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学者姓名：林焱
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Abstract ：
中国人聚食制的饮食文化习惯使幽门螺杆菌（Helicobacter pylori）在人群中传播的机会大幅提高。幽门螺杆菌可导致慢性胃炎、消化性溃疡甚至癌症发生。目前，幽门螺杆菌感染的治疗多采用“四联疗法”，但大量使用抗生素产生的副作用对患者伤害较大，同时增加了幽门螺杆菌耐药性的产生，导致愈后易复发、再感染等问题。蜂产品因其具有抗菌、抗炎、抗肿瘤、抗氧化、促进再生等多种功能，被研究作为辅助治疗幽门螺杆菌感染的手段，已有研究表明蜂产品具有抗幽门螺杆菌的效果，同时能增强免疫力、调节胃肠道菌群平衡。本综述总结目前蜂产品抗幽门螺杆菌感染的相关研究，以期对未来幽门螺杆菌感染的治疗提供线索。
Keyword ：
幽门螺杆菌 幽门螺杆菌 蜂毒 蜂毒 蜂王浆 蜂王浆 蜂胶 蜂胶 蜂蜜 蜂蜜
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| GB/T 7714 | 蔡榕璟 , 林安淇 , 林振宇 et al. 蜂产品辅助治疗幽门螺杆菌感染研究进展 [J]. | 中国蜂业 , 2025 , 76 (05) : 35-38 . |
| MLA | 蔡榕璟 et al. "蜂产品辅助治疗幽门螺杆菌感染研究进展" . | 中国蜂业 76 . 05 (2025) : 35-38 . |
| APA | 蔡榕璟 , 林安淇 , 林振宇 , 刘秋霞 , 林焱 , 苏松坤 . 蜂产品辅助治疗幽门螺杆菌感染研究进展 . | 中国蜂业 , 2025 , 76 (05) , 35-38 . |
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本发明公开了宝藿苷I在防治刺激隐核虫病中的应用，证明了从传统中草药淫羊藿中提取的宝藿苷I能够有效杀死刺激隐核虫，而低浓度宝藿苷I就能迅速抑制刺激隐核虫的生长、繁殖，减少其对养殖动物的侵害，降低水产养殖动物的感染率与死亡率。从环保角度来看，相较于一些化学合成药物，宝藿苷I源自天然植物，在使用过程中不会在水体及养殖生物体内残留难以降解的有害物质，不会对养殖环境造成污染，有利于维持生态平衡。另外，淫羊藿在我国分布广泛，资源丰富，这使得宝藿苷I的来源十分广泛，为大规模生产和应用提供了坚实基础，也能在一定程度上降低养殖成本，提高经济效益。
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| GB/T 7714 | 林焱 , 黄丽 , 顾承真 et al. 宝藿苷I在防治刺激隐核虫病中的应用 : CN202510103866.3[P]. | 2025-01-23 . |
| MLA | 林焱 et al. "宝藿苷I在防治刺激隐核虫病中的应用" : CN202510103866.3. | 2025-01-23 . |
| APA | 林焱 , 黄丽 , 顾承真 , 王蒙蒙 , 林洋正 . 宝藿苷I在防治刺激隐核虫病中的应用 : CN202510103866.3. | 2025-01-23 . |
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本发明提供了一种能促进伤口愈合和抗皮肤光老化的蜂王浆多肽CMKI‑21及其应用，属于生物医药技术领域。所述蜂王浆多肽氨基酸序列为KKELVREVGFEICFKDHHEKI，通过固相化学合成法获得。本发明的蜂王浆多肽CMKI‑21分子量小、制备方法简单易行、纯度高且具有良好的生物相容性，能显著促进HaCaT细胞的增殖和迁移，加快小鼠全层皮肤缺损伤口的愈合速率，减轻HaCaT细胞的光损伤，缓解紫外线（UVB）造成的皮肤光老化和晒伤。该蜂王浆多肽有潜力作为伤口愈合剂应用于临床各类皮肤创伤，也可用于抗皮肤光老化和晒伤修复的药物和化妆品中。
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| GB/T 7714 | 苏松坤 , 罗孝天 , 林焱 et al. 一种蜂王浆多肽CMKI-21及其应用 : CN202510050422.8[P]. | 2025-01-13 . |
| MLA | 苏松坤 et al. "一种蜂王浆多肽CMKI-21及其应用" : CN202510050422.8. | 2025-01-13 . |
| APA | 苏松坤 , 罗孝天 , 林焱 , 袁媛 , 刘秋霞 , 林天星 et al. 一种蜂王浆多肽CMKI-21及其应用 : CN202510050422.8. | 2025-01-13 . |
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Keratinocytes, the major cell types of the epidermis, proliferate and migrate during wound healing to restore the epithelial barrier. Royal jelly is a traditional remedy used in wound repair. Our previous study found that the mixture of major royal jelly protein (MRJP) 2, 3 and 7 exhibited in vitro wound healing-promoting effects; however, the exact functional constituents and the associated underlying mechanisms of action are still largely unknown. In this study, a partial fragment of MRJP3 was recombinantly expressed as a fusion protein MRJP3-C113-Fc which promoted wound healing in vitro and in vivo. By employing