In this study, we found that rice dwarf virus (RDV) infection activates the autophagy pathway in the leafhopper vector, Nephotettix cincticeps, and this autophagy activation also facilitates viral infection in the leafhopper. We identified that MYC transcription factor regulates the expression of autophagy proteins ATG5 and ATG8 by directly targeting their promoters. A transcription regulator SMARCB1 binds to MYC and impedes its recognition of the ATG5 and ATG8 promoters, thus negatively regulating their expression. Moreover, NcSMARCB1 negatively regulates ATG5 expression by directly binding to its promoter. RDV major outer capsid protein P8 blocks the nuclear translocation of SMARCB1, disrupting the SMARCB1-MYC interaction and thereby relieving the transcriptional inhibition of ATG5 and ATG8, which leads to autophagy activation. Furthermore, major outer capsid protein P8 of rice gall dwarf virus (RGDV), same to RDV belonging to plant reoviruses, also interacts with SMARCB1 in leafhopper Recilia dorsalis, preventing its nuclear translocation. Similarly, suppression of SMARCB1 expression enhances autophagy formation and promotes RGDV infection. These findings highlight the critical role of insect vector SMARCB1 and MYC in regulating autophagy in response to arbovirus infection.
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| GB/T 7714 | Wang, Hui , Liu, Runfa , Xiao, Guangming et al. Reoviruses hijack the SMARCB1-MYC transcriptional regulation complex to activate autophagy for persistent viral infection in leafhopper vector [J]. | PLOS PATHOGENS , 2025 , 21 (10) . |
| MLA | Wang, Hui et al. "Reoviruses hijack the SMARCB1-MYC transcriptional regulation complex to activate autophagy for persistent viral infection in leafhopper vector" . | PLOS PATHOGENS 21 . 10 (2025) . |
| APA | Wang, Hui , Liu, Runfa , Xiao, Guangming , Li, Yanan , Li, Bozhong , Chen, Qian et al. Reoviruses hijack the SMARCB1-MYC transcriptional regulation complex to activate autophagy for persistent viral infection in leafhopper vector . | PLOS PATHOGENS , 2025 , 21 (10) . |
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Co-infection with symbiotic viruses and arboviruses with synergistic effects in insect vectors are common in nature, but the underlying mechanism remains elusive. Here, we identify a novel symbiotic virus, leafhopper Recilia dorsalis bunyavirus (RdBV), which enhances the transmission efficiency of cytorhabdovirus rice stripe mosaic virus (RSMV, a plant rhabdovirus) in field. RSMV infection activates the expression of R. dorsalis E3 ubiquitin ligase Seven in absentia (RdSina), while RdBV infection suppresses its expression. We show that RdSina directly targets and mediates the degradation of RSMV phosphoprotein (P), thereby attenuating the formation of P-induced viroplasm that are crucial for viral replication. RdSina interacts with nonstructural protein NSs2 of RdBV but does not mediate its ubiquitination. However, NSs2 competes with RSMV P for binding to RdSina, thus neutralizing RdSina's ability in mediating P degradation. Furthermore, we find that the MYC transcription factor binds to the promoter sequences of RdSina, activating its transcription. However, NSs2 also directly binds to the same promoter sequences of RdSina and competitively suppresses MYC-activated RdSina transcription. Together, NSs2 obstructs the function of RdSina in mediating P degradation, ultimately promoting RSMV propagation in co-infected vectors. These findings elucidate how insect symbiotic viruses negatively regulate E3 ubiquitin ligases to benefit arbovirus transmission by co-infected insect vectors, which potentially is a common phenomenon in nature.
