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学者姓名：高江涛
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Abstract ：
Polysaccharide-based antifreeze hydrogels mark a significant advancement in cold-chain food preservation technology. This hydrogel exhibits excellent water retention and freeze resistance, thereby effectively safeguarding the quality of food in low-temperature environments. This review explores these materials' fundamental principles and practical applications in food science, focusing on their role in smart packaging systems. It examines the molecular design principles, including criteria for polysaccharide selection and mechanisms for preventing freezing, through the lenses of food safety requirements and industrial scalability. Recent advancements in temperature-responsive packaging and fresh produce preservation highlight these materials' practical impact. Integrating multiple preservation mechanisms with smart sensing capabilities opens new avenues for enhancing food quality control. Despite technical and regulatory challenges, ongoing research in biodegradable systems and optimization of mechanical properties indicates promising directions for commercial implementation. This review provides a framework for understanding antifreeze hydrogels' current state and future trajectory in food preservation applications.
Keyword ：
Antifreeze Antifreeze Food preservation Food preservation Hydrogels Hydrogels Polysaccharide Polysaccharide
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| GB/T 7714 | Wang, Yueguang , Huang, Zifeng , Li, Meining et al. Polysaccharide-based antifreeze hydrogels in food preservation: From molecular design to smart food packaging applications [J]. | FOOD RESEARCH INTERNATIONAL , 2025 , 211 . |
| MLA | Wang, Yueguang et al. "Polysaccharide-based antifreeze hydrogels in food preservation: From molecular design to smart food packaging applications" . | FOOD RESEARCH INTERNATIONAL 211 (2025) . |
| APA | Wang, Yueguang , Huang, Zifeng , Li, Meining , Lei, Xin , Zhou, Hanlin , Dai, Oujun et al. Polysaccharide-based antifreeze hydrogels in food preservation: From molecular design to smart food packaging applications . | FOOD RESEARCH INTERNATIONAL , 2025 , 211 . |
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Covering: 2000 to 2025This review explores the potential of artificial intelligence (AI) in addressing challenges and accelerating molecular insights in biosynthetic pathway research, which is crucial for developing bioactive natural products with applications in pharmacology, agriculture, and biotechnology. It provides an overview of various AI techniques relevant to this research field, including machine learning (ML), deep learning (DL), natural language processing, network analysis, and data mining. AI-powered applications across three main areas, namely, pathway discovery and mining, pathway design, and pathway optimization, are discussed, and the benefits and challenges of integrating omics data and AI for enhanced pathway research are also elucidated. This review also addresses the current limitations, future directions, and the importance of synergy between AI and experimental approaches in unlocking rapid advancements in biosynthetic pathway research. The review concludes with an evaluation of AI's current capabilities and future outlook, emphasizing the transformative impact of AI on biosynthetic pathway research and the potential for new opportunities in the discovery and optimization of bioactive natural products.
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| GB/T 7714 | Liao, Lijuan , Xie, Mengjun , Zheng, Xiaoshan et al. Molecular insights fast-tracked: AI in biosynthetic pathway research [J]. | NATURAL PRODUCT REPORTS , 2025 , 42 (5) : 911-936 . |
| MLA | Liao, Lijuan et al. "Molecular insights fast-tracked: AI in biosynthetic pathway research" . | NATURAL PRODUCT REPORTS 42 . 5 (2025) : 911-936 . |
| APA | Liao, Lijuan , Xie, Mengjun , Zheng, Xiaoshan , Zhou, Zhao , Deng, Zixin , Gao, Jiangtao . Molecular insights fast-tracked: AI in biosynthetic pathway research . | NATURAL PRODUCT REPORTS , 2025 , 42 (5) , 911-936 . |
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Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental and clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic and programmable materials to yield engineered nanomaterials with emerging and specific functionalities. This review elucidates a comprehensive examination of synthetic biology's pivotal role in advancing engineered nanomaterials for targeted drug delivery systems. It begins with exploring the fundamental synergy between synthetic biology and nanotechnology, then highlights the current landscape of nanomaterials in targeted drug delivery applications. Subsequently, the review discusses the design of novel nanomaterials informed by biological principles, focusing on expounding the synthetic biology tools and the potential for developing advanced nanomaterials. Afterward, the research advances of innovative materials design through synthetic biology were systematically summarized, emphasizing the integration of genetic circuitry to program nanomaterial responses. Furthermore, the challenges, current weaknesses and opportunities, prospective directions, and ethical and societal implications of SynBioNanoDesign in drug delivery are elucidated. Finally, the review summarizes the transformative impact that synthetic biology may have on drug-delivery technologies in the future.
