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学者姓名：胡丰晓
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Abstract ：
【背景】红树林作为一种生长在热带与亚热带潮间带的特殊植物群落，其沉积物中微生物种类繁多，是筛选植病生防菌株的潜在来源。【目的】从红树林沉积物中筛选抑制烟草黑胫病病原真菌烟草疫霉(Phytophthoraparasitica)的活性菌株。【方法】对厦门五缘湾红树林沉积物中的真菌进行分离培养，通过ITS序列测序鉴定，采用平板对峙法筛选能显著抑制烟草疫霉的真菌，并确定发酵条件对候选生防真菌产孢量的影响。【结果】从厦门五缘湾红树林沉积物分离得到2门15属真菌，其中对烟草疫霉抑制效果显著的菌株为哈茨木霉(Trichoderma harzianum) M312和绿木霉(Trichoderma virens) M552，发酵温度分别为25℃和31℃，pH 7.0且低盐度时产孢量最高。【结论】从厦门五缘湾红树林沉积物中筛选出的哈茨木霉M312和绿木霉M552可作为防治烟草黑胫病的候选功能菌，但其发酵条件仍需进一步优化以满足商业化应用。
Keyword ：
发酵条件 发酵条件 木霉 木霉 烟草疫霉 烟草疫霉 真菌多样性 真菌多样性 红树林沉积物 红树林沉积物
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| GB/T 7714 | 陈希 , 胡丰晓 . 两株抑制烟草疫霉的海洋源木霉的分离、鉴定及发酵条件优化 [J]. | 微生物学通报 , 2025 , 52 (03) : 1180-1192 . |
| MLA | 陈希 等. "两株抑制烟草疫霉的海洋源木霉的分离、鉴定及发酵条件优化" . | 微生物学通报 52 . 03 (2025) : 1180-1192 . |
| APA | 陈希 , 胡丰晓 . 两株抑制烟草疫霉的海洋源木霉的分离、鉴定及发酵条件优化 . | 微生物学通报 , 2025 , 52 (03) , 1180-1192 . |
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The occurrence of tire-derived chemical N-(1,3-dimethylbutyl)-N '-phenyl-p-phenylenediamine quinone (6PPD-Q) has raised concerns about its environmental toxicity. However, the toxicity of 6PPD-Q on aquatic invertebrates remains insufficiently characterized. In this study, a model organism, Daphnia magna, was exposed to 0, 0.2, 2, and 20 mu g/L 6PPD-Q for 21 days to assess the potential effects of 6PPD-Q on its growth, reproduction, and antioxidant defense. The results showed that long-term exposure to 6PPD-Q led to a pronounced reduction in the body length of D. magna, which was associated with disturbance of the ecdysteroid signaling pathway. 6PPD-Q was proven to be an antagonist of 20-Hydroxyecdysone (20-HE) through a dual-luciferase reporter assay, competitively binding to the heterodimer composed of ecdysone receptor (EcR) and ultraspiracle (USP), and ultimately interfering with the expression of downstream genes. 6PPD-Q markedly delayed the time to first brood and diminished the number of neonates per adult, the average number of neonates per time as well as spawning times. The declined expressions of reproduction-related genes vtg1, vtg2, and vmo1, regulated by an elevated juvenile hormone (JH) level, might account for the reduced fecundity of D. magna. In addition, 6PPD-Q activated the antioxidant defense of D. magna, enabling it to remove excessive ROS and prevent lipid oxidative damage. Collectively, a trade-off between growth, reproduction, and antioxidant defense was suggested in D. magna under 6PPD-Q stress. Our findings provide valuable information for the risk assessment of 6PPD-Q to the freshwater ecosystem.
