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学者姓名：王登峰
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Abstract ：
本发明公开了一种肉桂醛的应用，其中肉桂醛能够调节雄激素睾酮的合成与分泌，可应用于调节雄激素睾酮的合成与分泌的相关产品中。且本发明通过试验探明了肉桂醛通过提高类固醇激素合成核受体启动子活性，上调类固醇激素合成酶的表达，增加了睾丸间质细胞雄激素的合成与分泌。
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| GB/T 7714 | 王磊 , 黄晓宇 , 黄志坚 et al. 肉桂醛的应用 : CN202510598873.5[P]. | 2025-05-09 . |
| MLA | 王磊 et al. "肉桂醛的应用" : CN202510598873.5. | 2025-05-09 . |
| APA | 王磊 , 黄晓宇 , 黄志坚 , 殷光文 , 孟庆蕊 , 王登峰 et al. 肉桂醛的应用 : CN202510598873.5. | 2025-05-09 . |
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Coccidiosis is a major parasitic disease that suppresses poultry productivity and causes significant global economic losses. Currently, controlling Eimeria parasites relies primarily on the use of anticoccidial drugs or live vaccines. However, these conventional control strategies face the dual constraints of escalating drug resistance and unsustainable economic expenditures. In this study, the efficacy of a chimeric subunit vaccine comprising Eimeria maxima Elongation Factor-1 alpha (EmEF1 alpha) and chicken chemokine Ligand-1 (ChXCL1) was assessed for protection against experimental Eimeria maxima infection. The synthetic gene fragment ChXCL1-EmEF1 alpha was ligated to the pET28a vector and expressed in vitro. Western blot analysis confirmed the successful expression of the recombinant ChXCL1-EmEF1 alpha protein. Chickens immunized with the ChXCL1-EmEF1 alpha exhibited a significantly stronger IgY response and higher secretion of IL-2 and IL-17 compared to those vaccinated with recombinant ChXCL1 alone or challenged solely with E. maxima. Furthermore, the ChXCL1-EmEF1 alpha group demonstrated enhanced anticoccidial effects, including reduced intestinal lesions, higher body weight gain, and lower oocyst shedding compared to control groups. Following E. maxima challenge, the EmEF1 alpha and ChXCL1-EmEF1 alpha groups demonstrated robust protective efficacy, achieving high ACI values of 182 and 178, respectively. In contrast, the ChXCL1 and UC groups exhibited significantly lower ACI values (150 and 149, respectively), indicating minimal protection. This improvement was also reflected in the immune response, with significantly elevated levels of CD4+ and CD8+ T cells in the ChXCL1-EmEF1 alpha-treated chickens. Moreover, ChXCL1 acts as an effective adjuvant when fused with EmEF1 alpha, enhancing the vaccine's anticoccidial efficacy. These results suggest that the ChXCL1-EmEF1 alpha chimeric immunogen is a promising candidate for developing subunit vaccines against E. maxima infections.
Keyword ：
adjuvant adjuvant chicken chicken Eimeria Eimeria immune response immune response subunit vaccine subunit vaccine
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| GB/T 7714 | Chen, Rong , Lin, Xiao-Feng , Wu, Hong-Yan et al. Synergistic Enhancement of Eimeria maxima Vaccine Efficacy Through EF-1α Antigen and Chicken XCL1 Chemokine Adjuvant Combination [J]. | ANIMALS , 2025 , 15 (16) . |
| MLA | Chen, Rong et al. "Synergistic Enhancement of Eimeria maxima Vaccine Efficacy Through EF-1α Antigen and Chicken XCL1 Chemokine Adjuvant Combination" . | ANIMALS 15 . 16 (2025) . |
| APA | Chen, Rong , Lin, Xiao-Feng , Wu, Hong-Yan , Li, Li-Na , Wang, Lei , Wang, Deng-Feng et al. Synergistic Enhancement of Eimeria maxima Vaccine Efficacy Through EF-1α Antigen and Chicken XCL1 Chemokine Adjuvant Combination . | ANIMALS , 2025 , 15 (16) . |
