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学者姓名：熊延
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Abstract ：
The versatile and pivotal roles of the phytohormone auxin in regulating plant growth and development are typically linked to its directional transport, relying on the polarized PIN-FORMED (PIN) auxin exporters at the plasma membrane (PM). For decades, auxin has been proposed to promote PIN polarization, generating self-regulatory feedback mediating much of plant development, but mechanistic insight into this regulation is lacking. Here, we uncover an auxin-induced protein complex at the PM, containing auxin co-receptors trans-membrane kinases (TMKs) and PIN1 auxin exporter, as the core machinery that underlies this feedback regulation. Auxin promotes PIN1 phosphorylation by TMKs, modulating PIN1 polarization and transport activity. We also provide evidence that PIN1-exported extracellular auxin is crucial for TMK activation and cell elongation, thus forming the simplest two-element self-regulatory feedback circuit. Thus, these findings offer direct mechanistic insights into a potential self-organizing circuit for auxin signaling and transport to ensure proper plant development in Arabidopsis.
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| GB/T 7714 | Huang Rongfeng , Wang Jiacheng , Chang Mingzeng et al. TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis [J]. | DEVELOPMENTAL CELL , 2026 , 61 (1) . |
| MLA | Huang Rongfeng et al. "TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis" . | DEVELOPMENTAL CELL 61 . 1 (2026) . |
| APA | Huang Rongfeng , Wang Jiacheng , Chang Mingzeng , Tang Wenxin , Yu Yongqiang , Zhang Yi et al. TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis . | DEVELOPMENTAL CELL , 2026 , 61 (1) . |
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The target of rapamycin (TOR) is a central regulator of growth, development, and stress adaptation in plants. This review delves into the molecular intricacies of TOR signaling, highlighting its conservation and specificity across eukaryotic lineages. We explore the molecular architecture of TOR complexes, their regulation by a myriad of upstream signals, and their consequential impacts on plant physiology. The roles of TOR in orchestrating nutrient sensing, hormonal cues, and environmental signals are highlighted, illustrating its pivotal function in modulating plant growth and development. Furthermore, we examine the impact of TOR on plant responses to various biotic and abiotic stresses, underscoring its potential as a target for agricultural improvements. This synthesis of current knowledge on plant TOR signaling sheds light on the complex interplay between growth promotion and stress adaptation, offering a foundation for future research and applications in plant biology.
Keyword ：
amino acid sensing amino acid sensing glucose signaling glucose signaling SNF1-related protein kinase 1 SNF1-related protein kinase 1 target of rapamycin target of rapamycin trade-off trade-off
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| GB/T 7714 | Liu, Yanlin , Hu, Jun , Duan, Xiaoli et al. Target of Rapamycin (TOR): A Master Regulator in Plant Growth, Development, and Stress Responses [J]. | ANNUAL REVIEW OF PLANT BIOLOGY , 2025 , 76 : 341-371 . |
| MLA | Liu, Yanlin et al. "Target of Rapamycin (TOR): A Master Regulator in Plant Growth, Development, and Stress Responses" . | ANNUAL REVIEW OF PLANT BIOLOGY 76 (2025) : 341-371 . |
| APA | Liu, Yanlin , Hu, Jun , Duan, Xiaoli , Ding, Wenlong , Xu, Menglan , Xiong, Yan . Target of Rapamycin (TOR): A Master Regulator in Plant Growth, Development, and Stress Responses . | ANNUAL REVIEW OF PLANT BIOLOGY , 2025 , 76 , 341-371 . |
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The ability to sense cellular temperature and induce physiological changes is pivotal for plants to cope with warming climate. Biomolecular condensation is emerging as a thermo-sensing mechanism, but the underlying molecular basis remains elusive. Here we show that an intrinsically disordered protein FUST1 senses heat via its condensation in Arabidopsis thaliana. Heat-dependent condensation of FUST1 is primarily determined by its prion-like domain (PrLD). All-atom molecular dynamics simulation and experimental validation reveal that PrLD encodes a thermo-switch, experiencing lock-to-open conformational changes that control the intermolecular contacts. FUST1 interacts with integral stress granule (SG) components and localizes in the SGs. Importantly, FUST1 condensation is autonomous and precedes condensation of several known SG markers and is indispensable for SG assembly. Loss of FUST1 significantly delays SG assembly and impairs both basal and acquired heat tolerance. These findings illuminate the molecular basis for thermo-sensing by biomolecular condensation and shed light on the molecular mechanism of heat stress granule assembly.
