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学者姓名：曾峰
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Abstract ：
Tremella fuciformis polysaccharides have rich bioactivities, while low molecular weight polysaccharides have higher bioavailability and nutritional value. In this study, it was investigated that the structural characteristics of low molecular weight polysaccharides from Tremella fuciformis (TFLP) prepared by acid hydrolysis method, its impact on antioxidant capacity and stress resistance of Caenorhabditis elegans, and potential mechanisms. TFLP was an acidic polysaccharide mainly composed of mannose and xylose with a molecular weight of 106 kDa. TFLP could prolong the median lifespan of C. elegans under heat stress and acute oxidative stress conditions through significantly reducing the malondialdehyde (MDA) level and increasing the activity of antioxidant enzymes total-superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT). The intervention of high-dose TFLP significantly prolonged the median lifespan of C. elegans under heat stress and acute oxidative stress conditions by 24.47% and 7.84%, respectively. At the same time, the MDA level significantly decreased by 69.59%, and the levels of T-SOD, GSH-Px and CAT increased significantly by 2.22, 1.28 and 0.53 times, respectively. Meanwhile, the transcription levels of daf-16, fat-5, fat-7, and hsf-1 mRNA in C. elegans treated with TFLP were significantly increased, while the transcription levels of akt-1 and daf-2 mRNA were significantly reduced. In addition, propanoate metabolism, valine, leucine and isoleucine degradation metabolism and vitamin B6 metabolism were key metabolic pathways for TFLP to enhance antioxidant capacity and stress resistance in C. elegans. These results indicated that TFLP could enhance in vivo antioxidant capacity and stress resistance by improving the levels mRNA transcription and metabolites, and it provided new evidence for TFLP to exert in vivo antioxidant activity. (c) 2026 The authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keyword ：
Antioxidant activity Antioxidant activity Caenorhabditis elegans Caenorhabditis elegans Low molecular weight polysaccharides Low molecular weight polysaccharides Metabolites Metabolites Structural characteristics Structural characteristics Tremella fuciformis Tremella fuciformis
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| GB/T 7714 | Lee, Quancen , Xue, Zhixiang , Zheng, Mingfeng et al. Antioxidant activity of low molecular weight polysaccharides from Tremella fuciformis in Caenorhabditis elegans based on metabolomics analysis [J]. | JOURNAL OF FUTURE FOODS , 2026 , 6 (3) : 479-490 . |
| MLA | Lee, Quancen et al. "Antioxidant activity of low molecular weight polysaccharides from Tremella fuciformis in Caenorhabditis elegans based on metabolomics analysis" . | JOURNAL OF FUTURE FOODS 6 . 3 (2026) : 479-490 . |
| APA | Lee, Quancen , Xue, Zhixiang , Zheng, Mingfeng , Liu, Bin , Zeng, Feng . Antioxidant activity of low molecular weight polysaccharides from Tremella fuciformis in Caenorhabditis elegans based on metabolomics analysis . | JOURNAL OF FUTURE FOODS , 2026 , 6 (3) , 479-490 . |
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Type 2 diabetes mellitus (T2DM), a widespread chronic metabolic disorder, presents a global challenge. Metformin hydrochloride, although widely prescribed, is associated with notable side effects. This study aims to explore safer, more effective alternatives by assessing the impact of Ruditapes philippinarum polysaccharides (RPPs) on glycemic control and modulation of microbiota in T2DM mice. A T2DM mouse model was established through a high-sucrose/high-fat diet and intraperitioneal streptozotocin injection. Glycometabolism indicators, histopathological features, and gut microbiota composition in caecum samples were assessed. Following 4 weeks of RPPs intervention, fasting blood glucose (FBG), glycated serum protein (GSP), area under the curve (AUC) of oral glucose tolerance test (OGTT), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) levels were reduced in T2DM mice, while AKT-1 and GLUT-2 transcription levels were significant increased. Short-chain fatty acids (SCFAs) concentrations notably increased in the RPP-L group compared to the Model group, with improvements also observed in medium-chain fatty acids (MCFAs) and secondary bile acids (SBAs). Regarding gut microbiota, the Firmicutes-to-Bacteroidetes (F/B) ratio in RPP-L was substantially lower than in the Model group. At the genus level, beneficial bacteria, such as Akkermansia, Alloprevotella, Tidjanibacter, and Faecalibaculum demonstrated increased abundance. Correlation analysis identified Muribaculum, Paramuribaculum, Lacrimispora, and Turicibacter as microbial taxa associated with T2DM progression. RPPs significantly alleviated hyperglycemic symptoms in T2DM mice while enhancing the presence of beneficial gut bacteria, leading to a marked improvement in intestinal microbiota composition. This research offers foundational insights for the potential use of R. philippinarum in biomedical and nutraceutical applications.
