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学者姓名：邵建春
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Abstract ：
This study investigated the effects of supplementation with recombinant peroxiredoxin IV (Prx IV) on the innate immunity and intestinal health in large yellow croaker (Larimichthys crocea). Fish (n = 160) from triple replicates were fed diets containing 0.00 g kg-1 (Prx1), 0.05 g kg-1 (Prx2), 0.10 g kg-1 (Prx3), and 0.15 g kg-1 (Prx4) Prx IV for 8 weeks. Results demonstrated that Prx IV supplementation significantly improved systemic antioxidant capacity, evidenced by elevated activities of superoxide dismutase and catalase, and increased levels of reduced glutathione. Analysis of the head kidney inflammatory response revealed that dietary Prx IV significantly upregulated gene expression of the anti-inflammatory cytokine interleukin-10 and simultaneously down-regulated the expression of pro-inflammatory cytokines (interleukin 2, interleukin 8, and tumor necrosis factor). Furthermore, western blot analysis confirmed that Prx IV administration markedly suppressed nuclear trans-location of nuclear factor-kappa B p65 in the head kidney. Regarding intestinal effects, dietary Prx IV improved intestinal morphology and significantly enhanced the activities of key digestive enzymes (amylase, lipase, and trypsin). Additionally, Prx IV supplementation significantly upregulated the expression of tight junction proteins (claudin 11 and zona occludens 1, ZO-1). Moreover, dietary administration of 0.15 g kg-1 Prx IV significantly altered intestinal microbiota profiles. Specifically, it increased the abundance of Firmicutes, decreased the abundance of potential pathogens such as Haemophilus parainfluenzae and Klebsiella variicola, and increased the abundance of Bacteroides thetaiotaomicron, a bacterium associated with polysaccharide digestion and absorption. In conclusion, dietary administration of 0.15 g kg-1 Prx IV enhances antioxidant and anti-inflammatory capacities in the head kidney and promotes intestinal health in large yellow croaker. Modulation of the intestinal microbiota may contribute to these beneficial effects.
Keyword ：
Innate immunity Innate immunity Intestinal health Intestinal health Larimichthys crocea Larimichthys crocea Peroxiredoxin IV Peroxiredoxin IV
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| GB/T 7714 | Chen, Zhichu , Liu, Qianqian , Zeng, Chao et al. Dietary administration of recombinant peroxiredoxin IV contributes to innate immunity and intestinal health in Larimichthys crocea juveniles [J]. | AQUACULTURE , 2026 , 612 . |
| MLA | Chen, Zhichu et al. "Dietary administration of recombinant peroxiredoxin IV contributes to innate immunity and intestinal health in Larimichthys crocea juveniles" . | AQUACULTURE 612 (2026) . |
| APA | Chen, Zhichu , Liu, Qianqian , Zeng, Chao , You, Haokun , Hu, Bing , Zhang, Jiaonan et al. Dietary administration of recombinant peroxiredoxin IV contributes to innate immunity and intestinal health in Larimichthys crocea juveniles . | AQUACULTURE , 2026 , 612 . |
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To determine the optimum protein requirement of Siniperca scherzeri, this study was conducted to investigate the effects of dietary protein levels on the growth performance, feed utilization, serum biochemical and immune indices as well as hepatic health for Siniperca scherzeri. Five isolipidic diets were formulated containing 38.13 % (P38), 41.16 % (P41), 45.12 % (P45), 49.13 % (P49), 53.07 % (P53) protein levels, respectively, and fed to 375 Siniperca scherzeri (initial weight: 75.42 +/- 0.45 g) for 8 weeks. Results showed that the survival rate (SR) of fish fed with the P38 diet was significantly lower than that of other groups. The maximum weight gain rate (WG, 88.84 %), specific growth rate (SGR, 1.13 % day(-1)), protein efficiency ratio (PER, 1.18) and the best feed conversion ratio (FCR, 1.74) were recorded in fish fed with P49 diet. Serum biochemical parameters demonstrated that low-protein diet (P38) might cause disturbance of lipid metabolism [decreased triglycerides (TGs), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDLC) concentration] and protein metabolism [decreased total protein (TP) and increased ammonia as well as urea nitrogen (UN) concentration], and liver impairment [increased alanine