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学者姓名：楼轶
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Abstract ：
As China emerges as a synthetic biology (synbio) global leader, it faces distinct science-society challenges. Our series offers a snapshot of China's synbio state, emphasizing the intersection and its policy implications. The debut piece elucidates the intellectual property rights (IPR)-funding interplay in China's expanding synbio territory, underlining its key role in driving innovation and commercialization.
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| GB/T 7714 | Liao, Lijuan , Lou, Yi , Tang, Xianming et al. Intellectual property and funding: fueling Chinese synbio [J]. | TRENDS IN BIOTECHNOLOGY , 2024 , 42 (3) : 258-260 . |
| MLA | Liao, Lijuan et al. "Intellectual property and funding: fueling Chinese synbio" . | TRENDS IN BIOTECHNOLOGY 42 . 3 (2024) : 258-260 . |
| APA | Liao, Lijuan , Lou, Yi , Tang, Xianming , Deng, Zixin , Gao, Jiangtao . Intellectual property and funding: fueling Chinese synbio . | TRENDS IN BIOTECHNOLOGY , 2024 , 42 (3) , 258-260 . |
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Understanding protein function by deciphering 3D structure has distinct limitations. A recent study by Huang et al. used AlphaFold2, an artificial intelligence (AI) proteinfolding prediction model, to predict and classify deaminase proteins based on structural similarities, highlighting the untapped potential of AI in functional genomics and protein engineering.
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| GB/T 7714 | Lou, Yi , Deng, Zixin , Gao, Jiangtao . Genomics refined: AI-powered perspectives on structural analysis [J]. | TRENDS IN PLANT SCIENCE , 2024 , 29 (2) : 123-125 . |
| MLA | Lou, Yi et al. "Genomics refined: AI-powered perspectives on structural analysis" . | TRENDS IN PLANT SCIENCE 29 . 2 (2024) : 123-125 . |
| APA | Lou, Yi , Deng, Zixin , Gao, Jiangtao . Genomics refined: AI-powered perspectives on structural analysis . | TRENDS IN PLANT SCIENCE , 2024 , 29 (2) , 123-125 . |
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Addressing the burgeoning global obesity crisis, Zhao et al . recently presented innovative developments in celastrol synthesis, a potent antiobesity agent. They unified plant biochemistry, metabolic engineering, and chemistry to map an effective celastrol biosynthetic path in yeast. The study emphasizes new opportunities for the commercial production of celastrol, revealing future potential for specialized metabolite production.
Keyword ：
97 97
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| GB/T 7714 | Lou, Yi , Huang, Yifeng , Gao, Jiangtao . Brewing wellness: sugar-based synthesis of anti-obesity drug celastrol [J]. | TRENDS IN CHEMISTRY , 2024 , 6 (3) : 97-99 . |
| MLA | Lou, Yi et al. "Brewing wellness: sugar-based synthesis of anti-obesity drug celastrol" . | TRENDS IN CHEMISTRY 6 . 3 (2024) : 97-99 . |
| APA | Lou, Yi , Huang, Yifeng , Gao, Jiangtao . Brewing wellness: sugar-based synthesis of anti-obesity drug celastrol . | TRENDS IN CHEMISTRY , 2024 , 6 (3) , 97-99 . |
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Our second piece dissects China's intricate balancing act in synthetic biology (synbio), analyzing its adept maneuvering between fostering innovation and imposing strict regulations. The priority is enhancing biosecurity, biosafety, and public trust, crucial for sustainable gene editing advancements and preventing potential misuse of synthetic viruses.
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| GB/T 7714 | Lou, Yi , Tang, Xianming , Liao, Lijuan et al. Biosafety and biosecurity: treading China's synbio tightrope [J]. | TRENDS IN BIOTECHNOLOGY , 2024 , 42 (4) : 389-392 . |
| MLA | Lou, Yi et al. "Biosafety and biosecurity: treading China's synbio tightrope" . | TRENDS IN BIOTECHNOLOGY 42 . 4 (2024) : 389-392 . |
| APA | Lou, Yi , Tang, Xianming , Liao, Lijuan , Deng, Zixin , Gao, Jiangtao . Biosafety and biosecurity: treading China's synbio tightrope . | TRENDS IN BIOTECHNOLOGY , 2024 , 42 (4) , 389-392 . |
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In the final article of the series, we delve into the crucial role of public engagement and ethical guidelines in shaping the trajectory of synthetic biology (synbio) within China's evolving scientific landscape. We discuss the interconnectedness of enhanced public discourse, stronger ethics, and responsible, transparent advancements in the field.