Keyword ：
Antioxidant defense Antioxidant defense Growth inhibition Growth inhibition Microcrustacean Microcrustacean Reproductive toxicity Reproductive toxicity Tire wear particles Tire wear particles
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| GB/T 7714 | Zhuang, Ziyi , Wang, Yifan , Zhang, Zhourui et al. Trade-off strategy under stress: Growth, reproduction, and antioxidant defense in Daphnia magna exposed to 6PPD-Q [J]. | JOURNAL OF HAZARDOUS MATERIALS , 2025 , 496 . |
| MLA | Zhuang, Ziyi et al. "Trade-off strategy under stress: Growth, reproduction, and antioxidant defense in Daphnia magna exposed to 6PPD-Q" . | JOURNAL OF HAZARDOUS MATERIALS 496 (2025) . |
| APA | Zhuang, Ziyi , Wang, Yifan , Zhang, Zhourui , Zhang, Weiwei , Ding, Jieyu , Weng, Zufeng et al. Trade-off strategy under stress: Growth, reproduction, and antioxidant defense in Daphnia magna exposed to 6PPD-Q . | JOURNAL OF HAZARDOUS MATERIALS , 2025 , 496 . |
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Tris (2-chloroethyl) phosphate (TCEP), a commonly used organophosphate flame retardant, has garnered considerable concern owing to its pervasive presence in the environment and its toxic effects on living organisms. The perpetuation of populations and species hinges on successful reproduction, yet research into the mechanisms underlying reproductive toxicity remains scant, particularly in aquatic species. In this work, zebrafish embryos were exposed to TCEP (0, 0.8, 4, 20, and 100 mu g/L) for 120 days until sexual maturation, and multiple reproductive endpoints were investigated in male zebrafish. Our results showed that the body weight, body length, and gonadal-somatic index (GSI) were remarkably decreased in all TCEP treatment groups (except GSI in the 0.8 mu g/L TCEP-treated group). Long-term exposure to TCEP led to reduced reproductive capacity of male zebrafish, as evidenced by decreased fertilization. Histological observation gave an indication of delayed testicular development and inhibited spermatogenesis under TCEP stress. The content of testosterone (T) was significantly elevated in all TCEP treatment group, whereas 17 beta-estradiol (E2) levels remained stable. Transcriptome analysis revealed a lot of downregulated genes involved in steroid hormone biosynthesis, energy metabolism, and sperm motility, which might account for the imbalance of steroid hormone levels, retarded spermatogenesis and declined fertilization success. Overall, these findings offered a thorough understanding of the mechanisms underlying the male reproductive toxicity caused by TCEP, highlight the risk of TCEP on reproductive health of fish.
Keyword ：
Organophosphate flame retardant Organophosphate flame retardant Reproductive capacity Reproductive capacity Sex hormone Sex hormone Spermatogenesis Spermatogenesis Transcriptomic analysis Transcriptomic analysis
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| GB/T 7714 | Wang, Hongkai , Ding, Jieyu , Luo, Shiyi et al. Unveiling the mechanisms of reproductive toxicity induced by full life-cycle exposure to environmentally relevant concentrations of tris(2-chloroethyl) phosphate in male zebrafish [J]. | AQUATIC TOXICOLOGY , 2024 , 276 . |
| MLA | Wang, Hongkai et al. "Unveiling the mechanisms of reproductive toxicity induced by full life-cycle exposure to environmentally relevant concentrations of tris(2-chloroethyl) phosphate in male zebrafish" . | AQUATIC TOXICOLOGY 276 (2024) . |
