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学者姓名：赵超
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本发明提供了一种ATP5F1A及其同源基因作为调控糖代谢治疗靶点及浒苔寡糖的应用。本发明提出以ATP5F1A蛋白或其编码基因或转录产物作为高糖高脂饮食导致的2型糖尿病的生物标记物及治疗靶点，通过调控ATP5F1A蛋白的表达水平和/或巴豆酰化修饰水平，可起到缓解糖尿病作用。针对该靶点，本发明还开发了一种浒苔寡糖药物，可以针对性地提高ATP5F1A蛋白的表达量及其巴豆酰化修饰水平，并改善糖代谢，为2型糖尿病及其相关代谢疾病提供了一种新的治疗策略。
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| GB/T 7714 | 赵超 , 张丽珠 , 文愉熙 et al. ATP5F1A及其同源基因作为调控糖代谢治疗靶点及浒苔寡糖的应用 : CN202510572562.1[P]. | 2025-05-06 . |
| MLA | 赵超 et al. "ATP5F1A及其同源基因作为调控糖代谢治疗靶点及浒苔寡糖的应用" : CN202510572562.1. | 2025-05-06 . |
| APA | 赵超 , 张丽珠 , 文愉熙 , 吴雪 , 姚井月 , 郭俞辛 . ATP5F1A及其同源基因作为调控糖代谢治疗靶点及浒苔寡糖的应用 : CN202510572562.1. | 2025-05-06 . |
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本发明提供了一种用于合成乳酰‑N‑岩藻五糖I的无质粒基因工程菌及其构建方法与在抗EV71病毒中的应用。本发明从微生物中筛选出了一种来源于Rhodobacter sp.CACIA14H1的α‑1,2‑岩藻糖基转移酶(NCBI号为ESW60479.1)，命名为Rh2FT，α‑1,2‑岩藻糖基转移酶Rh2FT可用于合成LNFPⅠ，其氨基酸序列如SEQ ID NO.1所示，丰富了目前能实现乳酰‑N‑岩藻五糖I生物合成的酶的数量；此外，本发明还提供了一种重组工程菌株，该重组菌可通过无质粒无抗生素合成的方式高效转化乳糖生产LNFPⅠ；同时，所产出的LNFPⅠ在抑制EV71病毒侵染过程中发挥重要作用。
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| GB/T 7714 | 赵超 , 陈郑昕 , 刘璟谊 et al. 用于合成乳酰-N-岩藻五糖I的无质粒基因工程菌及其构建方法与在抗EV71病毒中的应用 : CN202510477203.8[P]. | 2025-04-16 . |
| MLA | 赵超 et al. "用于合成乳酰-N-岩藻五糖I的无质粒基因工程菌及其构建方法与在抗EV71病毒中的应用" : CN202510477203.8. | 2025-04-16 . |
| APA | 赵超 , 陈郑昕 , 刘璟谊 , 林祎楠 , 李思璐 , 何美佳 . 用于合成乳酰-N-岩藻五糖I的无质粒基因工程菌及其构建方法与在抗EV71病毒中的应用 : CN202510477203.8. | 2025-04-16 . |
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在海洋强国的背景下，各大高校相继开设海洋科学相关的专业。福建农林大学于2021年11月整合涉海领域的优势资源和团队，成立了海洋学院。学院根据相关专业国家标准，结合学校办学条件建立了海洋学院教学实验中心。实验中心的建成，为海洋、水产相关专业实践教学提供了必要条件，为学生科研活动、创新创业提供了重要的物质保障。本文介绍了海洋学院实验室建设背景、建设内容、实验室运行成效等方面的相关内容，旨在为更多海洋、水产类学科实验室、实践平台的规划与建设提供参考资料。
Keyword ：
实践教学 实践教学 实验室建设 实验室建设 水产养殖 水产养殖 海洋科学 海洋科学
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| GB/T 7714 | 李林明 , 何亮华 , 赵超 . 海洋、水产类教学实验室建设——以福建农林大学为例 [J]. | 河北渔业 , 2025 , 3 (04) : 38-40 . |
| MLA | 李林明 et al. "海洋、水产类教学实验室建设——以福建农林大学为例" . | 河北渔业 3 . 04 (2025) : 38-40 . |
| APA | 李林明 , 何亮华 , 赵超 . 海洋、水产类教学实验室建设——以福建农林大学为例 . | 河北渔业 , 2025 , 3 (04) , 38-40 . |
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The main goal of this study is to improve the bioactivity of citrus pomace by subjecting it to solid-state fermentation by Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus plantarum over varying periods of time. The viability of Lactobacillus, as well as the total phenolic content (TPC) and total antioxidant capacity (TAC) values of orange pomace (OP), varied depending on the Lactobacillus species and fermentation period. The incorporation of pomace into orange juice samples at a ratio of 5% considerably enhanced the viability of probiotics. The TPC and TAC of orange juice samples were reduced after fermentation. The addition of orange pomace to orange juice significantly increased prostaglandin H2 and improved antioxidant capacity with more pronounced effects at increased pomace concentrations. After postfermentation with L. plantarum, key bioactive compounds such as corynoxeine and phenolics were upregulated, while picroside III and allocryptopine levels were decreased. On the other hand, metabolomics analysis revealed significant changes after fermentation in amino acid, sphingolipid, and fatty acid metabolism and the synthesis of secondary metabolites improving the nutritional profile and bioactivity of fermented orange juice. These findings highlight the potential of pomace addition and fermentation to improve the health benefits and quality of orange juice products. Therefore, the combined use of fermentation and fortification with OP could be a promising approach to creating new functional foods and promoting the use of edible food waste and byproducts.
