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学者姓名：杨波
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Abstract ：
The study aimed to provide a possible strategy to evaluate the detoxifying efficacy of mycotoxin adsorbents in vivo by analyzing deoxynivalenol (DON) concentration in feces. Fifteen pigs were randomly assigned to five groups (groups A-E, 3 replicates/group). The pigs in each group were fed twice a day for 10 d with 500 g of designed diets (group A, commercial feedstuffs; group B, DON-contaminated (mildewed) feedstuffs; groups C, D, E, mildewed feedstuffs containing 0.2% adsorbent 1, 2, and 3, respectively). For each pig, 2-g fecal samples were collected pre-feeding and analyzed by ultra-performance liquid chromatography. Nondetectable or low concentrations of DON (<1.38 mu g/g) were found in fecal samples from groups A and B. High concentrations of DON (>20 mu g/g) were detected in six out of twenty fecal batches from pigs in group C. Moderate concentrations of DON (5.54-6.50 mu g/g) were detected in one out of twenty fecal batches from pigs in group D and two out of twenty in group E. Based on the predefined evaluation criteria, higher DON concentration and frequency in feces indicate better adsorbent efficacy. Notably, Absorbent 1 demonstrated a more pronounced detoxification efficacy in vivo compared to the other two absorbents.
Keyword ：
deoxynivalenol deoxynivalenol fecal sample fecal sample in vivo evaluation of detoxification efficacy of mycotoxin adsorbent in vivo evaluation of detoxification efficacy of mycotoxin adsorbent ultra-performance liquid chromatography ultra-performance liquid chromatography
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| GB/T 7714 | Yang, Bo , Deng, Hui , Jia, Yiwei et al. Validation of a Methodology for the Quantification of DON in Feces and Feedstuffs by UPLC as Possible Strategy to Evaluate the Detoxifying Efficacy of a Mycotoxin Adsorbent In Vivo [J]. | TOXINS , 2025 , 17 (7) . |
| MLA | Yang, Bo et al. "Validation of a Methodology for the Quantification of DON in Feces and Feedstuffs by UPLC as Possible Strategy to Evaluate the Detoxifying Efficacy of a Mycotoxin Adsorbent In Vivo" . | TOXINS 17 . 7 (2025) . |
| APA | Yang, Bo , Deng, Hui , Jia, Yiwei , Li, Dong , Chen, Rudeng , Chen, Ruiqing et al. Validation of a Methodology for the Quantification of DON in Feces and Feedstuffs by UPLC as Possible Strategy to Evaluate the Detoxifying Efficacy of a Mycotoxin Adsorbent In Vivo . | TOXINS , 2025 , 17 (7) . |
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Matrine (MT) is a potential resistance reversal agent. However, little is known about its pharmacokinetics (PK) in pigs. This study aimed to investigate the PK of MT in pigs after gavage administration alone and in combination with amoxicillin (AMO). Twenty-four pigs were randomly assigned to three groups: A (MT, 50 mg/kg), B (AMO, 50 mg/kg), and C (MT + AMO, 50 mg/kg each). Blood samples were collected at predetermined time points post-administration and analyzed using liquid chromatography-tandem mass spectrometry. PK parameters were calculated using a one-compartment model. The results showed that MT was absorbed and eliminated rapidly in pigs. The maximum concentration (Cmax), time to maximum concentration (Tmax), area under the curve from 0 to 36 h (AUC0-36 h), apparent clearance (Cl/F), elimination rate constant (ke), and absorption rate constant (ka) for group A were 1345.55 +/- 302.94 mu g/L, 2.03 +/- 0.14 h, 3979.10 +/- 1260.85 hmu g/L, 13.72 +/- 4.30 L/h/kg, 1.07 +/- 0.20 h-1, and 0.46 +/- 0.09 h-1, respectively, versus 2071.70 +/- 715.49 mu g/L, 1.27 +/- 0.36 h, 9113.80 +/- 3152.85 hmu g/L, 6.17 +/- 2.48 L/h/kg, 2.08 +/- 0.55 h-1, and 0.44 +/- 0.24 h-1 for group C. AMO significantly altered the PK profiles of MT.