| APA | Wang, Hongkai , Ding, Jieyu , Luo, Shiyi , Yan, Meijiao , Hu, Fengxiao . Unveiling the mechanisms of reproductive toxicity induced by full life-cycle exposure to environmentally relevant concentrations of tris(2-chloroethyl) phosphate in male zebrafish . | AQUATIC TOXICOLOGY , 2024 , 276 . |
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磺胺甲恶唑(sulfamethoxazole, SMX)作为一种广谱型抗生素，由于大量使用而在水体中广泛存在。为研究SMX对海洋多毛类动物双齿围沙蚕(Perinereis aibuhitensis)的毒性效应，将双齿围沙蚕暴露于1、10和100 μg·L~(-1)SMX的海水中15 d,从个体、细胞和分子水平探究SMX对双齿围沙蚕的生长、掘穴行为、抗氧化防御、非特异性免疫以及细胞凋亡等方面的影响。结果表明，1 μg·L~(-1)和10 μg·L~(-1)SMX对沙蚕体质量的影响不显著(P>0.05),但所有SMX处理组双齿围沙蚕的体长都显著高于对照组水平(P<0.05)。暴露于SMX的双齿围沙蚕掘穴率显著降低，且高浓度SMX(100 μg·L~(-1))对双齿围沙蚕有明显的神经毒性作用，表现为乙酰胆碱酯酶活性的显著降低。SMX暴露诱导了氧化应激，导致了超氧化物歧化酶(superoxide dismutase,SOD)、过氧化氢酶(catalase,CAT)活性的升高以及丙二醛(malondialdehyde,MDA)含量的下降。此外，10 μg·L~(-1)和100 μg·L~(-1)SMX暴露下酸性磷酸酶(ACP)活性显著降低，表明暴露于高浓度的SMX可能会降低双齿围沙蚕的免疫力。最后，高浓度SMX暴露下，双齿围沙蚕凋亡相关基因大都呈现下调趋势，抑制细胞凋亡。本研究有助于进一步了解SMX污染对水生无脊椎动物的毒性效应，增进对SMX生态毒性的认识。
Keyword ：
SMX SMX 双齿围沙蚕 双齿围沙蚕 基因毒性 基因毒性 氧化应激 氧化应激 神经毒性 神经毒性
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| GB/T 7714 | 陈志 , 陈銮淇 , 胡丰晓 et al. 磺胺甲恶唑(SMX)对双齿围沙蚕的毒性效应研究 [J]. | 生态毒理学报 , 2024 , 19 (04) : 350-359 . |
| MLA | 陈志 et al. "磺胺甲恶唑(SMX)对双齿围沙蚕的毒性效应研究" . | 生态毒理学报 19 . 04 (2024) : 350-359 . |
| APA | 陈志 , 陈銮淇 , 胡丰晓 , 周洪磊 , 何家博 , 霍朋辉 . 磺胺甲恶唑(SMX)对双齿围沙蚕的毒性效应研究 . | 生态毒理学报 , 2024 , 19 (04) , 350-359 . |
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Tris(2-chloroethyl) phosphate (TCEP), emerging as a predominant substitute for brominated flame retardants (BFRs), is now increasingly recognized as a prevalent contaminant in aquatic ecosystems. The extent of its reproductive toxicity in aquatic species, particularly in zebrafish ( Danio rerio), ), remains insufficiently characterized. This study subjected zebrafish embryos to various concentrations of TCEP (0, 0.8, 4, 20, and 100 mu g/L) over a period of 120 days, extending through sexual maturation, to assess its impact on female reproductive health. Notable reductions in body weight (0.59- and 0.76-fold) and length (0.71- and 0.77-fold) were observed at concentrations of 20 and 100 mu g/L, with a concomitant decrease by 0.21- to 0.61-fold in the gonadal somatic index across all treatment groups. The reproductive output, as evidenced by egg production and hatchability, was adversely affected. Histopathological analysis suggested that TCEP exposure impedes ovarian development. Endocrine alterations were also evident, with testosterone and 11-ketotestosterone levels significantly diminished by 0.38- and 0.08-fold at the highest concentration tested, while 17 beta-estradiol beta- estradiol was elevated by 0.09- to 0.14-fold in all exposed groups. Transcriptomic profiling illuminated numerous differentially expressed genes (DEGs) integral to reproductive processes, including hormone regulation, neuroactive ligand-receptor interactions, oocyte meiosis, and progesterone-mediated maturation pathways. Collectively, these findings indicate that lifelong exposure to TCEP disrupts ovarian development and maturation in female zebrafish, alters gene expression within the hypothalamic-pituitary-gonadal axis, and perturbs sex hormone synthesis, culminating in pronounced reproductive toxicity.