Keyword ：
Engineered nanomaterials Engineered nanomaterials Genetic circuitry Genetic circuitry Nanobiotechnology Nanobiotechnology Personalized medicine Personalized medicine Regulatory challenges Regulatory challenges Synthetic biology Synthetic biology Targeted drug delivery Targeted drug delivery
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| GB/T 7714 | Cai, Qian , Guo, Rui , Chen, Dafu et al. SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials [J]. | JOURNAL OF NANOBIOTECHNOLOGY , 2025 , 23 (1) . |
| MLA | Cai, Qian et al. "SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials" . | JOURNAL OF NANOBIOTECHNOLOGY 23 . 1 (2025) . |
| APA | Cai, Qian , Guo, Rui , Chen, Dafu , Deng, Zixin , Gao, Jiangtao . SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials . | JOURNAL OF NANOBIOTECHNOLOGY , 2025 , 23 (1) . |
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Glyphosate-based herbicides (GBHs) are used worldwide for weed management. However, GBHs pose a threat to soil fungal community, although fungi can degrade and use glyphosate as a nutrient source. How fungi respond to GBHs remains enigmatic. Here, we found that, not as in plants, the commercial GBH Roundup does not target the 5-enolpyruvyl-shikimate-3-phosphate synthase in the soil-derived fungus Trichoderma guizhouense, whereas it impairs fungal growth. We demonstrate that the herbicide adjuvant Triton CG-110 is more toxic to fungal cells than pure glyphosate. It limits nitrogen uptake, which induces the expression of proteinase YPS1 to catalyze the shedding of the MSB2 extracellular domain from the plasma membrane, leading to the activation of the MAPK TMK1 pheromone pathway. The downstream B2H2-type transcription factor STE12 directly regulates ergosterol biosynthesis, affecting membrane fluidity and stability. To our knowledge, this is the first evidence that the pheromone pathway is implicated in ergosterol biosynthesis and plasma membrane integrity.
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| GB/T 7714 | Pu, Jianwei , Long, Xiuju , Li, Yifan et al. MSB2-activated pheromone pathway regulates fungal plasma membrane integrity in response to herbicide adjuvant [J]. | SCIENCE ADVANCES , 2025 , 11 (9) . |
| MLA | Pu, Jianwei et al. "MSB2-activated pheromone pathway regulates fungal plasma membrane integrity in response to herbicide adjuvant" . | SCIENCE ADVANCES 11 . 9 (2025) . |
| APA | Pu, Jianwei , Long, Xiuju , Li, Yifan , Zhang, Jian , Qi, Fei , Gao, Jiangtao et al. MSB2-activated pheromone pathway regulates fungal plasma membrane integrity in response to herbicide adjuvant . | SCIENCE ADVANCES , 2025 , 11 (9) . |
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Unveiling a metabolic mystery, this article explores how 3-Oacylated bile acids, specifically 3-O-succinylated cholic acid (3sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).