Keyword ：
amoxicillin amoxicillin drug-drug interaction drug-drug interaction matrine matrine pharmacokinetics pharmacokinetics pig pig
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| GB/T 7714 | Li, Ruonan , Zhou, Danna , Hu, Huiyu et al. Pharmacokinetics of Matrine in Pigs After Gavage Administration of Matrine Alone and in Combination with Amoxicillin [J]. | ANIMALS , 2025 , 15 (17) . |
| MLA | Li, Ruonan et al. "Pharmacokinetics of Matrine in Pigs After Gavage Administration of Matrine Alone and in Combination with Amoxicillin" . | ANIMALS 15 . 17 (2025) . |
| APA | Li, Ruonan , Zhou, Danna , Hu, Huiyu , Wang, Fuhao , Lv, Xiaoling , Sun, Lei et al. Pharmacokinetics of Matrine in Pigs After Gavage Administration of Matrine Alone and in Combination with Amoxicillin . | ANIMALS , 2025 , 15 (17) . |
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BackgroundHeteroresistance represents a significant pathway through which sensitive bacteria evolve into resistant strains, posing challenges for current clinical laboratory detection methods.ObjectivesThis study aimed to investigate the differences in resistance among K. pneumoniae isolates from various sources, assess the prevalence of chloramphenicol heteroresistance (CHR), and explore the potential causes and key genes associated with CHR.MethodsK. pneumoniae was isolated from 801 samples obtained from various sources, and its susceptibility to antibacterial agents was assessed. The modified Kirby-Bauer disk diffusion method, population analysis profiling (PAP), and bactericidal curve assays were employed to identify heteroresistant bacteria. Additionally, the growth curve and stability of CHR strains were measured. To analyze the factors influencing the formation of CHR, we detected the resistance genes cmlA, cat1, and floR across 17 resistant subpopulations, along with virulence genes such as fimH, wabG, kfu, uge, and aerobactin.ResultsAmong the 198 K. pneumoniae tested, resistance rates to nitrofurantoin, tetracycline, and chloramphenicol were found to be 73.74%, 57.58%, and 51.01%, respectively. The prevalence of CHR was determined to be 8.59% (17 out of 198), which significantly diminished the in vitro bactericidal efficacy of chloramphenicol. Notably, 76.47% (13/17) of the isolates harbored the cat1 and/or floR genes, while the prevalence of the virulence genes wabG, fimH, uge, and kfu was 100%, 100%, 76.47%, and 47.06%, respectively.ConclusionThe floR and/or cat1 genes are pivotal in the mechanism underlying heteroresistance to chloramphenicol, and the presence of virulence genes could further contribute to the development of CHR.
Keyword ：
Chloramphenicol Chloramphenicol Heteroresistance Heteroresistance Klebsiella pneumoniae Klebsiella pneumoniae Resistance Resistance Subpopulations Subpopulations
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| GB/T 7714 | Kuang, Qihong , Zhang, Xiaorui , Ou, Fangping et al. Detection and characterization of heteroresistance to chloramphenicol in Klebsiella pneumoniae isolates [J]. | BMC MICROBIOLOGY , 2025 , 25 (1) . |
| MLA | Kuang, Qihong et al. "Detection and characterization of heteroresistance to chloramphenicol in Klebsiella pneumoniae isolates" . | BMC MICROBIOLOGY 25 . 1 (2025) . |
| APA | Kuang, Qihong , Zhang, Xiaorui , Ou, Fangping , Liu, Lingling , Deng, Hui , Yang, Bo et al. Detection and characterization of heteroresistance to chloramphenicol in Klebsiella pneumoniae isolates . | BMC MICROBIOLOGY , 2025 , 25 (1) . |
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Background: The impact of heat stress on intestinal bacterial antimicrobial resistance (AMR) and its underlying mechanisms is not fully understood. This study aims to explore how heat stress influences AMR in the gut and the mechanisms involved. Methods: A Specific-Pathogen-Free (SPF) mouse model was used, divided into a control group (maintained at 25 degrees C) and a heat stress group (exposed to 42 degrees C for 30 min twice daily for 55 days). The effectiveness of the model was verified by RT-qPCR and histopathological analysis. Antibiotic susceptibility testing and clonal analysis (ERIC-PCR) were performed. Colonization assays were conducted to determine the accumulation of resistant strains in the gut. Metagenomic sequencing was conducted to investigated microbial composition. Results: RT-qPCR and Histopathological analysis revealed intestinal damage and significant upregulation of genes related to stress response, intestinal barrier integrity and inflammation, indicating successful model establishment and physiological alterations. Antibiotic susceptibility testing revealed increased resistance to erythromycin, chloramphenicol, and tetracycline among Enterococcus strains. Clonal analysis demonstrated that these resistant strains were clonally unrelated. Sequencing identified a novel ermB-carrying integrative and conjugative element (ICEFZMF) among four erythromycin-resistant strains. The rectum harbored a higher proportion of erythromycin-resistant Enterococcus strains with elevated minimum inhibitory concentrations (MICs) after 25 days of heat stress exposure. Colonization assays confirmed that heat stress led to the accumulation of erythromycin-resistant Enterococcus in the rectum. Metagenomic sequencing revealed significant changes in microbial composition, favoring anaerobic metabolism. Conclusions: This study suggests that chronic heat stress can promote the emergence of antibiotic-resistant strains through ICE transfer, providing insight for environmental safety.
