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学者姓名：谭庆伟
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Abstract ：
The infection and resistance of pathogenic fungi pose a significant threat to food crop safety, highlighting the urgent need for new green antifungal agents. Fusarium acid (FA) with its simple and novel structure correlates with the principles of green pesticides and has demonstrated substantial broad-spectrum antifungal activity. In a previous study, several promising lead compounds were identified. This study focused on further optimizing lead compound A1. Its inhibitory effect was evaluated against six different pathogenic fungi and several new promising compounds were identified. Notably, the anti-Magnaporthe oryzae (M. oryzae) activity of compound B4 was significantly enhanced with an EC50 value of 910 ng/mL. Rice safety tests indicated that B4 not only exhibited no adverse effect on rice growth and chlorophyll synthesis but also induced plant immunity by increasing the levels of polyphenol oxidase (PPO), peroxidase (POD), and superoxide dismutase (SOD), and soluble sugars. Further investigations into the antifungal mechanism of B4 indicated that it enhanced the permeability and damage of the mycelial membrane, thereby leading to electrolyte leakage and the loss of essential cellular substances. Subsequently, B4 induced the production of reactive oxygen species (ROS) in M. oryzae cell, including center dot OH, center dot O2 -, and 1O2, while promoting increased levels of malondialdehyde (MDA) and SOD enzyme activity. Rice infection tests indicated that B4 effectively inhibited M. oryzae conidia activity and inhibited melanin production. These findings indicated that FA derivatives hold significant potential as a new strategy for M. oryzae disease management and offer valuable insights for the control of plant fungal diseases.
Keyword ：
3D-QSAR 3D-QSAR fungicidal activity fungicidal activity fusaric acid derivatives fusaric acid derivatives safety index safety index
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| GB/T 7714 | Huang, Bin Bin , Gao, Ming Wei , Wang, Xi Guang et al. From Spear to Shield: A Novel Antifungal Drug that Safely Enhances Rice Immune Defenses [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (13) : 7547-7561 . |
| MLA | Huang, Bin Bin et al. "From Spear to Shield: A Novel Antifungal Drug that Safely Enhances Rice Immune Defenses" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73 . 13 (2025) : 7547-7561 . |
| APA | Huang, Bin Bin , Gao, Ming Wei , Wang, Xi Guang , Huang, Xin Yi , Li, Guo , Song, Li Yan et al. From Spear to Shield: A Novel Antifungal Drug that Safely Enhances Rice Immune Defenses . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (13) , 7547-7561 . |
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Apoptosis is a genetically controlled process vital for homeostasis. This study examined the apoptotic response in the gut of Apis mellifera (A. mellifera) larvae to infection by Ascosphaera apis (A. apis) and its impact on host resistance and pathogen virulence. Here, Worker larvae of A. mellifera were inoculated with purified A. apis spores. We then quantified the expression of key apoptosis-related genes (AmCaspase-3, AmBax, and AmBcl-2) in the host gut and detected apoptotic cells via TUNEL assay. To functionally assess the role of apoptosis, larvae were treated with either the apoptosis inhibitor Z-VAD-FMK or the activator PAC-1, after which host survival, expression of apoptosis-associated genes, and the fungal virulence factor gene Ste11-like were analyzed. Our results showed that infection with A. apis significantly upregulated the expression of AmCaspase-3 and AmBax (p < 0.05) at 1-3 days post-inoculation (dpi), while the expression of AmBcl-2 was significantly reduced at 1 and 3 dpi (p < 0.05). Consistent with this, TUNEL assays revealed a markedly stronger green fluorescence signal in the guts of inoculated larvae at 3 dpi compared to uninfected controls, with clear co-localization of TUNEL and nuclear signals, confirming increased apoptosis. Pharmacological inhibition of apoptosis significantly enhanced the survival rate of A. apis-infected larvae, whereas apoptosis activation decreased larval survival. Accordingly, inhibiting apoptosis significantly suppressed the expression of AmCaspase-3 and AmBax (p < 0.001) and upregulated AmBcl-2 (p < 0.001). Conversely, apoptosis activation upregulated AmCaspase-3 (p > 0.05) and AmBax (p < 0.001), while significantly down-regulating AmBcl-2. Furthermore, apoptosis inhibition significantly down-regulated the fungal virulence gene Ste11-like, while its activation had the opposite effect. In summary, A. apis infection induces apoptosis in the larval gut by activating AmCaspase-3 and AmBax and suppressing AmBcl-2. Inhibiting this apoptotic response enhanced host survival by modulating the expression of host apoptosis-related genes and the fungal Ste11-like virulence factor. These findings provide new insights into the host response to A. apis and suggest a potential strategy for controlling chalkbrood disease.