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| GB/T 7714 | Tang, Xianming , Liao, Lijuan , Lou, Yi et al. Ethics and engagement: steering China 's synbio future [J]. | TRENDS IN BIOTECHNOLOGY , 2024 , 42 (5) : 513-516 . |
| MLA | Tang, Xianming et al. "Ethics and engagement: steering China 's synbio future" . | TRENDS IN BIOTECHNOLOGY 42 . 5 (2024) : 513-516 . |
| APA | Tang, Xianming , Liao, Lijuan , Lou, Yi , Deng, Zixin , Gao, Jiangtao . Ethics and engagement: steering China 's synbio future . | TRENDS IN BIOTECHNOLOGY , 2024 , 42 (5) , 513-516 . |
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文章从教学实践角度系统介绍和分析了合成生物学课程教学过程中存在的一些共性问题,并针对这些问题提出了一系列教学改革措施.通过提前预习课本知识、增加视频教学模式、结合专业特性讲解重点内容、增加课外实习参观流程等针对性教学方法改进,促使学生快速融入课堂,更为直观地了解合成生物学的发展趋势,深化学生对相关专业技术原理的理解,增强学生的学习主观能动性,从而提高课堂教学效果.
Keyword ：
合成生物学 合成生物学 教学改革 教学改革 教学方法 教学方法
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| GB/T 7714 | 楼轶 , 廖丽娟 , 高江涛 . 大数据时代下的合成生物学课程教学改革探索与实践 [J]. | 科教导刊（电子版） , 2024 , (28) : 168-170 . |
| MLA | 楼轶 et al. "大数据时代下的合成生物学课程教学改革探索与实践" . | 科教导刊（电子版） 28 (2024) : 168-170 . |
| APA | 楼轶 , 廖丽娟 , 高江涛 . 大数据时代下的合成生物学课程教学改革探索与实践 . | 科教导刊（电子版） , 2024 , (28) , 168-170 . |
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The Phox homology (PX) domain is a membrane recruitment module that binds to phosphoinositides (PI) mediating the selective sorting and transport of transmembrane proteins, lipids, and other critical cargo molecules via membrane trafficking processes. However, the mechanism of vesicular trafficking mediated by PX domain-containing proteins in phytopathogenic fungi and how this relates to the fungal development and pathogenicity remain unclear. Here, we systematically identified and characterized the functions of PX domain-containing proteins in the plant fungal pathogen Fusarium graminearum. Our data identified 14 PX domain-containing proteins in F. graminearum, all of which were required for plant infection and deoxynivalenol (DON) production, with the exception of FgMvp1 and FgYkr078. Furthermore, all the PX domain-containing proteins showed distinct localization patterns that were limited to the endosomes, vacuolar membrane, endoplasmic reticulum, cytoplasm, and hyphal septa/tips. Remarkably, among these proteins, FgBem1 targeted to surface crescent and septal pores and was retained at the septum pores even after actin constriction during septum development. Further analyses demonstrated that the surface crescent targeting of FgBem1 solely depended on its SH3 domains, while its septum and apex anchoring localization relied on its PX domain, which was also indispensable for reactive oxygen species (ROS) production, sexual development, and pathogenicity in F. graminearum. In summary, our study is the first detailed and comprehensive functional analysis of PX domain-containing proteins in filamentous fungi, and it provides new insight into the mechanism of FgBem1 involved in septum and apex anchorage mediated by its PX domain, which is necessary for sexual development and pathogenicity of F. graminearum. IMPORTANCE Fusarium head blight (FHB), caused predominantly by Fusarium graminearum, is an economically devastating disease of a wide range of cereal crops. Our previous study identified F. graminearum Vps17, Vps5, Snx41, and Snx4 as PX domaincontaining proteins that were involved in membrane trafficking mediating the fungal development and pathogenicity, but the identity and biological roles of the remaining members of this protein family remain unknown in this model phytopathogen. In this study, we first unveiled all the PX domain-containing proteins in F. graminearum and then established their subcellular localizations and biological functions in relation to the fungal development and pathogenesis. We found 14 PX domain-containing proteins that localized to distinct subcellular organelles, including the endosomes, vacuolar membrane, endoplasmic reticulum, cytoplasm, and hyphal septa/tips. Of these proteins, FgBem1 was found to be essential for sexual development and virulence of F. graminearum. Further analyses showed that the PX domain of FgBem1 was indispensable for its functions in septum and apex anchorage, which, in turn, was necessary for ROS production and pathogenicity of F. graminearum. Our findings are important because it not only served as the first comprehensive characterization of the PX domain family proteins in a plant-pathogenic fungus but also uncovered the novel roles of the PX domain involved in septation and apex targeting, which could provide new fungicidal targets for controlling the devastating FHB disease.
