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学者姓名：高江涛
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Abstract ：
Glyphosate-based herbicides (GBHs) are used worldwide for weed management. However, GBHs pose a threat to soil fungal community, although fungi can degrade and use glyphosate as a nutrient source. How fungi respond to GBHs remains enigmatic. Here, we found that, not as in plants, the commercial GBH Roundup does not target the 5-enolpyruvyl-shikimate-3-phosphate synthase in the soil-derived fungus Trichoderma guizhouense, whereas it impairs fungal growth. We demonstrate that the herbicide adjuvant Triton CG-110 is more toxic to fungal cells than pure glyphosate. It limits nitrogen uptake, which induces the expression of proteinase YPS1 to catalyze the shedding of the MSB2 extracellular domain from the plasma membrane, leading to the activation of the MAPK TMK1 pheromone pathway. The downstream B2H2-type transcription factor STE12 directly regulates ergosterol biosynthesis, affecting membrane fluidity and stability. To our knowledge, this is the first evidence that the pheromone pathway is implicated in ergosterol biosynthesis and plasma membrane integrity.
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| GB/T 7714 | Pu, Jianwei , Long, Xiuju , Li, Yifan et al. MSB2-activated pheromone pathway regulates fungal plasma membrane integrity in response to herbicide adjuvant [J]. | SCIENCE ADVANCES , 2025 , 11 (9) . |
| MLA | Pu, Jianwei et al. "MSB2-activated pheromone pathway regulates fungal plasma membrane integrity in response to herbicide adjuvant" . | SCIENCE ADVANCES 11 . 9 (2025) . |
| APA | Pu, Jianwei , Long, Xiuju , Li, Yifan , Zhang, Jian , Qi, Fei , Gao, Jiangtao et al. MSB2-activated pheromone pathway regulates fungal plasma membrane integrity in response to herbicide adjuvant . | SCIENCE ADVANCES , 2025 , 11 (9) . |
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Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental and clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic and programmable materials to yield engineered nanomaterials with emerging and specific functionalities. This review elucidates a comprehensive examination of synthetic biology's pivotal role in advancing engineered nanomaterials for targeted drug delivery systems. It begins with exploring the fundamental synergy between synthetic biology and nanotechnology, then highlights the current landscape of nanomaterials in targeted drug delivery applications. Subsequently, the review discusses the design of novel nanomaterials informed by biological principles, focusing on expounding the synthetic biology tools and the potential for developing advanced nanomaterials. Afterward, the research advances of innovative materials design through synthetic biology were systematically summarized, emphasizing the integration of genetic circuitry to program nanomaterial responses. Furthermore, the challenges, current weaknesses and opportunities, prospective directions, and ethical and societal implications of SynBioNanoDesign in drug delivery are elucidated. Finally, the review summarizes the transformative impact that synthetic biology may have on drug-delivery technologies in the future.
Keyword ：
Engineered nanomaterials Engineered nanomaterials Genetic circuitry Genetic circuitry Nanobiotechnology Nanobiotechnology Personalized medicine Personalized medicine Regulatory challenges Regulatory challenges Synthetic biology Synthetic biology Targeted drug delivery Targeted drug delivery
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| GB/T 7714 | Cai, Qian , Guo, Rui , Chen, Dafu et al. SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials [J]. | JOURNAL OF NANOBIOTECHNOLOGY , 2025 , 23 (1) . |
| MLA | Cai, Qian et al. "SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials" . | JOURNAL OF NANOBIOTECHNOLOGY 23 . 1 (2025) . |
| APA | Cai, Qian , Guo, Rui , Chen, Dafu , Deng, Zixin , Gao, Jiangtao . SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials . | JOURNAL OF NANOBIOTECHNOLOGY , 2025 , 23 (1) . |
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Ratiometric afterglow luminescence has emerged as a transformative approach for quantitative bio-imaging and disease monitoring, addressing fundamental limitations in conventional imaging techniques. This review examines recent advancements in ratiometric afterglow probes, concentrating on their design principles, energy transfer mechanisms, and applications in disease detection. The integration of dual-emission capabilities with prolonged luminescence enables reliable quantification by eliminating background interference and providing internal calibration. Recent advances have demonstrated exceptional performance in monitoring cancer immunotherapy, arthritis progression, and brain tumor development through the detection of specific biomarkers. Despite significant progress, challenges remain in material design, signal stability, and clinical translation. The review examines current engineering solutions and emerging opportunities, particularly in the integration of artificial intelligence, multiplexed sensing, and the development of point-of-care diagnostics. These advances establish ratiometric afterglow luminescence as a powerful platform for next-generation biomedical imaging and disease monitoring systems.