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| GB/T 7714 | Geng, Pan , Li, Changxuan , Quan, Xuebo et al. A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis [J]. | CELL RESEARCH , 2025 , 35 (7) : 483-496 . |
| MLA | Geng, Pan et al. "A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis" . | CELL RESEARCH 35 . 7 (2025) : 483-496 . |
| APA | Geng, Pan , Li, Changxuan , Quan, Xuebo , Peng, Jiaxuan , Yao, Zhiying , Wang, Yunhe et al. A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis . | CELL RESEARCH , 2025 , 35 (7) , 483-496 . |
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| GB/T 7714 | Geng, Pan , Li, Changxuan , Quan, Xuebo et al. A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis (may, 10.1038/s41422-025-01125-4, 2025) [J]. | CELL RESEARCH , 2025 , 35 (7) : 528-529 . |
| MLA | Geng, Pan et al. "A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis (may, 10.1038/s41422-025-01125-4, 2025)" . | CELL RESEARCH 35 . 7 (2025) : 528-529 . |
| APA | Geng, Pan , Li, Changxuan , Quan, Xuebo , Peng, Jiaxuan , Yao, Zhiying , Wang, Yunhe et al. A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis (may, 10.1038/s41422-025-01125-4, 2025) . | CELL RESEARCH , 2025 , 35 (7) , 528-529 . |
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Targeted insertion of large DNA sequences into plant genomes remains a major challenge in synthetic biology. Here, we evaluate the large serine recombinase Kp03 for site-specific integration of DNA fragments in rice and Arabidopsis. In transient protoplast assays, Kp03 mediates efficient insertion of donor DNA up to 27.3 kilobases (kb), with plasmid integration efficiencies reaching 99.1% for fragments up to 3.4 kb. Truncation experiments reveal that a minimal 15-bp attB sequence is necessary for integration. As a proof of concept, Kp03 successfully incorporates a 3.4-kb donor DNA into the rice genome at a locus containing this minimal attB sequence. Moreover, in rice callus, combining Kp03 with the NM-PE genome editing system to install a 26-bp attB site enables targeted integration of a 3.4-kb donor at the desired genomic locus. These findings establish Kp03 as a versatile tool for plant genome engineering, with broad applications for synthetic biology.
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| GB/T 7714 | Yan, Daqi , Meng, Yanyan , Zhang, Nan et al. Efficient site-specific integration of kilobase-length DNA fragments in plant cells via Kp03 recombinase [J]. | CELL REPORTS , 2025 , 44 (11) . |
| MLA | Yan, Daqi et al. "Efficient site-specific integration of kilobase-length DNA fragments in plant cells via Kp03 recombinase" . | CELL REPORTS 44 . 11 (2025) . |
| APA | Yan, Daqi , Meng, Yanyan , Zhang, Nan , Zhao, Yali , Ning, Conghui , Zhu, Lina et al. Efficient site-specific integration of kilobase-length DNA fragments in plant cells via Kp03 recombinase . | CELL REPORTS , 2025 , 44 (11) . |
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The flavor profile of tea is influenced not only by different tea varieties but also by the surrounding soil environment. Recent studies have indicated the regulatory role of soil microbes residing in plant roots in nutrient uptake and metabolism. However, the impact of this regulatory mechanism on tea quality remains unclear. In this study, we showed that a consortium of microbes isolated from tea roots enhanced ammonia uptake and facilitated the synthesis of theanine, a key determinant of tea taste. Variations were observed in the composition of microbial populations colonizing tea roots and the rhizosphere across different seasons and tea varieties. By comparing the root microorganisms of the high-theanine tea variety Rougui with the low-theanine variety Maoxie, we identified a specific group of microbes that potentially modulate nitrogen metabolism, subsequently influencing the theanine levels in tea. Furthermore, we constructed a synthetic microbial community (SynCom) mirroring the microbe population composition found in Rougui roots. Remarkably, applying SynCom resulted in a significant increase in the theanine content of tea plants and imparted greater tolerance to nitrogen deficiency in Arabidopsis. Our study provides compelling evidence supporting the use of root microorganisms as functional microbial fertilizers to enhance tea quality.