aminotransferase (ALT) activity]. Additionally, we found that an increment of dietary protein level (P49 and P53 diets) significantly enhanced body non-special immunity [increased lysozyme (LZM) concentration]. Moreover, results about hepatic health maintenance suggested that an increment of dietary protein level improved antioxidant ability [increased catalase (CAT) activity and total antioxidant capacity (T-AOC), and decreased malonyl dialdehyde (MDA) content] and abnormal lipid accumulation [decreased lipid droplet and TGs content] in the liver of Siniperca scherzeri. Besides, we found that an increment of dietary protein level significantly suppressed the processes of inflammation response, cell apoptosis and autophagy in the liver of Siniperca scherzeri. Cubic regression analysis suggested that the optimal protein requirements of Siniperca scherzeri were 49.82 % similar to 50.79 %, based on WG, SGR, PER and FCR. The present study provides new insights into the optimal dietary protein requirements of Siniperca scherzeri and establishes a theoretical basis for formula compound feed of Siniperca scherzeri in the future
Keyword ：
Dietary protein requirement Dietary protein requirement Feed utilization Feed utilization Growth performance Growth performance Liver health Liver health Siniperca scherzeri Siniperca scherzeri
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| GB/T 7714 | Wu, Liwen , Wang, Yujie , Wang, Henan et al. Integrative unveiling of optimum dietary protein requirement for Siniperca scherzeri: Growth performance, feed utilization, serum biochemical and immune parameters and hepatic health maintenance [J]. | AQUACULTURE , 2025 , 598 . |
| MLA | Wu, Liwen et al. "Integrative unveiling of optimum dietary protein requirement for Siniperca scherzeri: Growth performance, feed utilization, serum biochemical and immune parameters and hepatic health maintenance" . | AQUACULTURE 598 (2025) . |
| APA | Wu, Liwen , Wang, Yujie , Wang, Henan , Liang, Ping , Qin, Zhiqing , Lai, Mingyong et al. Integrative unveiling of optimum dietary protein requirement for Siniperca scherzeri: Growth performance, feed utilization, serum biochemical and immune parameters and hepatic health maintenance . | AQUACULTURE , 2025 , 598 . |
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Asprosin takes part in glucose and lipid metabolism, as well as appetite regulation in mammals. To investigate physiological role of Asprosin in teleosts, the grass carp was selected as the animal model. First, the asprosin sequence was isolated from adipose tissue of grass carp, and its expression characterization was tested by realtime PCR. Recombinant Asprosin protein was produced in Escherichia coli (E. coli). The physiological functions of the Asprosin protein were evaluated through both in vivo and in vitro experiments. The result indicated that grass carp asprosin gene was 405 bp, encoding 134 amino acids. The fibrillin 1 (fbn1), asprosin precursor gene, was highly expressed in adipose tissue, white muscle, and spleen. The fbn1 level was noticeably decreased in adipose tissue and muscle following glucose treatment during the oral glucose tolerance test (OGTT). Additionally, the fbn1 level in liver, hypothalamus, adipose tissue and muscle were significantly elevated in fast group. In overfeeding-induced experiment, fbn1 expression in liver, adipose tissue and kidney was enhanced in the induced group. In primary hepatocytes, fbn1 levels were significantly reduced following glucose or glucagon treatment, while oleic acid and insulin treatment promoted fbn1 expression. Recombinant Asprosin protein was produced in E.coil. The expression of phosphoenolpyruvate carboxykinase (pepck), glucose-6-phosphatase (g6pase), glycogen phosphorylase (pygl), acetyl-CoA carboxylase (acc1), fatty acid synthetase (fas), and protein kinase A (pka) were increased, whereas glucokinase (gk), glycogen synthase (gys), and hormone sensitive lipase (hsl) were inhibited by treatment with recombinant Asprosin in both in vitro and in vivo experiments. Furthermore, the glucose, triglycerides (TG), and total cholesterol (T-CHO) contents were elevated, while the contents of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were decreased. These results reveal regulatory role of Asprosin in glucose and lipid metabolism in teleosts for the first time.