Keyword ：
antimicrobial resistance antimicrobial resistance Enterococcus isolates Enterococcus isolates heat stress heat stress mobile genetic elements mobile genetic elements one health one health
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| GB/T 7714 | Yi, Lingxian , Ren, Zining , Feng, Yu et al. Chronic Heat Stress Can Induce Conjugation of a Novel ermB-Containing ICEFZMF, Increasing Resistance to Erythromycin Among Enterococcus Strains in Diverse Intestinal Segments in the Mouse Model [J]. | ANTIBIOTICS-BASEL , 2025 , 14 (5) . |
| MLA | Yi, Lingxian et al. "Chronic Heat Stress Can Induce Conjugation of a Novel ermB-Containing ICEFZMF, Increasing Resistance to Erythromycin Among Enterococcus Strains in Diverse Intestinal Segments in the Mouse Model" . | ANTIBIOTICS-BASEL 14 . 5 (2025) . |
| APA | Yi, Lingxian , Ren, Zining , Feng, Yu , Zhang, Yechun , Liu, Jianshuo , Yuan, Xiaowu et al. Chronic Heat Stress Can Induce Conjugation of a Novel ermB-Containing ICEFZMF, Increasing Resistance to Erythromycin Among Enterococcus Strains in Diverse Intestinal Segments in the Mouse Model . | ANTIBIOTICS-BASEL , 2025 , 14 (5) . |
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Introduction Matrine (MT) has been found to restore the susceptibility of Escherichia coli to a variety of antibiotics in vitro. Nevertheless, the absence of pharmacokinetic data makes it uncertain whether MT exhibits efficacy in vivo. The study aimed to investigate the kinetic behavior of MT in pig intestinal lumen, the primary site for the colonization of enterotoxigenic Escherichia coli, and to develop a minimal physiologically based pharmacokinetic (PBPK) model for MT in pig intestinal lumen.Methods Two animal experiments were carried out for these purposes. In experiment 1, 12 pigs were implanted with a sterile T-cannula, and then were given a single oral dose of MT or MT-Amoxicillin (AMO) combination at 40 or 70 mg/kg. In experiment 2, 25 pigs were administered with MT at 50 mg/kg/d by oral gavage for 5 d. Intestinal contents were collected at predetermined times and analysed by liquid chromatography tandem mass spectrometry (LC-MS/MS) method. The concentration-time data were analysed by non-compartmental method. Subsequently, a four-compartment PBPK model was developed and validated.Results After oral administrations, the MT concentrations in pig intestinal lumen increased rapidly and reached their peaks within 2 h, then decreased in a two-phase decay pattern. The co-administered AMO did not alter the kinetic behavior of MT in pig intestinal lumen. The PBPK model gave an accurate prediction of MT concentrations in pig intestinal lumen at most time points.Discussion A dosage regimen of 70 mg/kg every 8 h was recommended to ensure a sufficient drug exposure.