protein inhibitors and immunoblots technology, it was initially found that the wound-repairing mechanisms of MRJP3-C113-Fc were correlated to the activation of EGFR/AKT/mTOR signaling pathway in keratinocytes (HaCaT cells). LC-MS/MS-based proteomic analysis demonstrated that the proteins present in the MRJP3-C113-Fc-treated HaCaT cells were different from the untreated ones, in which rhomboid 5 homolog 2 (RHBDF2) might be the potential regulator for the EGFR/AKT/mTOR signaling pathway. Silencing of RHBDF2 diminished the pro-proliferative and -migratory effectiveness of MRJP3-C113-Fc on HaCaT cells, as well as the phosphorylation of EGFR/AKT/mTOR, suggesting that the wound healing-promoting efficacy was attributable to the RHBDF2-mediated activation of EGFR/AKT/mTOR signaling pathway. Hence, this study is the first to discover the single fragment of MRJPs possessing pro-healing properties, and also the first to disclose the regulatory role of RHBDF2 in EGFR/AKT/mTOR signaling pathway-modulated wound healing. It will facilitate the development of MRJP3-C113-based therapeutic agent for skin wounds, and provide a novel target for treating cutaneous trauma.
Keyword ：
Fusion protein Fusion protein Major royal jelly protein 3 Major royal jelly protein 3 Mechanism Mechanism Proteomics Proteomics Wound healing Wound healing
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| GB/T 7714 | Huang, Lei , Lin, Tianxing , Wang, Yuzhen et al. MRJP3-C113, a major royal jelly protein 3-derived fragment, accelerated cutaneous wound healing through RHBDF2-mediated activation of EGFR/AKT/mTOR signaling pathway [J]. | FOOD SCIENCE AND HUMAN WELLNESS , 2025 , 14 (10) . |
| MLA | Huang, Lei et al. "MRJP3-C113, a major royal jelly protein 3-derived fragment, accelerated cutaneous wound healing through RHBDF2-mediated activation of EGFR/AKT/mTOR signaling pathway" . | FOOD SCIENCE AND HUMAN WELLNESS 14 . 10 (2025) . |
| APA | Huang, Lei , Lin, Tianxing , Wang, Yuzhen , Luo, Xiaotian , Zhang, Meng , Cai, Rongjing et al. MRJP3-C113, a major royal jelly protein 3-derived fragment, accelerated cutaneous wound healing through RHBDF2-mediated activation of EGFR/AKT/mTOR signaling pathway . | FOOD SCIENCE AND HUMAN WELLNESS , 2025 , 14 (10) . |
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本发明提供了一种促进伤口愈合的蜂王浆多肽AMLK11及其应用，其属于生物医药技术领域。所述促伤口愈合的蜂王浆多肽AMLK11氨基酸序列为LLLTAAVSAGK，可通过固相化学合成法获得。本发明的蜂王浆多肽AMLK11能促进HaCaT细胞和HFF‑1细胞的增殖和迁移，同时能加快小鼠伤口愈合，有望作为伤口愈合剂应用于临床各类皮肤创伤。
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| GB/T 7714 | 林焱 , 王钰祯 , 罗孝天 et al. 一种蜂王浆促伤口愈合多肽AMLK11及其应用 : CN202311473546.4[P]. | 2023-11-07 . |
| MLA | 林焱 et al. "一种蜂王浆促伤口愈合多肽AMLK11及其应用" : CN202311473546.4. | 2023-11-07 . |