Keyword ：
Asprosin Asprosin Glucose metabolism Glucose metabolism Grass carp Grass carp Lipid metabolism Lipid metabolism
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| GB/T 7714 | Yang, Guokun , Yin, Mingyue , Wang, Hao et al. Molecular identification of asprosin and its function on glucose and lipid metabolism in grass carp (Ctenopharyngodon idella) [J]. | AQUACULTURE , 2025 , 600 . |
| MLA | Yang, Guokun et al. "Molecular identification of asprosin and its function on glucose and lipid metabolism in grass carp (Ctenopharyngodon idella)" . | AQUACULTURE 600 (2025) . |
| APA | Yang, Guokun , Yin, Mingyue , Wang, Hao , Li, Chengquan , Feng, Shikun , Zhang, Yanmin et al. Molecular identification of asprosin and its function on glucose and lipid metabolism in grass carp (Ctenopharyngodon idella) . | AQUACULTURE , 2025 , 600 . |
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Eucommia ulmoides leaf extract (ELE) and Astragalus polysaccharides (APS) have been widely used as immunopotentiators in aquaculture. Our prior research on large yellow croaker (Larimichthys crocea) demonstrated that dietary 1 g/kg APS bolstered fish immunity and antioxidant defense. However, the combined effect of ELE and APS in juvenile large yellow croaker remains unknown. Hence, this study aimed to investigate the synergistic effect of ELE and APS on the growth, antioxidant capacity, and intestinal inflammation in large yellow croaker. A total of 1200 fish were divided into five groups and fed diets with 1 g/kg APS and varying ELE levels: 0 g/kg (ELE0), 0.25 g/kg (ELE0.25), 0.5 g/kg (ELE0.5), 1 g/kg (ELE1), and 2 g/kg (ELE2). After an 8-week feeding period, the ELE0.5 and ELE1 groups showed superior weight gain rate, specific growth rate, and feed efficiency compared to other groups. The ELE1 group also had elevated trypsin and lipase activities in the intestine, whereas alpha-amylase activity was not influenced by ELE addition. Antioxidant enzyme activities, such as hepatopancreas superoxide dismutase (SOD) and glutathione peroxidase (GPX) in the ELE1 group were significantly enhanced, while malondialdehyde (MDA) levels decreased with increasing ELE. Intestinal morphology revealed the highest villi height in proximal and distal intestines of ELE1 group, with no significant change in mucosal thickness. In terms of cytokines, the ELE1 group showed significant down-regulation of pro-inflammatory (tnf-alpha, il-1 beta and il-6) and up-regulation of anti-inflammatory (il-4/13a, il-10 and tgf-beta) markers, modulated by MAPK and mTOR signaling. In conclusion, this study indicates that supplementing diets with 1 g/kg ELE alongside 1 g/kg APS in juvenile large yellow croaker offers the best synergistic effect on fish immunity, including enhanced growth, antioxidant capacity, and relieved intestinal inflammation through MAPK and mTOR signaling.
