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学者姓名：林向民
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Abstract ：
Aeromonas hydrophila, an antibiotic-and multi-metal-resistant pathogen, threatens aquaculture, yet its adaptation to cadmium chloride (CdCl2) remains poorly understood. A.hydrophilla was grown with CdCl2 exposure, and data-independent acquisition (DIA)-based proteomics was employed to identify the 253 upregulated and 163 downregulated proteins. GO and KEGG enrichment analyses revealed upregulated proteins involved in sulfate metabolism, siderophore-and iron transport, and other transition metal transport processes, while down-regulated proteins were linked to amino acid metabolism, the tricarboxylic acid (TCA) cycle, and fatty acid metabolism. Gene Set Enrichment Analysis (GSEA) indicated positive enrichment of ribosome, RNA degradation, sulfur metabolism, and riboflavin metabolism, and negative enrichment of valine, leucine, and isoleucine degradation, two-component system, and bacterial chemotaxis. CdCl2 tolerance assays of four gene-deletion mutants confirmed proteomics predictions: Delta AHA_3605 (uncharacterized protein) and Delta AHA_1796 (GGDEFdomain deletion) were significantly more sensitive to CdCl2, suggesting a role for cyclic di-GMP (c-di-GMP) signaling in cadmium resistance. Collectively, these results provide novel insights into the adaptive strategies of A. hydrophila, revealing key molecular determinants of CdCl2 stress tolerance. Significance: Cadmium contamination increasingly co-selects for antibiotic-resistant pathogens in aquaculture, yet the molecular basis of cadmium tolerance in Aeromonas hydrophila-one of the most problematic Gramnegative fish pathogens-has been unknown. Here, we provide the first comprehensive, DIA-based quantitative proteome map of A. hydrophila under CdCl2 stress, uncovering a tightly orchestrated stress response that simultaneously remodels metal acquisition, down-regulates energy-intensive metabolism (TCA cycle, branched chain amino acid and fatty acid degradation), and activates sulfur-riboflavin-ribosome pathways to repair oxidative damage. Functional validation using gene-deletion mutants demonstrated that loss of AHA_3605 (uncharacterized) or AHA_1796 (GGDEF domain protein) significantly increased CdCl2 sensitivity, implicating cyclic di-GMP signaling in cadmium resistance. These findings advance our mechanistic understanding of heavymetal adaptation in aquatic pathogens and offer proteome informed targets to disrupt metal-driven co-selection of multidrug-resistant A. hydrophila in aquaculture ecosystems.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila Cadmium chloride Cadmium chloride DIA-based proteomics DIA-based proteomics Metabolism Metabolism Metal transportation Metal transportation
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| GB/T 7714 | Xie, Xiaofang , Zhang, Binghui , Chen, Xin et al. Quantitative proteomic analysis of cadmium chloride tolerance mechanisms in Aeromonas hydrophila [J]. | JOURNAL OF PROTEOMICS , 2026 , 323 . |
| MLA | Xie, Xiaofang et al. "Quantitative proteomic analysis of cadmium chloride tolerance mechanisms in Aeromonas hydrophila" . | JOURNAL OF PROTEOMICS 323 (2026) . |
| APA | Xie, Xiaofang , Zhang, Binghui , Chen, Xin , Tang, Jiaqi , Qiu, Zhen , Shen, Chenghao et al. Quantitative proteomic analysis of cadmium chloride tolerance mechanisms in Aeromonas hydrophila . | JOURNAL OF PROTEOMICS , 2026 , 323 . |
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The extensive use of the herbicide quinclorac has led to significant residues in agricultural soil, posing adverse effects on crop safety and high-quality production. In this study, using the tobacco variety CB-1 as material, we found that oxidizing agent K2S2O8 can significantly reduce quinclorac-induced phytotoxicity symptoms in tobacco. Furthermore, we integrated biochemical methods, metagenomics, metabolomics, and transcriptomics to investigate the effects of K2S2O8 on both quinclorac-contaminated soil and tobacco plants. Soil physicochemical properties analysis showed that the incorporation of K2S2O8-based remediation significantly mitigated the negative effects of quinclorac and largely restored the soil properties affected by quinclorac stress. Metagenomic analysis found that quinclorac significantly reduced soil species diversity, while K2S2O8-based remediation soil exhibited higher richness of microbial communities, with increased abundance of Sphingomonas and Bradyrhizobium, and decreased abundance of Alphaproteobacteria. Differential gene expression analysis showed significant up-regulation and down-regulation of genes under C10H5Cl2NO2 stress, which was partially mitigated by K2S2O8 treatment. Gene Ontology (GO) enrichment analysis indicated that these genes were mainly involved in cellular processes, metabolic pathways, and biological regulation. Metabolomic analysis further confirmed significant changes in metabolite profiles, with K2S2O8 treatment restoring many metabolites to near control levels. Integrated metabolomic-transcriptomic analysis revealed enrichment of differentially expressed genes (DEGs) and metabolites in six key pathways: (1) lysine degradation, (2) stilbenoid diarylheptanoid and gingerol biosynthesis, (3) arginine and proline metabolism, (4) phenylalanine biosynthesis, (5) tyrosine metabolism, and (6) flavonoid biosynthesis. Additionally, the levels of 4-hydroxyphenylacetylglutamic and 5-aminovaleric acid were down-regulated, along with the expression of genes associated with these metabolites, when quinclorac residual soil was treated by K2SO8. The results of this study provide a theoretical basis for the remediation of pesticide residue soil in rice tobacco rotation areas, offering valuable insights for sustainable agricultural practices.
