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Antioxidant activity of low molecular weight polysaccharides from Tremella fuciformis in Caenorhabditis elegans based on metabolomics analysis ESCI
期刊论文 | 2026 , 6 (3) , 479-490 | JOURNAL OF FUTURE FOODS
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Tremella fuciformis polysaccharides have rich bioactivities, while low molecular weight polysaccharides have higher bioavailability and nutritional value. In this study, it was investigated that the structural characteristics of low molecular weight polysaccharides from Tremella fuciformis (TFLP) prepared by acid hydrolysis method, its impact on antioxidant capacity and stress resistance of Caenorhabditis elegans, and potential mechanisms. TFLP was an acidic polysaccharide mainly composed of mannose and xylose with a molecular weight of 106 kDa. TFLP could prolong the median lifespan of C. elegans under heat stress and acute oxidative stress conditions through significantly reducing the malondialdehyde (MDA) level and increasing the activity of antioxidant enzymes total-superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT). The intervention of high-dose TFLP significantly prolonged the median lifespan of C. elegans under heat stress and acute oxidative stress conditions by 24.47% and 7.84%, respectively. At the same time, the MDA level significantly decreased by 69.59%, and the levels of T-SOD, GSH-Px and CAT increased significantly by 2.22, 1.28 and 0.53 times, respectively. Meanwhile, the transcription levels of daf-16, fat-5, fat-7, and hsf-1 mRNA in C. elegans treated with TFLP were significantly increased, while the transcription levels of akt-1 and daf-2 mRNA were significantly reduced. In addition, propanoate metabolism, valine, leucine and isoleucine degradation metabolism and vitamin B6 metabolism were key metabolic pathways for TFLP to enhance antioxidant capacity and stress resistance in C. elegans. These results indicated that TFLP could enhance in vivo antioxidant capacity and stress resistance by improving the levels mRNA transcription and metabolites, and it provided new evidence for TFLP to exert in vivo antioxidant activity. (c) 2026 The authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keyword :

Antioxidant activity Antioxidant activity Caenorhabditis elegans Caenorhabditis elegans Low molecular weight polysaccharides Low molecular weight polysaccharides Metabolites Metabolites Structural characteristics Structural characteristics Tremella fuciformis Tremella fuciformis

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GB/T 7714 Lee, Quancen , Xue, Zhixiang , Zheng, Mingfeng et al. Antioxidant activity of low molecular weight polysaccharides from Tremella fuciformis in Caenorhabditis elegans based on metabolomics analysis [J]. | JOURNAL OF FUTURE FOODS , 2026 , 6 (3) : 479-490 .
MLA Lee, Quancen et al. "Antioxidant activity of low molecular weight polysaccharides from Tremella fuciformis in Caenorhabditis elegans based on metabolomics analysis" . | JOURNAL OF FUTURE FOODS 6 . 3 (2026) : 479-490 .
APA Lee, Quancen , Xue, Zhixiang , Zheng, Mingfeng , Liu, Bin , Zeng, Feng . Antioxidant activity of low molecular weight polysaccharides from Tremella fuciformis in Caenorhabditis elegans based on metabolomics analysis . | JOURNAL OF FUTURE FOODS , 2026 , 6 (3) , 479-490 .
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Effects of waterlogging at different duration on growth and physiological characteristics of Cenchrus fungigraminus SCIE
期刊论文 | 2025 , 231 | ENVIRONMENTAL AND EXPERIMENTAL BOTANY
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Waterlogging, or excessive accumulation of water in the soil, poses significant stress to riparian ecosystems and agroforestry, especially with increasing global rainfall. Cenchrus fungigraminus is a vital agricultural resource, biomaterial, and super-energy plant with high resistance and adaptability. This study examined its morphological and physiological responses under root and above-ground waterlogging for up to 30 days. Results showed that waterlogging significantly inhibited growth, reducing membrane permeability, and root activity, and accelerating leaf senescence (P < 0.05). Despite this, C. fungigraminus achieved 100 % survival after 30 days of waterlogging. The plant adapted to the hypoxic environment by enhancing oxygen channels through cortex cell loosening, lysigenous tissue formation, and adventitious root development. It also activated defense mechanisms, increasing the activities of antioxidant enzymes (SOD, POD, and CAT), levels of non-enzymatic antioxidants (AsA and GSH), osmotic regulators (SS, SP, and Pro), and anaerobic respiratory enzymes (PDC, ADH, and LDH), and hormones (ABA, IAA, GA, and ETH). Under two levels of waterlogging depth, the plant initially adopted the LowO2 escape strategy (LOES), but over time, it transitioned to the Low-O2 quiescence strategy (LOQS), while still retaining some features of the LOES. Our results revealed that C. fungigraminus demonstrates strong adaptability to waterlogging, especially in response to root waterlogging. By employing anatomical adjustments and exceptional cellular defense mechanisms, the species effectively mitigates damage, establishing itself as an excellent forage grass for slope protection under waterlogged conditions. These results offer valuable guidance for selecting waterlogging-tolerant species to restore and rehabilitate degraded riparian ecosystems in the Yellow River Basin, optimize land use in waterlogging-prone areas, and advance the genetic improvement of waterlogging tolerance in other forage varieties.