Keyword ：
Anti-inflammation Anti-inflammation Antioxidant capacity Antioxidant capacity Astragalus polysaccharides Astragalus polysaccharides Eucommia ulmoides leaf extracts Eucommia ulmoides leaf extracts Large yellow croaker ( Larimichthys crocea ) Large yellow croaker ( Larimichthys crocea )
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| GB/T 7714 | Shao, Jianchun , Wang, Xuexi , Liu, Qianqian et al. Eucommia ulmoides leaf extracts combined with Astragalus polysaccharides: Effects on growth, antioxidant capacity, and intestinal inflammation in juvenile large yellow croaker (Larimichthys crocea) [J]. | FISH & SHELLFISH IMMUNOLOGY , 2025 , 161 . |
| MLA | Shao, Jianchun et al. "Eucommia ulmoides leaf extracts combined with Astragalus polysaccharides: Effects on growth, antioxidant capacity, and intestinal inflammation in juvenile large yellow croaker (Larimichthys crocea)" . | FISH & SHELLFISH IMMUNOLOGY 161 (2025) . |
| APA | Shao, Jianchun , Wang, Xuexi , Liu, Qianqian , Lv, Huiyuan , Qi, Qiong , Li, Changhui et al. Eucommia ulmoides leaf extracts combined with Astragalus polysaccharides: Effects on growth, antioxidant capacity, and intestinal inflammation in juvenile large yellow croaker (Larimichthys crocea) . | FISH & SHELLFISH IMMUNOLOGY , 2025 , 161 . |
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Larimichthys crocea, an economically significant fish species, has experienced significant resource depletion due to overfishing, prompting the expansion of aquaculture. However, the utilization of plant-based protein sources, like soybean globulin, in aquafeeds may induce intestinal inflammation, compromising fish health. In this study, models of Toll-like receptor (TLR) gene expression were constructed using dual-luciferase reporter vectors. TLR5M and TLR5S were identified as key mediators of inflammatory responses through the activation of the MAPK and NF-kappa B signaling. Molecular docking analyses confirmed their high binding affinity with soybean globulin. Western blot analyses further validated significant changes in key proteins of these pathways. This study provides theoretical insights into plant protein-induced intestinal inflammation and supports the optimization of aquafeed formulations to enhance aquaculture efficiency.
Keyword ：
intestinal inflammatory intestinal inflammatory Larimichthys crocea Larimichthys crocea pattern recognition receptor pattern recognition receptor soybean globulin soybean globulin Toll-like receptor Toll-like receptor
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| GB/T 7714 | Shao, Jianchun , Jia, Nan , Liu, Qianqian et al. Regulation of Intestinal Inflammation in Large Yellow Croaker (Larimichthys crocea) by Soybean Globulin via Toll-Like Receptor Signaling [J]. | MOLECULAR NUTRITION & FOOD RESEARCH , 2025 , 69 (19) . |
| MLA | Shao, Jianchun et al. "Regulation of Intestinal Inflammation in Large Yellow Croaker (Larimichthys crocea) by Soybean Globulin via Toll-Like Receptor Signaling" . | MOLECULAR NUTRITION & FOOD RESEARCH 69 . 19 (2025) . |
| APA | Shao, Jianchun , Jia, Nan , Liu, Qianqian , Zeng, Chao , Zhang, Jiaonan , Wang, Lei et al. Regulation of Intestinal Inflammation in Large Yellow Croaker (Larimichthys crocea) by Soybean Globulin via Toll-Like Receptor Signaling . | MOLECULAR NUTRITION & FOOD RESEARCH , 2025 , 69 (19) . |
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Dietary Astragalus polysaccharides (APS) get wide application in aquaculture due to their excellent immunoregulatory effects. However, little is known about the effects of dietary APS on vaccine potency in fish. In the present study, large yellow croakers (Larimichthys crocea) were injected with formalin-inactivated Pseudomonas plecoglossicida after APS feeding for 14 d and then challenged by live P. plecoglossicida on 28 d post-vaccination. The results showed that dietary APS combined with inactivated vaccine could improve the survival rate, and alleviate splenic lesions and bacteria load post-challenge, thus exhibiting a better protection in large yellow croaker against P. plecoglossicida infection than inactivated vaccine treatment alone. Fish in APS + P. plecoglossicida vaccine group expressed a better antioxidant status by possessing a relatively higher serum total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) activity and a significantly lower malondialdehyde (MDA) content than those in vaccine alone group. Serum lysozyme (LZM) and alkaline phosphatase (AKP) activities, and immunoglobulin M (IgM) titers were all improved in fish of APS + P. plecoglossicida vaccine group compared to fish in vaccine group. Furthermore, fish in APS + P. plecoglossicida vaccine group showed a lower down-regulation of pro-inflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-6, and a higher up-regulation of antiinflammatory cytokine IL-10, immunoglobulin (IgM) and T cell immunity-related cytokines, interferon-gamma (IFN-gamma), IL-4/13A, and IL-4/13B, when compared with those in fish of vaccine group. These results suggested that dietary APS could assist inactivated vaccine to trigger stronger innate and adaptive immune responses against P. plecoglossicida infection. These findings further uncover the immunoregulatory mechanism of dietary APS, and provide valuable information for prevention and control of bacteriosis in fish.