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Cinnamon (Cinnamomum cassia (L.) D. Don) is a commonly used drug in traditional Chinese medicine; it is especially useful for improving the reproductive performance in males and females. Cinnamaldehyde is the main component of cinnamon, which has bactericidal and disinfectant properties, promotes gastrointestinal motility and regulates testosterone secretion in the male. The present study aimed to investigate the mechanisms by which cinnamaldehyde regulates testosterone secretion in male animals. For this purpose, four-month-old male mice (n=25) were randomly divided into five groups (n=5 each) and treated with PBS, DMSO and three doses of cinnamaldehyde (25, 50 and 75mg/kg) by gavage for 2 weeks. Histological (IHC), ELISA and molecular analyses (WB, RTqPCR) were used to assess effects of cinnamaldehyde on murine liver, serum testosterone levels, and testicular enzymes associated with testosterone production. The mechanisms by which cinnamaldehyde affects testosterone secretion in testis Leydig cells were explored using ELISA, flow cytometry, WB, fluorescent quantitative PCR, and dual luciferase reporter systems. The results showed that cinnamaldehyde elevated murine body weight, serum testosterone, testicular interstitial cell density, and steroidogenic enzyme expression (StAR, CYP11A1, 3 beta- HSD) without altering hepatic tissue and testicular indices. Cinnamaldehyde treatment at 5x10-5M increased the expression of steroid hormone synthase in Leydig cells, increased the proportion of cells in the S phase, significantly increased the promoter activity of the steroid hormone synthesis nuclear receptor steroidogenic factor 1 (SF-1), and up-regulated the expression of the nuclear receptor SF-1. The present study showed that cinnamaldehyde can upregulate the expression of steroid hormone synthase by increasing the activity of the steroid hormone synthesis nuclear receptor promoter, which in turn increases the synthesis and secretion of testosterone from testicular interstitial cells.
Keyword ：
Cinnamaldehyde Cinnamaldehyde Leydig cells Leydig cells Nuclear receptors Nuclear receptors Steroidogenic-related genes Steroidogenic-related genes Testosterone Testosterone
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| GB/T 7714 | Meng, Qingrui , Huang, Xiaoyu , Cai, Congguang et al. The Effect and Mechanism of Cinnamaldehyde on Testosterone Secretion in Murine Model [J]. | PAKISTAN VETERINARY JOURNAL , 2025 , 45 (2) : 683-692 . |
| MLA | Meng, Qingrui et al. "The Effect and Mechanism of Cinnamaldehyde on Testosterone Secretion in Murine Model" . | PAKISTAN VETERINARY JOURNAL 45 . 2 (2025) : 683-692 . |
| APA | Meng, Qingrui , Huang, Xiaoyu , Cai, Congguang , Guo, Yuxin , Yang, Yang , Huang, Zhijian et al. The Effect and Mechanism of Cinnamaldehyde on Testosterone Secretion in Murine Model . | PAKISTAN VETERINARY JOURNAL , 2025 , 45 (2) , 683-692 . |
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| GB/T 7714 | Yang, Yang , Deng, Xin , Chen, Zhanghang et al. Dissolving cinnamaldehyde HA/PVA microneedles for the treatment of skin diseases caused by Microsporum canis (107, 106841, 2025) [J]. | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY , 2025 , 113 . |
| MLA | Yang, Yang et al. "Dissolving cinnamaldehyde HA/PVA microneedles for the treatment of skin diseases caused by Microsporum canis (107, 106841, 2025)" . | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 113 (2025) . |