| APA | 林焱 , 王钰祯 , 罗孝天 , 苏松坤 , 黄蕾 , 林天星 . 一种蜂王浆促伤口愈合多肽AMLK11及其应用 : CN202311473546.4. | 2023-11-07 . |
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本发明公开了一种分泌抗大黄鱼T淋巴细胞表面CD4‑2单克隆抗体的杂交瘤细胞株CD4‑2‑2E7，其已于2024年5月29日在中国典型培养物保藏中心登记保藏，保藏编号为CCTCC NO：C2024143。杂交瘤细胞株CD4‑2‑2E7分泌的抗大黄鱼T淋巴细胞表面CD4‑2单克隆抗体特异性强，灵敏度高，可为大黄鱼CD4+T淋巴细胞的增殖、分化、功能及相关免疫学机制研究提供有力工具，对大黄鱼适应性免疫应答规律研究及疾病的免疫防控具有重要理论和现实意义，具有广阔的前景。
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| GB/T 7714 | 陈新华 , 李欣然 , 林焱 . 一种分泌抗大黄鱼T淋巴细胞表面CD4-2分子单克隆抗体的杂交瘤细胞株 : CN202411246554.X[P]. | 2024-09-06 . |
| MLA | 陈新华 et al. "一种分泌抗大黄鱼T淋巴细胞表面CD4-2分子单克隆抗体的杂交瘤细胞株" : CN202411246554.X. | 2024-09-06 . |
| APA | 陈新华 , 李欣然 , 林焱 . 一种分泌抗大黄鱼T淋巴细胞表面CD4-2分子单克隆抗体的杂交瘤细胞株 : CN202411246554.X. | 2024-09-06 . |
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近年来,由于抗生素研发停滞和细菌耐药性日益严重,从天然产物中发现的抗菌物质受到广泛关注。由于蜂蜜具有极强的抗菌活性,数千年来一直被用作治疗皮肤创伤及肠胃疾病,然而,药用植物来源的蜂蜜是否具有特殊的抗菌活性仍未知。因此本研究测定了一系列本土药用植物单花蜂蜜的抗菌活性。结果显示,玄参蜂蜜表现出与麦卢卡蜂蜜相当的体内外抗菌效果,且玄参蜂蜜能够通过破坏细菌细胞膜和基因组DNA来诱导细菌死亡。本研究首次深入研究了中国本土药用植物单花蜂蜜的抗菌活性和机制,为抗菌药物的研发提供了新思路,并促进了蜂蜜的精准应用。
Keyword ：
体内研究 体内研究 体外研究 体外研究 作用机制 作用机制 抗菌 抗菌 蜂蜜 蜂蜜
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| GB/T 7714 | 林天星 , 黄蕾 , 程宁娜 et al. 玄参蜂蜜的体内外抗菌作用及机制研究 [C] //2023年中国（浙江·江山）蜂业博览会暨全国蜂产品市场信息交流会 . 2023 . |
| MLA | 林天星 et al. "玄参蜂蜜的体内外抗菌作用及机制研究" 2023年中国（浙江·江山）蜂业博览会暨全国蜂产品市场信息交流会 . (2023) . |
| APA | 林天星 , 黄蕾 , 程宁娜 , 王钰祯 , 宁珍 , 黄少康 et al. 玄参蜂蜜的体内外抗菌作用及机制研究 2023年中国（浙江·江山）蜂业博览会暨全国蜂产品市场信息交流会 . (2023) . |
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Sacbrood virus (SBV) is a significant problem that impedes brood development in both eastern and western honeybees. Whole-genome sequencing has become an important tool in researching population genetic variations. Numerous studies have been conducted using multiple techniques to suppress SBV infection in honeybees, but the genetic markers and molecular mechanisms underlying SBV resistance have not been identified. To explore single nucleotide polymorphisms (SNPs), insertions, deletions (Indels), and genes at the DNA level related to SBV resistance, we conducted whole-genome resequencing on 90 Apis cerana cerana larvae raised in vitro and challenged with SBV. After filtering, a total of 337.47 gigabytes of clean data and 31,000,613 high-quality SNP loci were detected in three populations. We used ten databases to annotate 9359 predicted genes. By combining population differentiation index (F-ST) and nucleotide polymorphisms (p), we examined genome variants between resistant (R) and susceptible (S) larvae, focusing on site integrity (INT < 0.5) and minor allele frequency (MAF < 0.05). A selective sweep analysis with the top 1% and top 5% was used to identify significant regions. Two SNPs on the 15th chromosome with GenBank KZ288474.1_322717 (Guanine > Cytosine) and