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学者姓名：林榕光
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Abstract ：
Building on our innovative approach to combatting cancer, this study explores the development of a sophisticated hybrid nanocarrier system leveraging the unique properties of allyl oxide cucurbit[6]uril with galactose clusters (AOQ[6]@Gal) to modify ZIF-8 nanoparticles. These nanoparticles are designed to encapsulate and efficiently deliver the anticancer drugs doxorubicin (DOX) and curcumin (CUR), enhancing their water solubility and stability, while also providing active targeting towards hepatocellular carcinoma cells. The comprehensive characterization of AOQ[6]@Gal@ZIF-8@Drug nanoparticles revealed promising outcomes, including drug loading efficiencies of 9.7% for DOX and 8.3% for CUR, alongside a pH-responsive release profile that ensures effective drug delivery in the tumor microenvironment. Cytotoxicity studies underscored the hybrid system's superior safety profile, exhibiting minimal toxicity towards normal hepatocytes HL7702 and pronounced cytotoxic effects against hepatocellular carcinoma cells HepG2. These results highlight the hybrid nanocarrier's potential as a targeted, efficient, and safe platform for the delivery of chemotherapy agents in the treatment of liver cancer.
Keyword ：
chemotherapeutic drugs chemotherapeutic drugs Metal-organic frameworks (MOFs) Metal-organic frameworks (MOFs) multivalent effects multivalent effects pH-responsive pH-responsive targeted therapy targeted therapy
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| GB/T 7714 | Zheng, Mu-Yue , Zheng, Hao , Zeng, Yan et al. Enhanced targeted drug delivery to hepatocellular carcinoma using Cucurbit[6]uril-modified ZIF-8 nanoparticle [J]. | JOURNAL OF BIOMATERIALS APPLICATIONS , 2025 , 39 (8) : 920-932 . |
| MLA | Zheng, Mu-Yue et al. "Enhanced targeted drug delivery to hepatocellular carcinoma using Cucurbit[6]uril-modified ZIF-8 nanoparticle" . | JOURNAL OF BIOMATERIALS APPLICATIONS 39 . 8 (2025) : 920-932 . |
| APA | Zheng, Mu-Yue , Zheng, Hao , Zeng, Yan , Sun, Tong , Zhang, Fang-Zhong , Wang, Yu-Lin et al. Enhanced targeted drug delivery to hepatocellular carcinoma using Cucurbit[6]uril-modified ZIF-8 nanoparticle . | JOURNAL OF BIOMATERIALS APPLICATIONS , 2025 , 39 (8) , 920-932 . |
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Ensuring food safety and quality has driven significant research into antimicrobial packaging films based on natural biomaterials. This study developed antimicrobial composite films by incorporating lysozyme-lactoferrin@HZIF-8 into chitosan/gelatin matrices at varying concentrations (1%, 2%, 4%, and 8%). The chitosan/gelatin loaded lysozyme-lactoferrin@HZIF-8 (LLH-CS/G) composite films were characterized using SEM, FT-IR, and contact angle measurements, among others, to evaluate their structural, mechanical, and physicochemical properties. Antimicrobial tests demonstrated that the 8% LLH-CS/G film achieved a remarkable inhibition rate of over 99.9% against Staphylococcus aureus and Escherichia coli within 3 h, while the 4% LLH-CS/G film also showed excellent antimicrobial performance with inhibition rates exceeding 99% for both bacteria. Practical application experiments revealed that these films effectively inhibited bacterial growth on bread, significantly extending its shelf life. The results highlight the potential of LLH-CS/G films for use in food preservation, particularly for breads packaging, offering an innovative approach to integrating metal-organic frameworks into food packaging applications. © 2025, The Authors. All rights reserved.