Keyword ：
gut microbiota gut microbiota hypoglycemic hypoglycemic polysaccharides polysaccharides Ruditapes philippinarum Ruditapes philippinarum type 2 diabetes mellitus type 2 diabetes mellitus
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| GB/T 7714 | Chen, Zhuo , Ge, Xiaodong , Wang, Yaolin et al. Ruditapes philippinarum Polysaccharide Alleviates Hyperglycemia by Modulating Gut Microbiota in a Mouse Model of Type 2 Diabetes Mellitus [J]. | MOLECULAR NUTRITION & FOOD RESEARCH , 2025 , 69 (7) . |
| MLA | Chen, Zhuo et al. "Ruditapes philippinarum Polysaccharide Alleviates Hyperglycemia by Modulating Gut Microbiota in a Mouse Model of Type 2 Diabetes Mellitus" . | MOLECULAR NUTRITION & FOOD RESEARCH 69 . 7 (2025) . |
| APA | Chen, Zhuo , Ge, Xiaodong , Wang, Yaolin , Zhang, Jiawei , Sui, Yinzi , Yin, Xuemei et al. Ruditapes philippinarum Polysaccharide Alleviates Hyperglycemia by Modulating Gut Microbiota in a Mouse Model of Type 2 Diabetes Mellitus . | MOLECULAR NUTRITION & FOOD RESEARCH , 2025 , 69 (7) . |
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Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory-enhancing, anti-inflammatory, hypoglycemic, and hypolipidemic effects, as well as skin-protective properties and gut microbiota modulation. Due to these multifunctional properties, TFP has garnered considerable attention in the food, pharmaceutical, and cosmetic industries. This review summarizes recent research on TFP, focusing on its preparation methods, structural characteristics, and diverse biological activities. Additionally, it provides a theoretical basis for the potential applications of TFP in the food, pharmaceutical, and cosmetic industries, while also discussing future research directions and development prospects.
Keyword ：
application application bioactivities bioactivities functionality functionality structure structure TFP TFP
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| GB/T 7714 | Rui, Yanlin , Lee, Quancen , Guo, Yue et al. Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review [J]. | JOURNAL OF FOOD SCIENCE , 2025 , 90 (8) . |
| MLA | Rui, Yanlin et al. "Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review" . | JOURNAL OF FOOD SCIENCE 90 . 8 (2025) . |
| APA | Rui, Yanlin , Lee, Quancen , Guo, Yue , Huang, Ying , Xu, Huanyi , Liu, Bin et al. Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review . | JOURNAL OF FOOD SCIENCE , 2025 , 90 (8) . |
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本发明公开了一种即食型燕窝食品颗粒冲剂及其制备方法，该即食型燕窝食品颗粒冲剂根据白天和夜晚人体不同需求分为白天燕窝食品颗粒冲剂和夜晚燕窝食品颗粒冲剂；所述白天燕窝食品颗粒冲剂由燕窝、甜荞麦、杏仁、核桃、枸杞、红枣制备而成；所述夜晚燕窝食品颗粒冲剂由燕窝、苦荞麦、杏仁、核桃、枸杞、红枣制备而成。本发明提供的即食型燕窝食品颗粒冲剂，同时具备增强免疫力、滋肝养肾、降低血糖血脂和胆固醇、改善睡眠质量等多种功效，旨在全面调节身体机能，有效解决了中年男性职场人士面临的多种健康问题。