KZ288479.1_95621 (Cytosine > Thiamine) were found to be significantly associated with SBV resistance based on their associated allele frequencies after SNP validation. Each SNP was authenticated in 926 and 1022 samples, respectively. The enrichment and functional annotation pathways from significantly predicted genes to SBV resistance revealed immune response processes, signal transduction mechanisms, endocytosis, peroxisomes, phagosomes, and regulation of autophagy, which may be significant in SBV resistance. This study presents novel and useful SNP molecular markers that can be utilized as assisted molecular markers to select honeybees resistant to SBV for breeding and that can be used as a biocontrol technique to protect honeybees from SBV.
Keyword ：
Apis cerana cerana Apis cerana cerana larva larva nucleotide polymorphisms nucleotide polymorphisms population differentiation index population differentiation index sacbrood virus sacbrood virus sequencing sequencing single nucleotide polymorphism single nucleotide polymorphism variants variants
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| GB/T 7714 | Hassanyar, Aqai Kalan , Nie, Hongyi , Li, Zhiguo et al. Discovery of SNP Molecular Markers and Candidate Genes Associated with Sacbrood Virus Resistance in Apis cerana cerana Larvae by Whole-Genome Resequencing [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (7) . |
| MLA | Hassanyar, Aqai Kalan et al. "Discovery of SNP Molecular Markers and Candidate Genes Associated with Sacbrood Virus Resistance in Apis cerana cerana Larvae by Whole-Genome Resequencing" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 . 7 (2023) . |
| APA | Hassanyar, Aqai Kalan , Nie, Hongyi , Li, Zhiguo , Lin, Yan , Huang, Jingnan , Woldegiorgis, Samuel Tareke et al. Discovery of SNP Molecular Markers and Candidate Genes Associated with Sacbrood Virus Resistance in Apis cerana cerana Larvae by Whole-Genome Resequencing . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (7) . |
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兽医临床具有复杂性、多变性、严谨性和实践性，兽医临床诊疗技能是动物医学专业的一项重要核心技能。为提高学生兽医临床诊疗技能和创新实践能力，基于福建省教育科学“十四五”规划课题建设，结合福建农业职业技术学院畜牧兽医专业群的优势和特色，依据以创新实践能力培养为导向的教学理念，通过校企科研项目驱动、新建互动实训基地、兽医技能大赛促进、创新创业竞赛引领、重构课程教学体系等5个维度，对“兽医临床诊疗技术”课程进行教学模式和课程内容改革与实践，解决了现有教学中创新创业能力、兽医技术技能和课程教育教学结合松散的“痛点”，提高了畜牧兽医人才培养质量。本文为畜牧兽医专业课程教学改革提供了参考。
Keyword ：
兽医临床诊疗技能 兽医临床诊疗技能 创新实践能力 创新实践能力 畜牧兽医专业 畜牧兽医专业 高职院校 高职院校
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| GB/T 7714 | 徐磊 , 余勋信 , 廖惠珍 et al. 基于创新实践能力培养的兽医临床诊疗技能教学改革与实践 [J]. | 中国动物检疫 , 2023 , 40 (09) : 55-60 . |
| MLA | 徐磊 et al. "基于创新实践能力培养的兽医临床诊疗技能教学改革与实践" . | 中国动物检疫 40 . 09 (2023) : 55-60 . |
| APA | 徐磊 , 余勋信 , 廖惠珍 , 杨慧 , 游开铿 , 林焱 et al. 基于创新实践能力培养的兽医临床诊疗技能教学改革与实践 . | 中国动物检疫 , 2023 , 40 (09) , 55-60 . |