Keyword ：
liquid chromatography tandem mass spectrometry liquid chromatography tandem mass spectrometry matrine matrine pharmacodynamic evaluation pharmacodynamic evaluation physiologically based pharmacokinetic model physiologically based pharmacokinetic model pig intestinal lumen pig intestinal lumen
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| GB/T 7714 | Yang, Bo , Jia, YiWei , Wang, FuHao et al. The kinetic behavior of matrine in pig intestinal lumen after oral administration and its physiologically based pharmacokinetic modeling [J]. | FRONTIERS IN VETERINARY SCIENCE , 2025 , 12 . |
| MLA | Yang, Bo et al. "The kinetic behavior of matrine in pig intestinal lumen after oral administration and its physiologically based pharmacokinetic modeling" . | FRONTIERS IN VETERINARY SCIENCE 12 (2025) . |
| APA | Yang, Bo , Jia, YiWei , Wang, FuHao , Lv, XiaoLing , Ma, SuYang , Tan, YaXin et al. The kinetic behavior of matrine in pig intestinal lumen after oral administration and its physiologically based pharmacokinetic modeling . | FRONTIERS IN VETERINARY SCIENCE , 2025 , 12 . |
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Background/Objectives: Curcumin (CUR), a natural polyphenol with poor solubility and significant first-pass metabolism, shows extremely low oral bioavailability. Although CUR-loaded nanostructured lipid carriers (CUR-NLCs) have demonstrated potential in enhancing oral absorption, direct evidence regarding their intestinal lymphatic transport mechanism remains insufficient, and current understanding largely relies on indirect speculation. Methods: CUR-NLCs were prepared by emulsion-ultrasonication and evaluated for their physicochemical properties including particle size, zeta potential, polydispersity index, encapsulation efficiency, drug loading, stability and release profile. A mesenteric lymph duct-jugular vein shunt rat model combined with transmission electron microscopy was employed to assess the pharmacokinetic behavior and lymphatic transport pathway. Results: CUR-NLCs had a mean size of 117.28 +/- 1.32 nm, 99.99% encapsulation efficiency, and 1.73% drug loading. They exhibited good gastrointestinal stability and sustained release (<55% in 24 h). CUR-NLCs significantly enhanced oral absorption versus free CUR, with 5.13-fold higher relative bioavailability, 5.25-fold greater C-max, and extended half-life (33.49 +/- 3.15 h). CUR was detected only in the lymph of the CUR-NLCs group, confirming intestinal lymphatic transport. TEM revealed abundant chylomicrons (0.1-2 mu m) in jejunal epithelial cells, providing morphological support. Conclusions: This study directly demonstrates that CUR-NLCs improve oral bioavailability via intestinal lymphatic absorption, offering a viable strategy for delivering poorly soluble hydrophobic drugs.
Keyword ：
curcumin curcumin lymphatic transport lymphatic transport nanostructured lipid carriers (NLCs) nanostructured lipid carriers (NLCs) oral bioavailability oral bioavailability pharmacokinetics pharmacokinetics
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| GB/T 7714 | Chi, Haoming , Zhang, Xiaorui , Chen, Zhiyuan et al. Lymph-Targeted Delivery of CUR-NLCs Enhances Oral Bioavailability: Evidence from a Double-Catheterized Rat Model [J]. | PHARMACEUTICS , 2025 , 17 (11) . |
| MLA | Chi, Haoming et al. "Lymph-Targeted Delivery of CUR-NLCs Enhances Oral Bioavailability: Evidence from a Double-Catheterized Rat Model" . | PHARMACEUTICS 17 . 11 (2025) . |
| APA | Chi, Haoming , Zhang, Xiaorui , Chen, Zhiyuan , Chen, Qiuyong , Yang, Bo , Deng, Hui et al. Lymph-Targeted Delivery of CUR-NLCs Enhances Oral Bioavailability: Evidence from a Double-Catheterized Rat Model . | PHARMACEUTICS , 2025 , 17 (11) . |
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Matrine (MT), a phytochemical with various anti-infection activities, is expected to become a therapeutic agent for infectious diseases in pigs. However, the food safety risk associated with MT has not been evaluated. In this study, a liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for determining of total residues of MT in porcine edible tissues. The tissue samples were hydrolyzed with trypsin to release the non-extractable MT. The hydrolysates were extracted with trichloroacetic acid solution. The tissue extracts were purified by solid-phase extraction and subjected to LC-MS/MS analysis. The method was fully validated according to USFDA guidelines and was applied to investigate the tissue residue depletion of MT in pigs. Obvious accumulation of MT was observed in porcine edible tissues. Nevertheless, MT showed no persistent tissue residue in this study and could be accepted as a safe anti-infective agent in pigs. © 2024, The Authors. All rights reserved.
