Query：
学者姓名：颜世红
Refining：
Year
Type
Indexed by
Source
Complex
Co-Author
Language
Clean All
Abstract ：
Vaccination is one of the most effective methods for controlling animal infectious diseases, and the use of adjuvants plays crucial role in enhancing the immune efficacy of vaccines, particularly in inactivated and subunit vaccines. With the continuous advancement of research in animal immunology and immune mechanisms, our understanding of the functions of cells and cytokines in immune responses has become increasingly comprehensive, laying a solid foundation for the development of novel vaccines and adjuvants. Cytokines are a class of proteins secreted by the animal body that regulate innate and adaptive immune responses through interaction with specific receptors. To date, numerous studies have investigated the potential of using cytokines as adjuvants to enhance the efficacy of veterinary vaccines. This review focuses on cytokines as veterinary vaccine adjuvants, with special attention to the current research progress and mechanisms of cytokines such as interleukins, interferons, chemokines, and colony-stimulating factors. Additionally, examples of the application of cytokine-based adjuvants in combination with veterinary vaccines will be discussed to provide further insights and references for the development of cytokine-based veterinary adjuvants.
Keyword ：
cytokines cytokines immune enhancement immune enhancement vaccination vaccination vaccine adjuvant vaccine adjuvant veterinary vaccine veterinary vaccine
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Yan, Shihong , Chen, Huimin , Liu, Qiao et al. Harnessing cytokines: innovative adjuvants for improved veterinary vaccine efficacy [J]. | FRONTIERS IN IMMUNOLOGY , 2025 , 16 . |
| MLA | Yan, Shihong et al. "Harnessing cytokines: innovative adjuvants for improved veterinary vaccine efficacy" . | FRONTIERS IN IMMUNOLOGY 16 (2025) . |
| APA | Yan, Shihong , Chen, Huimin , Liu, Qiao , Zhang, Xinyu , Wei, Qiulu , Hu, Chenqi et al. Harnessing cytokines: innovative adjuvants for improved veterinary vaccine efficacy . | FRONTIERS IN IMMUNOLOGY , 2025 , 16 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Long non-coding RNAs (lncRNAs) are critical regulators of various biological processes, yet their roles in chicken host-virus interactions remain largely unknown. This study investigated the impact of influenza A virus (IAV) H9N2 infection on the expression of two lncRNAs, Lnc9101 and Lnc8475, and the regulatory roles of these lncRNAs in the innate immune response. The results demonstrated that the expression of both lncRNAs were significantly upregulated in H9N2-infected chickens and could be induced by viral genomic RNA, poly (I:C) or LPS. Disruption of Lnc9101 expression in DF-1 cells enhanced the IAV replication, while its overexpression suppressed it. Conversely, Lnc8475 had the opposite effect on the IAV replication compared with Lnc9101. Silencing Lnc8475 expression in DF-1 cells attenuated IAV replication, while its overexpression promoted viral replication. Furthermore, we found that both lncRNAs regulated the expression of type I and type III interferons (IFNs), thereby affecting multiple interferon-stimulating genes (ISGs) expression and STAT1 activation upon IAV infection. Moreover, Lnc9101 knockdown impaired the expression of TLR7 and MDA5 and reduced IRF7 phosphorylation, whereas Lnc8475 knockdown promoted the expression of TLR3 and TLR7. In summary, Lnc9101 inhibits IAV replication by positively regulating the innate immune response, whereas Lnc8475 promotes IAV replication by suppressing it. These findings suggest that LncRNA9101 and Lnc8475 play important roles in pattern recognition receptors (PRRs)-dependent innate immune signaling and antiviral responses, advancing a better understanding of lncRNA functioning in chickens.