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| GB/T 7714 | Wang, Hui , Zhang, Jieting , Liu, Runfa et al. An insect symbiotic virus promotes the transmission of a phytoarbovirus via inhibiting E3 ubiquitin ligase Sina [J]. | PLOS PATHOGENS , 2025 , 21 (5) . |
| MLA | Wang, Hui et al. "An insect symbiotic virus promotes the transmission of a phytoarbovirus via inhibiting E3 ubiquitin ligase Sina" . | PLOS PATHOGENS 21 . 5 (2025) . |
| APA | Wang, Hui , Zhang, Jieting , Liu, Runfa , Li, You , Du, Yu , Wei, Taiyun . An insect symbiotic virus promotes the transmission of a phytoarbovirus via inhibiting E3 ubiquitin ligase Sina . | PLOS PATHOGENS , 2025 , 21 (5) . |
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In this study, we report the discovery of a novel virus, Yunxiao leafhopper virus 1 (YXLeV1), found in the insect vector Recilia dorsalis, a significant pest of rice crop. The complete genome of YXLeV1, consisting of 14,115 bp, was sequenced and analyzed. The whole viral genome shares only 36.32% identity with the RNA-dependent RNA polymerase (RdRp) of Hubei diptera virus 11, belonging to genus Alasvirus. It contains four open reading frames encoding a nucleoprotein (N), a hypothetical protein (p78) of unknown function, a glycoprotein (G), and an RNA-dependent RdRp. The N, G, and RdRp proteins of YXLeV1 share 22.0%, 34.05%, and 36.32% amino acid sequence identity with the corresponding sequence of Hubei diptera virus 11. As per the genus demarcation criteria of the family Xinmoviridae, viruses sharing less than 60% amino acid identity in the RdRp sequence with known members are considered to belong to new genera, so the observed 36.32% identity between YXLeV1 and Hubei diptera virus 11 supports the classification of YXLeV1 as the first member of a novel genus, which we propose to name Recilivirus. Phylogenetic analysis further confirms that YXLeV1 is distantly related to Hubei diptera virus 11, the sole member of the genus Alasvirus, and forms a separate clade supporting its classification as a member of a new genus. Given the ecological significance of R. dorsalis as a vector, this discovery adds to the catalog of viruses associated with this species and contributes to our understanding of virus vector associations.
Keyword ：
Leafhopper Leafhopper Phylogenetic analysis Phylogenetic analysis Recilia dorsalis Recilia dorsalis Recilivirus Recilivirus Virus Virus
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| GB/T 7714 | Naseem, Muqmirah , Li, Bozhong , Xiao, Guangming et al. Discovery and genome analysis of Yunxiao leafhopper virus 1 in Recilia dorsalis [J]. | VIRUS GENES , 2025 , 61 (6) : 767-771 . |
| MLA | Naseem, Muqmirah et al. "Discovery and genome analysis of Yunxiao leafhopper virus 1 in Recilia dorsalis" . | VIRUS GENES 61 . 6 (2025) : 767-771 . |
| APA | Naseem, Muqmirah , Li, Bozhong , Xiao, Guangming , Xu, Zhongtian , Wei, Taiyun , Wang, Hui . Discovery and genome analysis of Yunxiao leafhopper virus 1 in Recilia dorsalis . | VIRUS GENES , 2025 , 61 (6) , 767-771 . |
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Using high-throughput sequencing, a novel mastrevirus was discovered infecting the weed Leptochloa chinensis and was designated as "Leptochloa chinensis mastrevirus" (LcMAV). The full genome sequence of LcMAV is a 2825 nt long. Phylogenetic analysis and sequence comparisons revealed that LcMAV is genetically distinct but shares significant sequence similarity with Sporobolus striate mosaic virus 1 (SSMV-1), suggesting a close evolutionary relationship. The LcMAV genome contains four major open reading frames encoding a movement protein (MP), a capsid protein (CP), and two replication-associated proteins (RepA and Rep) and also contains two intergenic regions (IRs). The virus was identified through comprehensive genomic sequencing, utilizing both RNA and DNA extraction methods, as well as rolling-circle amplification (RCA) for recovery of the full genome. These findings emphasize the role of L. chinensis as a host for newly emerging viruses that might endanger nearby rice crops, highlighting the need for enhanced surveillance and monitoring of viral diversity in agricultural systems. This discovery contributes to our understanding of the evolutionary dynamics of the family Geminiviridae and emphasizes the role of weeds in the transmission of viruses to economically important crops.