Keyword ：
Hypothalamic-pituitary-gonadal axis Hypothalamic-pituitary-gonadal axis Organophosphorus flame retardant Organophosphorus flame retardant Ovarian development Ovarian development Sex hormone Sex hormone Transcriptome analysis Transcriptome analysis
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| GB/T 7714 | Ding, Jieyu , Wang, Hongkai , He, Jiabo et al. Elucidating the reproductive toxicity mechanisms in female zebrafish: A transcriptomic study of lifetime tris(2-chloroethyl) phosphate exposure [J]. | SCIENCE OF THE TOTAL ENVIRONMENT , 2024 , 948 . |
| MLA | Ding, Jieyu et al. "Elucidating the reproductive toxicity mechanisms in female zebrafish: A transcriptomic study of lifetime tris(2-chloroethyl) phosphate exposure" . | SCIENCE OF THE TOTAL ENVIRONMENT 948 (2024) . |
| APA | Ding, Jieyu , Wang, Hongkai , He, Jiabo , Jing, Chen , Zhao, Haocheng , Hu, Fengxiao . Elucidating the reproductive toxicity mechanisms in female zebrafish: A transcriptomic study of lifetime tris(2-chloroethyl) phosphate exposure . | SCIENCE OF THE TOTAL ENVIRONMENT , 2024 , 948 . |
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2-ethylhexyl-4-methoxycinnamate (EHMC) is a commonly used UV filter, and is receiving increasing concerns due to its ubiquitous occurrence in a variety of environmental media and potential adverse effects. This study was aimed to assess the ecotoxicological potentials of EHMC on the marine polychaete Perinereis aibuhitensis. To this end, ragworms were exposed to 2, 20, 200 mu g/L EHMC for 14 days and multiple toxicological endpoints were investigated. The results showed that EHMC significantly reduced burrowing rate, but did not affect AChE activity. Exposure to EHMC significantly elevated the activities of SOD and CAT and decreased the levels of lipid peroxidation. Besides, the induction of AKP activity indicated a stimulated immune response in the ragworms when exposed to high concentration of EHMC. Furthermore, the upregulated expression of caspase-8 suggested that EHMC might induce apoptosis in ragworms via the death receptor -mediated extrinsic pathway. Our findings highlight the potential environmental risks of EHMC to marine ecosystems.
Keyword ：
2-ethylhexyl-4-methoxycinnamate 2-ethylhexyl-4-methoxycinnamate Apoptosis Apoptosis Behavior Behavior Oxidative stress Oxidative stress Polychaete Polychaete
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| GB/T 7714 | He, Jiabo , Chen, Zhi , Jing, Chen et al. Behavioral and biochemical responses of the marine polychaete Perinereis aibuhitensis to 2-ethylhexyl-4-methoxycinnamate (EHMC) exposure [J]. | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY , 2024 , 279 . |
| MLA | He, Jiabo et al. "Behavioral and biochemical responses of the marine polychaete Perinereis aibuhitensis to 2-ethylhexyl-4-methoxycinnamate (EHMC) exposure" . | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 279 (2024) . |
| APA | He, Jiabo , Chen, Zhi , Jing, Chen , Zhang, Weiwei , Peng, Hangke , Zhou, Honglei et al. Behavioral and biochemical responses of the marine polychaete Perinereis aibuhitensis to 2-ethylhexyl-4-methoxycinnamate (EHMC) exposure . | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY , 2024 , 279 . |
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Tris (2-chloroethyl) phosphate (TCEP) has been receiving great concerns owing to its ubiquitous occurrence in various environmental compartments and potential risks to wildlife and humans. Gill is structural basis for ion regulation and homeostasis in fish and susceptible to xenobiotics. However, current knowledge on the impacts of long-term exposure to TCEP on the structure and physiological function of fish gills are insufficient. In this work, zebrafish were exposed to environmental realistic concentrations (0.8, 4, 20 and 100 mu g/L) of TCEP from 3 h post ferterlization (hpf) till 120 days post ferterlization (dpf). Our results demonstrated that life-cycle exposure to TCEP significantly decreased the activity of glutathione S-transferase (GST), but elevated the activities of anti -oxidative enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and increased malondialdehyde (MDA) content in zebrafish gills. Gene transcription analysis implied that the mRNA expressions of antioxidant-related genes (nrf2, cat and nqo1) were induced, while the transcription of gst alpha 1, hmox1, keap1 were down-regulated, indicating that Nrf2-Keap1 pathway might be activated to defend the oxidative stress induced by TCEP. Additionally, the ion homeostasis was disrupted by TCEP exposure, evidenced by reduced activities of Na+/K+-ATPase (NKA), Ca2+-ATPase and Mg2+-ATPase and downregulated transcription levels of ncc,nkcc, cftr and clc-3. Besides, whole-life exposure to TCEP resulted in a series of structural damages to gills, including epithelial lifting, epithelial rupture, telangiectasis, vacuolation, edema and shortened gill lamellae. Overall, our results demonstrated that long-term TCEP exposure could induce oxidative stress, affect ion regulation and cause histological changes in zebrafish gills.