Keyword ：
C10H5C2NO2 C10H5C2NO2 K2S2O8 K2S2O8 muti-omics muti-omics oxidation repair oxidation repair tobacco tobacco
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| GB/T 7714 | Zhang, Binghui , Yang, Ting , Cheng, Chenliang et al. Multi-omics analysis reveals the alleviating effect of oxidation remediation on tobacco quinclorac stress [J]. | FRONTIERS IN MICROBIOLOGY , 2025 , 16 . |
| MLA | Zhang, Binghui et al. "Multi-omics analysis reveals the alleviating effect of oxidation remediation on tobacco quinclorac stress" . | FRONTIERS IN MICROBIOLOGY 16 (2025) . |
| APA | Zhang, Binghui , Yang, Ting , Cheng, Chenliang , Li, Tong , Zhang, Ni , Wang, Fei et al. Multi-omics analysis reveals the alleviating effect of oxidation remediation on tobacco quinclorac stress . | FRONTIERS IN MICROBIOLOGY , 2025 , 16 . |
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The emergence of Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a major public health concern, primarily driven by its ability to evade a wide range of antibiotics. Despite extensive genomic studies, proteomic insights into antibiotic resistance mechanisms remain scarce. Here, we employed a Data-Independent Acquisition (DIA)-based quantitative proteomics approach to investigate proteomic differences between 78 CRKP and 18 Carbapenem-sensitive K. pneumoniae (CSKP) clinical isolates. A total of 3380 proteins were identified, with 946 showing significant differential expression. CRKP isolates exhibited increased expression of efflux pumps, beta-lactamases, and transcriptional regulators, while proteins associated with transport were enriched in CSKP isolates. To validate our findings, a quantitative proteomics analysis in an independent cohort of 10 CRKP and 11 CSKP isolates was performed. The key biomarkers identified via machine learning in the discovery cohort, including aldehyde dehydrogenase (KPN_03361), acyltransferase (KPN_02072), uncharacterized protein (YjeJ), plasmid partition protein B (ParaB), HTH-type transcriptional activator (RhaR), and beta-lactamase (Bla), were evaluated. They collectively achieved AUC > 0.7 in the validation cohort, confirming their discriminatory capacity as diagnostic markers. These findings provide novel insights into the molecular mechanisms of antibiotic resistance and identify promising biomarkers for diagnosing carbapenem-resistant K. pneumoniae, offering potential avenues for therapeutic intervention.