Keyword :

Anatomy Anatomy Cenchrus fungigraminus Cenchrus fungigraminus Growth strategy Growth strategy Morphology Morphology Physiology Physiology Waterlogging Waterlogging

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GB/T 7714 Song, Simeng , Zhou, Hengyu , Luo, Yuan et al. Effects of waterlogging at different duration on growth and physiological characteristics of Cenchrus fungigraminus [J]. | ENVIRONMENTAL AND EXPERIMENTAL BOTANY , 2025 , 231 .
MLA Song, Simeng et al. "Effects of waterlogging at different duration on growth and physiological characteristics of Cenchrus fungigraminus" . | ENVIRONMENTAL AND EXPERIMENTAL BOTANY 231 (2025) .
APA Song, Simeng , Zhou, Hengyu , Luo, Yuan , Yu, Shikui , Su, Dewei , Zheng, Dan et al. Effects of waterlogging at different duration on growth and physiological characteristics of Cenchrus fungigraminus . | ENVIRONMENTAL AND EXPERIMENTAL BOTANY , 2025 , 231 .
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Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review SCIE
期刊论文 | 2025 , 90 (8) | JOURNAL OF FOOD SCIENCE
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Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory-enhancing, anti-inflammatory, hypoglycemic, and hypolipidemic effects, as well as skin-protective properties and gut microbiota modulation. Due to these multifunctional properties, TFP has garnered considerable attention in the food, pharmaceutical, and cosmetic industries. This review summarizes recent research on TFP, focusing on its preparation methods, structural characteristics, and diverse biological activities. Additionally, it provides a theoretical basis for the potential applications of TFP in the food, pharmaceutical, and cosmetic industries, while also discussing future research directions and development prospects.

Keyword :

application application bioactivities bioactivities functionality functionality structure structure TFP TFP

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GB/T 7714 Rui, Yanlin , Lee, Quancen , Guo, Yue et al. Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review [J]. | JOURNAL OF FOOD SCIENCE , 2025 , 90 (8) .
MLA Rui, Yanlin et al. "Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review" . | JOURNAL OF FOOD SCIENCE 90 . 8 (2025) .
APA Rui, Yanlin , Lee, Quancen , Guo, Yue , Huang, Ying , Xu, Huanyi , Liu, Bin et al. Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review . | JOURNAL OF FOOD SCIENCE , 2025 , 90 (8) .
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复方菌草灵芝颗粒的水提工艺及其质量标准研究
期刊论文 | 2025 , 53 (03) , 66-82 | 陕西师范大学学报(自然科学版)
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为探究复方菌草灵芝颗粒的水提工艺及其质量标准,以浸膏得率和浸膏多糖含量为指标,采用单因素和响应面实验考察提取温度、提取时间、料液比、提取次数和浸泡时间对浸膏得率和浸膏多糖含量的影响;参考2015版《中国药典》和国标检测复方菌草灵芝颗粒的粒度、水分含量、干燥失重、装量差异、可溶性、微生物限量和重金属含量;通过薄层色谱法对复方菌草灵芝颗粒中的菌草灵芝、紫苏和富硒茶原材料进行鉴定;通过高效液相色谱法测定复方菌草灵芝颗粒中单糖和茶多酚含量。结果表明:复方菌草灵芝颗粒的最佳水提工艺为提取温度80℃、超声时间2.5 h、料液比(g/mL)1∶25、提取次数2次、浸泡时间6 h;其颗粒粒度、水分含量、干燥失重、装量差异和可溶性均符合2015版《中国药典》要求,微生物限量和重金属含量均符合国标要求,其中硒平均质量分数为0.058 3 mg/kg;得到的菌草灵芝、紫苏和富硒茶的薄层色谱条带清晰,分离效果好,阴性对照对其测定无干扰;复方菌草灵芝颗粒中甘露糖、鼠李糖、葡萄糖、半乳糖、阿拉伯糖、表没食子儿茶素没食子酸酯、表儿茶素没食子酸酯、儿茶素、没食子酸的质量分数分别为1.310、1.166、8.708、1.265、0.824、5.79、2.58、1.72和1.67 mg/g。以上结果表明优化得到的复方菌草灵芝颗粒水提工艺稳定可靠,颗粒的各项指标均符合相关要求,建立的复方菌草灵芝颗粒水提工艺质量标准科学可行。