Keyword ：
Apis mellifera Apis mellifera apoptosis apoptosis Ascosphaera apis Ascosphaera apis infection infection survival survival TUNEL TUNEL
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| GB/T 7714 | Zhang, Tianze , Li, Jingxian , Yang, Jiarun et al. Apoptosis and Relevant Genes Are Engaged in the Response of Apis mellifera Larvae to Ascosphaera apis Invasion [J]. | INSECTS , 2025 , 16 (9) . |
| MLA | Zhang, Tianze et al. "Apoptosis and Relevant Genes Are Engaged in the Response of Apis mellifera Larvae to Ascosphaera apis Invasion" . | INSECTS 16 . 9 (2025) . |
| APA | Zhang, Tianze , Li, Jingxian , Yang, Jiarun , Fan, Xiaoxue , Mi, Shiyu , Guo, Xi et al. Apoptosis and Relevant Genes Are Engaged in the Response of Apis mellifera Larvae to Ascosphaera apis Invasion . | INSECTS , 2025 , 16 (9) . |
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Rice stripe disease caused by the rice stripe virus (RSV), which infects many Poaceae species in nature, is one of the most devastating plant viruses in rice that causes enormous losses in production. Ailanthone is one of the typical C20 quassinoids synthesized by the secondary metabolism of Ailanthus altissima, which has been proven to be a biologically active natural product with promising prospects and great potential for use as a lead structure for pesticide development. Based on the achievement of the systemic infection and replication of RSV in Nicotiana benthamiana plants and rice protoplasts, the antiviral properties of Ailanthone were investigated by determining its effects on viral-coding RNA gene expression using reverse transcription polymerase chain reaction, and Western blot analysis. Ailanthone exhibited a dose-dependent inhibitory effect on RSV NSvc3 expression in the assay in both virus-infected tobacco plants and rice protoplasts. Further efforts revealed a potent inhibitory effect of Ailanthone on the expression of seven RSV protein-encoding genes, among which NS3, NSvc3, NS4, and NSvc4 are the most affected genes. These facts promoted an extended and greater depth of understanding of the antiviral nature of Ailanthone against plant viruses, in addition to the limited knowledge of its anti-tobacco mosaic virus properties. Moreover, the leaf disc method introduced and developed in the study for the detection of the antiviral activity of Ailanthone facilitates an available and convenient screening method for anti-RSV natural products or synthetic chemicals.
Keyword ：
ailanthone ailanthone coat protein coat protein in vivo antiviral in vivo antiviral movement protein movement protein quassinoid quassinoid rice stripe virus rice stripe virus
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| GB/T 7714 | Tan, Qingwei , Zhu, Jianxuan , Ju, Yuanyuan et al. Antiviral Activity of Ailanthone from Ailanthus altissima on the Rice Stripe Virus [J]. | VIRUSES-BASEL , 2024 , 16 (1) . |
| MLA | Tan, Qingwei et al. "Antiviral Activity of Ailanthone from Ailanthus altissima on the Rice Stripe Virus" . | VIRUSES-BASEL 16 . 1 (2024) . |
| APA | Tan, Qingwei , Zhu, Jianxuan , Ju, Yuanyuan , Chi, Xinlin , Cao, Tangdan , Zheng, Luping et al. Antiviral Activity of Ailanthone from Ailanthus altissima on the Rice Stripe Virus . | VIRUSES-BASEL , 2024 , 16 (1) . |
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A new phenolic derivative, 4-hydroxyphenol-1-O-[6-O-(E)-feruloyl-beta-d-glucopyranosyl]-(1 -> 6)-beta-d-glucopyranoside (1), and a new terpenylated coumarin, named altissimacoumarin H (2) were identified from the fruit of Ailanthus altissima (Mill.) Swingle (Simaroubaceae), together with ten known compounds (3-12), including two coumarins and eight phenylpropanoids. Their structures were determined on the basis of chemical method and spectroscopic data. Antiviral effect against Tobacco mosaic virus (TMV) of all the compounds obtained were evaluated using leaf-disc method. [GRAPHICS] .
