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学者姓名：胡君
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Abstract ：
Phase separation, particularly liquid-liquid phase separation (LLPS), has emerged as a powerful tool in biological research, offering unique advantages for visualizing and analyzing biomolecular interactions. This review highlights recent advances in leveraging LLPS to develop experimental techniques for studying protein-protein interactions (PPIs), protein-RNA interactions, and enzyme activity. The integration of LLPS with advanced techniques has expanded its applications, offering new possibilities for unraveling the complexities of cellular function and disease mechanisms. Looking forward, the development of more versatile, sensitive, and targeted LLPS-based methods is poised to transform molecular biology, providing deeper insights into cellular dynamics and facilitating therapeutic advancements.
Keyword ：
kinase sensors kinase sensors phase separation phase separation protein-protein interactions protein-protein interactions
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| GB/T 7714 | Huang, Huizhen , Hu, Jun . Applications of Liquid-Liquid Phase Separation in Biosensing [J]. | CHEMBIOCHEM , 2025 , 26 (8) . |
| MLA | Huang, Huizhen 等. "Applications of Liquid-Liquid Phase Separation in Biosensing" . | CHEMBIOCHEM 26 . 8 (2025) . |
| APA | Huang, Huizhen , Hu, Jun . Applications of Liquid-Liquid Phase Separation in Biosensing . | CHEMBIOCHEM , 2025 , 26 (8) . |
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Abstract ：
基因编码的靶向蛋白降解是一种以遗传信息为基础的降解分子在细胞内表达编码的治疗方法，已经在许多癌症疾病的“不可药用”蛋白的降解中发挥着极为重要的作用。综述了GE-TPD近年来的一些进展及其E3连接酶和目标蛋白结合域的设计和模块选择；并展望了GE-TPD个性化定制的前景和挑战。
Keyword ：
E3泛素连接酶 E3泛素连接酶 GE-TPD GE-TPD 特异性 特异性 结合域 结合域 蛋白降解 蛋白降解
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| GB/T 7714 | 吴雨晴 , 黄惠珍 , 闫大琦 et al. 基因编码的靶向蛋白降解 [J]. | 福建师范大学学报(自然科学版) , 2025 , 41 (01) : 102-108 . |
| MLA | 吴雨晴 et al. "基因编码的靶向蛋白降解" . | 福建师范大学学报(自然科学版) 41 . 01 (2025) : 102-108 . |
| APA | 吴雨晴 , 黄惠珍 , 闫大琦 , 胡君 . 基因编码的靶向蛋白降解 . | 福建师范大学学报(自然科学版) , 2025 , 41 (01) , 102-108 . |
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Abstract ：
The regulation of protein levels in plants is essential for improving agricultural productivity. Recent studies have explored inducible degradation systems in plants, with some showing promising advancements. This study introduces the NRDN degradation tag as a novel tool for regulating protein stability within the nucleus in Arabidopsis thaliana. Unlike traditional gene knockout methods, NRDN offers real-time, dynamic control over protein degradation, enabling precise studies of nuclear-localized proteins. This discovery provides a valuable tool for regulating protein stability in specific cellular compartments, which presents a versatile approach for dissecting complex cellular processes and offers broad applications in functional genomics and cellular research.
Keyword ：
Arabidopsis Arabidopsis Degradation Degradation Nucleus Nucleus Peptides Peptides Tag Tag
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| GB/T 7714 | Shen, Liting , Huang, Huizhen , Yan, Daqi et al. NRDN: A novel nuclear degradation tag for targeted protein regulation in Arabidopsis [J]. | PLANT SCIENCE , 2025 , 356 . |
| MLA | Shen, Liting et al. "NRDN: A novel nuclear degradation tag for targeted protein regulation in Arabidopsis" . | PLANT SCIENCE 356 (2025) . |
| APA | Shen, Liting , Huang, Huizhen , Yan, Daqi , Ye, Yongsheng , Hu, Jun . NRDN: A novel nuclear degradation tag for targeted protein regulation in Arabidopsis . | PLANT SCIENCE , 2025 , 356 . |
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The target of rapamycin (TOR) is a central regulator of growth, development, and stress adaptation in plants. This review delves into the molecular intricacies of TOR signaling, highlighting its conservation and specificity across eukaryotic lineages. We explore the molecular architecture of TOR complexes, their regulation by a myriad of upstream signals, and their consequential impacts on plant physiology. The roles of TOR in orchestrating nutrient sensing, hormonal cues, and environmental signals are highlighted, illustrating its pivotal function in modulating plant growth and development. Furthermore, we examine the impact of TOR on plant responses to various biotic and abiotic stresses, underscoring its potential as a target for agricultural improvements. This synthesis of current knowledge on plant TOR signaling sheds light on the complex interplay between growth promotion and stress adaptation, offering a foundation for future research and applications in plant biology.
