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学者姓名：Raul Martin Giurfa
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Abstract ：
The neuropeptide F (NPF) and its short version (sNPF) mediate food- and stress-related responses in solitary insects. In the honeybee, a social insect where food collection and defensive responses are socially regulated, only sNPF has an identified receptor. Here we increased artificially sNPF levels in honeybee foragers and studied the consequences of this manipulation in various forms of appetitive and aversive responsiveness. Increasing sNPF in partially fed bees turned them into the equivalent of starved animals, enhancing both their food consumption and responsiveness to appetitive gustatory and olfactory stimuli. Neural activity in the olfactory circuits of fed animals was reduced and could be rescued by sNPF treatment to the level of starved bees. In contrast, sNPF had no effect on responsiveness to nociceptive stimuli. Our results thus identify sNPF as a key modulator of hunger and food-related responses in bees, which are at the core of their foraging activities.
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| GB/T 7714 | Bestea, Louise , Paoli, Marco , Arrufat, Patrick et al. The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect [J]. | ISCIENCE , 2022 , 25 (1) . |
| MLA | Bestea, Louise et al. "The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect" . | ISCIENCE 25 . 1 (2022) . |
| APA | Bestea, Louise , Paoli, Marco , Arrufat, Patrick , Ronsin, Brice , Carcaud, Julie , Sandoz, Jean-Christophe et al. The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect . | ISCIENCE , 2022 , 25 (1) . |
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Abstract ：
Honey bees are reputed for their remarkable visual learning and navigation capabilities. These capacities can be studied in virtual reality (VR) environments, which allow studying performances of tethered animals in stationary flight or walk under full control of the sensory environment. Here, we used a 2D VR setup in which a tethered bee walking stationary under restrictive closed-loop conditions learned to discriminate vertical rectangles differing in color and reinforcing outcome. Closed-loop conditions restricted stimulus control to lateral displacements. Consistently with prior VR analyses, bees learned to discriminate the trained stimuli. Ex vivo analyses on the brains of learners and non-learners showed that successful learning led to a downregulation of three immediate early genes in the main regions of the visual circuit, the optic lobes (OLs) and the calyces of the mushroom bodies (MBs). While Egr1 was downregulated in the OLs, Hr38 and kakusei were coincidently downregulated in the calyces of the MBs. Our work thus reveals that color discrimination learning induced a neural signature distributed along the sequential pathway of color processing that is consistent with an inhibitory trace. This trace may relate to the motor patterns required to solve the discrimination task, which are different from those underlying pathfinding in 3D VR scenarios allowing for navigation and exploratory learning and which lead to IEG upregulation.
Keyword ：
brain brain honey bee (Apis mellifera) honey bee (Apis mellifera) IEG expression IEG expression mushroom bodies mushroom bodies optic lobes optic lobes virtual reality virtual reality vision vision visual learning visual learning
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| GB/T 7714 | Lafon, Gregory , Geng, Haiyang , Avargues-Weber, Aurore et al. The Neural Signature of Visual Learning Under Restrictive Virtual-Reality Conditions [J]. | FRONTIERS IN BEHAVIORAL NEUROSCIENCE , 2022 , 16 . |
| MLA | Lafon, Gregory et al. "The Neural Signature of Visual Learning Under Restrictive Virtual-Reality Conditions" . | FRONTIERS IN BEHAVIORAL NEUROSCIENCE 16 (2022) . |
| APA | Lafon, Gregory , Geng, Haiyang , Avargues-Weber, Aurore , Buatois, Alexis , Massou, Isabelle , Giurfa, Martin . The Neural Signature of Visual Learning Under Restrictive Virtual-Reality Conditions . | FRONTIERS IN BEHAVIORAL NEUROSCIENCE , 2022 , 16 . |
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Objectives: Biogenic amines modulate the honeybees' behavioral development, especially olfactory learning behavior. Diverse behavioral protocols have been developed to investigate the olfactory learning behavior of bees to process appetitive olfaction information. Apis mellifera ligustica is a well-known eusocial insect to examine the olfactory learning behavior. This study evaluated the relationship between olfactory learning success and biogenic amines and uncovered the role of biogenic amines to regulate the olfactory learning behavior of bees.Methods: We used high-performance liquid chromatography (HPLC) with an electrochemical detection (ECD) system to quantify neurotransmitters levels in the bee brain following olfactory learning trials. Furthermore, the bees of the control group and the dopamine flupenthixol blocker injected group were trained to evaluate the olfactory learning performance.Results: Our finding showed that learning success was directly correlated with the levels of DA and serotonin (5-HT), furthermore, bees of the control group showed higher proboscis extension response than dopamine blocker injected group. Taken together, these findings revealed that dopamine (DA) and serotonin (5-HT) could thus act together to define optimal motivational or attentional levels and improve learning success and indicated that dopamine blocker flupenthixol has to modulate influence on the olfactory learning performance of bees.Conclusion: The results strongly imply that biogenic amines can durably modify the learning behavior in future model insects.(c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keyword ：
1-hexanol 1-hexanol 1-nonanol 1-nonanol Apis mellifera Apis mellifera Biogenic amines Biogenic amines Odor Odor Proboscis extension response Proboscis extension response Su) Su)
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| GB/T 7714 | Raza, Muhammad Fahad , Wang, Tianbao , Li, Zhiguo et al. Biogenic amines mediate learning success in appetitive odor conditioning in honeybees [J]. | JOURNAL OF KING SAUD UNIVERSITY SCIENCE , 2022 , 34 (4) . |
| MLA | Raza, Muhammad Fahad et al. "Biogenic amines mediate learning success in appetitive odor conditioning in honeybees" . | JOURNAL OF KING SAUD UNIVERSITY SCIENCE 34 . 4 (2022) . |
| APA | Raza, Muhammad Fahad , Wang, Tianbao , Li, Zhiguo , Nie, Hongyi , Giurfa, Martin , Husain, Arif et al. Biogenic amines mediate learning success in appetitive odor conditioning in honeybees . | JOURNAL OF KING SAUD UNIVERSITY SCIENCE , 2022 , 34 (4) . |
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The biological bases of wanting have been characterized in mammals, but whether an equivalent wanting system exists in insects remains unknown. In this study, we focused on honey bees, which perform intensive foraging activities to satisfy colony needs, and sought to determine whether foragers leave the hive driven by specific expectations about reward and whether they recollect these expectations during their waggle dances. We monitored foraging and dance behavior and simultaneously quantified and interfered with biogenic amine signaling in the bee brain. We show that a dopamine-dependent wanting system is activated transiently in the bee brain by increased appetite and individual recollection of profitable food sources, both en route to the goal and during waggle dances. Our results show that insects share with mammals common neural mechanisms for encoding wanting of stimuli with positive hedonic value.