Keyword ：
biomarkers biomarkers carbapenem resistance mechanisms carbapenem resistance mechanisms Klebsiella pneumoniae Klebsiella pneumoniae machine learning machine learning proteomics proteomics
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| GB/T 7714 | Wang, Guibin , Cao, Ling , Lian, Lingli et al. Machine Learning and DIA Proteomics Reveal New Insights into Carbapenem Resistance Mechanisms in Klebsiella pneumoniae [J]. | JOURNAL OF PROTEOME RESEARCH , 2025 , 24 (8) : 4002-4014 . |
| MLA | Wang, Guibin et al. "Machine Learning and DIA Proteomics Reveal New Insights into Carbapenem Resistance Mechanisms in Klebsiella pneumoniae" . | JOURNAL OF PROTEOME RESEARCH 24 . 8 (2025) : 4002-4014 . |
| APA | Wang, Guibin , Cao, Ling , Lian, Lingli , Wang, Yuqian , Lian, Juanqi , Liu, Ziqiu et al. Machine Learning and DIA Proteomics Reveal New Insights into Carbapenem Resistance Mechanisms in Klebsiella pneumoniae . | JOURNAL OF PROTEOME RESEARCH , 2025 , 24 (8) , 4002-4014 . |
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Biofilms play a pivotal role in the survival and persistence of microorganisms, endowing them with heightened resistance to environmental stressors and antimicrobial agents. The EamB protein, which encodes an inner membrane transporter, acted as a negative regulator of biofilm formation, and the gene eamB deletion in the pathogen Aeromonas hydrophila LP-2 resulted in a significant increase in biofilm formation. Proteomic analysis revealed a total of 616 differentially abundant proteins between the Delta eamB and wild-type (WT) strains, with 308 downregulated and 308 upregulated. RT-qPCR was employed to verify the stability and accuracy of the proteomics data. Bioinformatic analysis indicated that EamB is involved in critical bacterial biological processes, including flagellar assembly, amino acid metabolism, and fatty acid degradation. Biofilm formation assays further revealed that supplementation with exogenous lysine significantly inhibited biofilm formation in the Delta eamB strain, conversely, exogenous cysteine and O-acetylserine obviously increased biofilm formation in the Delta eamB strain. These findings demonstrated that EamB may modulate bacterial biofilm formation in A. hydrophila through the regulation of amino acid metabolism. This finding provides novel insights into the regulatory mechanism underlying biofilm formation and highlights potential targets for the development of future antibacterial strategies. Significance statement: This study elucidates the critical role of the eamB gene in Aeromonas hydrophila, a significant aquatic pathogen, by demonstrating its impact on biofilm formation and physiological traits. Through comparative proteomic analysis, we identified 616 differentially abundant proteins in the Delta eamB mutant, revealing its involvement in key metabolic pathways such as amino acid metabolism, flagellar assembly, and fatty acid degradation. Notably, eamB deletion enhanced biofilm formation, while exogenous amino acids like cysteine and O-acetylserine obviously increased biofilm formation in the Delta eamB strain. These findings highlight EamB as a regulator of biofilm formation, offering novel molecular insights into bacterial pathogenicity. This research advances our understanding of biofilm-associated antibiotic resistance and provides potential targets for developing strategies to mitigate infections caused by A. hydrophila in aquaculture and public health.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila Amino acid transport Amino acid transport Biofilm formation Biofilm formation EamB EamB Proteomics Proteomics
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| GB/T 7714 | Xu, Qiaozhen , Tian, Feng , Wang, Xinyun et al. Proteomics reveals the role of the EamB transporter from Aeromonas hydrophila LP-2 in biofilm formation [J]. | JOURNAL OF PROTEOMICS , 2025 , 321 . |
| MLA | Xu, Qiaozhen et al. "Proteomics reveals the role of the EamB transporter from Aeromonas hydrophila LP-2 in biofilm formation" . | JOURNAL OF PROTEOMICS 321 (2025) . |
| APA | Xu, Qiaozhen , Tian, Feng , Wang, Xinyun , Lian, Juanqi , Zhang, Xiaowei , Lin, Xiangmin et al. Proteomics reveals the role of the EamB transporter from Aeromonas hydrophila LP-2 in biofilm formation . | JOURNAL OF PROTEOMICS , 2025 , 321 . |