Keyword ：
amino acid sensing amino acid sensing glucose signaling glucose signaling SNF1-related protein kinase 1 SNF1-related protein kinase 1 target of rapamycin target of rapamycin trade-off trade-off
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| GB/T 7714 | Liu, Yanlin , Hu, Jun , Duan, Xiaoli et al. Target of Rapamycin (TOR): A Master Regulator in Plant Growth, Development, and Stress Responses [J]. | ANNUAL REVIEW OF PLANT BIOLOGY , 2025 , 76 : 341-371 . |
| MLA | Liu, Yanlin et al. "Target of Rapamycin (TOR): A Master Regulator in Plant Growth, Development, and Stress Responses" . | ANNUAL REVIEW OF PLANT BIOLOGY 76 (2025) : 341-371 . |
| APA | Liu, Yanlin , Hu, Jun , Duan, Xiaoli , Ding, Wenlong , Xu, Menglan , Xiong, Yan . Target of Rapamycin (TOR): A Master Regulator in Plant Growth, Development, and Stress Responses . | ANNUAL REVIEW OF PLANT BIOLOGY , 2025 , 76 , 341-371 . |
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Cucurbit [8]uril (CB[8]) exhibits high binding affinity to specific peptide sequences, allowing the peptide-CB[8] system to operate effectively in diverse biological applications. However, it is imperative to identify effective regulation factors for the binding of peptides with CB[8], making it a more promising and responsive host -guest system. In this study, we discovered that phosphorylation at the side chain of tyrosine residue can completely disrupt the binding of a tripeptide motif (YLA or MYA) with CB[8]. This discovery introduces a novel enzymatic strategy for regulating the peptide-CB[8] host -guest interaction. Furthermore, it has been applied to detect the activity of phosphatases by supramolecular tandem assays.
Keyword ：
cucurbit[8]uril cucurbit[8]uril Logic gates Logic gates Peptides Peptides Phosphorylation Phosphorylation
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| GB/T 7714 | Hu, Jun , Wang, Shi-Hao , Zhao, Yu -Fen et al. Phosphorylation-responsive system for enzyme activity detection based on peptide-cucurbit[8]uril interactions [J]. | DYES AND PIGMENTS , 2024 , 229 . |
| MLA | Hu, Jun et al. "Phosphorylation-responsive system for enzyme activity detection based on peptide-cucurbit[8]uril interactions" . | DYES AND PIGMENTS 229 (2024) . |
| APA | Hu, Jun , Wang, Shi-Hao , Zhao, Yu -Fen , Li, Gao , Chen, Yong -Xiang . Phosphorylation-responsive system for enzyme activity detection based on peptide-cucurbit[8]uril interactions . | DYES AND PIGMENTS , 2024 , 229 . |
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Protein kinases are involved in almost all biological activities. The activities of different kinases reflect the normal or abnormal status of the human body. Therefore, detecting the activities of different kinases is important for disease diagnosis and drug discovery. Fluorescent probes offer opportunities for studying kinase behaviors at different times and spatial locations. In this review, we summarize different kinds of fluorescent chemosensors that have been used to detect the activities of many different kinases.
Keyword ：
ATP ATP chemosensors chemosensors fluorescent fluorescent kinase kinase phosphorylation phosphorylation
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| GB/T 7714 | Hu, Jun , Li, Gao . Recent Advances in Fluorescent Chemosensors for Protein Kinases [J]. | CHEMISTRY-AN ASIAN JOURNAL , 2022 , 17 (14) . |
| MLA | Hu, Jun et al. "Recent Advances in Fluorescent Chemosensors for Protein Kinases" . | CHEMISTRY-AN ASIAN JOURNAL 17 . 14 (2022) . |
| APA | Hu, Jun , Li, Gao . Recent Advances in Fluorescent Chemosensors for Protein Kinases . | CHEMISTRY-AN ASIAN JOURNAL , 2022 , 17 (14) . |
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