Keyword ：
Histological changes Histological changes Ion homeostasis Ion homeostasis Oxidative stress Oxidative stress Tris (2-chloroethyl) phosphate Tris (2-chloroethyl) phosphate Zebrafish Zebrafish
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| GB/T 7714 | Peng, Hangke , Wang, Hongkai , Li, Wen et al. Life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in antioxidative status, ion regulation and histology of zebrafish gills [J]. | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY , 2023 , 274 . |
| MLA | Peng, Hangke et al. "Life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in antioxidative status, ion regulation and histology of zebrafish gills" . | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 274 (2023) . |
| APA | Peng, Hangke , Wang, Hongkai , Li, Wen , Jing, Chen , Zhang, Weiwei , Zhao, Haocheng et al. Life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in antioxidative status, ion regulation and histology of zebrafish gills . | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY , 2023 , 274 . |
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Tris (2-chloroethyl) phosphate (TCEP), a typical organophosphate flame retardant, is of increasingly great concern considering their ubiquitous presence in aquatic environments and potential ecotoxicity. The present work was aimed to investigate the potential growth inhibition and hepatic stress induced by whole life-cycle exposure to TCEP (0.8, 4, 20 and 100 mu g/L) in zebrafish. The results revealed that the body length, body mass and hepatic-somatic index (HSI) of zebrafish were significantly declined after exposure to TCEP for 120 days. GPx activity and GSH content were increased in the liver of zebrafish treated with low concentrations (0.8 and 4 mu g/L) of TCEP, while exposure to high concentrations (20 and 100 mu g/L) of TCEP reduced antioxidative capacity and elevated lipid peroxidation (LPO) levels. Gene transcription analysis demonstrated that the mRNA levels of nrf2 were altered in a similar manner to the transcription of the downstream genes nqo1 and hmox1, suggesting that Nrf2-Keap1 pathway mediated TCEP-induced oxidative stress in zebrafish liver. In addition, TCEP exposure might alleviate inflammatory response through down-regulating transcription of inflammatory cytokines (il-1 beta, il-6 and inos), and induce apoptosis via activating the p53-Bax pathway. Moreover, whole life-cycle exposure to TCEP caused a series of histopathological anomalies in zebrafish liver. Overall, our results revealed that lifetime exposure to environmentally relevant concentrations of TCEP could result in growth retardation and induce significant hepatotoxicity in zebrafish.
Keyword ：
Apoptosis Apoptosis Histological changes Histological changes Inflammatory response Inflammatory response Oxidative stress Oxidative stress TCEP TCEP Zebrafish Zebrafish
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| GB/T 7714 | Hu, Fengxiao , Li, Wen , Wang, Hongkai et al. Environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) induce hepatotoxicity in zebrafish (Danio rerio): a whole life-cycle assessment [J]. | FISH PHYSIOLOGY AND BIOCHEMISTRY , 2023 , 49 (6) : 1421-1433 . |
| MLA | Hu, Fengxiao et al. "Environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) induce hepatotoxicity in zebrafish (Danio rerio): a whole life-cycle assessment" . | FISH PHYSIOLOGY AND BIOCHEMISTRY 49 . 6 (2023) : 1421-1433 . |
| APA | Hu, Fengxiao , Li, Wen , Wang, Hongkai , Peng, Hangke , He, Jiabo , Ding, Jieyu et al. Environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) induce hepatotoxicity in zebrafish (Danio rerio): a whole life-cycle assessment . | FISH PHYSIOLOGY AND BIOCHEMISTRY , 2023 , 49 (6) , 1421-1433 . |