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| GB/T 7714 | Yuan, Meng , Bao, Shuaiming , Wu, Kejun et al. Ratiometric afterglow luminescence: Emerging paradigm for reliable quantitative bio-imaging and disease monitoring [J]. | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 191 . |
| MLA | Yuan, Meng et al. "Ratiometric afterglow luminescence: Emerging paradigm for reliable quantitative bio-imaging and disease monitoring" . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY 191 (2025) . |
| APA | Yuan, Meng , Bao, Shuaiming , Wu, Kejun , Deng, Zixin , Yang, Huanghao , Gao, Jiangtao . Ratiometric afterglow luminescence: Emerging paradigm for reliable quantitative bio-imaging and disease monitoring . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 191 . |
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Electric fields in sediments and soils are critical yet overlooked drivers of microbial ecology. This review examines the importance of electrotaxis in shaping microbial community dynamics and ecology models, surpassing traditional frameworks centered on chemotaxis. We analyze evidence that electric field gradients influence microbial community structure, function, and biogeochemical cycles in natural environments. Current mechanistic models, primarily based on eukaryotic systems, insufficiently explain bacterial electrotactic responses, necessitating new conceptual frameworks that integrate electrochemical and biological perspectives. We also evaluate its applications in environmental and microbiome engineering, with future research recommendations and methodologies in electrotaxis research. This synthesis aims to establish electrotaxis as an essential consideration in microbial ecology, presenting both challenges and opportunities for advancing our understanding of microbial ecosystems.
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| GB/T 7714 | Zhang, Dong , Gao, Jiang Tao , Zhou, Shun Gui . Microbial electrotaxis: rewiring environmental microbiomes [J]. | TRENDS IN MICROBIOLOGY , 2025 , 33 (9) : 989-1002 . |
| MLA | Zhang, Dong et al. "Microbial electrotaxis: rewiring environmental microbiomes" . | TRENDS IN MICROBIOLOGY 33 . 9 (2025) : 989-1002 . |
| APA | Zhang, Dong , Gao, Jiang Tao , Zhou, Shun Gui . Microbial electrotaxis: rewiring environmental microbiomes . | TRENDS IN MICROBIOLOGY , 2025 , 33 (9) , 989-1002 . |
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本发明属于农药技术领域，具体涉及天然膦酸化合物Argolaphos A的除草新用途。所述天然膦酸化合物Argolaphos A的结构式为：本发明研究发现，天然膦酸化合物Argolaphos A对十字花科植物拟南芥具有显著的除草效果，可抑制拟南芥叶片生长、减小拟南芥根长、减小拟南芥总鲜重。因此，天然膦酸化合物Argolaphos A可作为或制备成除草剂使用。
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| GB/T 7714 | 高江涛 , 廖丽娟 , 郑晓珊 . 天然膦酸化合物Argolaphos A的除草新用途 : CN202411638259.9[P]. | 2024-11-16 . |
| MLA | 高江涛 et al. "天然膦酸化合物Argolaphos A的除草新用途" : CN202411638259.9. | 2024-11-16 . |
| APA | 高江涛 , 廖丽娟 , 郑晓珊 . 天然膦酸化合物Argolaphos A的除草新用途 : CN202411638259.9. | 2024-11-16 . |
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Unveiling a metabolic mystery, this article explores how 3-Oacylated bile acids, specifically 3-O-succinylated cholic acid (3sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).