Keyword ：
Astragalus polysaccharides Astragalus polysaccharides Immune response Immune response Inactivated vaccine Inactivated vaccine Large yellow croaker ( Larimichthys crocea ) Large yellow croaker ( Larimichthys crocea ) Pseudomonas plecoglossicida Pseudomonas plecoglossicida
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| GB/T 7714 | Song, Yueyang , Chen, Hui , An, Huimin et al. Dietary Astragalus polysaccharides enhance potency of inactivated Pseudomonas plecoglossicida vaccine in large yellow croaker ( Larimichthys crocea) [J]. | FISH & SHELLFISH IMMUNOLOGY , 2025 , 157 . |
| MLA | Song, Yueyang et al. "Dietary Astragalus polysaccharides enhance potency of inactivated Pseudomonas plecoglossicida vaccine in large yellow croaker ( Larimichthys crocea)" . | FISH & SHELLFISH IMMUNOLOGY 157 (2025) . |
| APA | Song, Yueyang , Chen, Hui , An, Huimin , Wang, Yongyang , Shao, Jianchun , Yan, Meijiao et al. Dietary Astragalus polysaccharides enhance potency of inactivated Pseudomonas plecoglossicida vaccine in large yellow croaker ( Larimichthys crocea) . | FISH & SHELLFISH IMMUNOLOGY , 2025 , 157 . |
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Glycinin, a major anti-nutrient in soybean meal, may trigger enteritis and oxidative stress in fish with overconsumption. However, its impact on intestinal inflammation and underlying signaling mechanisms in Larimichthys crocea remains unclear. The purpose of this study was to assess the effects of glycinin on growth, antioxidant function, inflammatory response, and gut microbiota. Four isonitrogenous and isolipidic experimental feeds were prepared, supplemented with 0%(G0), 3%(G3), 6%(G6), and 12%(G12) glycinin, respectively, and fed to juvenile L. crocea for 10 weeks. The findings indicated that dietary glycinin markedly decreased the growth, feed utilization, and survival rate of L. crocea. In addition, L. crocea fed with G6 and G12 diets showed lower trypsin activity compared with those fed with G0 and G3 diets. Similarly, fish fed with G6 and G12 diets showed higher malondialdehyde content and lower superoxide dismutase activity in the liver compared with those fed with G0 and G3 diets, suggesting that glycinin induced oxidative stress and led to the imbalance of the antioxidant system. Dietary glycinin significantly increased the mRNA expression levels of toll-like receptors in the gut. Moreover, dietary glycinin resulted in a heightened expression of both C-rel and p65 proteins, while also elevating the phosphorylation levels of JNK and ERK proteins, indicating that glycinin activated the MAPK/NF-κB signaling route. In addition, dietary glycinin increased the abundance of pathogenic bacteria in the gut, including Bacteroides and Streptococcus, and reduced the Bifidobacterium abundance. The findings suggested that L. crocea is highly sensitive to glycinin, and a 3% level can cause growth decline and enteritis. © 2024 The Author(s). Food Frontiers published by Nanchang University, Northwest University, Jiangsu University, Fujian Agriculture and Forestry University, International Association of Dietetic Nutrition and Safety and John Wiley & Sons Australia, Ltd.