Keyword ：
Histology Histology Liquid chromatography Liquid chromatography Mammals Mammals Mass spectrometry Mass spectrometry Phase separation Phase separation Tissue Tissue Trichloroacetic acid Trichloroacetic acid
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| GB/T 7714 | Yang, Bo , Wang, Fuhao , Hu, Huiyu et al. A Lc-Ms/Ms Method for Determining of Total Residues of Matrine in Porcine Edible Tissues and its Application to a Tissue Residue Depletion Study [J]. | SSRN , 2024 . |
| MLA | Yang, Bo et al. "A Lc-Ms/Ms Method for Determining of Total Residues of Matrine in Porcine Edible Tissues and its Application to a Tissue Residue Depletion Study" . | SSRN (2024) . |
| APA | Yang, Bo , Wang, Fuhao , Hu, Huiyu , Li, Ruonan , Lv, Xiaoling , Sun, Xueyan et al. A Lc-Ms/Ms Method for Determining of Total Residues of Matrine in Porcine Edible Tissues and its Application to a Tissue Residue Depletion Study . | SSRN , 2024 . |
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Heat stress is a common environmental factor in livestock breeding that has been shown to impact the development of antibiotic resistance within the gut microbiota of both human and animals. However, studies investigating the effect of temperature on antibiotic resistance in Enterococcus isolates remain limited. In this study, specific pathogen free (SPF) mice were divided into a control group maintained at normal temperature and an experimental group subjected to daily 1-h heat stress at 38 degrees C, respectively. Gene expression analysis was conducted to evaluate the activation of heat shock responsive genes in the liver of mice. Additionally, the antibiotic-resistant profile and antibiotic resistant genes (ARGs) in fecal samples from mice were analyzed. The results showed an upregulation of heat-inducible proteins HSP27, HSP70 and HSP90 following heat stress exposure, indicating successful induction of cellular stress within the mice. Furthermore, heat stress resulted in an increase in the proportion of erythromycin-resistant Enterococcus isolates, escalating from 0 % to 0.23 % over a 30-day duration of heat stress. The resistance of Enterococcus isolates to erythromycin also had a 128-fold increase in minimum inhibitory concentration (MIC) within the heated-stressed group compared to the control group. Additionally, a 2 similar to 8-fold rise in chloramphenicol MIC was observed among these erythromycin-resistant Enterococcus isolates. The acquisition of ermB genes was predominantly responsible for mediating the erythromycin resistance in these Enterococcus isolates. Moreover, the abundance of macrolide, lincosamide and streptogramin (MLS) resistant-related genes in the fecal samples from the heat-stressed group exhibited a significant elevation compared to the control group, primarily driven by changes in bacterial community composition, especially Enterococcaceae and Planococcaceae, and the transfer of mobile genetic elements (MGEs), particularly insertion elements. Collectively, these results highlight the role of environmental heat stress in promoting antibiotic resistance in Enterococcus isolates and partly explain the increasing prevalence of erythromycin-resistant Enterococcus isolates observed among animals in recent years.
Keyword ：
Antibiotic resistance Antibiotic resistance Enterococcus isolates Enterococcus isolates Heat stress Heat stress Intestinal flora Intestinal flora
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| GB/T 7714 | Yi, Lingxian , Xu, Rui , Yuan, Xiaowu et al. Heat stress enhances the occurrence of erythromycin resistance of Enterococcus isolates in mice feces [J]. | JOURNAL OF THERMAL BIOLOGY , 2024 , 120 . |
| MLA | Yi, Lingxian et al. "Heat stress enhances the occurrence of erythromycin resistance of Enterococcus isolates in mice feces" . | JOURNAL OF THERMAL BIOLOGY 120 (2024) . |
| APA | Yi, Lingxian , Xu, Rui , Yuan, Xiaowu , Ren, Zining , Song, Huihui , Lai, Huamin et al. Heat stress enhances the occurrence of erythromycin resistance of Enterococcus isolates in mice feces . | JOURNAL OF THERMAL BIOLOGY , 2024 , 120 . |
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Introduction: Matrine (MT) is a potential resistance reversal agent. However, it remains unclear whether MT can reverse the resistance of Haemophilus parasuis (H. parasuis) to beta-lactams, and, if so, by what mechanism MT works. Methods: We screened one cefaclor (CEC)-resistant strain (clinical strain C7) from eight clinical (H. parasuis) strains and determined the underlying resistance mechanism. Then, we investigated the reversal effect of MTon the resistance of this strain to CEC. Results and Discussion: The production of beta-lactamase, overexpression of AcrAB-TolC system, and formation of biofilm might not be responsible for the resistance of clinical strain C7 to CEC. Fourteen mutation sites were found in four PBP genes (ftsI, pbp1B, mrcA, and prcS) of clinical strain C7, among which the mutation sites located in ftsI (Y103D and L517R) and mrcA (A(639)V) genes triggered the resistance to CEC. The minimum inhibitory concentration (MIC) of CEC against clinical strain C7 was reduced by two to eight folds after MT treatment, accompanied by the significant down-regulated expression of mutated ftsI and mrcA genes. Based on such results, we believed that MT could reverse the resistance of H. parasuis to CEC by inhibiting the mutations in ftsI and mrcA genes. Our research would provide useful information for restoring the antimicrobial activity of beta-lactams and improving the therapeutic efficacy of Gl & auml;sser's disease.