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| GB/T 7714 | Xin, Wei , Zhang, Jianming , Yu, Yongdong et al. Root microbiota of tea plants regulate nitrogen homeostasis and theanine synthesis to influence tea quality [J]. | CURRENT BIOLOGY , 2024 , 34 (4) . |
| MLA | Xin, Wei et al. "Root microbiota of tea plants regulate nitrogen homeostasis and theanine synthesis to influence tea quality" . | CURRENT BIOLOGY 34 . 4 (2024) . |
| APA | Xin, Wei , Zhang, Jianming , Yu, Yongdong , Tian, Yunhe , Li, Hao , Chen, Xiaolu et al. Root microbiota of tea plants regulate nitrogen homeostasis and theanine synthesis to influence tea quality . | CURRENT BIOLOGY , 2024 , 34 (4) . |
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Phosphorylation of histone H3 at threonine 11 (H3T11ph) affects transcription and chromosome stability. However, the enzymes responsible for depositing H3T11ph and the functions of H3T11ph in plants remain unknown. Here we report that in Arabidopsis thaliana, PYRUVATE KINASE 6 (PK6), PK7 and PK8 enter the nucleus under conditions of sufficient glucose and light exposure, where they interact with SWI2/SNF2-RELATED 1 COMPLEX 4 (SWC4) and phosphorylate H3 at threonine 11. Mutations in these kinases or knockdown of SWC4 resulted in FLC-dependent early flowering, short hypocotyls and short pedicels. Genome-wide, H3T11ph is highly enriched at transcription start sites and transcription termination sites, and positively correlated with gene transcript levels. PK6 and SWC4 targeted FLC, MYB73, PRE1, TCP4 and TCP10, depositing H3T11ph at these loci and promoting their transcription, and PK6 occupancy at these loci requires SWC4. Together, our results reveal that nuclear-localized PK6, PK7 and PK8 modulate H3T11ph and plant growth. This study reports that the nucleocytoplasmic shuttling of pyruvate kinase 6 (PK6), PK7 and PK8 mediates phosphorylation of H3 at threonine 11, represses flowering time, and promotes hypocotyl and pedicel elongation in Arabidopsis.
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| GB/T 7714 | Hu, Pengcheng , Xu, Yanmei , Su, Yanhua et al. Nuclear-localized pyruvate kinases control phosphorylation of histone H3 on threonine 11 [J]. | NATURE PLANTS , 2024 . |
| MLA | Hu, Pengcheng et al. "Nuclear-localized pyruvate kinases control phosphorylation of histone H3 on threonine 11" . | NATURE PLANTS (2024) . |
| APA | Hu, Pengcheng , Xu, Yanmei , Su, Yanhua , Wang, Yuxin , Xiong, Yan , Ding, Yong . Nuclear-localized pyruvate kinases control phosphorylation of histone H3 on threonine 11 . | NATURE PLANTS , 2024 . |
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To ensure survival and promote growth, sessile plants have developed intricate internal signaling networks tailored in diverse cells and organs with both shared and specialized functions that respond to various internal and external cues. A fascinating question arises: how can a plant cell or organ diagnose the spatial and temporal information it is experiencing to know "where I am,"and then is able to make the accurate specific responses to decide "where to go"and "how to go,"despite the absence of neuronal systems found in mammals. Drawing inspiration from recent comprehensive investigations into diverse nutrient signaling pathways in plants, this review focuses on the interactive nutrient signaling networks mediated by various nutrient sensors and transducers. We assess and illustrate examples of how cells and organs exhibit specific responses to changing spatial and temporal information within these interactive plant nutrient networks. In addition, we elucidate the underlying mechanisms by which plants employ posttranslational modification codes to integrate different upstream nutrient signals, thereby conferring response specificities to the signaling hub proteins. Furthermore, we discuss recent breakthrough studies that demonstrate the potential of modulating nutrient sensing and signaling as promising strategies to enhance crop yield, even with reduced fertilizer application.