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| GB/T 7714 | Chen, Runzhi , Chen, Xinhua , Gao, Jiangtao . Forum 3-O-acylated bile acids: disrupters or harmonizers of metabolism? [J]. | TRENDS IN MOLECULAR MEDICINE , 2025 , 31 (2) : 103-105 . |
| MLA | Chen, Runzhi et al. "Forum 3-O-acylated bile acids: disrupters or harmonizers of metabolism?" . | TRENDS IN MOLECULAR MEDICINE 31 . 2 (2025) : 103-105 . |
| APA | Chen, Runzhi , Chen, Xinhua , Gao, Jiangtao . Forum 3-O-acylated bile acids: disrupters or harmonizers of metabolism? . | TRENDS IN MOLECULAR MEDICINE , 2025 , 31 (2) , 103-105 . |
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This review critically examines the emerging role of hyodeoxycholic acid (HDCA) in metabolic and inflammatory disorders. We analyze the current understanding of HDCA biosynthesis, highlighting species-specific differences and challenges in identifying HDCA-producing bacteria. The study evaluated the signaling mechanism by which HDCA simultaneously activates intestinal G protein-coupled bile acid receptor 1 (TGR5) and farnesoid X receptor (FXR), challenging the traditional paradigm of bile acid (BA)signaling. We assess HDCA's immunomodulatory effects, particularly its Toll-like receptor 4 (TLR4) inhibition, and discuss potential therapeutic applications in metabolic diseases and sepsis. The review addresses challenges in translating rodent studies to human applications and explores future directions, including the development of HDCA derivatives and integration with microbiome modulation strategies. Ethical and regulatory considerations for microbiome-derived therapeutics are also discussed. We propose that HDCA research may catalyze paradigm shifts in understanding hostmicrobiome-BA interactions, calling for interdisciplinary approaches to harness its potential fully.
Keyword ：
Bile acid signaling pathways Bile acid signaling pathways Hyodeoxycholic acid Hyodeoxycholic acid Immunomodulatory effects Immunomodulatory effects Metabolic and inflammatory disorders Metabolic and inflammatory disorders Microbiome-derived therapeutics Microbiome-derived therapeutics Therapeutic applications in sepsis Therapeutic applications in sepsis
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| GB/T 7714 | Zhan, Zhikun , Chen, Runzhi , Deng, Zixin et al. Burgeoning momentum: the present and future of hyodeoxycholic acid in host microbiome dynamics [J]. | BIOCHEMICAL PHARMACOLOGY , 2025 , 240 . |
| MLA | Zhan, Zhikun et al. "Burgeoning momentum: the present and future of hyodeoxycholic acid in host microbiome dynamics" . | BIOCHEMICAL PHARMACOLOGY 240 (2025) . |
| APA | Zhan, Zhikun , Chen, Runzhi , Deng, Zixin , Gao, Jiangtao . Burgeoning momentum: the present and future of hyodeoxycholic acid in host microbiome dynamics . | BIOCHEMICAL PHARMACOLOGY , 2025 , 240 . |
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Polysaccharide-based antifreeze hydrogels mark a significant advancement in cold-chain food preservation technology. This hydrogel exhibits excellent water retention and freeze resistance, thereby effectively safeguarding the quality of food in low-temperature environments. This review explores these materials' fundamental principles and practical applications in food science, focusing on their role in smart packaging systems. It examines the molecular design principles, including criteria for polysaccharide selection and mechanisms for preventing freezing, through the lenses of food safety requirements and industrial scalability. Recent advancements in temperature-responsive packaging and fresh produce preservation highlight these materials' practical impact. Integrating multiple preservation mechanisms with smart sensing capabilities opens new avenues for enhancing food quality control. Despite technical and regulatory challenges, ongoing research in biodegradable systems and optimization of mechanical properties indicates promising directions for commercial implementation. This review provides a framework for understanding antifreeze hydrogels' current state and future trajectory in food preservation applications.