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| GB/T 7714 | Naseem, Muqmirah , Xiao, Guangming , Li, Yanan et al. Genomic and phylogenetic insights into a new mastrevirus from Leptochloa chinensis [J]. | ARCHIVES OF VIROLOGY , 2025 , 170 (11) . |
| MLA | Naseem, Muqmirah et al. "Genomic and phylogenetic insights into a new mastrevirus from Leptochloa chinensis" . | ARCHIVES OF VIROLOGY 170 . 11 (2025) . |
| APA | Naseem, Muqmirah , Xiao, Guangming , Li, Yanan , Xu, Zhongtian , Wei, Taiyun , Wang, Hui . Genomic and phylogenetic insights into a new mastrevirus from Leptochloa chinensis . | ARCHIVES OF VIROLOGY , 2025 , 170 (11) . |
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Insects are the host or vector of diverse viruses including those that infect vertebrates, plants, and fungi. Insect viruses reside inside their insect hosts and are vertically transmitted from parent to offspring. The insect virus-host relationship is intricate, as these viruses can impact various aspects of insect biology, such as development, reproduction, sex ratios, and immunity. Arthropod-borne viruses (arboviruses) that cause substantial global health or agricultural problems can also be vertically transmitted to insect vector progeny. Multiple infections with insect viruses and arboviruses are common in nature. Such coinfections involve complex interactions, including synergism, dependence, and antagonism. Recent studies have shed light on the influence of insect viruses on the competence of insect vectors for arboviruses. In this review, we focus on the biological effects of insect viruses on the transmission of arboviruses by insects. We also discuss the potential mechanisms by which insect viruses affect the ability of hosts to transmit arboviruses, as well as potential strategies for disease control through manipulation of insect viruses. Analyses of the interactions among insect vectors, insect viruses and arboviruses will provide new opportunities for development of innovative strategies to control arbovirus transmission.
Keyword ：
arbovirus arbovirus insect biology insect biology insect vectors insect vectors insect virus insect virus interaction interaction transmission transmission
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| GB/T 7714 | Wang, Hui , Chen, Qian , Wei, Taiyun . Complex interactions among insect viruses-insect vector-arboviruses [J]. | INSECT SCIENCE , 2023 , 31 (3) : 683-693 . |
| MLA | Wang, Hui et al. "Complex interactions among insect viruses-insect vector-arboviruses" . | INSECT SCIENCE 31 . 3 (2023) : 683-693 . |
| APA | Wang, Hui , Chen, Qian , Wei, Taiyun . Complex interactions among insect viruses-insect vector-arboviruses . | INSECT SCIENCE , 2023 , 31 (3) , 683-693 . |
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Arboviruses and symbiotic viruses can be paternally transmitted by male insects to their offspring, but the mechanism remains largely unknown. Here, the authors identify the sperm-specific serpin protein HongrES1 of the leafhopper Recilia dorsalis as a mediator of paternal transmission of the reovirus rice gall dwarf virus and of a previously undescribed symbiotic virus of the Virgaviridae family, Recilia dorsalis filamentous virus, via direct binding of virions to leafhopper sperm surfaces and subsequent paternal transmission via interaction with both viral capsid proteins. Arboviruses and symbiotic viruses can be paternally transmitted by male insects to their offspring for long-term viral persistence in nature, but the mechanism remains largely unknown. Here, we identify the sperm-specific serpin protein HongrES1 of leafhopper Recilia dorsalis as a mediator of paternal transmission of the reovirus Rice gall dwarf virus (RGDV) and a previously undescribed symbiotic virus of the Virgaviridae family, Recilia dorsalis filamentous virus (RdFV). We show that HongrES1 mediates the direct binding of virions to leafhopper sperm surfaces and subsequent paternal transmission via interaction with both viral capsid proteins. Direct interaction of viral capsid proteins mediates simultaneously invasion of two viruses into male reproductive organs. Moreover, arbovirus activates HongrES1 expression to suppress the conversion of prophenoloxidase to active phenoloxidase, potentially producing a mild antiviral melanization defense. Paternal virus transmission scarcely affects offspring fitness. These findings provide insights into how different viruses cooperatively hijack insect sperm-specific proteins for paternal transmission without disturbing sperm functions.