| APA | Yang, Yang , Deng, Xin , Chen, Zhanghang , Lin, Xiaofeng , Hu, Yuhao , Zeng, Qihui et al. Dissolving cinnamaldehyde HA/PVA microneedles for the treatment of skin diseases caused by Microsporum canis (107, 106841, 2025) . | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY , 2025 , 113 . |
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试验旨在探究海藻酶解产物对大黄鱼生长、消化吸收及免疫指标的影响。选取315尾健康状况良好、体重（109.30±2.94） g的大黄鱼幼鱼，随机分为3组，每组3个重复，每个重复35尾大黄鱼。A组在基础饲料中添加0.5%的复合海藻酶解产物，B组在基础饲料中添加0.5%的海带酶解产物，对照组（C组）饲喂基础饲料。试验期56 d。结果显示：A组和B组大黄鱼末重、存活率（SR）、平均增重（AWG）、增重率（WGR）显著高于C组（P<0.05）。A组肌肉中粗蛋白含量显著高于C组（P<0.05），水分和灰分含量显著低于C组（P<0.05）。A组和B组大黄鱼肠道绒毛高度（VH）和隐窝深度（CD）均显著大于C组（P<0.05）。C组大黄鱼血清补体C3水平显著高于A组和B组（P<0.05），补体C4水平显著高于B组（P<0.05）。研究表明，在饲料中添加0.5%海藻酶解产物或0.5%海带酶解产物可提升大黄鱼生长性能及SR，改善肌肉营养成分，促进肠道营养物质的吸收，增加抗病力，以0.5%复合海藻酶解产物添加效果较好。
Keyword ：
大黄鱼 大黄鱼 抗病力 抗病力 海藻酶解产物 海藻酶解产物 肌肉营养成分 肌肉营养成分 肠道功能 肠道功能
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| GB/T 7714 | 熊宇明 , 曾企辉 , 梁萍 et al. 海藻酶解产物对大黄鱼生长、消化吸收及免疫指标的影响 [J]. | 饲料研究 , 2025 , 48 (03) : 56-60 . |
| MLA | 熊宇明 et al. "海藻酶解产物对大黄鱼生长、消化吸收及免疫指标的影响" . | 饲料研究 48 . 03 (2025) : 56-60 . |
| APA | 熊宇明 , 曾企辉 , 梁萍 , 陈度煌 , 黄志坚 , 殷光文 et al. 海藻酶解产物对大黄鱼生长、消化吸收及免疫指标的影响 . | 饲料研究 , 2025 , 48 (03) , 56-60 . |
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Microsporum canis (M. cains) skin diseases are zoonotic, which cause serious diseases. Therefore, it is crucial to prevent and treat M. cain's skin diseases in companion animals for public health security and animal welfare. This study analyzed the potential anti-inflammatory mechanisms of Cinnamaldehyde (CA) in treating M. cains skin diseases through network pharmacology and molecular docking. CA was formulated into a dissolving microneedle for application. The findings suggest that CA may interact with Interleukin-1(3 (IL-1(3), Cellular tumor antigen p53 (P53), Microtubule-Associated Protein Kinase 14 (P38 alpha), and Tumor necrosis factor (TNF) to target pathways such as TNF signaling, Toll-like receptor signaling, and IL-17 signaling, ultimately reducing skin inflammation associated with M. cains skin diseases. Microneedles administration significantly enhances efficacy compared to traditional delivery methods. In vivo studies demonstrated that the efficacy of CA-HA/PVA DMNs was comparable to that of TER-HA/PVA DMNs. Compared to the use of DMNs alone, the symptom score decline index (SSDI) in the TER-HA/PVA DMNs group (TM group) and CA-HA/PVA DMNs group (CM group) increased by 25.01 % and 21.1 %, respectively, and both were superior to TER treatment alone. CA-HA/PVA DMNs and TER-HA/PVA DMNs effectively alleviate skin erythema, reduce dander production, and decrease skin keratinization at the superficial level. Moreover, at the histopathological level, they are successful in preventing fungal invasion of hair follicles. In summary, this study introduces a novel approach for treating M. cains skin diseases in companion animals.
Keyword ：
Cinnamaldehyde Cinnamaldehyde Fungal skin diseases Fungal skin diseases Microneedles Microneedles Microsporum canis Microsporum canis Network pharmacology Network pharmacology Treatment Treatment
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| GB/T 7714 | Yang, Yang , Deng, Xin , Chen, Zhanghang et al. Dissolving cinnamaldehyde HA/PVA microneedles for the treatment of skin diseases caused by Microsporum canis [J]. | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY , 2025 , 107 . |