Keyword ：
FgBem1 FgBem1 Fusarium graminearum Fusarium graminearum pathogenicity pathogenicity PX domain PX domain septum development septum development
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| GB/T 7714 | Lou, Yi , Zhang, Jing , Wang, Guanghui et al. Genome-Wide Characterization of PX Domain-Containing Proteins Involved in Membrane Trafficking-Dependent Growth and Pathogenicity of Fusarium graminearum [J]. | MBIO , 2021 , 12 (6) . |
| MLA | Lou, Yi et al. "Genome-Wide Characterization of PX Domain-Containing Proteins Involved in Membrane Trafficking-Dependent Growth and Pathogenicity of Fusarium graminearum" . | MBIO 12 . 6 (2021) . |
| APA | Lou, Yi , Zhang, Jing , Wang, Guanghui , Fang, Wenqin , Wang, Shumin , Abubakar, Yakubu Saddeeq et al. Genome-Wide Characterization of PX Domain-Containing Proteins Involved in Membrane Trafficking-Dependent Growth and Pathogenicity of Fusarium graminearum . | MBIO , 2021 , 12 (6) . |
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SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) facilitate intracellular vesicle trafficking and membrane fusion in eukaryotic cells, and play a vital role in growth, development and pathogenicity of phytopathogens. Fusarium head blight (FHB) caused by F. graminearum is one of the most devastating diseases of wheat and barley worldwide. Sec22 is a member of the SNARE family of proteins and its homologues have been shown to have diverse biological roles in different organisms. However, the functions of this protein in the development and pathogenesis of F. graminearum are currently unknown. In this study, we employed integrated biochemical, microbiological and molecular genetic approaches to investigate the roles of FgSec22 in F. graminearum. Our data reveal that this SNARE protein is localized to endoplasmic reticulum (ER) and is indispensable for normal conidiation, conidial morphology and pathogenesis of this phytopathogenic fungus. Our biochemical assay of deoxynivalenol ( DON) reveals the active involvement of this protein in the production of this mycotoxin in F. graminearum. This has further been confirmed by qRT-PCR analyses of trichothecene (TRI) genes' expression where the. Fgsec22 deletion mutant demonstrated a significant down-regulation of these genes in comparison to the wild-type PH-1. Unlike the wild-type and the complemented strain, the mutant strain presents a remarkable defect in colony formation which reflects the critical role it plays in vegetative growth. Collectively, our data support that the SNARE protein FgSec22 is required for vegetative growth, pathogenesis and DON biosynthesis in F. graminearum.