Keyword :

水提工艺 水提工艺 菌草灵芝 菌草灵芝 薄层色谱 薄层色谱 质量标准 质量标准 高效液相色谱 高效液相色谱

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GB/T 7714 张桂清 , 梁志豪 , 刘青 et al. 复方菌草灵芝颗粒的水提工艺及其质量标准研究 [J]. | 陕西师范大学学报(自然科学版) , 2025 , 53 (03) : 66-82 .
MLA 张桂清 et al. "复方菌草灵芝颗粒的水提工艺及其质量标准研究" . | 陕西师范大学学报(自然科学版) 53 . 03 (2025) : 66-82 .
APA 张桂清 , 梁志豪 , 刘青 , 吴小平 , 罗海凌 , 姚俊新 et al. 复方菌草灵芝颗粒的水提工艺及其质量标准研究 . | 陕西师范大学学报(自然科学版) , 2025 , 53 (03) , 66-82 .
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灰树花醇提物对秀丽隐杆线虫的抗氧化及降脂作用
期刊论文 | 2025 , 41 (07) , 117-124 | 现代食品科技
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为研究灰树花醇提物的抗氧化及降脂作用,该研究首先测定了灰树花醇提物的总糖、蛋白、多酚和三萜含量,接着利用体外抗氧化实验和秀丽隐杆线虫模型分析其抗氧化能力。此外,通过油红O染色观察线虫体内脂质沉积情况,同时测定TG浓度和LPS活力探究其降脂潜力。结果发现灰树花醇提物主要以蛋白质为主,含量为233.67 mg/g;其对DPPH、ABTS

Keyword :

抗氧化 抗氧化 灰树花醇提物 灰树花醇提物 秀丽隐杆线虫 秀丽隐杆线虫 降脂 降脂

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GB/T 7714 赖美英 , 许欢怡 , 李泉岑 et al. 灰树花醇提物对秀丽隐杆线虫的抗氧化及降脂作用 [J]. | 现代食品科技 , 2025 , 41 (07) : 117-124 .
MLA 赖美英 et al. "灰树花醇提物对秀丽隐杆线虫的抗氧化及降脂作用" . | 现代食品科技 41 . 07 (2025) : 117-124 .
APA 赖美英 , 许欢怡 , 李泉岑 , 刘斌 , 曾峰 . 灰树花醇提物对秀丽隐杆线虫的抗氧化及降脂作用 . | 现代食品科技 , 2025 , 41 (07) , 117-124 .
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Saline-Alkali Tolerance Evaluation of Giant Reed (Arundo donax) Genotypes Under Saline-Alkali Stress at Seedling Stage SCIE
期刊论文 | 2025 , 15 (2) | AGRONOMY-BASEL
WoS CC Cited Count: 1
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Soil salinization and alkalization are serious global challenges that adversely affect crop growth and yield. In this study, six genotypes of giant reed (Arundo donax) seedlings (LvZhou_No.1, LvZhou_No.3, LvZhou_No.6, LvZhou_No.11, LvZhou_No.12 and LvZhou_Var.) originating from different regions of China and Rwanda were utilized as experimental materials. This study aimed to investigate the physiological and biochemical responses of various genotypes to saline-alkali stress and to identify stress-tolerant resources. A mixture saline-alkali solution with a molar ratio of NaCl: Na2SO4: NaHCO3: Na2CO3 = 1:1:1:1 was prepared at three concentrations (75, 150 and 225 millimolar (mM)) for a 7-day pot experiment. Growth and physiological indices were measured at the seedling stage, and salt tolerance was evaluated accordingly. The results indicated the following: the growth indices were significantly reduced across seedlings of all genotypes when the concentration of stress exceeded 150 mM (p < 0.05). There was no significant difference in chlorophyll content (SPAD value) and maximum photochemical efficiency of PS II (F-v/F-m) with increasing saline-alkali stress. However, the photosynthetic rate (P-n), stomatal conductance (G(s)) and transpiration rate (T-r) exhibited decreasing trends, reaching their lowest levels at 225 mM. In contrast, the intercellular CO2 concentration (C-i) value decreased to its lowest at 150 mM but increased at 225 mM. Relative electrical conductivity (REC) and the contents of malondialdehyde (MDA), proline (Pro) and soluble sugar (SS) increased progressively with higher stress concentrations. The activities of superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) were significantly enhanced at stress concentrations above 150 mM. The saline-alkali tolerance of A. donax seedlings was comprehensively evaluated using principal component analysis and membership function analysis based on 15 parameters. The results indicate that P-n, T-r and G(s) are effective physiological indicators for assessing saline-alkali tolerance of A. donax seedlings. The six genotypes were ranked for saline-alkali tolerance as follows: LZ_No.1 > LZ_No.11 > LZ_No.12 > LZ_Var. > LZ_No.3 > LZ_No.6. This indicates that LZ_No.1 shows the highest resistance to saline-alkali stress, whereas LZ_No.6 is the most severely affected, classifying it as a salinity-sensitive genotype. In conclusion, LZ_No.1 exhibits robust saline-alkali tolerance and represents a valuable germplasm resource for improving saline-alkali tolerance in A. donax propagation. The results not only support the development of resilient plants for saline-alkali environments but also offer insights into the mechanisms of salinity tolerance.