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| GB/T 7714 | 冯珂萱 , 曾峰 . 一种即食型燕窝食品颗粒冲剂及其制备方法 : CN202411585456.9[P]. | 2024-11-07 . |
| MLA | 冯珂萱 et al. "一种即食型燕窝食品颗粒冲剂及其制备方法" : CN202411585456.9. | 2024-11-07 . |
| APA | 冯珂萱 , 曾峰 . 一种即食型燕窝食品颗粒冲剂及其制备方法 : CN202411585456.9. | 2024-11-07 . |
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为研究灰树花醇提物的抗氧化及降脂作用，该研究首先测定了灰树花醇提物的总糖、蛋白、多酚和三萜含量，接着利用体外抗氧化实验和秀丽隐杆线虫模型分析其抗氧化能力。此外，通过油红O染色观察线虫体内脂质沉积情况，同时测定TG浓度和LPS活力探究其降脂潜力。结果发现灰树花醇提物主要以蛋白质为主，含量为233.67 mg/g；其对DPPH、ABTS
Keyword ：
抗氧化 抗氧化 灰树花醇提物 灰树花醇提物 秀丽隐杆线虫 秀丽隐杆线虫 降脂 降脂
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| GB/T 7714 | 赖美英 , 许欢怡 , 李泉岑 et al. 灰树花醇提物对秀丽隐杆线虫的抗氧化及降脂作用 [J]. | 现代食品科技 , 2025 , 41 (07) : 117-124 . |
| MLA | 赖美英 et al. "灰树花醇提物对秀丽隐杆线虫的抗氧化及降脂作用" . | 现代食品科技 41 . 07 (2025) : 117-124 . |
| APA | 赖美英 , 许欢怡 , 李泉岑 , 刘斌 , 曾峰 . 灰树花醇提物对秀丽隐杆线虫的抗氧化及降脂作用 . | 现代食品科技 , 2025 , 41 (07) , 117-124 . |
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以银耳多糖(TFP1和TFP2)为研究对象,分析其分子量与单糖组成等结构特性,研究其预防酒精性胃粘膜损伤的功效机制。结果发现,TFP1分子量394,683 u,含半乳糖、甘露糖等9种单糖;TFP2分子量2,238,035 u,含甘露糖等5种单糖。建立乙醇诱导大鼠急性胃粘膜损伤模型,二者的干预均能降低胃粘膜损伤指数、改善胃组织形态,提高血常规(红细胞、白细胞等)、组胺、前列腺素2水平及胃组织抗氧化能力,降低血清炎症因子(TNF-α、IL-6、IL-1β),且TFP1效果更优。进一步通过血清非靶向代谢组学和蛋白质组学发现,TFP1-H可提高血清中α-酮戊二酸、L-色氨酸等代谢物含量,通过精氨酸生物合成等通路发挥作用;下调胃组织Rela蛋白、上调Mapk3蛋白,且Mapk3等上调蛋白与L-色氨酸正相关、与磷酸丙酮酸负相关,下调的Rela与L-天冬氨酸正相关。综上,TFP1预防酒精性胃粘膜损伤的机制可能与提高胃组织的抗氧化能力、提高抗炎能力和促进胃防御因子的产生有关,并且调节血清代谢物和胃组织蛋白质的表达。
Keyword ：
代谢组学 代谢组学 胃粘膜 胃粘膜 蛋白质组学 蛋白质组学 银耳多糖 银耳多糖
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| GB/T 7714 | 许欢怡 , 李泉岑 , 汪鹏翼 et al. 银耳多糖的结构特性及其预防酒精性胃粘膜损伤的功效机制研究 [C] //中国食品科学技术学会第二十二届年会 . 2025 . |
| MLA | 许欢怡 et al. "银耳多糖的结构特性及其预防酒精性胃粘膜损伤的功效机制研究" 中国食品科学技术学会第二十二届年会 . (2025) . |
| APA | 许欢怡 , 李泉岑 , 汪鹏翼 , 刘斌 , 郑明锋 , 曾峰 . 银耳多糖的结构特性及其预防酒精性胃粘膜损伤的功效机制研究 中国食品科学技术学会第二十二届年会 . (2025) . |
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The gastro-intestinal (GI) mucosa can be damaged by various factors, and the bioactivity of edible and medicinal mushroom polysaccharides (EMMPs) in protecting the GI mucosa has garnered significant attention in research. Studies have shown that EMMPs can play a role in maintaining GI health in various ways. This paper summarizes the relationship between the structural characteristics of polysaccharides from EMMPs and their functions and elucidates the differences in protective effects among EMMPs with distinct structural features. This review systematically examines the mechanisms by which drugs, pathogens, dietary habits, and psychological stress damage the GI mucosa. It emphasizes how EMMPs protect the GI mucosa by enhancing the mucosal barrier, suppressing oxidative stress, regulating immune function, and reshaping the gut microbiota. The review also outlines future research directions, aiming to provide a theoretical foundation for further studies on the functions and applications of EMMPs.