Keyword ：
Antifreeze Antifreeze Food preservation Food preservation Hydrogels Hydrogels Polysaccharide Polysaccharide
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| GB/T 7714 | Wang, Yueguang , Huang, Zifeng , Li, Meining et al. Polysaccharide-based antifreeze hydrogels in food preservation: From molecular design to smart food packaging applications [J]. | FOOD RESEARCH INTERNATIONAL , 2025 , 211 . |
| MLA | Wang, Yueguang et al. "Polysaccharide-based antifreeze hydrogels in food preservation: From molecular design to smart food packaging applications" . | FOOD RESEARCH INTERNATIONAL 211 (2025) . |
| APA | Wang, Yueguang , Huang, Zifeng , Li, Meining , Lei, Xin , Zhou, Hanlin , Dai, Oujun et al. Polysaccharide-based antifreeze hydrogels in food preservation: From molecular design to smart food packaging applications . | FOOD RESEARCH INTERNATIONAL , 2025 , 211 . |
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This review systematically analyzes recent advances in transition metal-catalyzed carbene and nitrene insertion into unactivated aliphatic C(sp3)-H bonds through inner-sphere mechanisms, offering a critical synthesis of mechanistic insights and synthetic applications from 2016 to 2024. By contrasting inner- and outer-sphere pathways, we elucidate how metal-substrate coordination governs regioselectivity, catalyst design, and substrate compatibility. Key discussions focus on breakthroughs in Rh(III), Pd(II), Co(III), Ir(III), and Ni(II) catalytic systems, emphasizing their distinct electronic and steric control strategies for directing C-H activation and migratory insertion. Notable achievements include the functionalization of sterically hindered substrates, enantioselective aminations via chiral ligand engineering, and cascade transformations enabled by metal-mediated beta-elimination. We highlight emerging trends in sustainable catalysis using earth-abundant metals (e.g., Co, Ni), while addressing persistent challenges such as directing group dependency, catalyst deactivation, and limited substrate scope. The review further proposes strategic frameworks for future innovation, including (1) computational ligand optimization to enhance regiochemical control, (2) transient directing group strategies for native functional group tolerance, and (3) bifunctional catalyst design to differentiate electronically equivalent C-H bonds. By bridging mechanistic understanding with practical synthetic goals, this work establishes a roadmap for advancing precision C(sp3)-H functionalization in complex molecule synthesis and industrial applications.
Keyword ：
Carbene and nitrene insertion Carbene and nitrene insertion Inner-sphere pathway Inner-sphere pathway Regioselectivity Regioselectivity Transition metal-catalyzed Transition metal-catalyzed Unactivated C(sp(3))-H bonds Unactivated C(sp(3))-H bonds
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| GB/T 7714 | Zhang, Peng , Hao, Youjia , Shi, Ke et al. Breaking Bonds, Breaking Paradigms: Critical Insights into Inner-Sphere C(sp3)-H Functionalization via Metal-Catalyzed Carbene and Nitrene Insertion [J]. | TOPICS IN CURRENT CHEMISTRY , 2025 , 383 (3) . |
| MLA | Zhang, Peng et al. "Breaking Bonds, Breaking Paradigms: Critical Insights into Inner-Sphere C(sp3)-H Functionalization via Metal-Catalyzed Carbene and Nitrene Insertion" . | TOPICS IN CURRENT CHEMISTRY 383 . 3 (2025) . |
| APA | Zhang, Peng , Hao, Youjia , Shi, Ke , Deng, Zixin , Gao, Jiangtao . Breaking Bonds, Breaking Paradigms: Critical Insights into Inner-Sphere C(sp3)-H Functionalization via Metal-Catalyzed Carbene and Nitrene Insertion . | TOPICS IN CURRENT CHEMISTRY , 2025 , 383 (3) . |
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Covering: 2000 to 2025This review explores the potential of artificial intelligence (AI) in addressing challenges and accelerating molecular insights in biosynthetic pathway research, which is crucial for developing bioactive natural products with applications in pharmacology, agriculture, and biotechnology. It provides an overview of various AI techniques relevant to this research field, including machine learning (ML), deep learning (DL), natural language processing, network analysis, and data mining. AI-powered applications across three main areas, namely, pathway discovery and mining, pathway design, and pathway optimization, are discussed, and the benefits and challenges of integrating omics data and AI for enhanced pathway research are also elucidated. This review also addresses the current limitations, future directions, and the importance of synergy between AI and experimental approaches in unlocking rapid advancements in biosynthetic pathway research. The review concludes with an evaluation of AI's current capabilities and future outlook, emphasizing the transformative impact of AI on biosynthetic pathway research and the potential for new opportunities in the discovery and optimization of bioactive natural products.
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| GB/T 7714 | Liao, Lijuan , Xie, Mengjun , Zheng, Xiaoshan et al. Molecular insights fast-tracked: AI in biosynthetic pathway research [J]. | NATURAL PRODUCT REPORTS , 2025 , 42 (5) : 911-936 . |
| MLA | Liao, Lijuan et al. "Molecular insights fast-tracked: AI in biosynthetic pathway research" . | NATURAL PRODUCT REPORTS 42 . 5 (2025) : 911-936 . |
| APA | Liao, Lijuan , Xie, Mengjun , Zheng, Xiaoshan , Zhou, Zhao , Deng, Zixin , Gao, Jiangtao . Molecular insights fast-tracked: AI in biosynthetic pathway research . | NATURAL PRODUCT REPORTS , 2025 , 42 (5) , 911-936 . |
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