Keyword :

Arundo donax Arundo donax correlation analysis correlation analysis physiological and biochemical responses physiological and biochemical responses saline-alkali stress saline-alkali stress saline-alkali tolerance evaluation saline-alkali tolerance evaluation

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GB/T 7714 Cai, Yangxing , Cao, Xiuming , Liu, Bin et al. Saline-Alkali Tolerance Evaluation of Giant Reed (Arundo donax) Genotypes Under Saline-Alkali Stress at Seedling Stage [J]. | AGRONOMY-BASEL , 2025 , 15 (2) .
MLA Cai, Yangxing et al. "Saline-Alkali Tolerance Evaluation of Giant Reed (Arundo donax) Genotypes Under Saline-Alkali Stress at Seedling Stage" . | AGRONOMY-BASEL 15 . 2 (2025) .
APA Cai, Yangxing , Cao, Xiuming , Liu, Bin , Lin, Hui , Luo, Hailing , Liu, Fengshan et al. Saline-Alkali Tolerance Evaluation of Giant Reed (Arundo donax) Genotypes Under Saline-Alkali Stress at Seedling Stage . | AGRONOMY-BASEL , 2025 , 15 (2) .
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Improvement of Quality of Sour Camel Milk by Extract of Sparassis crispa: Physicochemical Properties, Sensory Quality and Metabolic Changes SCIE
期刊论文 | 2025 , 14 (17) | FOODS
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Sour camel milk, as a nutritious fermented dairy product, faces challenges in terms of quality stability. Sparassis crispa, due to its antioxidant and antibacterial properties, shows potential in improving food quality. This study aimed to investigate the effects of different active components of Sparassis crispa on the quality of sour camel milk. The results indicated that Component I was the most effective Sparassis crispa component in enhancing the quality of sour camel milk. The components of Component I were identified as LysoPC(0_0_18_2(9Z,12Z)), LysoPC(18_1(11Z)_0_0), and N-(2-hydroxymethyl-3-chloro-4-hydroxyphenyl) anthranilic acid, among others. It increased the total viable count of lactic acid bacteria (LAB) and water-holding capacity (WHC) while improving the texture of sour camel milk. Metabolomics analysis revealed that the first component of sour camel milk (FCS) and Sparassis crispa sour camel milk (SS) have a high degree of similarity in the composition of flavor substances. The characteristic flavor metabolites included 2-amylfuran, isoamyl alcohol, 2-methylbutyraldehyde, and 2-ethyl-1-hexanol. Additionally, the supplementation of Component I increased the levels of metabolites such as amino acids, free fatty acids, organic acids, and carbohydrates, thereby contributing to the enhanced taste and nutritional quality of sour camel milk. This intervention also strengthened carbohydrate and amino acid metabolism in LAB. These findings provide a theoretical basis for utilizing Component I to improve the quality of sour camel milk.