Keyword ：
Cell wall integrity Cell wall integrity Fusarium head blight Fusarium head blight Membrane fusion Membrane fusion Phenotypic characterization Phenotypic characterization Vesicle trafficking Vesicle trafficking
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| GB/T 7714 | Adnan, Muhammad , Fang, Wenqin , Sun, Peng et al. R-SNARE FgSec22 is essential for growth, pathogenicity and DON production of Fusarium graminearum [J]. | CURRENT GENETICS , 2020 , 66 (2) . |
| MLA | Adnan, Muhammad et al. "R-SNARE FgSec22 is essential for growth, pathogenicity and DON production of Fusarium graminearum" . | CURRENT GENETICS 66 . 2 (2020) . |
| APA | Adnan, Muhammad , Fang, Wenqin , Sun, Peng , Zheng, Yangling , Abubakar, Yakubu Saddeeq , Zhang, Jing et al. R-SNARE FgSec22 is essential for growth, pathogenicity and DON production of Fusarium graminearum . | CURRENT GENETICS , 2020 , 66 (2) . |
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衔接蛋白(adaptor protein, AP)复合物在真核细胞膜运输途径中参与多种囊泡的形成。禾谷镰刀菌是重要的植物病原真菌,囊泡运输及蛋白转运是其生长发育及致病性所必需的。本研究通过同源比对,在禾谷镰刀菌中共鉴定到12个AP蛋白复合物相关基因,其编码的蛋白质组成3个异源四聚体(AP-1, AP-2和AP-3)。氨基酸序列分析表明AP-1、AP-2和AP-3复合体中的相同亚基具有保守的功能结构域以及保守基序。系统进化分析显示,子囊菌门、担子菌门和壶菌门的AP蛋白复合物相应亚基聚为一类,而植物和动物另聚为一类,说明了真菌的AP蛋白复合体进化可能早于真菌与动植物的分化。基因表达分析显示,Fg AP-1σ亚基在营养菌丝、分生孢子和子囊的表达量是其他亚基的2～5倍,AP-1和AP-3复合体中所有亚基的基因在营养菌丝中表达量最高,AP-2复合体中所有亚基的基因则在分生孢子阶段表达量最高;AP-1、AP-2和AP-3复合体中各个亚基的基因在侵染小麦后的不同时间段均有表达,暗示AP蛋白在禾谷镰刀菌生长发育及侵染致病过程中可能起重要作用。
Keyword ：
基因表达量 基因表达量 序列特征 序列特征 衔接蛋白 衔接蛋白 进化关系 进化关系
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| GB/T 7714 | 袁明月 , 楼轶 , 张竞 et al. 禾谷镰刀菌AP蛋白家族的生物信息学分析 [J]. | 基因组学与应用生物学 , 2020 , 39 (06) : 2590-2598 . |
| MLA | 袁明月 et al. "禾谷镰刀菌AP蛋白家族的生物信息学分析" . | 基因组学与应用生物学 39 . 06 (2020) : 2590-2598 . |
| APA | 袁明月 , 楼轶 , 张竞 , 郑文辉 , 周洁 . 禾谷镰刀菌AP蛋白家族的生物信息学分析 . | 基因组学与应用生物学 , 2020 , 39 (06) , 2590-2598 . |
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Fungi are a source of novel phytotoxic compounds to be explored in the search for effective and environmentally safe herbicides. The genetic inactivation of the biosynthetic pathway of the new phytotoxin cichorine has led to the isolation of three novel phytotoxins from the fungus Aspergillus nidulans: 8-methoxycichorine (4), 8-epi-methoxycichorine (5), and N-(4'-carboxybutyl) cichorine (6). The structure of the new compounds was clearly determined by a combination of nuclear magnetic resonance (NMR) analysis and high-resolution electrospray ionization (HRESIMS). The phytotoxic bioassay was studied on leaves from Zea mays and Medicago polymorpha L. at the concentration of 5 x 10(-3) M by using a moist chamber technique. Novel phytotoxins 8-methoxycichorine (4), 8-epi-methoxycichorine (5), and N-(4'-carboxybutyl) cichorine (6) exhibited a better phytotoxic effect than cichorine.
Keyword ：
Aspergillus nidulans Aspergillus nidulans pathway inactivation pathway inactivation phytotoxic assay phytotoxic assay phytotoxins phytotoxins
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| GB/T 7714 | Liao, Lijuan , Zhang, Xiaolei , Lou, Yi et al. Discovery of Three New Phytotoxins from the Fungus Aspergillus nidulans by Pathway Inactivation [J]. | MOLECULES , 2019 , 24 (3) . |
| MLA | Liao, Lijuan et al. "Discovery of Three New Phytotoxins from the Fungus Aspergillus nidulans by Pathway Inactivation" . | MOLECULES 24 . 3 (2019) . |
| APA | Liao, Lijuan , Zhang, Xiaolei , Lou, Yi , Zhou, Chengzeng , Yuan, Qianqian , Gao, Jiangtao . Discovery of Three New Phytotoxins from the Fungus Aspergillus nidulans by Pathway Inactivation . | MOLECULES , 2019 , 24 (3) . |
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