Keyword ：
Ailanthus altissima Ailanthus altissima coumarin coumarin phenylpropanoid phenylpropanoid Simaroubaceae Simaroubaceae Tobacco mosaic virus (TMV) Tobacco mosaic virus (TMV)
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| GB/T 7714 | Ni, Jian-Cheng , Shi, Jian-Ting , Tan, Qing-Wei et al. Two new compounds from the fruit of Ailanthus altissima [J]. | NATURAL PRODUCT RESEARCH , 2019 , 33 (1) : 101-107 . |
| MLA | Ni, Jian-Cheng et al. "Two new compounds from the fruit of Ailanthus altissima" . | NATURAL PRODUCT RESEARCH 33 . 1 (2019) : 101-107 . |
| APA | Ni, Jian-Cheng , Shi, Jian-Ting , Tan, Qing-Wei , Chen, Qi-Jian . Two new compounds from the fruit of Ailanthus altissima . | NATURAL PRODUCT RESEARCH , 2019 , 33 (1) , 101-107 . |
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Quassinoids are bitter constituents characteristic of the family Simaroubaceae. A total of 18 C-20 quassinoids, including nine new quassinoid glycosides, named chuglycosides A-I (1-6 and 8-10), were identified from the samara of Ailanthus altissima (Mill.) Swingle. All of the quassinoids showed potent anti-tobacco mosaic virus (TMV) activity. A preliminary structure-anti-TMV activity relationship of quassinoids was discussed. The effects of three quassinoids, including chaparrinone (12), glaucarubinone (15), and ailanthone (16), on the accumulation of TMV coat protein (CP) were studied by western blot analysis. Ailanthone (16) was further investigated for its influence on TMV spread in the Nicotiana benthamiana plant.
Keyword ：
Ailanthus altissima (Mill.) Swingle Ailanthus altissima (Mill.) Swingle quassinoids quassinoids structure-activity relationship (SAR) structure-activity relationship (SAR) tobacco mosaic virus (TMV) tobacco mosaic virus (TMV)
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| GB/T 7714 | Tan, Qing-Wei , Ni, Jian-Cheng , Zheng, Lu-Ping et al. Anti-Tobacco Mosaic Virus Quassinoids from Ailanthus altissima (Mill.) Swingle [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2018 , 66 (28) : 7347-7357 . |
| MLA | Tan, Qing-Wei et al. "Anti-Tobacco Mosaic Virus Quassinoids from Ailanthus altissima (Mill.) Swingle" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66 . 28 (2018) : 7347-7357 . |
| APA | Tan, Qing-Wei , Ni, Jian-Cheng , Zheng, Lu-Ping , Fang, Pei-Hua , Shi, Jian-Ting , Chen, Qj-Jian . Anti-Tobacco Mosaic Virus Quassinoids from Ailanthus altissima (Mill.) Swingle . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2018 , 66 (28) , 7347-7357 . |
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A new Erythrina alkaloid glycoside, named erythraline-11 beta-O-glucopyranoside, was isolated from the seeds of Erythrina crista-galli L., together with five known Erythrina alkaloids and an indole alkaloid. The structure of the new alkaloid glycoside was elucidated by spectroscopic methods, and all of the compounds were evaluated for their antiviral activity against tobacco mosaic virus.
Keyword ：
antiviral activity antiviral activity Erythrina crista-galli Erythrina crista-galli Erythrinan alkaloid Erythrinan alkaloid fabaceae fabaceae tobacco mosaic virus tobacco mosaic virus
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| GB/T 7714 | Tan, Qing-Wei , Ni, Jian-Cheng , Fang, Pei-Hua et al. A New Erythrinan Alkaloid Glycoside from the Seeds of Erythrina crista-galli [J]. | MOLECULES , 2017 , 22 (9) . |
| MLA | Tan, Qing-Wei et al. "A New Erythrinan Alkaloid Glycoside from the Seeds of Erythrina crista-galli" . | MOLECULES 22 . 9 (2017) . |
| APA | Tan, Qing-Wei , Ni, Jian-Cheng , Fang, Pei-Hua , Chen, Qi-Jian . A New Erythrinan Alkaloid Glycoside from the Seeds of Erythrina crista-galli . | MOLECULES , 2017 , 22 (9) . |
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Four novel compoundstwo phenylpropionamides, one piperidine, and one phenolic derivativeswere isolated and identified from the fruit of a medicinal plant, Ailanthus altissima (Mill.) Swingle (Simaroubaceae), together with one known phenylpropionamide, 13 known phenols, and 10 flavonoids. The structures of the new compounds were elucidated as 2-hydroxy-N-[(2-O--d-glucopyranosyl)phenyl]propionamide (1), 2-hydroxy-N-[(2-O--d-glucopyranosyl-(16)--d-glucopyranosyl)phenyl]propionamide (2), 2-carboxyl-piperidine-4-acetic acid methyl ester (4), and 4-hydroxyphenyl-1-O-[6-(hydrogen-3-hydroxy-3-methylpentanedioate)]--d-glucopyranoside (5) based on spectroscopic analysis. All the isolated compounds were evaluated for their inhibitory activity against Tobacco mosaic virus (TMV) using the leaf-disc method. Among the compounds isolated, arbutin (6), -d-glucopyranosyl-(16)-arbutin (7), 4-methoxyphenylacetic acid (10), and corilagin (18) showed moderate inhibition against TMV with IC50 values of 0.49, 0.51, 0.27, and 0.45 mM, respectively.