Keyword ：
Acetobacter Acetobacter Biological materials preservation Biological materials preservation Composite films Composite films Escherichia coli Escherichia coli Food preservatives Food preservatives Listeria Listeria
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| GB/T 7714 | Zheng, Hao , Zeng, Yan , Zheng, Mu-Yue et al. Study on the Antimicrobial Performance of Chitosan/Gelatin Composite Films Loaded with Lysozyme-Lactoferrin@Hzif-8 for Breads Preservation [J]. | SSRN , 2025 . |
| MLA | Zheng, Hao et al. "Study on the Antimicrobial Performance of Chitosan/Gelatin Composite Films Loaded with Lysozyme-Lactoferrin@Hzif-8 for Breads Preservation" . | SSRN (2025) . |
| APA | Zheng, Hao , Zeng, Yan , Zheng, Mu-Yue , Sun, Tong , Wang, Yu-Lin , Lin, Zu-Jin et al. Study on the Antimicrobial Performance of Chitosan/Gelatin Composite Films Loaded with Lysozyme-Lactoferrin@Hzif-8 for Breads Preservation . | SSRN , 2025 . |
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Ag NPs were generated by reducing silver ions with sodium borohydride and then loaded into a zirconium-based MOF, PCN-222, resulting in a deep purple powder, PCN-222@AgNPs, which exhibited photocatalytic activity. The material was characterized and found to have Ag NPs uniformly dispersed in the pores of PCN-222, with a content of 6.0306%. PCN-222@AgNPs had rod-shaped structures of micrometer sizes with irregular spherical Ag NPs on their surfaces, as revealed by scanning electron microscopy and transmission electron microscopy. In experiments on Ag NPs release and reactive oxygen species (ROS) detection, PCN-222@AgNPs effectively released Ag NPs into an aqueous solution and promote ROS generation. Finally, the antibacterial activities of PCN-222@AgNPs against Escherichia coli and Staphylococcus aureus were assessed by in vitro experiments. Results indicated that PCN-222@AgNPs had lower minimum bactericidal concentration (MBC) compared to PCN-222 in both light and dark environments. The MBC further decreased under light conditions due to the enhanced photocatalytic performance of the composite material and the promotion of Ag NPs release by ROS. These findings demonstrate that PCN-222@AgNPs have synergistic antibacterial effects under visible light irradiation.
Keyword ：
antibacterial activity antibacterial activity metal-organic frameworks metal-organic frameworks photodynamic therapy photodynamic therapy reactive oxygen species reactive oxygen species Silver nanoparticles Silver nanoparticles
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| GB/T 7714 | Zhang, Fang-Zhong , Zeng, Yan , Zheng, Mu-Yue et al. Photocatalytic activity and synergistic antibacterial effects of PCN-222@AgNPs under visible light irradiation [J]. | JOURNAL OF COORDINATION CHEMISTRY , 2024 , 77 (1-2) : 188-202 . |
| MLA | Zhang, Fang-Zhong et al. "Photocatalytic activity and synergistic antibacterial effects of PCN-222@AgNPs under visible light irradiation" . | JOURNAL OF COORDINATION CHEMISTRY 77 . 1-2 (2024) : 188-202 . |
| APA | Zhang, Fang-Zhong , Zeng, Yan , Zheng, Mu-Yue , Zheng, Hao , Fang, Meng , Xie, Bao-Xuan et al. Photocatalytic activity and synergistic antibacterial effects of PCN-222@AgNPs under visible light irradiation . | JOURNAL OF COORDINATION CHEMISTRY , 2024 , 77 (1-2) , 188-202 . |
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Pathogenic bacteria have consistently posed a formidable challenge to human health, creating the critical need for effective antibacterial solutions. In response, enzyme-metal-organic framework (MOF) composites have emerged as a promising class of antibacterial agents. This study focuses on the development of an enzyme-MOF composite based on HZIF-8, incorporating the advantages of simple synthesis, ZIF-8 antibacterial properties, lysozyme hydrolysis, and high biological safety. Through a one-pot method, core-shell nanoparticles (HZIF-8) were synthesized. This structure enables efficient immobilization of lysozyme and lactoferrin within the HZIF-8, resulting in the formation of the lysozyme-lactoferrin@HZIF-8 (LYZ-LF@HZIF-8) composite. Upon exposure to light irradiation, HZIF-8 itself possessed antibacterial properties. Lysozyme initiated the degradation of bacterial peptidoglycan and lactoferrin synergistically enhanced the antibacterial effect of lysozyme. All of the above ultimately contributed to comprehensive antibacterial activity. Antibacterial assessments demonstrated the efficacy of the LYZ-LF@HZIF-8 composite, effectively eradicating Staphylococcus aureus at a cell density of 1.5 x 10(6) CFU/mL with a low dosage of 200 mu g/mL and completely inactivating Escherichia coli at 400 mu g/mL with the same cell density. The enzyme-MOF composite exhibited significant and durable antibacterial efficacy, with no apparent cytotoxicity in vitro, thereby unveiling expansive prospects for applications in the medical and food industries.