Keyword ：
Fish Fish Medicinal chemistry Medicinal chemistry Pathology Pathology Superoxide dismutase Superoxide dismutase
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| GB/T 7714 | Shao, Jianchun , Li, Zhangqi , You, Haokun et al. Soybean Glycinin Reduced Growth Performance and Antioxidant Capacity and Caused Intestinal Inflammation and Microbiome Changes in Large Yellow Croaker (Larimichthys crocea) [J]. | Food Frontiers , 2025 , 6 (1) : 248-258 . |
| MLA | Shao, Jianchun et al. "Soybean Glycinin Reduced Growth Performance and Antioxidant Capacity and Caused Intestinal Inflammation and Microbiome Changes in Large Yellow Croaker (Larimichthys crocea)" . | Food Frontiers 6 . 1 (2025) : 248-258 . |
| APA | Shao, Jianchun , Li, Zhangqi , You, Haokun , Wang, Dejuan , Zhang, Jiaonan , Wang, Lei et al. Soybean Glycinin Reduced Growth Performance and Antioxidant Capacity and Caused Intestinal Inflammation and Microbiome Changes in Large Yellow Croaker (Larimichthys crocea) . | Food Frontiers , 2025 , 6 (1) , 248-258 . |
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Research on finding alternative protein sources to replace fishmeal (FM) has become a central issue in the nutrition field. Extensive research has been carried out on the replacement of FM with soybean meal (SBM); however, little is known about the replacement of FM with enzyme-treated SBM (ESBM). In this study, five isolipidic and isonitrogenous diets were formulated by substituting FM with ESBM at the levels of 0% (FM, control diet), 5% (ESBM25), 10% (ESBM50), and 15% (ESBM75) which were fed to juvenile shrimp for 8 weeks. And we found that replacing FM with ESBM at 5%-10% levels in shrimp diets had no impact on shrimp growth performance and feed utilization. However, substituting 10% ESBM for FM in the shrimp diets promoted the expression of growth-related genes and maintained consistent intestinal microbiota compared to the control group. Replacing FM with 15% ESBM in the shrimp diets inhibited shrimp growth, suppressed mTOR gene expression, and promoted the proliferation of harmful intestinal bacteria. Furthermore, replacing FM with different ESBM did not affect the intestinal health of shrimp. Taken together, our research provides that replacing FM with 10% ESBM is feasible. These findings not only enrich our knowledge of FM proteinogen replacement but also provide a reference for the use of ESBM as a substitute for FM in commercial feeds for shrimp Penaeus vannamei as well as other shrimp species.
Keyword ：
enzyme-treated soybean meal enzyme-treated soybean meal fishmeal fishmeal Penaeus vannamei Penaeus vannamei replacement replacement
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| GB/T 7714 | Shao, Jianchun , Zheng, Qingyin , Chen, Zhengbang et al. Enzyme-Treated Soybean Meal Serves as an Effective Alternative to Fishmeal in the Diet of the Shrimp Penaeus vannamei [J]. | AQUACULTURE NUTRITION , 2025 , 2025 (1) . |
| MLA | Shao, Jianchun et al. "Enzyme-Treated Soybean Meal Serves as an Effective Alternative to Fishmeal in the Diet of the Shrimp Penaeus vannamei" . | AQUACULTURE NUTRITION 2025 . 1 (2025) . |
| APA | Shao, Jianchun , Zheng, Qingyin , Chen, Zhengbang , Zhu, Wenbo , Ren, Qiulei , Yuan, Kai et al. Enzyme-Treated Soybean Meal Serves as an Effective Alternative to Fishmeal in the Diet of the Shrimp Penaeus vannamei . | AQUACULTURE NUTRITION , 2025 , 2025 (1) . |
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The aquaculture industry relies heavily on fishmeal as the primary protein source in aquafeeds. However, the increasing demand and limited availability of wild fish resources have led to a significant increase in fishmeal prices, posing a major challenge for the industry. Microbially fermented animal, plant, and single-cell proteins have emerged as potential alternative protein sources that offer a balanced nutritional profile at a lower cost. This review provides a comprehensive overview of the recent advancements in the utilization of fermented feed ingredients in aquaculture. This article focuses on research progress made in understanding the effects of fermented ingridient on nutrient absorption, growth performance, immune response of intestinal epithelial tissue, maintenance of intestinal microbial barriers, and impact on water quality in aquaculture systems. The two main types of fermentation processes, solid-state and liquid fermentation, are discussed along with their advantages and challenges. Factors affecting the quality of fermented ingredients, such as the type of microorganisms used, fermentation conditions, and substrate composition, were also explored. This review proposes strategies to promote and implement the use of microbial fermented ingredients in aquaculture practices, with the aim of developing a sustainable and cost-effective solution for aquafeed. The adoption of fermented feed ingredients has the potential to enhance the sustainability and profitability of the aquaculture industry, while meeting the growing global demand for aquatic products.