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| GB/T 7714 | Chen, Runzhi , Chen, Xinhua , Gao, Jiangtao . Forum 3-O-acylated bile acids: disrupters or harmonizers of metabolism? [J]. | TRENDS IN MOLECULAR MEDICINE , 2025 , 31 (2) : 103-105 . |
| MLA | Chen, Runzhi et al. "Forum 3-O-acylated bile acids: disrupters or harmonizers of metabolism?" . | TRENDS IN MOLECULAR MEDICINE 31 . 2 (2025) : 103-105 . |
| APA | Chen, Runzhi , Chen, Xinhua , Gao, Jiangtao . Forum 3-O-acylated bile acids: disrupters or harmonizers of metabolism? . | TRENDS IN MOLECULAR MEDICINE , 2025 , 31 (2) , 103-105 . |
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Ratiometric afterglow luminescence has emerged as a transformative approach for quantitative bio-imaging and disease monitoring, addressing fundamental limitations in conventional imaging techniques. This review examines recent advancements in ratiometric afterglow probes, concentrating on their design principles, energy transfer mechanisms, and applications in disease detection. The integration of dual-emission capabilities with prolonged luminescence enables reliable quantification by eliminating background interference and providing internal calibration. Recent advances have demonstrated exceptional performance in monitoring cancer immunotherapy, arthritis progression, and brain tumor development through the detection of specific biomarkers. Despite significant progress, challenges remain in material design, signal stability, and clinical translation. The review examines current engineering solutions and emerging opportunities, particularly in the integration of artificial intelligence, multiplexed sensing, and the development of point-of-care diagnostics. These advances establish ratiometric afterglow luminescence as a powerful platform for next-generation biomedical imaging and disease monitoring systems.
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| GB/T 7714 | Yuan, Meng , Bao, Shuaiming , Wu, Kejun et al. Ratiometric afterglow luminescence: Emerging paradigm for reliable quantitative bio-imaging and disease monitoring [J]. | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 191 . |
| MLA | Yuan, Meng et al. "Ratiometric afterglow luminescence: Emerging paradigm for reliable quantitative bio-imaging and disease monitoring" . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY 191 (2025) . |
| APA | Yuan, Meng , Bao, Shuaiming , Wu, Kejun , Deng, Zixin , Yang, Huanghao , Gao, Jiangtao . Ratiometric afterglow luminescence: Emerging paradigm for reliable quantitative bio-imaging and disease monitoring . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 191 . |
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This review evaluates duramycin, a lantibiotic antimicrobial peptide, focusing on its biochemical properties, biosynthetic mechanisms, structural characteristics, and therapeutic applications. We examine the critical role of lanthionine and methyllanthionine in antimicrobial efficacy and trace duramycin's development trajectory. Molecular analysis of duramycin highlights the significance of post-translational modifications and leader peptide interactions in its functionality. The peptide's mechanism of action, which involves disrupting membrane integrity through phosphatidylethanolamine binding, forms the foundation of its antimicrobial activity. We assess duramycin's clinical progress, particularly its advancement to Phase II trials for cystic fibrosis therapy, and evaluate its potential against viral infections. The review addresses challenges in production, resistance development, and clinical delivery while exploring emerging applications in cancer treatment, diagnostics, and molecular probes for studying membrane dynamics. We conclude by examining future directions for lantibiotic engineering and the broader implications of duramycin research for antimicrobial therapy and biomedicine.