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| GB/T 7714 | Zheng, Hao , Sun, Tong , Zeng, Yan et al. Hierarchical Micro- and Mesoporous Zeolitic Imidazolate Framework-8-Based Enzyme Hybrid for Combination Antimicrobial by Lysozyme and Lactoferrin [J]. | INORGANIC CHEMISTRY , 2024 , 63 (26) : 12377-12384 . |
| MLA | Zheng, Hao et al. "Hierarchical Micro- and Mesoporous Zeolitic Imidazolate Framework-8-Based Enzyme Hybrid for Combination Antimicrobial by Lysozyme and Lactoferrin" . | INORGANIC CHEMISTRY 63 . 26 (2024) : 12377-12384 . |
| APA | Zheng, Hao , Sun, Tong , Zeng, Yan , Zheng, Mu-Yue , Zhang, Fang-Zhong , Wang, Yu-Lin et al. Hierarchical Micro- and Mesoporous Zeolitic Imidazolate Framework-8-Based Enzyme Hybrid for Combination Antimicrobial by Lysozyme and Lactoferrin . | INORGANIC CHEMISTRY , 2024 , 63 (26) , 12377-12384 . |
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Abstract ：
Pathogenic bacteria have consistently posed a formidable challenge to human health, emphasizing the critical need for effective antibacterial solutions. In response, metal-organic framework (MOF)-enzyme composite materials have emerged as a promising class of antibacterial agents. This study focuses on the development of a nanoenzyme hybrid based on HZIF-8, harnessing the synergistic potential of simple synthesis, ZIF-8 antibacterial properties, lysozyme hydrolysis, and high biological safety. Through a one-pot method, core-shell nanoparticles (HZIF-8) were synthesized to efficiently immobilize lysozyme and lactoferrin within the HZIF-8 structure, resulting in the formation of the lysozyme-lactoferrin@HZIF-8 (LYZ-LF@HZIF-8) nanoenzyme hybrid. Upon exposure to light irradiation, lysozyme initiated the degradation of bacterial peptidoglycan, HZIF-8 efficiently captured photogenerated reactive oxygen species (ROS), and lactoferrin synergistically enhanced the antibacterial effect of lysozyme, culminating in a comprehensive antibacterial activity. Antibacterial assessments demonstrated the efficacy of the LYZ-LF@HZIF-8 nanoenzyme hybrid, effectively eradicating S. aureus at a cell density of 1.5×106 with a low dosage of 200 μg/mL, and completely inactivating E. coli at 400 μg/mL with the same cell density. The nanoenzyme hybrid exhibited significant and durable antibacterial efficacy, with no apparent cytotoxicity in vitro, thereby unveiling expansive prospects for applications in the medical and food industries. © 2024, The Authors. All rights reserved.