Keyword ：
Influenza A virus Influenza A virus Innate immune response Innate immune response Interferon Interferon Long non-coding RNA Long non-coding RNA Signaling pathway Signaling pathway
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Lin, Jiaqi , Hu, Pengcheng , Mei, Guiheng et al. Role of long non-coding RNA Lnc9101 and Lnc8475 in regulation of innate immune response to influenza virus infection [J]. | POULTRY SCIENCE , 2025 , 104 (12) . |
| MLA | Lin, Jiaqi et al. "Role of long non-coding RNA Lnc9101 and Lnc8475 in regulation of innate immune response to influenza virus infection" . | POULTRY SCIENCE 104 . 12 (2025) . |
| APA | Lin, Jiaqi , Hu, Pengcheng , Mei, Guiheng , Guo, Bolun , Wang, Song , Yan, Shihong et al. Role of long non-coding RNA Lnc9101 and Lnc8475 in regulation of innate immune response to influenza virus infection . | POULTRY SCIENCE , 2025 , 104 (12) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Amidst increasing concern about antibiotic resistance resulting from the overuse of antibiotics, there is a growing interest in exploring alternative agents. One such agent is citric acid, an organic compound commonly used for various applications. Our research findings indicate that the inclusion of citric acid can have several beneficial effects on the tight junctions found in the mouse intestine. Firstly, the study suggests that citric acid may contribute to weight gain by stimulating the growth of intestinal epithelial cells (IE-6). Citric acid enhances the small intestinal villus-crypt ratio in mice, thereby promoting intestinal structural morphology. Additionally, citric acid has been found to increase the population of beneficial intestinal microorganisms, including Bifidobacterium and Lactobacillus. It also promotes the expression of important protein genes such as occludin, ZO-1, and claudin-1, which play crucial roles in maintaining the integrity of the tight junction barrier in the intestines. Furthermore, in infected IEC-6 cells with H9N2 avian influenza virus, citric acid augmented the expression of genes closely associated with the influenza virus infection. Moreover, it reduces the inflammatory response caused by the viral infection and thwarted influenza virus replication. These findings suggest that citric acid fortifies the intestinal tight junction barrier, inhibits the replication of influenza viruses targeting the intestinal tract, and boosts intestinal immune function.
Keyword ：
citric acid citric acid gut microorganisms gut microorganisms intestinal barrier intestinal barrier metabolomics metabolomics
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Hu, Pengcheng , Yuan, Meng , Guo, Bolun et al. Citric Acid Promotes Immune Function by Modulating the Intestinal Barrier [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2024 , 25 (2) . |
| MLA | Hu, Pengcheng et al. "Citric Acid Promotes Immune Function by Modulating the Intestinal Barrier" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25 . 2 (2024) . |
| APA | Hu, Pengcheng , Yuan, Meng , Guo, Bolun , Lin, Jiaqi , Yan, Shihong , Huang, Huiqing et al. Citric Acid Promotes Immune Function by Modulating the Intestinal Barrier . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2024 , 25 (2) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Vaccine adjuvants, serving as non-specific immune enhancers, play a pivotal role in the immunoprevention and control of animal diseases. This study utilized prokaryotic expression systems to express and purify chickenderived cIFITM1, cIFITM3, and cViperin, which were then formulated as adjuvants with H9N2 avian influenza virus antigens to create inactivated vaccines. These vaccines were administered to SPF chickens to investigate their immunopotentiating functions. Additionally, the proteins were assessed for their ability to act as standalone immune enhancers. The results demonstrated that cIFITM1, cIFITM3, and cViperin significantly elevated serum hemagglutination inhibition (HI) antibody titers. Notably, when used individually, these proteins markedly enhanced the antiviral capabilities of challenged chickens, leading to alleviated clinical symptoms, reduced tracheal virus replication, diminished virus shedding, and lessened histopathological damage, with cIFITM1 exhibiting the most pronounced effect. Furthermore, the protective efficacy of two H9N2 recombinant virus inactivated vaccines supplemented with cIFITM1 adjuvant was validated, achieving a 100% vaccine protection efficiency. In conclusion, cIFITM1, cIFITM3, and cViperin as adjuvants for influenza vaccines effectively inhibit virus replication and shedding, highlighting their significant potential in influenza prevention and control.
Keyword ：
Antiviral Protein Antiviral Protein Avian vaccine adjuvant Avian vaccine adjuvant Protection efficiency Protection efficiency
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Yan, Shihong , Chen, Yikai , Lin, Jin et al. Recombinant avian-derived antiviral proteins cIFITM1, cIFITM3, and cViperin as effective adjuvants in inactivated H9N2 subtype avian influenza vaccines [J]. | VETERINARY MICROBIOLOGY , 2024 , 298 . |
| MLA | Yan, Shihong et al. "Recombinant avian-derived antiviral proteins cIFITM1, cIFITM3, and cViperin as effective adjuvants in inactivated H9N2 subtype avian influenza vaccines" . | VETERINARY MICROBIOLOGY 298 (2024) . |
| APA | Yan, Shihong , Chen, Yikai , Lin, Jin , Chen, Huimin , Hu, Chenqi , Liu, Hongyang et al. Recombinant avian-derived antiviral proteins cIFITM1, cIFITM3, and cViperin as effective adjuvants in inactivated H9N2 subtype avian influenza vaccines . | VETERINARY MICROBIOLOGY , 2024 , 298 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Animal experiments have played a significant role in advancing scientific knowledge and enhancing people's quality of life. In order to better understand the opinions and knowledge of veterinary students in the domain of laboratory animal welfare and to explore and advance the teaching methods used in animal ethics education, a questionnaire was designed and used to conduct a survey among undergraduate and postgraduate students majoring in veterinary medicine. The survey encompassed various topics, such as students' level of knowledge about animal welfare, their perspectives on laboratory animals, their proficiency with animal experiments, and their opinions on teaching methods and content. The respondents were a total of 150 undergraduate students and 148 graduate students. The survey results indicated that most students expressed a strong sense of responsibility for the safeguarding of the welfare of experimental animals. However, there were a few students who lacked compassion for animals. Additionally, there was a general lack of basic theoretical knowledge of animal ethics and an inadequate grasp of experimental techniques among current students. Furthermore, most of the participants expressed a strong sense of responsibility to advocate for animal welfare. Although a substantial number of students were unaware of the existence of agencies for the supervision of work involving laboratory animals, they supported teaching and supervision in the domain of animal welfare and were open to various teaching methods and topics of content. In conclusion, targeted training and education regarding laboratory animal welfare and ethics should be conducted in the future to address the specific needs of students. This study provides a foundation for future animal welfare education and will help to improve the professional skills and humanistic qualities of veterinary students.