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| GB/T 7714 | Wenjie Zhou , Yongpeng Huang , Haisheng Li et al. The structure-function relationship of edible and medicinal mushroom polysaccharides and their protective effects on the gastrointestinal mucosa: A review. [J]. | International journal of biological macromolecules , 2025 . |
| MLA | Wenjie Zhou et al. "The structure-function relationship of edible and medicinal mushroom polysaccharides and their protective effects on the gastrointestinal mucosa: A review." . | International journal of biological macromolecules (2025) . |
| APA | Wenjie Zhou , Yongpeng Huang , Haisheng Li , Xianjing Han , Zhixiang Xue , Huanyi Xu et al. The structure-function relationship of edible and medicinal mushroom polysaccharides and their protective effects on the gastrointestinal mucosa: A review. . | International journal of biological macromolecules , 2025 . |
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BACKGROUND: It is reported that anti-enterovirus 71 (EV71) drugs have some side effects on human health. Notably, fungi plays a crucial role in promoting human health and anti-virus. Grifola frondosa is a type of large medicinal and edible fungi, rich in active substances. The present study aimed to investigate the anti-EV71 effect of G. frondosa and the potential active substances. RESULTS: In the present study, the water extract of G. frondosa was subjected to ethanol precipitation to obtain the water-extracted supernatant of G. frondosa (GFWS) and water-extracted precipitation of G. frondosa. Their inhibitory effects on EV71 virus were studied based on a cell model. The results showed that GFWS had stronger security and anti-EV71 effects. In addition, the chemical constituents of GFWS were identified by ultra-high performance liquid chromatography-tandem mass spectrometry, which were selected for further separation and purification. Three compounds, N-butylaniline, succinic acid and l-tryptophan, were isolated from GFWS by NMR spectroscopy. It is noteworthy that N-butylaniline and l-tryptophan were isolated and identified from the G. frondosa fruiting bodies for the first time. Our study found that l-tryptophan has anti-EV71 virus activity, which reduced EV71-induced apoptosis and significantly inhibited the replication process after virus adsorption. Furthermore, it could also bind to capsid protein VP1 to prevent the virus from attaching to the cells. CONCLUSION: l-tryptophan was an inhibitor of the EV71 virus, which could be used in infant nutrition and possibly provide a new drug to treat hand, foot and mouth disease. (c) 2024 Society of Chemical Industry.
Keyword ：
Enterovirus 71 Enterovirus 71 Grifola frondosa Grifola frondosa Isolation and identification Isolation and identification l-tryptopha l-tryptopha
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| GB/T 7714 | Xiong, Wenyu , Jiang, Xiaoqin , He, Junqiang et al. Isolation and identification of active components from Grifola frondosa and its anti-EV71 virus effect [J]. | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE , 2024 , 104 (7) : 4453-4464 . |
| MLA | Xiong, Wenyu et al. "Isolation and identification of active components from Grifola frondosa and its anti-EV71 virus effect" . | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 104 . 7 (2024) : 4453-4464 . |
| APA | Xiong, Wenyu , Jiang, Xiaoqin , He, Junqiang , Zhong, Yue , Ge, Xiaodong , Liu, Bin et al. Isolation and identification of active components from Grifola frondosa and its anti-EV71 virus effect . | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE , 2024 , 104 (7) , 4453-4464 . |
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Low molecular weight polysaccharides had higher bio-activity and bioavailability compared to ultra-high molecular weight polysaccharides, this study aimed to obtain low molecular weight polysaccharides from Tremella fuciformis (TFLP) by using high-temperature and high-pressure assisted hydrochloric acid method to degrade Tremella fuciformis polysaccharides (TFP), and the structural characteristics, in vivo antioxidant and immune enhancing activities of TFP and TFLP was explored through Caenorhabditis elegans (C. elegans) and mice model. It was found that TFP and TFLP were acidic polysaccharides with molecular weights of 2238 kDa and 3 kDa, respectively. The glycosidic bonding of TFP and TFLP was mainly composed of different configurations of mannopyranose. TFP and TFLP had excellent in vivo antioxidant activity and stress resistance by regulating the mRNA transcription level and metabolites in C. elegans. Results also showed that TFP and TFLP could enhance the antioxidant capacity and immunity of serum, spleen and small intestine tissues in normal mice and cyclophosphamide-induced immunosuppressive mice through regulating the relative transcription and expression levels of anti-inflammatory related signaling factors, and it has found that TFLP showed better immune enhancement and antioxidant activity than TFP. In addition, Akkermansia, Bacteroides and Alloprevotella were characteristic bacteria at the genus level in immunosuppressed mice intervened with TFLP, with a significant increase in relative abundance. The content of SCFAs significantly increased in immunosuppressed mice by TFLP. These results indicated that TFP and TFLP had potential in vivo antioxidant and immune enhancing activities.