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Protein lysine crotonylation (Kcr) has been reported to play a role in the regulation of prokaryotic cell metabolism. However, its distribution and functional significance remain largely unexplored. In this study, a global proteomic landscape of Kcr in Aeromonas hydrophila was mapped, identifying 4424 Kcr sites on 1248 proteins using LC-MS/MS. Gene ontology analysis revealed that Kcr-modified proteins are primarily enriched in cellular and primary metabolic processes, stress responses, macromolecule biosynthesis, and transmembrane transport. Moreover, Kcr proteins are involved in diverse metabolic pathways, such as the pentose phosphate pathway, TCA cycle, and methane metabolism. Functional validation assays revealed that the maltodextrin-binding protein (MalE) at the K57 site, as well as the maltose/maltodextrin import ATP-binding protein (MalK) at the K11 and K181 sites, positively regulated maltose transport, whereas the K223 site on MalE had a negative regulatory effect. Bioinformatics analysis further demonstrated that the different Kcr status at the K11 site of MalK may positively regulate the cavity volume within the MalFGK2 complex, which may be involved in the regulation of bacterial maltose transport. Overall, our findings indicate the important role of Kcr modification in the nutrient transport system, providing insights into the regulatory roles of bacterial protein post-translational modifications.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila lysine crotonylation modification lysine crotonylation modification MalFGK2 maltose transporter MalFGK2 maltose transporter
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| GB/T 7714 | Fu, Yuying , Zhang, Xiaowei , Lin, Meizhen et al. Protein Lysine Crotonylation Analysis Reveals an Important Role in the Regulation of Aeromonas hydrophila Maltose Transport [J]. | JOURNAL OF PROTEOME RESEARCH , 2025 , 24 (11) : 5640-5652 . |
| MLA | Fu, Yuying et al. "Protein Lysine Crotonylation Analysis Reveals an Important Role in the Regulation of Aeromonas hydrophila Maltose Transport" . | JOURNAL OF PROTEOME RESEARCH 24 . 11 (2025) : 5640-5652 . |
| APA | Fu, Yuying , Zhang, Xiaowei , Lin, Meizhen , Hou, Qian , Jiang, Wenjia , Wu, Xiaoyun et al. Protein Lysine Crotonylation Analysis Reveals an Important Role in the Regulation of Aeromonas hydrophila Maltose Transport . | JOURNAL OF PROTEOME RESEARCH , 2025 , 24 (11) , 5640-5652 . |
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Post-translational modifications are crucial in regulating biological functions across both prokaryotes and eukaryotes. In Aeromonas hydrophila, CobQ, a recently identified novel deacetylase, plays a significant role in lysine deacetylation, influencing bacterial metabolism and stress responses. The present study utilized quantitative proteomics to investigate the impact of cobQ deletion on the global protein expression profile in A. hydrophila. Through data-independent acquisition mass spectrometry, we identified 233 upregulated and 41 downregulated proteins in the cobQ deletion mutant (Delta ahcobQ) strain compared to the wild-type (WT) strain. Key differentially expressed proteins were involved in oxidative phosphorylation, bacterial secretion, and ribosomal function. Additionally, phenotypic assays demonstrated that the Delta ahcobQ strain exhibited an increased resistance to oxidative phosphorylation inhibitors, suggesting a pivotal role for AhCobQ in energy metabolism. Outer membrane proteins and efflux pumps also showed altered expression, indicating potential implications for membrane permeability and antibiotic resistance. These results suggested that AhCobQ plays a vital regulatory role in maintaining metabolic homeostasis and responding to environmental stress, highlighting its potential as a target for therapeutic interventions against A. hydrophila infections.
Keyword ：
Aeromonashydrophila Aeromonashydrophila CobQ deacetylase CobQ deacetylase oxidativephosphorylation oxidativephosphorylation proteomics proteomics stress response stress response
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| GB/T 7714 | Wang, Guibin , Chen, Linxin , Lian, Juanqi et al. Proteomic Insights into the Regulatory Role of CobQ Deacetylase in Aeromonas hydrophila [J]. | JOURNAL OF PROTEOME RESEARCH , 2025 , 24 (1) : 333-343 . |
| MLA | Wang, Guibin et al. "Proteomic Insights into the Regulatory Role of CobQ Deacetylase in Aeromonas hydrophila" . | JOURNAL OF PROTEOME RESEARCH 24 . 1 (2025) : 333-343 . |
| APA | Wang, Guibin , Chen, Linxin , Lian, Juanqi , Gong, Lanqing , Tian, Feng , Wang, Yuqian et al. Proteomic Insights into the Regulatory Role of CobQ Deacetylase in Aeromonas hydrophila . | JOURNAL OF PROTEOME RESEARCH , 2025 , 24 (1) , 333-343 . |