Keyword ：
animal welfare animal welfare Chinese veterinary students Chinese veterinary students laboratory animal laboratory animal survey research survey research university education university education
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Yan, Shihong , Li, Hongyang , Lin, Jin et al. An investigation of the perceptions of laboratory animal welfare issues among undergraduate and graduate veterinary students in southeastern China [J]. | FRONTIERS IN VETERINARY SCIENCE , 2024 , 10 . |
| MLA | Yan, Shihong et al. "An investigation of the perceptions of laboratory animal welfare issues among undergraduate and graduate veterinary students in southeastern China" . | FRONTIERS IN VETERINARY SCIENCE 10 (2024) . |
| APA | Yan, Shihong , Li, Hongyang , Lin, Jin , Chen, Huimin , Liu, Shasha , Diao, Hongxiu . An investigation of the perceptions of laboratory animal welfare issues among undergraduate and graduate veterinary students in southeastern China . | FRONTIERS IN VETERINARY SCIENCE , 2024 , 10 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
H9N2 is currently the main subtype of avian influenza in China. In order to use reverse genetics to rapid preparation of seed strains for vaccine produc-tion, and intend to prevent and control the H9N2 sub-type epidemic strains of avian influenza virus (AIV). In this study, we successfully rescued 2 H9N2 recombinant viruses based on the representative viruses of Southeast China and confirmed by RT-PCR and sequencing. Genetic stability, pathogenicity, transmissibility, and antigenicity of 2 recombinant viruses were evaluated. Compared to the FZ1, the growth kinetics of H9N2(HA + NA)/PR8 showed no significant difference, H9N2(HA + NA+M+PB1)/PR8 was slightly lower. Our study also confirmed 2 recombinant viruses had good genetic sta-bility after 10 passages but possessed lower pathogenic-ity than FZ1. Although both recombinant viruses led to seroconversion in all inoculated birds on 14 dpi, they complete loss of viral transmission of the virus to contact birds. In addition, birds were immunized via hypodermic route by inactivated vaccines of H9N2(HA+NA)/ PR8, H9N2(HA+NA+M+PB1)/PR8 and wild-type virus with a single dose, and the results showed that the hemagglutination inhibition titers on 21 dpv were 10.5, 9.6, and 10.5 log2, respectively. And recombinant viruses both provided a certain protection against wild -type virus challenge. In conclusion, these data indicated that 2 recombinant viruses will be expected to be used as inactivated vaccines to controlling the spread of H9N2 subtype AIV even have potential application for attenuated viral vaccines, which provides a reference for the prevention and control of influenza virus pandemics.