Keyword :

metabolomics metabolomics sour camel milk sour camel milk Sparassis crispa Sparassis crispa texture texture

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GB/T 7714 Zhao, Lina , Ma, Ruping , Zhu, Linyan et al. Improvement of Quality of Sour Camel Milk by Extract of Sparassis crispa: Physicochemical Properties, Sensory Quality and Metabolic Changes [J]. | FOODS , 2025 , 14 (17) .
MLA Zhao, Lina et al. "Improvement of Quality of Sour Camel Milk by Extract of Sparassis crispa: Physicochemical Properties, Sensory Quality and Metabolic Changes" . | FOODS 14 . 17 (2025) .
APA Zhao, Lina , Ma, Ruping , Zhu, Linyan , Wang, Jinzhi , Wang, Rui , Wu, Xiaojun et al. Improvement of Quality of Sour Camel Milk by Extract of Sparassis crispa: Physicochemical Properties, Sensory Quality and Metabolic Changes . | FOODS , 2025 , 14 (17) .
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灰树花醇提物体外抗氧化及降血糖活性分析
期刊论文 | 2025 , 44 (01) , 41-49 | 中国食用菌
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为研究灰树花醇提物的抗氧化及降血糖活性,以灰树花为原料,制备灰树花70%醇提物,并测定了醇提物中多酚、三萜、总糖和蛋白质的含量,通过DPPH自由基、ABTS自由基的清除能力和总还原能力测定灰树花醇提物的抗氧化能力,利用α-葡萄糖苷酶和α-淀粉酶的抑制作用评价灰树花醇提物的降血糖活性。此外,用高浓度胰岛素构建HepG2细胞胰岛素抵抗模型(IR-HepG2),进一步研究灰树花醇提物的抗氧化及降血糖活性。结果表明,灰树花70%醇提物中主要以蛋白质为主,其含量为504.14 mg·g

Keyword :

抗氧化 抗氧化 灰树花 灰树花 醇提物 醇提物 降血糖 降血糖

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GB/T 7714 仇晨晨 , 刘云 , 刘斌 . 灰树花醇提物体外抗氧化及降血糖活性分析 [J]. | 中国食用菌 , 2025 , 44 (01) : 41-49 .
MLA 仇晨晨 et al. "灰树花醇提物体外抗氧化及降血糖活性分析" . | 中国食用菌 44 . 01 (2025) : 41-49 .
APA 仇晨晨 , 刘云 , 刘斌 . 灰树花醇提物体外抗氧化及降血糖活性分析 . | 中国食用菌 , 2025 , 44 (01) , 41-49 .
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Carbon, nitrogen, and phosphorus ecological stoichiometry in Cenchrus fungigraminus and soil under waterlogging stress SCIE
期刊论文 | 2025 , 514 (2) , 1677-1701 | PLANT AND SOIL
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Background and aims Global climate change has exacerbated waterlogging in riparian ecosystems, necessitating research on plant nutrient adaptation and soil responses under waterlogging stress for ecological restoration. This study focuses on Cenchrus fungigraminus, a key slope-protecting plant in the Yellow River Basin, under controlled waterlogging conditions. Methods Plants were subjected to 30 days of three treatments: non-waterlogged management (CK), root waterlogging (Wr), and above-ground waterlogging (Wa). Growth traits, C, N, and P stoichiometry in plant organs, rhizosphere soil nutrients, enzyme activities, and nutrient dynamics were evaluated. Results Waterlogging significantly suppressed plant height, stem diameter, tiller number, and leaf morphological traits, with the most pronounced inhibition observed in the Wa group. Nevertheless, the plant survival rate remained at 100%. In the rhizosphere soil, total K, available K, available P, NO3--N contents, and INV, URE, and AKP activities declined, whereas NH4+-N and CAT activity increased. Waterlogging enhanced the plant's C and N contents, raising the C:N, C:P, and N:P ratios, while reducing P content and the uptake of K, and Mg. However, the uptake of Ca and Fe increased. Under nutrient-limited and hypoxic conditions, C. fungigraminus reduced its growth rate but enhanced N and P utilization efficiency to better adapt to waterlogging. The plant's C, N, and P stoichiometric characteristics were closely related to soil properties, with the element stability ranked as N > C > P, and the stability of ratios as N:P > C:P > C:N. C. fungigraminus growth was nitrogen-limited, with increased limitation under deeper waterlogging. Nitrogen fertilization could alleviate this limitation. Conclusions By slowing growth, optimizing nutrient allocation, and improving nutrient use efficiency, C. fungigraminus adopts a Quiescence strategy to cope with waterlogging stress. It shows strong survival in waterlogged conditions and plays a key role in maintaining the stability of riparian vegetation community structure and ecosystem functions.