| MLA | Yang, Yang et al. "Dissolving cinnamaldehyde HA/PVA microneedles for the treatment of skin diseases caused by Microsporum canis" . | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 107 (2025) . |
| APA | Yang, Yang , Deng, Xin , Chen, Zhanghang , Lin, Xiaofeng , Hu, Yuhao , Zeng, Qihui et al. Dissolving cinnamaldehyde HA/PVA microneedles for the treatment of skin diseases caused by Microsporum canis . | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY , 2025 , 107 . |
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This experiment investigated the effects of seaweed polysaccharide (SP) and seaweed enzymatic hydrolysate (SEH) on the growth performance, serum biochemical indices, antioxidant capacity, and intestinal function of Muscovy ducks. A total of 240 healthy 1 day female Muscovy ducks (48.85 +/- 0.45 g) were randomly divided into 3 treatment groups, with 4 replicates per group and 20 ducks per replicate. The control (CON) group received a basic diet supplemented with 20 mL/kg of water, the SP group received a basic diet supplemented with 20 mL/kg of SP, and the SEH group received a basic diet supplemented with 20 mL/kg of SEH. The experimental period lasted for 28 d. The results indicate that, compared to the CON group, the average daily feed intake (ADFI) and feed to gain (F/G) of the SP and SEH groups of ducks significantly decreased at 28 d (p < 0.05). In the SP group, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the concentrations of glucose (GLU), triglycerides (TG), total cholesterol (TCHO), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), were significantly reduced (p < 0.05). In the SEH group, the activities of ALT and AST were also significantly lower (p < 0.05). Additionally, serum total antioxidant capacity (T-AOC) levels and superoxide dismutase (SOD) activity in the SEH group were significantly higher than those in the CON group (p < 0.05), while the malondialdehyde (MDA) content was significantly reduced (p < 0.05). Compared to the CON group, serum levels of immunoglobulin A (IgA), immunoglobulin G (IgG), interleukin-4 (IL-4), and interleukin-10 (IL-10) in the SP group were significantly increased (p < 0.05), whereas the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) were significantly decreased (p < 0.05). In the SP and SEH groups, the villus height (VH) and the villus height to crypt depth (V/C) of the Muscovy ducks significantly increased (p < 0.05), while the crypt depth (CD) significantly decreased (p < 0.05). A significant increase in the abundance of Barnesiella was observed in the SP and SEH groups (p < 0.05), whereas the abundances of UCG-005 and Romboutsia significantly decreased (p < 0.05). LEfSe analysis indicated that g__Bacillus and g__Veillonella were significantly abundant in the SP group (p < 0.05), while g__Coriobacteriaceae_UCG_002 was significantly abundant in the SEH group (p < 0.05). In summary, the addition of SP and SEH to the feed can promote the healthy growth of ducks by improving intestinal morphology, regulating the structure of intestinal microbiota, enhancing antioxidant capacity and immune function, and optimizing metabolic indicators. This occurs while reducing feed intake and feed-to-weight ratio, and there is a certain specificity in their mechanisms of action.
Keyword ：
antioxidant capacity antioxidant capacity feed additives feed additives growth performance growth performance gut microbiome gut microbiome Muscovy ducks Muscovy ducks seaweed enzymatic hydrolysate (SEH) seaweed enzymatic hydrolysate (SEH) seaweed polysaccharide (SP) seaweed polysaccharide (SP)