Keyword ：
pathogenicity pathogenicity protective effect protective effect recombinant viruses recombinant viruses
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Liu, Hongyang , Chen, Yikai , Li, Hongyang et al. Pathogenicity, transmissibility, and immunogenicity of recombinant H9N2 avian influenza viruses based on representative viruses of Southeast China [J]. | POULTRY SCIENCE , 2023 , 102 (6) . |
| MLA | Liu, Hongyang et al. "Pathogenicity, transmissibility, and immunogenicity of recombinant H9N2 avian influenza viruses based on representative viruses of Southeast China" . | POULTRY SCIENCE 102 . 6 (2023) . |
| APA | Liu, Hongyang , Chen, Yikai , Li, Hongyang , Yang, Lingen , Yang, Shili , Luo, Xiaoying et al. Pathogenicity, transmissibility, and immunogenicity of recombinant H9N2 avian influenza viruses based on representative viruses of Southeast China . | POULTRY SCIENCE , 2023 , 102 (6) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
本发明公开了抗病毒蛋白免疫增强剂在H9N2禽流感灭活苗中的应用，其中，所述免疫增强剂为鸡源抗病毒蛋白IFITM1，本方案的鸡源抗病毒蛋白IFITM1作为免疫增强剂配合H9N2亚型禽流感灭活疫苗免疫，能够诱导免疫鸡产生更高水平的H9N2亚型禽流感血清HI抗体，提升排毒抑制效果。且抗病毒蛋白IFITM1作为免疫增强剂单独颈部皮下接种后21天，也可有效抑制鸡H9N2亚型禽流感病毒的排毒，使鸡组织损伤情况明显降低。目前国内尚无禽用抗病毒蛋白免疫增强剂灭活疫苗上市，本方案的禽用免疫增强剂配备H9N2亚型禽流感灭活疫苗可以更加有效的防控禽流感，同时也能弥补当前禽类市场免疫增强剂的空缺。
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 陈吉龙 , 颜世红 , 池晓娟 . 抗病毒蛋白免疫增强剂在H9N2禽流感灭活苗中的应用 : CN202210513190.1[P]. | 2022-05-12 . |
| MLA | 陈吉龙 et al. "抗病毒蛋白免疫增强剂在H9N2禽流感灭活苗中的应用" : CN202210513190.1. | 2022-05-12 . |
| APA | 陈吉龙 , 颜世红 , 池晓娟 . 抗病毒蛋白免疫增强剂在H9N2禽流感灭活苗中的应用 : CN202210513190.1. | 2022-05-12 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
<正>宠物意外烧伤的病例时有发生，烧伤不仅会导致动物体液大面积渗出，创面局部感染和影响宠物美观，甚至可能引起肝和肾等重要器官的损伤，进而对宠物生命造成威胁。因此，合理有效的治疗方法对宠物烧伤的恢复至关重要。随着生物医学领域的发展，一种新型生物敷料——罗非鱼皮被应用于人类的烧伤治疗中~([1]),已有临床试验表明罗非鱼皮比其他传统敷料具有更好的抗感染和镇痛作用，减少换药时给患者带来的撕痛感~([2-3])。
Keyword ：
排异反应 排异反应 治疗效果 治疗效果 烧伤治疗 烧伤治疗 罗非鱼皮 罗非鱼皮 肉芽组织 肉芽组织
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 赵飞杨 , 黄慧清 , 钟友本 et al. 罗非鱼皮在犬背部烧伤治疗中的应用 [J]. | 中国兽医杂志 , 2022 , 58 (06) : 110-113 . |
| MLA | 赵飞杨 et al. "罗非鱼皮在犬背部烧伤治疗中的应用" . | 中国兽医杂志 58 . 06 (2022) : 110-113 . |
| APA | 赵飞杨 , 黄慧清 , 钟友本 , 刘鸿扬 , 刁洪秀 , 颜世红 . 罗非鱼皮在犬背部烧伤治疗中的应用 . | 中国兽医杂志 , 2022 , 58 (06) , 110-113 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
本发明公开了一种H9N2亚型禽流感和鸡滑液囊支原体的二联灭活疫苗，其包括抗原和疫苗佐剂，其中抗原为灭活的甲型流感病毒FZ株与滑液囊支原体MS‑FJ01；FZ株与MS‑FJ01株均属于福建省典型代表性毒株；本方案的二联灭活疫苗能够诱导鸡产生较高水平的H9N2亚型禽流感抗体和滑液囊支原体抗体，且抗体持续期长，免疫后可有效降低免疫鸡H9N2亚型禽流感病毒的排毒，可使鸡滑液囊支原体的发病率明显减少，能够同时且有效的预防H9N2亚型禽流感和鸡滑液囊支原体的流行。目前国内尚无H9N2亚型禽流感和鸡滑液囊支原体二联灭活疫苗上市，本方案的H9N2亚型禽流感和鸡滑液囊支原体二联灭活疫苗可以有效的防控这两种禽病，同时也能弥补当前禽类市场空缺。
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 陈吉龙 , 颜世红 , 李训良 et al. 一种H9N2亚型禽流感和鸡滑液囊支原体的二联灭活疫苗 : CN202111186799.4[P]. | 2021-10-12 . |
| MLA | 陈吉龙 et al. "一种H9N2亚型禽流感和鸡滑液囊支原体的二联灭活疫苗" : CN202111186799.4. | 2021-10-12 . |
| APA | 陈吉龙 , 颜世红 , 李训良 , 王松 . 一种H9N2亚型禽流感和鸡滑液囊支原体的二联灭活疫苗 : CN202111186799.4. | 2021-10-12 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