Keyword ：
Ailanthus altissima Ailanthus altissima flavonoid flavonoid phenols phenols phenylpropionamide phenylpropionamide piperidine piperidine Simaroubaceae Simaroubaceae Tobacco mosaic virus (TMV) Tobacco mosaic virus (TMV)
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| GB/T 7714 | Ni, Jian-Cheng , Shi, Jian-Ting , Tan, Qing-Wei et al. Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima [J]. | MOLECULES , 2017 , 22 (12) . |
| MLA | Ni, Jian-Cheng et al. "Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima" . | MOLECULES 22 . 12 (2017) . |
| APA | Ni, Jian-Cheng , Shi, Jian-Ting , Tan, Qing-Wei , Chen, Qi-Jian . Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima . | MOLECULES , 2017 , 22 (12) . |
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The fermentation and isolation of metabolites produced by an endophytic fungus, which was identified as Phomopsis sp. FJBR-11, based on phylogenetic analysis, led to the identification of six compounds, including dothiorelones A-C, and H, and cytosporones C and U. Among these compounds, cytosporone U exhibited potent inhibitory activity against Tobacco mosaic virus (TMV). Moreover, the crude and a purified exopolysaccharide were proved to possess strong inhibitory effects against the virus infection.
Keyword ：
cytosporone cytosporone dothiorelone dothiorelone Phomopsis Phomopsis Tobacco mosaic virus Tobacco mosaic virus
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| GB/T 7714 | Tan, Qing-Wei , Fang, Pei-Hua , Ni, Jian-Cheng et al. Metabolites Produced by an Endophytic Phomopsis sp and Their Anti-TMV Activity [J]. | MOLECULES , 2017 , 22 (12) . |
| MLA | Tan, Qing-Wei et al. "Metabolites Produced by an Endophytic Phomopsis sp and Their Anti-TMV Activity" . | MOLECULES 22 . 12 (2017) . |
| APA | Tan, Qing-Wei , Fang, Pei-Hua , Ni, Jian-Cheng , Gao, Fangluan , Chen, Qi-Jian . Metabolites Produced by an Endophytic Phomopsis sp and Their Anti-TMV Activity . | MOLECULES , 2017 , 22 (12) . |
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本发明涉及一株代谢产物对病毒具有抑制作用的真菌菌株及其应用，该菌株为链格孢(Altemaria altemata)FJA14，已于2015年06月05日在中国微生物菌种保藏管理委员会普通微生物中心登记保藏，保藏编号为CGMCC No. 10902。菌株FJA14可用于制备病毒病防治制剂。本发明的菌株FJA14来源于植物内生菌，制备的活性化学成分具有抗病毒活性高、对环境无污染等特点，因此，从FJA14发酵液中分离提取抗病毒活性物质，并将其研制成天然抗病毒剂，具有广阔的应用前景。
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| GB/T 7714 | 陈启建 , 谭庆伟 , 杨波 . 一株产抗病毒活性物质的真菌菌株及其应用 : CN201610071084.7[P]. | 2016-02-02 . |
| MLA | 陈启建 et al. "一株产抗病毒活性物质的真菌菌株及其应用" : CN201610071084.7. | 2016-02-02 . |
| APA | 陈启建 , 谭庆伟 , 杨波 . 一株产抗病毒活性物质的真菌菌株及其应用 : CN201610071084.7. | 2016-02-02 . |
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本发明涉及一株具有抗病毒活性的菌株及其应用，该菌株为塔宾曲霉菌(Aspergillus tubingensis)FJBJll，已于2015年1月26日在中国微生物菌种保藏管理委员会普通微生物中心登记保藏，保藏编号为CGMCC No.10435。将菌株用于制备病毒病防治制剂。本发明通过从菌株发酵液中分离纯化抗病毒活性物质，并将其研制成微生物源抗病毒剂，具有广阔的应用前景。本发明中制备的活性物质抗病毒活性高，不污染环境，可用于防治由烟草花叶病毒(TMV)引起的植物病毒病害，适合推广应用。
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| GB/T 7714 | 谭庆伟 , 王福荣 , 陈启建 . 一种具有抗病毒活性的菌株及其应用 : CN201510138624.4[P]. | 2015-03-27 . |
| MLA | 谭庆伟 et al. "一种具有抗病毒活性的菌株及其应用" : CN201510138624.4. | 2015-03-27 . |
| APA | 谭庆伟 , 王福荣 , 陈启建 . 一种具有抗病毒活性的菌株及其应用 : CN201510138624.4. | 2015-03-27 . |
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