Keyword ：
cefaclor cefaclor ftsI ftsI Haemophilus parasuis Haemophilus parasuis matrine matrine mrcA mrcA penicillin-binding protein penicillin-binding protein resistance resistance
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| GB/T 7714 | Zhao, JingChao , Yang, Wen , Deng, Hui et al. Matrine reverses the resistance of Haemophilus parasuis to cefaclor by inhibiting the mutations in penicillin-binding protein genes (ftsI and mrcA) [J]. | FRONTIERS IN MICROBIOLOGY , 2024 , 15 . |
| MLA | Zhao, JingChao et al. "Matrine reverses the resistance of Haemophilus parasuis to cefaclor by inhibiting the mutations in penicillin-binding protein genes (ftsI and mrcA)" . | FRONTIERS IN MICROBIOLOGY 15 (2024) . |
| APA | Zhao, JingChao , Yang, Wen , Deng, Hui , Li, Dong , Wang, QianYong , Yi, LingXian et al. Matrine reverses the resistance of Haemophilus parasuis to cefaclor by inhibiting the mutations in penicillin-binding protein genes (ftsI and mrcA) . | FRONTIERS IN MICROBIOLOGY , 2024 , 15 . |
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Matrine (MT), a phytochemical with various anti-infective activities, is expected to become a therapeutic agent against bacterial, viral, and parasitic infections in pigs. However, food safety risks associated with MT have not yet been evaluated. In the present study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to determine total MT residues in edible porcine tissues. The tissue samples were hydrolyzed with trypsin to release non-extractable MT. The hydrolysates were extracted with a trichloroacetic acid solution. Tissue extracts were purified using solid-phase extraction and subjected to LC-MS/MS. The method was fully validated according to the United States Food and Drug Administration (USFDA) guidelines and applied to investigate the tissue residue depletion of MT in pigs. Significant accumulation of MT was observed in edible porcine tissues. Notably, MT showed no persistent tissue residue in this study and could be accepted as a safe anti-infective agent in pigs.
Keyword ：
Edible porcine tissue Edible porcine tissue Enzymolysis Enzymolysis Liquid chromatography-tandem mass spectrometry Liquid chromatography-tandem mass spectrometry Matrine Matrine Non-extractable residue Non-extractable residue
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| GB/T 7714 | Yang, Bo , Wang, Fuhao , Hu, Huiyu et al. A liquid chromatography-tandem mass spectrometry method to determine total matrine residues in edible porcine tissues and its application in a tissue residue depletion study [J]. | MICROCHEMICAL JOURNAL , 2024 , 207 . |
| MLA | Yang, Bo et al. "A liquid chromatography-tandem mass spectrometry method to determine total matrine residues in edible porcine tissues and its application in a tissue residue depletion study" . | MICROCHEMICAL JOURNAL 207 (2024) . |
| APA | Yang, Bo , Wang, Fuhao , Hu, Huiyu , Li, Ruonan , Lv, Xiaoling , Sun, Xueyan et al. A liquid chromatography-tandem mass spectrometry method to determine total matrine residues in edible porcine tissues and its application in a tissue residue depletion study . | MICROCHEMICAL JOURNAL , 2024 , 207 . |
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