Keyword :

Cenchrus fungigraminus Cenchrus fungigraminus C:N:P stoichiometry C:N:P stoichiometry Enzyme activities Enzyme activities Homeostasis Homeostasis Soil properties Soil properties Waterlogging Waterlogging

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GB/T 7714 Song, Simeng , Zhou, Hengyu , Li, Pingxuan et al. Carbon, nitrogen, and phosphorus ecological stoichiometry in Cenchrus fungigraminus and soil under waterlogging stress [J]. | PLANT AND SOIL , 2025 , 514 (2) : 1677-1701 .
MLA Song, Simeng et al. "Carbon, nitrogen, and phosphorus ecological stoichiometry in Cenchrus fungigraminus and soil under waterlogging stress" . | PLANT AND SOIL 514 . 2 (2025) : 1677-1701 .
APA Song, Simeng , Zhou, Hengyu , Li, Pingxuan , Zhang, Lin , Su, Dewei , Zheng, Dan et al. Carbon, nitrogen, and phosphorus ecological stoichiometry in Cenchrus fungigraminus and soil under waterlogging stress . | PLANT AND SOIL , 2025 , 514 (2) , 1677-1701 .
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Investigating the biosynthesis pathways and hypolipidemic mechanisms of monacolin K in Monascus species SCIE
期刊论文 | 2025 , 147 | PHYTOMEDICINE
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Background: Metabolic syndrome (MetS) encompasses a cluster of conditions, including atherosclerotic dyslipidemia, hypercholesterolemia, hypertension, hyperglycemia, impaired glucose homeostasis, and central obesity. The current drug interventions are still not therapeutic, highlighting the critical need for pleiotropic natural compounds capable of simultaneously targeting insulin signaling, lipid redistribution, and inflammatory cascades. Purpose: This review meticulously evaluates recent advancements in the monacolin family, focusing on the structure, gene cluster analysis, biosynthetic pathways, and biological activities of monacolin K. It aims to provide the potential theory for further exploration of monacolin K's lipid-lowering functions. Methods: This review systematically analyzes contemporary research on monacolin K, focusing on its molecular mechanisms influencing lipid metabolism. Emphasis is placed on its modes of action, including the inhibition of cholesterol biosynthesis, modulation of hepatic cholesterol utilization, and restriction of lipid accumulation, all of which have been substantiated through in vivo studies. Results: The accumulated evidence confirms that monacolin K significantly lowers lipid levels, as reflected in decreased plasma cholesterol concentrations and reduced liver cholesterol buildup. Furthermore, monacolin K demonstrates a variety of biological activities, including anti-inflammatory, antitumor, anticancer, and neuroprotective effects, highlighting its potential in managing MetS. Conclusion: Monacolin K represents a promising bioactive compound with diverse health benefits, particularly in regulating cholesterol levels and preventing cardiovascular disease. Future studies should focus on determining the optimal dosage, long-term efficacy, and safety of monacolin K, facilitating its integration into standard treatment regimens for metabolic abnormality and related conditions.

Keyword :

Biological activity Biological activity Lipid-lowering mechanisms Lipid-lowering mechanisms Monacolin K Monacolin K Synthetic pathways Synthetic pathways

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GB/T 7714 Zheng, Ying , Zheng, Yueting , Huang, Zirui et al. Investigating the biosynthesis pathways and hypolipidemic mechanisms of monacolin K in Monascus species [J]. | PHYTOMEDICINE , 2025 , 147 .
MLA Zheng, Ying et al. "Investigating the biosynthesis pathways and hypolipidemic mechanisms of monacolin K in Monascus species" . | PHYTOMEDICINE 147 (2025) .
APA Zheng, Ying , Zheng, Yueting , Huang, Zirui , Zhang, Yuli , Li, Jishan , Zhao, Chao et al. Investigating the biosynthesis pathways and hypolipidemic mechanisms of monacolin K in Monascus species . | PHYTOMEDICINE , 2025 , 147 .
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