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Aeromonas hydrophila is a pervasive opportunistic fish pathogen, often leading to severe infections. However, the combination of its extensive genetic variety and the complexity of its virulence factors has hindered our ability to fully comprehend its pathogenic mechanisms to date. In this study, the pathogenicity and potential virulence factors of strain LP-2, a representative member of the high virulent ST251 clones isolated from a diseased silver carp were investigated. LP-2 was identified through Rimler-Shotts medium and 16S rRNA sequencing as A. hydrophila. Genome sequencing and comparative genomics revealed that LP-2 was an ST251-type bacterium and exhibited a genetic closeness to other fish epidemic-causing ST251 clones. Pathogenicity assays showed LP2's robust virulence, marked by its significantly lower LD50 value (5.64 x 103 CFU) compared to the non-virulent strain ATCC 7966, as well as by its siderophore production, hemolysis, and protease activity. Moreover, using Virulence Factor Database, we identified diverse virulence genes in LP-2, with siderophore, polar flagella, and chemotaxis systems being the most prevalent. LP-2 also harbored aerolysin, enterotoxin and type IV pili (Flp and MSHA), which were commonly associated with the virulence profile of ST251. In addition, we generated 15 virulence gene deletion strains via gene recombination and assessed their impact on zebrafish survival. Notably, deleting orf00306 (enterobactin receptor) and orf03433 (ABC-type heme transporter) significantly reduced zebrafish mortality, highlighting their crucial role in LP-2 virulence. Overall, this study provides insights into the virulence characteristics of LP-2 strain, enhancing our understanding of A. hydrophila pathogenicity.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila Genome sequencing Genome sequencing Pathogenicity Pathogenicity Virulence factors Virulence factors Zebrafish survival Zebrafish survival
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| GB/T 7714 | Lian, Lingli , Sun, Lina , Zhao, Xinrui et al. Analysis of pathogenicity factors in the highly virulent Aeromonas hydrophila strain LP-2 [J]. | AQUACULTURE , 2025 , 598 . |
| MLA | Lian, Lingli et al. "Analysis of pathogenicity factors in the highly virulent Aeromonas hydrophila strain LP-2" . | AQUACULTURE 598 (2025) . |
| APA | Lian, Lingli , Sun, Lina , Zhao, Xinrui , Chen, Linxin , Zhang, Binghui , Liu, Yanling et al. Analysis of pathogenicity factors in the highly virulent Aeromonas hydrophila strain LP-2 . | AQUACULTURE , 2025 , 598 . |
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Post-translational modifications (PTMs) play pivotal roles in modulating protein functions. In Aeromonas hydrophila, a freshwater Gram-negative pathogen threatening human and animal health, the host factor for RNA phage Q(3 replicase (Hfq) is a key regulatory protein. Its K56 site undergoes succinylation modification, suggesting important functions. However, the exact roles of Hfq and its K56 site in A. hydrophila were unclear. Our physiological assays showed that hfq deletion increased protease activity and motility, but reduced biofilm formation, chemotaxis, stress response, and antibiotic resistance. K56 succinylation enhanced protease activity and biofilm formation, and altered chemotaxis. Comprehensive transcriptome and proteome analysis further revealed that hfq deletion led to an increase in 11 peptidases and 8 flagellar proteins, as well as a decrease in 5 stress-related proteins. It also suppressed the pathways involved in chemotaxis and beta-lactam resistance. On the other hand, K56 succinylation enhanced fatty acid synthesis pathway and the expression of methyl-accepting chemotaxis proteins (MCPs). Consistent with the omics data, qPCR validation confirmed the expression of 12 genes, including metalloprotease and MCPs. Overall, this study deepened insights into Hfq regulation in A. hydrophila and revealed the previously unknown molecular switch function of post-translational modifications (PTMs) on this protein.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila Lysine succinylation modification Lysine succinylation modification RNA chaperone Hfq RNA chaperone Hfq
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| GB/T 7714 | Lian, Lingli , Zhang, Lishan , Shen, Chenghao et al. The impact of lysine succinylation modification of host factor for RNA phage Q(3 replicase at K56 site on the biological functions of Aeromonas hydrophila [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 310 . |