Keyword ：
Antioxidant activity Antioxidant activity Caenorhabditis elegans Caenorhabditis elegans Gut microbiota Gut microbiota Immune enhancing activity Immune enhancing activity Immunosuppressive mice Immunosuppressive mice Low molecular weight polysaccharides Low molecular weight polysaccharides Tremella fuciformis polysaccharide Tremella fuciformis polysaccharide
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| GB/T 7714 | Lee, Quancen , Xue, Zhixiang , Luo, Yijuan et al. Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 281 . |
| MLA | Lee, Quancen et al. "Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 281 (2024) . |
| APA | Lee, Quancen , Xue, Zhixiang , Luo, Yijuan , Lin, Yanpeng , Lai, Meiying , Xu, Huanyi et al. Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 281 . |
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Sanghuangporus vaninii is a traditional edible and medicinal fungi with a long history in China. Recent studies have focused on its potential in treating diabetes, although the underlying mechanism remains unclear. This study aimed to investigate the antidiabetic and hypolipidemic effects of the formula of S. vaninii compounds (SVC) in diabetic mice and explore the potential improvement in the intestinal microbiota. Oral administration of SVC significantly reduced fasting blood glucose and improved insulin sensitivity and lipid indexes. In addition to its direct effects on glucose levels and insulin sensitivity, SVC was found to have an impact on the intestinal microbiota. The levels of short-chain fatty acids receiving SVC intervention increased, and 16S rRNA sequencing revealed changes in the abundances of certain bacteria, such as Harryflintia, Helicobacter, Candidatus_Soleaferrea, Klebsiella, and Candidatus_Stoquefichus. These bacteria were found to be negatively associated with glucose and lipid indexes and positively related to body weight and insulin sensitivity. Overall, this study highlights the potential of SVC in treating diabetes and provides a novel perspective for understanding its antidiabetic mechanism through modulation of the intestinal microbiota. © 2024 The Author(s). eFood published by John Wiley & Sons Australia, Ltd on behalf of International Association of Dietetic Nutrition and Safety.
Keyword ：
Glucose Glucose Medicinal chemistry Medicinal chemistry
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| GB/T 7714 | Huang, Zirui , Chen, Kewen , Li, Tiantian et al. Antidiabetic and hypolipidemic activities of Sanghuangporus vaninii compounds in streptozotocin-induced diabetic mice via modulation of intestinal microbiota [J]. | eFood , 2024 , 5 (5) . |
| MLA | Huang, Zirui et al. "Antidiabetic and hypolipidemic activities of Sanghuangporus vaninii compounds in streptozotocin-induced diabetic mice via modulation of intestinal microbiota" . | eFood 5 . 5 (2024) . |
| APA | Huang, Zirui , Chen, Kewen , Li, Tiantian , He, Xiaoyu , Ge, Xiaodong , Liu, Xiaoyan et al. Antidiabetic and hypolipidemic activities of Sanghuangporus vaninii compounds in streptozotocin-induced diabetic mice via modulation of intestinal microbiota . | eFood , 2024 , 5 (5) . |
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