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| GB/T 7714 | Wu, Hong-Yan , Lin, Xiao-Feng , Fu, Chang-Sheng et al. Effects of Seaweed Polysaccharide (SP) and Seaweed Enzymatic Hydrolysate (SEH) on Growth Performance, Antioxidant Capacity, Immune Function, and Gut Microbiota in Muscovy Ducks [J]. | ANIMALS , 2025 , 15 (20) . |
| MLA | Wu, Hong-Yan et al. "Effects of Seaweed Polysaccharide (SP) and Seaweed Enzymatic Hydrolysate (SEH) on Growth Performance, Antioxidant Capacity, Immune Function, and Gut Microbiota in Muscovy Ducks" . | ANIMALS 15 . 20 (2025) . |
| APA | Wu, Hong-Yan , Lin, Xiao-Feng , Fu, Chang-Sheng , Yang, Yang , Wang, Lei , Wu, Hai-Yan et al. Effects of Seaweed Polysaccharide (SP) and Seaweed Enzymatic Hydrolysate (SEH) on Growth Performance, Antioxidant Capacity, Immune Function, and Gut Microbiota in Muscovy Ducks . | ANIMALS , 2025 , 15 (20) . |
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为明确海藻酶解物饲喂大黄鱼的应用效果及对肠道菌群的影响，2022年11—12月在福建宁德海域使用添加0.5%复合海藻酶解物和0.5%海带酶解物的自配饲料饲养网箱养殖的大黄鱼8周，测定大黄鱼的存活率和平均增重，并采用NovaSeq PE250方案对肠道内容物进行16S rDNA扩增子测序，分析肠道菌群组成和特定菌群的相对丰度。结果显示：0.5%的复合海藻酶解物或0.5%的海带酶解物均可显著提高大黄鱼的存活率和平均增重（P<0.05）；肠道菌群分析显示0.5%复合海藻酶解物组大黄鱼肠道中扩增子序列变体（ASVs）达1 353种，以厚壁菌门（Firmicutes）、变形菌门（Proteobacteria）、拟杆菌门（Bacteroidota）、梭杆菌门（Fusobacteriota）和放线菌门（Actinobacteriota）为主，而0.5%海带酶解物组大黄鱼肠道中ASVs仅242种，各样本中以厚壁菌门和脱硫杆菌门（Desulfobacterota）为主，变形菌门相对丰度较低，均与对照组（749个ASVs，各样本中菌门相对丰度无规律）有较大差异；基于KEGG的肠道菌群功能分析显示在淀粉和蔗糖代谢、谷胱甘肽代谢、磷酸转移酶系统、氰基氨基酸代谢、亨廷顿病和其他糖降解上3组存在显著差异（P<0.05）；进一步分析发现，0.5%复合海藻酶解物增加了大黄鱼肠道菌群α多样性并提高了拟杆菌属及丁酸合成相关细菌的相对丰度，而0.5%海带酶解物则降低了大黄鱼肠道菌群α多样性，但可抑制肠道中假单胞菌属细菌的生长，且体外培养试验证实褐藻寡糖可极显著抑制变形假单胞菌生长（P<0.01）。综上可知，本试验制备的2种海藻酶解物可调节大黄鱼形成不同的肠道菌群结构，并均可促进大黄鱼的健康和生长，该结果可为大黄鱼海藻类饲料添加剂的开发和通过调整大黄鱼肠道菌群改善大黄鱼健康和生长的饲料添加剂研发提供数据参考。
Keyword ：
健康 健康 大黄鱼 大黄鱼 海藻酶解物 海藻酶解物 生长 生长 肠道菌群 肠道菌群
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| GB/T 7714 | 张露 , 熊宇明 , 董黎黎 et al. 海藻酶解物对大黄鱼生长和肠道菌群结构的影响 [J]. | 动物营养学报 , 2024 , 36 (03) : 1819-1833 . |
| MLA | 张露 et al. "海藻酶解物对大黄鱼生长和肠道菌群结构的影响" . | 动物营养学报 36 . 03 (2024) : 1819-1833 . |
| APA | 张露 , 熊宇明 , 董黎黎 , 梁萍 , 秦志清 , 王磊 et al. 海藻酶解物对大黄鱼生长和肠道菌群结构的影响 . | 动物营养学报 , 2024 , 36 (03) , 1819-1833 . |
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本发明公开了一种降低LmrS外排活性的靶点、方法及LmrS活性抑制剂和应用，多药外排泵LmrS的N29和Q30是影响其外排活性的关键氨基酸，本发明以LmrS的TM1的第29位N和/或第30位氨基酸Q为靶点，通过单个或联合突变N29和Q30为非极性氨基酸，可降低LmrS对抗生素的外排活性。此外，本发明还提供了靶向LmrS的N29或Q30靶点的中药植物源化合物抑制剂，其能够降低LmrS对抗生素的外排活性，该抑制剂可作为抗生素的佐剂提高金葡菌对相应抗生素的药物敏感性，进而提高金葡菌感染的治愈率，适宜进一步推广应用。
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| GB/T 7714 | 王登峰 , 曾企辉 , 殷光文 et al. 一种降低LmrS外排活性的靶点、方法及LmrS活性抑制剂和应用 : CN202411297221.X[P]. | 2024-09-18 . |
| MLA | 王登峰 et al. "一种降低LmrS外排活性的靶点、方法及LmrS活性抑制剂和应用" : CN202411297221.X. | 2024-09-18 . |
| APA | 王登峰 , 曾企辉 , 殷光文 , 王磊 , 郭盼盼 , 黄志坚 . 一种降低LmrS外排活性的靶点、方法及LmrS活性抑制剂和应用 : CN202411297221.X. | 2024-09-18 . |
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本发明属于饲料和中兽药领域，具体涉及一种药食同源组合物及其制备方法和应用。本发明提供一种药食同源组合物，由甘草、金荞麦、牛蒡子制成。本发明药食同源组合物中金荞麦、甘草和牛蒡子能够达到协同增效的作用，能够取得提高猪的生长性能、降低料肉比、改善猪应激性、改善猪肝脏性能、提高猪免疫力、改善猪肠道菌群等效果。
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| GB/T 7714 | 王登峰 , 曾金哲 , 徐骏 et al. 一种药食同源组合物及其制备方法和应用 : CN202410110046.2[P]. | 2024-01-26 . |
| MLA | 王登峰 et al. "一种药食同源组合物及其制备方法和应用" : CN202410110046.2. | 2024-01-26 . |
| APA | 王登峰 , 曾金哲 , 徐骏 , 黄志坚 , 邓莉萍 , 胡宇豪 et al. 一种药食同源组合物及其制备方法和应用 : CN202410110046.2. | 2024-01-26 . |
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