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| GB/T 7714 | Huang, Jingnan , Zhang, Zhaonan , Feng, Wangjiang et al. Food wanting is mediated by transient activation of dopaminergic signaling in the honey bee brain [J]. | SCIENCE , 2022 , 376 (6592) : 508-, . |
| MLA | Huang, Jingnan et al. "Food wanting is mediated by transient activation of dopaminergic signaling in the honey bee brain" . | SCIENCE 376 . 6592 (2022) : 508-, . |
| APA | Huang, Jingnan , Zhang, Zhaonan , Feng, Wangjiang , Zhao, Yuanhong , Aldanondo, Anna , Sanchez, Maria Gabriela de Brito et al. Food wanting is mediated by transient activation of dopaminergic signaling in the honey bee brain . | SCIENCE , 2022 , 376 (6592) , 508-, . |
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Motivation can critically influence learning and memory. Multiple neural mechanisms regulate motivational states, among which signalling via specific neuropeptides, such as NPY in vertebrates and NPF and its short variant sNPF in invertebrates, plays an essential role. The honey bee (Apis mellifera) is a privileged model for the study of appetitive learning and memory. Bees learn and memorize sensory cues associated with nectar reward while foraging, and their learning is affected by their feeding state. However, the neural underpinnings of their motivational states remain poorly known. Here we focused on the short neuropeptide F (sNPF) and studied if it modulates the acquisition and formation of colour memories. Artificially increasing sNPF levels in partially fed foragers with a reduced motivation to learn colours resulted in significant colour learning and memory above the levels exhibited by starved foragers. Our results thus identify sNPF as a critical component of motivational processes involved in foraging and in the cognitive processes associated with this activity in honey bees.
Keyword ：
appetitive motivation appetitive motivation honey bees honey bees learning learning memory memory short neuropeptide F (sNPF) short neuropeptide F (sNPF)
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| GB/T 7714 | Bestea, Louise , Briard, Emmanuelle , Carcaud, Julie et al. The short neuropeptide F (sNPF) promotes the formation of appetitive visual memories in honey bees [J]. | BIOLOGY LETTERS , 2022 , 18 (2) . |
| MLA | Bestea, Louise et al. "The short neuropeptide F (sNPF) promotes the formation of appetitive visual memories in honey bees" . | BIOLOGY LETTERS 18 . 2 (2022) . |
| APA | Bestea, Louise , Briard, Emmanuelle , Carcaud, Julie , Sandoz, Jean-Christophe , Velarde, Rodrigo , Giurfa, Martin et al. The short neuropeptide F (sNPF) promotes the formation of appetitive visual memories in honey bees . | BIOLOGY LETTERS , 2022 , 18 (2) . |
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Free-flying bees learn efficiently to solve numerous visual tasks. Yet, the neural underpinnings of this capacity remain unexplored. We used a 3D virtual reality (VR) environment to study visual learning and determine if it leads to changes in immediate early gene (IEG) expression in specific areas of the bee brain. We focused on kakusei, Hr38 and Egr1, three IEGs that have been related to bee foraging and orientation, and compared their relative expression in the calyces of the mushroom bodies, the optic lobes and the rest of the brain after color discrimination learning. Bees learned to discriminate virtual stimuli displaying different colors and retained the information learned. Successful learners exhibited Egr1 upregulation only in the calyces of the mushroom bodies, thus uncovering a privileged involvement of these brain regions in associative color learning and the usefulness of Egr1 as a marker of neural activity induced by this phenomenon. The neural bases of visual learning in bees have been understudied, relative to the olfactory learning process. Using a 3D virtual reality environment and gene expression analyses, the neural underpinnings of visual learning are explored here.
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| GB/T 7714 | Geng, Haiyang , Lafon, Gregory , Avargues-Weber, Aurore et al. Visual learning in a virtual reality environment upregulates immediate early gene expression in the mushroom bodies of honey bees [J]. | COMMUNICATIONS BIOLOGY , 2022 , 5 (1) . |
| MLA | Geng, Haiyang et al. "Visual learning in a virtual reality environment upregulates immediate early gene expression in the mushroom bodies of honey bees" . | COMMUNICATIONS BIOLOGY 5 . 1 (2022) . |
| APA | Geng, Haiyang , Lafon, Gregory , Avargues-Weber, Aurore , Buatois, Alexis , Massou, Isabelle , Giurfa, Martin . Visual learning in a virtual reality environment upregulates immediate early gene expression in the mushroom bodies of honey bees . | COMMUNICATIONS BIOLOGY , 2022 , 5 (1) . |
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