| MLA | Lian, Lingli et al. "The impact of lysine succinylation modification of host factor for RNA phage Q(3 replicase at K56 site on the biological functions of Aeromonas hydrophila" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 310 (2025) . |
| APA | Lian, Lingli , Zhang, Lishan , Shen, Chenghao , Zhang, Binghui , Zhang, Huaiyao , Xie, Yuyue et al. The impact of lysine succinylation modification of host factor for RNA phage Q(3 replicase at K56 site on the biological functions of Aeromonas hydrophila . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 310 . |
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本发明涉及一种靶向嗜水气单胞菌AerA蛋白的特异性药物及其应用。所述药物为甜菊糖，所述甜菊糖为A甙甜菊糖。本发明通过实验验证了A甙甜菊糖对嗜水气单胞菌AerA蛋白具有高亲和力；溶血性检测和斑马鱼攻毒感染实验表明，A甙甜菊糖能显著抑制嗜水气单胞菌的溶血性和毒力，提高斑马鱼的生存率；生物安全检测显示，A甙甜菊糖对宿主细胞无明显毒性，不影响细菌生长。可见，甜菊糖（A甙甜菊糖）在抑制嗜水气单胞菌、拮抗嗜水气单胞菌感染中具有很好的作用。本发明为水产病害的防治提供一种全新的解决方案。
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| GB/T 7714 | 林向民 , 张丽珊 , 黄雅雯 et al. 一种靶向嗜水气单胞菌AerA蛋白的特异性药物及其应用 : CN202510512768.5[P]. | 2025-04-23 . |
| MLA | 林向民 et al. "一种靶向嗜水气单胞菌AerA蛋白的特异性药物及其应用" : CN202510512768.5. | 2025-04-23 . |
| APA | 林向民 , 张丽珊 , 黄雅雯 , 谢小芳 , 连玲丽 , 庞欢瑛 . 一种靶向嗜水气单胞菌AerA蛋白的特异性药物及其应用 : CN202510512768.5. | 2025-04-23 . |
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As global food demand rises, land-based production faces challenges such as limited arable land and sustainability concerns, whereas seafood offers a nutritionally diverse and environmentally sustainable alternative for future food security. Intensified farming has increased Vibrio spp. infections due to their genetic diversity and adaptability to environmental changes. The misuse or overuse of antibiotics in aquaculture exacerbates this issue, contributing to antibiotic resistance, environmental contamination, and residue accumulation in aquatic ecosystems. Given these challenges, exploring alternatives such as essential oil compounds with antibacterial, anti-quorum sensing, and anti-biofilm properties presents a promising approach to enhancing disease management in aquaculture while minimizing environmental impact. Although several studies have investigated the antipathogenic potential of essential oil compounds against Vibrio spp., a comprehensive review specifically addressing their antibacterial, anti-quorum sensing, and antibiofilm activities in aquaculture is lacking. This review aims to fill that gap by providing an in-depth analysis of essential oil compounds, focusing on their mechanisms of action, protective efficacy in aquatic animals, and potential to combat Vibrio-related infections. It also examines how nanoencapsulation systems enhance the stability and functional efficacy of essential oil compounds in seafood applications and reviews recent patents targeting their use against Vibrio spp. Additionally, this review identifies current research gaps. It proposes future directions for the sustainable use of essential oil compounds in aquaculture, emphasizing their potential as natural, eco-friendly alternatives to antibiotics and synthetic chemicals. Ultimately, it seeks to guide researchers in developing environmentally sustainable strategies for managing infectious diseases and improving the health of aquatic animals.
Keyword ：
antibacterial antibacterial antibiofilm antibiofilm anti-quorum sensing anti-quorum sensing aquaculture aquaculture essential oil compounds essential oil compounds Vibrio Vibrio
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| GB/T 7714 | Srinivasan, Ramanathan , Jin, Xingkun , Lin, Xiangmin et al. Essential Oil Compounds as Antibiotic Alternatives: A Comprehensive Review of Antibacterial, Anti-Quorum Sensing, and Antibiofilm Effects Against Vibrio spp. in Aquaculture [J]. | REVIEWS IN AQUACULTURE , 2025 , 17 (4) . |
| MLA | Srinivasan, Ramanathan et al. "Essential Oil Compounds as Antibiotic Alternatives: A Comprehensive Review of Antibacterial, Anti-Quorum Sensing, and Antibiofilm Effects Against Vibrio spp. in Aquaculture" . | REVIEWS IN AQUACULTURE 17 . 4 (2025) . |
| APA | Srinivasan, Ramanathan , Jin, Xingkun , Lin, Xiangmin , Zhao, Zhe . Essential Oil Compounds as Antibiotic Alternatives: A Comprehensive Review of Antibacterial, Anti-Quorum Sensing, and Antibiofilm Effects Against Vibrio spp. in Aquaculture . | REVIEWS IN AQUACULTURE , 2025 , 17 (4) . |
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