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二苯甲酮-3 (BP-3)、4-甲基苄亚基樟脑(4-MBC)和4-甲氧基肉桂酸-2-乙基己酯(EHMC)是三种常用的有机紫外吸收剂,在水环境中被频繁检出,对水生生态系统安全构成潜在威胁。为探究三种有机紫外吸收剂对菲律宾蛤仔(Ruditapes philippinarum)鳃组织抗氧化响应和相关细胞凋亡基因的影响,将蛤仔分别暴露于环境相关浓度的三种紫外吸收剂溶液中,检测鳃组织抗氧化酶活性和细胞凋亡相关基因转录水平,并通过第二代整合生物标志物响应法(IBRv2)对三种紫外吸收剂的生物毒性进行比较分析。结果显示,三种紫外吸收剂短期暴露会诱导抗氧化响应提高抗氧化能力,而长期高浓度暴露会导致抗氧化能力的降低。BP-3、4-MBC和EHMC可能通过启动线粒体途径和fas介导的死亡受体途径诱导菲律宾蛤仔鳃组织产生细胞凋亡。通过IBRv2分析发现,在环境常见浓度1μg/L的暴露水平下,短期(1 d, 7 d)暴露时, BP-3对菲律宾蛤仔鳃组织表现出的综合毒性效应最强,而随着暴露时间的延长(28 d),三种紫外吸收剂表现出的综合毒性效应相近。研究结果为水环境中有机紫外吸收剂的生态风险评估提供了参考数据。
Keyword ：
整合生物标志物响应法 整合生物标志物响应法 有机紫外吸收剂 有机紫外吸收剂 氧化胁迫 氧化胁迫 细胞凋亡 细胞凋亡 菲律宾蛤仔 菲律宾蛤仔 鳃 鳃
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| GB/T 7714 | 张韦炜 , 董飞龙 , 荆晨 et al. 三种有机紫外吸收剂对菲律宾蛤仔(Ruditapes philippinarum)鳃组织抗氧化能力和细胞凋亡相关基因表达的影响 [J]. | 海洋与湖沼 , 2023 , 54 (06) : 1693-1703 . |
| MLA | 张韦炜 et al. "三种有机紫外吸收剂对菲律宾蛤仔(Ruditapes philippinarum)鳃组织抗氧化能力和细胞凋亡相关基因表达的影响" . | 海洋与湖沼 54 . 06 (2023) : 1693-1703 . |
| APA | 张韦炜 , 董飞龙 , 荆晨 , 刘尚书 , 胡丰晓 . 三种有机紫外吸收剂对菲律宾蛤仔(Ruditapes philippinarum)鳃组织抗氧化能力和细胞凋亡相关基因表达的影响 . | 海洋与湖沼 , 2023 , 54 (06) , 1693-1703 . |
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The unprecedented proliferation of disposable face masks during the COVID-19 pandemic, coupled with their improper disposal, threatens to exacerbate the already concerning issue of plastic pollution. This study evaluates the role of environmentally weathered masks as potential sources of microplastics (MPs) and nanoplastics (NPs) and assesses their adverse impact on the early life stages of zebrafish. Experimental findings revealed that a single disposable mask could release approximately 1.79 x 109 particles, with nearly 70% measuring less than 1 mu m, following 60 days of sunlight exposure and subsequent sand-induced physical abrasion. Remarkably, the MPs/NPs (MNPs) emanating from face masks have the potential to permeate the outer layer (chorion) of zebrafish embryos. Furthermore, due to their minute size, these particles can be consumed by the larvae's digestive system and subsequently circulated to other tissues, including the brain. Exposure to mask-derived MNPs at concentrations of 1 and 10 mu g/L led to significant cases of developmental toxicity, incited oxidative stress, and prompted cell apoptosis. A subsequent metabolomics analysis indicated that the accumulation of these plastic particles perturbed metabolic functions in zebrafish larvae, primarily disrupting amino acid and lipid metabolism. The outcomes of this research underscore the accelerating possibility of environmental aging processes and physical abrasion in the release of MNPs from disposable face masks. Most importantly, these results shed light on the possible ecotoxicological risk posed by improperly disposed of face masks.
Keyword ：
COVID-19 pandemic COVID-19 pandemic Face mask Face mask Metabolome Metabolome Nanoplastics Nanoplastics Naturally weathering Naturally weathering
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| GB/T 7714 | Hu, Fengxiao , Zhao, Haocheng , Ding, Jieyu et al. Uptake and toxicity of micro-/nanoplastics derived from naturally weathered disposable face masks in developing zebrafish: Impact of COVID-19 pandemic on aquatic life [J]. | ENVIRONMENTAL POLLUTION , 2023 , 343 . |
| MLA | Hu, Fengxiao et al. "Uptake and toxicity of micro-/nanoplastics derived from naturally weathered disposable face masks in developing zebrafish: Impact of COVID-19 pandemic on aquatic life" . | ENVIRONMENTAL POLLUTION 343 (2023) . |
| APA | Hu, Fengxiao , Zhao, Haocheng , Ding, Jieyu , Jing, Chen , Zhang, Weini , Chen, Xinhua . Uptake and toxicity of micro-/nanoplastics derived from naturally weathered disposable face masks in developing zebrafish: Impact of COVID-19 pandemic on aquatic life . | ENVIRONMENTAL POLLUTION , 2023 , 343 . |
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