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| GB/T 7714 | Wan, Jiajia , Liang, Qifu , Zhang, Ruonan et al. Arboviruses and symbiotic viruses cooperatively hijack insect sperm-specific proteins for paternal transmission [J]. | NATURE COMMUNICATIONS , 2023 , 14 (1) . |
| MLA | Wan, Jiajia et al. "Arboviruses and symbiotic viruses cooperatively hijack insect sperm-specific proteins for paternal transmission" . | NATURE COMMUNICATIONS 14 . 1 (2023) . |
| APA | Wan, Jiajia , Liang, Qifu , Zhang, Ruonan , Cheng, Yu , Wang, Xin , Wang, Hui et al. Arboviruses and symbiotic viruses cooperatively hijack insect sperm-specific proteins for paternal transmission . | NATURE COMMUNICATIONS , 2023 , 14 (1) . |
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Hemipteran insects that transmit plant viruses in a persistent circulative manner acquire, retain and transmit viruses for their entire life. The mechanism enabling this persistence has remained unclear for many years. Here, we determined how wheat dwarf virus (WDV) persists in its leafhopper vector Psammotettix alienus. We found that WDV caused the up-regulation of actin-depolymerizing factor (ADF) at the mRNA and protein levels in the midgut cells of leafhoppers after experiencing a WDV acquisition access period (AAP) of 6, 12 or 24 h. Experimental inhibition of F-actin depolymerization by jasplakinolide and dsRNA injection led to lower virus accumulation levels and transmission efficiencies, suggesting that depolymerization of F-actin regulated by ADF is essential for WDV invasion of midgut cells. Exogenous viral capsid protein (CP) inhibited ADF depolymerization of actin filaments in vitro and in Spodoptera frugiperda 9 (Sf9) cells because the CP competed with actin to bind ADF and then blocked actin filament disassembly. Interestingly, virions colocalized with ADF after a 24-h AAP, just as actin polymerization occurred, indicating that the binding of CP with ADF affects the ability of ADF to depolymerize F-actin, inhibiting WDV entry. Similarly, the luteovirus barley yellow dwarf virus also induced F-actin depolymerization and then polymerization in the gut cells of its vector Schizaphis graminum. Thus, F-actin dynamics are altered by nonpropagative viruses in midgut cells to enable virus persistence in vector insects.
Keyword ：
F-actin dynamics F-actin dynamics geminivirus geminivirus hemipteran hemipteran luteovirus luteovirus persistent transmission persistent transmission
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| GB/T 7714 | Wang, Hui , Liu, Yan , Liu, Wenwen et al. F-actin dynamics in midgut cells enables virus persistence in vector insects [J]. | MOLECULAR PLANT PATHOLOGY , 2022 , 23 (11) : 1671-1685 . |
| MLA | Wang, Hui et al. "F-actin dynamics in midgut cells enables virus persistence in vector insects" . | MOLECULAR PLANT PATHOLOGY 23 . 11 (2022) : 1671-1685 . |
| APA | Wang, Hui , Liu, Yan , Liu, Wenwen , Wu, Kongming , Wang, Xifeng . F-actin dynamics in midgut cells enables virus persistence in vector insects . | MOLECULAR PLANT PATHOLOGY , 2022 , 23 (11) , 1671-1685 . |
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APETALA2 (AP2) subfamily transcription factors participate in plant growth and development, but their roles in plant immunity remain unclear. Here, we discovered that the AP2 transcription factor CaAIL1 functions in immunity against Ralstonia solanacearum infection (RSI) in pepper (Capsicum annuum). CaAIL1 expression was upregulated by RSI, and loss- and gain-of-function assays using virus-induced gene silencing and transient overexpression, respectively, revealed that CaAIL1 plays a positive role in immunity to RSI in pepper. Chromatin immunoprecipitation sequencing (Ch IP-seq) uncovered a subset of transcription-factor-encoding genes, including CaRAP2-7, CaGATA17, CaGtf3a and CaTCF25, that were directly targeted by CaAIL1 via their cis-elements, such as GT or AGGCA motifs. ChIP-qPCR and electrophoretic mobility shift assays confirmed these findings. These genes, encoding transcription factors with negative roles in immunity, were repressed by CaAIL1 during pepper response to RSI, whereas genes encoding positive immune regulators such as CaEAS were derepressed by CaAIL1. Importantly, we showed that the atypical EAR motif (LXXLXXLXX) in CaAIL1 is indispensable for its function in immunity. These findings indicate that CaAIL1 enhances the immunity of pepper against RSI by repressing a subset of negative immune regulators during the RSI response through its binding to several cis-elements in their promoters.