Keyword ：
Antimicrobial peptides Antimicrobial peptides Duramycin Duramycin Lantibiotics Lantibiotics Phosphatidylethanolamine Phosphatidylethanolamine Therapeutic applications Therapeutic applications
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| GB/T 7714 | Yuan, Meng , Bao, Shuaiming , Wu, Kejun et al. Duramycin: Exploring the therapeutic frontier of a unique lantibiotic [J]. | PEPTIDES , 2025 , 193 . |
| MLA | Yuan, Meng et al. "Duramycin: Exploring the therapeutic frontier of a unique lantibiotic" . | PEPTIDES 193 (2025) . |
| APA | Yuan, Meng , Bao, Shuaiming , Wu, Kejun , Deng, Zixin , Gao, Jiangtao . Duramycin: Exploring the therapeutic frontier of a unique lantibiotic . | PEPTIDES , 2025 , 193 . |
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Electric fields in sediments and soils are critical yet overlooked drivers of microbial ecology. This review examines the importance of electrotaxis in shaping microbial community dynamics and ecology models, surpassing traditional frameworks centered on chemotaxis. We analyze evidence that electric field gradients influence microbial community structure, function, and biogeochemical cycles in natural environments. Current mechanistic models, primarily based on eukaryotic systems, insufficiently explain bacterial electrotactic responses, necessitating new conceptual frameworks that integrate electrochemical and biological perspectives. We also evaluate its applications in environmental and microbiome engineering, with future research recommendations and methodologies in electrotaxis research. This synthesis aims to establish electrotaxis as an essential consideration in microbial ecology, presenting both challenges and opportunities for advancing our understanding of microbial ecosystems.
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| GB/T 7714 | Zhang, Dong , Gao, Jiang Tao , Zhou, Shun Gui . Microbial electrotaxis: rewiring environmental microbiomes [J]. | TRENDS IN MICROBIOLOGY , 2025 , 33 (9) : 989-1002 . |
| MLA | Zhang, Dong et al. "Microbial electrotaxis: rewiring environmental microbiomes" . | TRENDS IN MICROBIOLOGY 33 . 9 (2025) : 989-1002 . |
| APA | Zhang, Dong , Gao, Jiang Tao , Zhou, Shun Gui . Microbial electrotaxis: rewiring environmental microbiomes . | TRENDS IN MICROBIOLOGY , 2025 , 33 (9) , 989-1002 . |
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| GB/T 7714 | Zhao, Kailin , Wang, Luyao , Deng, Zixin et al. Beyond Erucamide: Reimagining Chemical Ecology in the Food-Agriculture Continuum [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (25) : 15464-15466 . |
| MLA | Zhao, Kailin et al. "Beyond Erucamide: Reimagining Chemical Ecology in the Food-Agriculture Continuum" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73 . 25 (2025) : 15464-15466 . |
| APA | Zhao, Kailin , Wang, Luyao , Deng, Zixin , Gao, Jiangtao . Beyond Erucamide: Reimagining Chemical Ecology in the Food-Agriculture Continuum . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (25) , 15464-15466 . |
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This review analyzes peptide backbone modifications in drug design, examining fundamental principles and applications in pharmaceutical development. A systematic classification of modification approaches encompasses amide bond alterations, a-carbon modifications, backbone extensions and conformational constraints. The analysis evaluates synthetic methodologies, computational tools and biological outcomes, emphasizing clinical translation barriers. Critical examination of current design paradigms reveals systematic biases and unexpected effects while advancing theoretical frameworks incorporating multi-scale phenomena. The work addresses computational modeling limitations, regulatory requirements and production challenges, presenting evidence-based solutions. This integration of chemical, biological and computational perspectives provides a foundation for advancing peptide-based therapeutics.
Keyword ：
artificial intelligence artificial intelligence modified peptide synthesis modified peptide synthesis peptide backbone modifications peptide backbone modifications Peptide-based drugs Peptide-based drugs rational peptide backbone engineering rational peptide backbone engineering
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| GB/T 7714 | Zhang, Peng , Hao, Youjia , Xie, Mengjun et al. Molecular craftsmanship: reforging peptide backbones for enhanced drug design [J]. | DRUG DISCOVERY TODAY , 2025 , 30 (7) . |
| MLA | Zhang, Peng et al. "Molecular craftsmanship: reforging peptide backbones for enhanced drug design" . | DRUG DISCOVERY TODAY 30 . 7 (2025) . |
| APA | Zhang, Peng , Hao, Youjia , Xie, Mengjun , Wang, Huan , Gao, Jiangtao . Molecular craftsmanship: reforging peptide backbones for enhanced drug design . | DRUG DISCOVERY TODAY , 2025 , 30 (7) . |
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