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MicroRNAs (miRNAs) play a vital role in the nerve regulation of honey bees (Apis mellifera). This study aims to investigate the differences in expression of miRNAs in a honey bee's brain for olfactory learning tasks and to explore their potential role in a honey bee's olfactory learning and memory. In this study, 12 day old honey bees with strong and weak olfactory performances were utilized to investigate the influence of miRNAs on olfactory learning behavior. The honey bee brains were dissected, and a small RNA-seq technique was used for high-throughput sequencing. The data analysis of the miRNA sequences revealed that 14 differentially expressed miRNAs (DEmiRNAs) between the two groups, strong (S) and weak (W), for olfactory performance in honey bees were identified, which included seven up-regulated and seven down-regulated. The qPCR verification results of the 14 miRNAs showed that four miRNAs (miR-184-3p, miR-276-3p, miR-87-3p, and miR-124-3p) were significantly associated with olfactory learning and memory. The target genes of these DEmiRNAs were subjected to the GO database annotation and KEGG pathway enrichment analyses. The functional annotation and pathway analysis showed that the neuroactive ligand-receptor interaction pathway, oxidative phosphorylation, biosynthesis of amino acids, pentose phosphate pathway, carbon metabolism, and terpenoid backbone biosynthesis may be a great important pathway related to olfactory learning and memory in honey bees. Our findings together further explained the relationship between olfactory performance and the brain function of honey bees at the molecular level and provides a basis for further study on miRNAs related to olfactory learning and memory in honey bees.
Keyword ：
Apis mellifera Apis mellifera brain brain miRNAs miRNAs olfactory performance olfactory performance proboscis extension response (PER) proboscis extension response (PER)
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| GB/T 7714 | Huang, Jingnan , Wang, Tianbao , Qiu, Yuanmei et al. Differential Brain Expression Patterns of microRNAs Related to Olfactory Performance in Honey Bees (Apis mellifera) [J]. | GENES , 2023 , 14 (5) . |
| MLA | Huang, Jingnan et al. "Differential Brain Expression Patterns of microRNAs Related to Olfactory Performance in Honey Bees (Apis mellifera)" . | GENES 14 . 5 (2023) . |
| APA | Huang, Jingnan , Wang, Tianbao , Qiu, Yuanmei , Hassanyar, Aqai Kalan , Zhang, Zhaonan , Sun, Qiaoling et al. Differential Brain Expression Patterns of microRNAs Related to Olfactory Performance in Honey Bees (Apis mellifera) . | GENES , 2023 , 14 (5) . |
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