Keyword ：
Fermented ingredients Fermented ingredients Fishmeal Fishmeal Microorganism Microorganism Nutritional immunity Nutritional immunity Sustainable aquaculture Sustainable aquaculture
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| GB/T 7714 | Li, Bin , Boukhennou, Abir , Shao, Jianchun et al. Application status and development prospect of fermented ingredients in aquaculture [J]. | AQUACULTURE REPORTS , 2025 , 42 . |
| MLA | Li, Bin et al. "Application status and development prospect of fermented ingredients in aquaculture" . | AQUACULTURE REPORTS 42 (2025) . |
| APA | Li, Bin , Boukhennou, Abir , Shao, Jianchun , Miao, Liang , Du, Yang , Chen, Jiong . Application status and development prospect of fermented ingredients in aquaculture . | AQUACULTURE REPORTS , 2025 , 42 . |
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The present feeding study was carried out on Larimichthys crocea, with an initial weight of 18.36 +/- 1.72 g, to assess the effects of substituting fish meal (FM) with meat and bone meal (MBM) on various factors, such as growth, intestinal morphology and microbiota, protein metabolism, and antioxidant ability. The five diets were created with varying percentages of FM replaced by MBM: 0% (MBM0), 25% (MBM25), 50% (MBM50), 75% (MBM75), and completely without FM (MBM100). The results exhibited that replacing 50% of dietary FM with MBM had no significant impact on fish growth or feed efficiency. An examination of intestinal morphology indicated notable reductions in villus width (VW), villus height (VH), and muscle thickness (MT) in the MBM75 and MBM100 groups. The MBM75 and MBM100 diets significantly reduced the activity levels of amylase (AMS), lipase (LPS), catalase (CAT), total superoxide dismutase (T-SOD), and total antioxidant capacity (T-AOC), while concurrently elevating the malondialdehyde (MDA) content considerably. 16S rRNA sequencing indicated that the MBM75 and MBM100 diets led to an elevation in the proportion of Proteobacteria and a reduction in the proportion of Firmicutes. Furthermore, immunoblotting analysis showed that in the muscle tissue, the MBM75 and MBM100 diets caused a notable reduction in the protein levels of 4E-BP1 (Thr37/46) and mTOR (Ser2448). Broken-line analysis revealed that the optimal substitution levels of meat and bone meal for fish meal were 40.60%, 50.00%, 42.08%, and 50.00% based on weight gain (WG), specific growth rate (SGR), feed conversion rate (FCR), and protein efficiency ratio (PER), respectively.
Keyword ：
Growth performance Growth performance Intestinal morphology Intestinal morphology Larimichthys crocea Larimichthys crocea Meat and bone meal Meat and bone meal Protein metabolism Protein metabolism
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| GB/T 7714 | Zhang, Dianguang , Li, Zhangqi , Liu, Qianqian et al. Fish meal substitution by meat and bone meal in large yellow croaker Larimichthys crocea diet: integrated insights on growth performance, intestinal morphology and microflora, antioxidant capacity, and protein metabolism [J]. | AQUACULTURE INTERNATIONAL , 2025 , 33 (5) . |
| MLA | Zhang, Dianguang et al. "Fish meal substitution by meat and bone meal in large yellow croaker Larimichthys crocea diet: integrated insights on growth performance, intestinal morphology and microflora, antioxidant capacity, and protein metabolism" . | AQUACULTURE INTERNATIONAL 33 . 5 (2025) . |
| APA | Zhang, Dianguang , Li, Zhangqi , Liu, Qianqian , Chen, Zhengbang , Shao, Jianchun , Chen, Xinhua . Fish meal substitution by meat and bone meal in large yellow croaker Larimichthys crocea diet: integrated insights on growth performance, intestinal morphology and microflora, antioxidant capacity, and protein metabolism . | AQUACULTURE INTERNATIONAL , 2025 , 33 (5) . |
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