Keyword ：
Core shell nanoparticles Core shell nanoparticles Enzymes Enzymes Escherichia coli Escherichia coli Organometallics Organometallics Synthesis (chemical) Synthesis (chemical)
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| GB/T 7714 | Zheng, Hao , Sun, Tong , Zeng, Yan et al. Hierarchical Micro- and Mesoporous Zeolitic Imidazolate Framework-8 Based Enzyme Hybrid for Combination Antimicrobial by Lysozyme and Lactoferrin [J]. | SSRN , 2024 . |
| MLA | Zheng, Hao et al. "Hierarchical Micro- and Mesoporous Zeolitic Imidazolate Framework-8 Based Enzyme Hybrid for Combination Antimicrobial by Lysozyme and Lactoferrin" . | SSRN (2024) . |
| APA | Zheng, Hao , Sun, Tong , Zeng, Yan , Zheng, Mu-Yue , Zhang, Fang-Zhong , Wang, Yu-Lin et al. Hierarchical Micro- and Mesoporous Zeolitic Imidazolate Framework-8 Based Enzyme Hybrid for Combination Antimicrobial by Lysozyme and Lactoferrin . | SSRN , 2024 . |
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Abstract ：
立德树人是当代高等教育的生命和灵魂，学校是实施立德树人的主渠道。在学校教育中使各类课程与德育教育有机结合，是实现全程育人、全方位育人的重要举措。通过以“润湿作用”作为教学设计案例，深入挖掘了思政元素，将思政元素与BOPPPS教学模式自然融合，潜移默化地实现立德树人的育人理念。
Keyword ：
BOPPPS BOPPPS 教学设计 教学设计 润湿作用 润湿作用 立德树人 立德树人
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| GB/T 7714 | 赵艳 , 杨金梅 , 谢勇平 et al. 立德树人理念下BOPPPS教学模式设计与实践——以“润湿作用”为例 [J]. | 云南化工 , 2024 , 51 (10) : 212-215 . |
| MLA | 赵艳 et al. "立德树人理念下BOPPPS教学模式设计与实践——以“润湿作用”为例" . | 云南化工 51 . 10 (2024) : 212-215 . |
| APA | 赵艳 , 杨金梅 , 谢勇平 , 江茂生 , 林榕光 . 立德树人理念下BOPPPS教学模式设计与实践——以“润湿作用”为例 . | 云南化工 , 2024 , 51 (10) , 212-215 . |
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Abstract ：
Ensuring food safety and quality has driven significant research into antimicrobial packaging films based on natural biomaterials. This study developed antimicrobial composite films by incorporating lysozyme-lactoferrin@HZIF-8 into chitosan/gelatin matrices at varying concentrations (1%, 2%, 4%, and 8%). The LLH-CS/G composite films were characterized using SEM, FT-IR, and contact angle measurements, among others, to evaluate their structural, mechanical, and physicochemical properties. Antimicrobial tests demonstrated that the 8% LLH-CS/G film achieved a remarkable inhibition rate of over 99.9% against Staphylococcus aureus and Escherichia coli within 3 h, while the 4% LLH-CS/G film also showed excellent antimicrobial performance with inhibition rates exceeding 99% for both bacteria. Practical application experiments revealed that these films effectively inhibited bacterial growth on bread, significantly extending its shelf life. The results highlight the potential of LLH-CS/G films for use in food preservation, particularly for dry food packaging, offering an innovative approach to integrating metal-organic frameworks into food packaging applications. © 2024, The Authors. All rights reserved.
Keyword ：
Chitosan Chitosan Escherichia coli Escherichia coli Food preservation Food preservation Shelf life Shelf life
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| GB/T 7714 | Zheng, Hao , Zeng, Yan , Zheng, Mu-Yue et al. Study on the Antimicrobial Performance of Chitosan/Gelatin Composite Films Loaded with Lysozyme-Lactoferrin@Hzif-8 for Food Preservation [J]. | SSRN , 2024 . |
| MLA | Zheng, Hao et al. "Study on the Antimicrobial Performance of Chitosan/Gelatin Composite Films Loaded with Lysozyme-Lactoferrin@Hzif-8 for Food Preservation" . | SSRN (2024) . |
| APA | Zheng, Hao , Zeng, Yan , Zheng, Mu-Yue , Sun, Tong , Wang, Yu-Lin , Lin, Zu-Jin et al. Study on the Antimicrobial Performance of Chitosan/Gelatin Composite Films Loaded with Lysozyme-Lactoferrin@Hzif-8 for Food Preservation . | SSRN , 2024 . |
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Abstract ：
立德树人是当代高等教育的生命和灵魂,学校是实施立德树人的主渠道.在学校教育中使各类课程与德育教育有机结合,是实现全程育人、全方位育人的重要举措.通过以"润湿作用"作为教学设计案例,深入挖掘了思政元素,将思政元素与BOPPPS教学模式自然融合,潜移默化地实现立德树人的育人理念.