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| GB/T 7714 | Zhang, Zhenzhen , Zhong, Zhaochen , Xiong, Yan . Sailing in complex nutrient signaling networks Where I am, where to go, and how to go? [J]. | MOLECULAR PLANT , 2023 , 16 (10) : 1635-1660 . |
| MLA | Zhang, Zhenzhen et al. "Sailing in complex nutrient signaling networks Where I am, where to go, and how to go?" . | MOLECULAR PLANT 16 . 10 (2023) : 1635-1660 . |
| APA | Zhang, Zhenzhen , Zhong, Zhaochen , Xiong, Yan . Sailing in complex nutrient signaling networks Where I am, where to go, and how to go? . | MOLECULAR PLANT , 2023 , 16 (10) , 1635-1660 . |
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营养元素的吸收、转换和代谢是所有生物生命活动的核心部分。目前对营养元素的感受和转导,以及营养元素之间互作调控植物生长发育的分子机制还知之甚少。雷帕霉素靶蛋白(TOR)激酶是存在于真核生物体中的一种高度保守的丝氨酸/苏氨酸蛋白激酶。TOR通过整合营养分子、能量水平和生长因子等上游信号来调节基因转录、蛋白质翻译、代谢和细胞自噬等多个生物学过程,在细胞增殖、生长和代谢过程中发挥核心调节作用。本课题组一直聚焦"植物营养信号转导网络",以TOR激酶为核心,从多层次解析了碳氮营养一TOR信号通路和多种植物激素交叉互作调控植物生长的分子机制:(1)发现葡萄糖-TOR和乙烯-CTR1分别调控EIN2蛋白的不同磷酸化位点,而这些不同磷酸化位点特异性驱动相互独立的下游信号通路,最终调控不同的生理功能。该"磷酸化密码"模型为回答多功能调控中枢蛋白如何响应不同上游信号来特异驱动下游生理功能这一重要科学问题提供了新的理论模型和参考。(2)阐明了根茎组织对碳氮营养胁迫不同响应的内在机理,揭示了TOR和ROP2作为一个联合核心调控中枢可以整合氮素营养,葡萄糖能量信号以及生长素信号来感受动态的环境变化,调整生长策略从而精细调控植物生长发育。因此,TOR可以作为营养信号网络通路的定位导航仪来精准的调控植物在复杂环境中的生长和胁迫应答。
Keyword ：
根茎发育 根茎发育 氮素 氮素 营养信号 营养信号 葡萄糖 葡萄糖 雷帕霉素靶蛋白 雷帕霉素靶蛋白
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| GB/T 7714 | 刘岩林 , 付力文 , 张楠 et al. TOR激酶——营养信号网络通路的定位导航仪 [C] //首届植物科学前沿学术大会摘要集（一） . 2022 . |
| MLA | 刘岩林 et al. "TOR激酶——营养信号网络通路的定位导航仪" 首届植物科学前沿学术大会摘要集（一） . (2022) . |
| APA | 刘岩林 , 付力文 , 张楠 , 孟彦彦 , 熊延 . TOR激酶——营养信号网络通路的定位导航仪 首届植物科学前沿学术大会摘要集（一） . (2022) . |
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Target of rapamycin (TOR) is an evolutionarily conserved protein kinase that functions as a central signaling hub to integrate diverse internal and external cues to precisely orchestrate cellular and organismal physiology. During evolution, TOR both maintains the highly conserved TOR complex compositions, and cellular and molecular functions, but also evolves distinctive roles and strategies to modulate cell growth, proliferation, metabolism, survival, and stress responses in eukaryotes. Here, we review recent discoveries on the plant TOR signaling network. We present an overview of plant TOR complexes, analyze the signaling landscape of the plant TOR signaling network from the upstream signals that regulate plant TOR activation to the downstream effectors involved in various biological processes, and compare their conservation and specificities within different biological contexts. Finally, we summarize the impact of dysregulation of TOR signaling on every stage of plant growth and development, from embryogenesis and seedling growth, to flowering and senescence.
Keyword ：
abiotic and biotic stress abiotic and biotic stress hormone sensing hormone sensing metabolism regulation metabolism regulation nutrient sensing nutrient sensing plant growth and development plant growth and development target of rapamycin target of rapamycin transcriptional reprogramming transcriptional reprogramming translational regulation translational regulation
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| GB/T 7714 | Liu, Yanlin , Xiong, Yan . Plant target of rapamycin signaling network: Complexes, conservations, and specificities [J]. | JOURNAL OF INTEGRATIVE PLANT BIOLOGY , 2022 , 64 (2) : 342-370 . |
| MLA | Liu, Yanlin et al. "Plant target of rapamycin signaling network: Complexes, conservations, and specificities" . | JOURNAL OF INTEGRATIVE PLANT BIOLOGY 64 . 2 (2022) : 342-370 . |
| APA | Liu, Yanlin , Xiong, Yan . Plant target of rapamycin signaling network: Complexes, conservations, and specificities . | JOURNAL OF INTEGRATIVE PLANT BIOLOGY , 2022 , 64 (2) , 342-370 . |
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