Keyword ：
CaAIL1 CaAIL1 Immuinity Immuinity Pepper Pepper Ralstonia solanacearum Ralstonia solanacearum Regulation Regulation Target gene Target gene
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| GB/T 7714 | Zheng, Yutong , He, Shicong , Cai, Weiwei et al. CaAIL1 Acts Positively in Pepper Immunity against Ralstonia solanacearum by Repressing Negative Regulators [J]. | PLANT AND CELL PHYSIOLOGY , 2021 , 62 (11) : 1702-1717 . |
| MLA | Zheng, Yutong et al. "CaAIL1 Acts Positively in Pepper Immunity against Ralstonia solanacearum by Repressing Negative Regulators" . | PLANT AND CELL PHYSIOLOGY 62 . 11 (2021) : 1702-1717 . |
| APA | Zheng, Yutong , He, Shicong , Cai, Weiwei , Shen, Lei , Huang, Xueying , Yang, Sheng et al. CaAIL1 Acts Positively in Pepper Immunity against Ralstonia solanacearum by Repressing Negative Regulators . | PLANT AND CELL PHYSIOLOGY , 2021 , 62 (11) , 1702-1717 . |
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Cultivated peanut is grown worldwide as rich-source of oil and protein. A broad genetic base is needed for cultivar improvement. The objectives of this study were to develop highly informative simple sequence repeat (SSR) markers and to assess the genetic diversity and population structure of peanut cultivars and breeding lines from different breeding programs in China, India and the US. A total of 111 SSR markers were selected for this study, resulting in a total of 472 alleles. The mean values of gene diversity and polymorphic information content (PIC) were 0.480 and 0.429, respectively. Country-wise analysis revealed that alleles per locus in three countries were similar. The mean gene diversity in the US, China and India was 0.363, 0.489 and 0.47 with an average PIC of 0.323, 0.43 and 0.412, respectively. Genetic analysis using the STRUCTURE divided these peanut lines into two populations (P1, P2), which was consistent with the dendrogram based on genetic distance (G1, G2) and the clustering of principal component analysis. The groupings were related to peanut market types and the geographic origin with a few admixtures. The results could be used by breeding programs to assess the genetic diversity of breeding materials to broaden the genetic base and for molecular genetics studies.
Keyword ：
Arachis hypogaea Arachis hypogaea breeding breeding genetic diversity genetic diversity population structure population structure simple sequence repeat simple sequence repeat
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| GB/T 7714 | Wang, Hui , Khera, Pawan , Huang, Bingyan et al. Analysis of genetic diversity and population structure of peanut cultivars and breeding lines from China, India and the US using simple sequence repeat markers [J]. | JOURNAL OF INTEGRATIVE PLANT BIOLOGY , 2016 , 58 (5) : 452-465 . |
| MLA | Wang, Hui et al. "Analysis of genetic diversity and population structure of peanut cultivars and breeding lines from China, India and the US using simple sequence repeat markers" . | JOURNAL OF INTEGRATIVE PLANT BIOLOGY 58 . 5 (2016) : 452-465 . |
| APA | Wang, Hui , Khera, Pawan , Huang, Bingyan , Yuan, Mei , Katam, Ramesh , Zhuang, Weijian et al. Analysis of genetic diversity and population structure of peanut cultivars and breeding lines from China, India and the US using simple sequence repeat markers . | JOURNAL OF INTEGRATIVE PLANT BIOLOGY , 2016 , 58 (5) , 452-465 . |
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