Keyword ：
BOPPPS BOPPPS 教学设计 教学设计 润湿作用 润湿作用 立德树人 立德树人
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| GB/T 7714 | 赵艳 , 杨金梅 , 谢勇平 et al. 立德树人理念下BOPPPS教学模式设计与实践 [J]. | 云南化工 , 2024 , 51 (10) : 212-215 . |
| MLA | 赵艳 et al. "立德树人理念下BOPPPS教学模式设计与实践" . | 云南化工 51 . 10 (2024) : 212-215 . |
| APA | 赵艳 , 杨金梅 , 谢勇平 , 江茂生 , 林榕光 . 立德树人理念下BOPPPS教学模式设计与实践 . | 云南化工 , 2024 , 51 (10) , 212-215 . |
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Abstract ：
Bacterial infectious diseases are severe threats to human health and increase substantial financial burdens. Nanomaterials have shown great potential in timely and accurate bacterial identification, detection, and monitoring to improve the cure rate and reduce mortality. Recently, carbon dots have been evidenced to be ideal candidates for bacterial identification and detection due to their superior physicochemical properties and biocompatibility. This review outlines the detailed recognition elements and recognition strategies with functionalized carbon dots (FCDs) for bacterial identification and detection. The advantages and limitations of different kinds of FCDs-based sensors will be critically discussed. Meanwhile, the ongoing challenges and perspectives of FCDs-based sensors for bacteria sensing are put forward.
Keyword ：
Bacterial identification and detection Bacterial identification and detection Functionalized carbon dots Functionalized carbon dots Recognition elements Recognition elements Recognition strategies Recognition strategies
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| GB/T 7714 | Lin, Liping , Fang, Meng , Liu, Wei et al. Recent advances and perspectives of functionalized carbon dots in bacteria sensing [J]. | MICROCHIMICA ACTA , 2023 , 190 (9) . |
| MLA | Lin, Liping et al. "Recent advances and perspectives of functionalized carbon dots in bacteria sensing" . | MICROCHIMICA ACTA 190 . 9 (2023) . |
| APA | Lin, Liping , Fang, Meng , Liu, Wei , Zheng, Meixia , Lin, Rongguang . Recent advances and perspectives of functionalized carbon dots in bacteria sensing . | MICROCHIMICA ACTA , 2023 , 190 (9) . |
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Bacterial infections and inflammation pose a severe threat to human health and the social economy. The existence of super-bacteria and the increasingly severe phenomenon of antibiotic resistance highlight the development of new antibacterial agents. Due to low cytotoxicity, high biocompatibility, and different antibacterial mechanisms from those for antibiotics, functionalized carbon dots (FCDs) promise a new platform for the treatment of bacterial infectious diseases. However, few articles have systematically sorted out the available antibacterial mechanisms for FCDs and their application in the treatment of bacterial inflammation. This review focuses on the available antibacterial mechanisms for FCDs, including covalent and non-covalent interactions, reactive oxygen species, photothermal therapy, and size effect. Meanwhile, the design of antibacterial FCDs is introduced, including surface modification, doping, and combination with other nanomaterials. Furthermore, this review specifically concentrates on the research advances of antibacterial FCDs in the treatment of bacterial inflammation. Finally, the advantages and challenges of applying FCDs in practical antimicrobial applications are discussed. Antimicrobial mechanisms of functionalized carbon dots: covalent and non-covalent interactions, reactive oxygen species, photothermal effect, and size effect (E. coli was used as a model).
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| GB/T 7714 | Fang, Meng , Lin, Liping , Zheng, Muyue et al. Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2023 , 11 (39) : 9386-9403 . |
| MLA | Fang, Meng et al. "Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation" . | JOURNAL OF MATERIALS CHEMISTRY B 11 . 39 (2023) : 9386-9403 . |
| APA | Fang, Meng , Lin, Liping , Zheng, Muyue , Liu, Wei , Lin, Rongguang . Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation . | JOURNAL OF MATERIALS CHEMISTRY B , 2023 , 11 (39) , 9386-9403 . |
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