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| GB/T 7714 | Dikmetas, Dilara Nur , Nemli, Elifsu , Karbancioglu-Guler, Funda et al. Lactic Acid Bacterial Culture Selection for Orange Pomace Fermentation and Its Potential Use in Functional Orange Juice [J]. | ACS OMEGA , 2025 , 10 (11) : 11038-11053 . |
| MLA | Dikmetas, Dilara Nur et al. "Lactic Acid Bacterial Culture Selection for Orange Pomace Fermentation and Its Potential Use in Functional Orange Juice" . | ACS OMEGA 10 . 11 (2025) : 11038-11053 . |
| APA | Dikmetas, Dilara Nur , Nemli, Elifsu , Karbancioglu-Guler, Funda , Apak, Resat , Bener, Mustafa , Zhang, Wenbo et al. Lactic Acid Bacterial Culture Selection for Orange Pomace Fermentation and Its Potential Use in Functional Orange Juice . | ACS OMEGA , 2025 , 10 (11) , 11038-11053 . |
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Phycoerythrin (PE) is a naturally occurring plant protein of algal origin. The colour, bioactivity and stability of PE are inextricably linked to its structure. PE has powerful antioxidant properties that effectively prevent oxidative stress and cellular damage, for which the chromophore structure plays a key role. However, the relationship between the chromophore and thermal stability is unclear in PE. The environmental factors affecting the thermal stability of PE are mainly light, high temperature and extreme pH. PE stability can be enhanced through various techniques, including the incorporation of additives, cross-linking processes, and the formation of complexes. Improving the stability of PE is of significant importance for its applications within the food industry. This paper outlines the structural characteristics of PE, discusses the relationship between its structure and antioxidant activity, and focuses on the application of PE in the food industry, as well as the factors affecting its stability and strategies for its improvement.
Keyword ：
Antioxidants Antioxidants Chromophore Chromophore Food application Food application Phycoerythrin Phycoerythrin Structure stability Structure stability
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| GB/T 7714 | Wen, Yuxi , Shan, Shuo , Ye, Fangting et al. Prospects of phycoerythrin: Structural features, antioxidation and in food [J]. | FOOD CHEMISTRY , 2025 , 463 . |
| MLA | Wen, Yuxi et al. "Prospects of phycoerythrin: Structural features, antioxidation and in food" . | FOOD CHEMISTRY 463 (2025) . |
| APA | Wen, Yuxi , Shan, Shuo , Ye, Fangting , Liao, Wei , Wu, Xue , Chen, Weichao et al. Prospects of phycoerythrin: Structural features, antioxidation and in food . | FOOD CHEMISTRY , 2025 , 463 . |
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Background: Polysaccharides from algae provide a range of biology and health benefits. Lately, there has been a significant interest in how algal polysaccharides affect the immune microenvironment around tumors. Purpose: To elucidate the subtle interactions between algal polysaccharides and the tumor immune microenvironment to further understand the medicinal potential of algal polysaccharides. Study design: To give a summary of the sources, bioactivities and characteristics of the tumor immune microenvironment of algal polysaccharides, and to analyze alteration of the immunological milieu surrounding tumors by algal polysaccharides and their potential as immunomodulators of chemotherapeutic agents. Methods: Search popular academic search engines using selected keywords for articles ending before September 2024 using selected keywords Google Scholar, PubMed, ScienceDirect, Scopus, Web of Science, Springer, and official websites. Results: Algal polysaccharides can fight tumors by changing how immune cells work and affecting inflammation in different ways. Moreover, algal polysaccharides have shown promise in mitigating the adverse effects associated with conventional cancer treatments, such as chemotherapy. Algal polysaccharides, through their immunomodulatory effects, can alleviate some of these side effects, leading to an enhanced overall treatment outcome. Conclusion: As research continues to uncover the underlying mechanisms of their antitumor effects, algal polysaccharides are poised to become a vital component in the development of novel cancer treatments, providing new hope for patients and advancing the field of oncology.
Keyword ：
Algal polysaccharides Algal polysaccharides Immune cells Immune cells Inflammatory responses Inflammatory responses Tumor immune microenvironment Tumor immune microenvironment
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| GB/T 7714 | Wu, Yinfeng , Jia, Nan , Sun, Jingyu et al. The roles of algal polysaccharides in modulating tumor immune microenvironment [J]. | PHYTOMEDICINE , 2025 , 140 . |
| MLA | Wu, Yinfeng et al. "The roles of algal polysaccharides in modulating tumor immune microenvironment" . | PHYTOMEDICINE 140 (2025) . |
| APA | Wu, Yinfeng , Jia, Nan , Sun, Jingyu , Liao, Wei , Xu, Jingxiang , Chen, Weichao et al. The roles of algal polysaccharides in modulating tumor immune microenvironment . | PHYTOMEDICINE , 2025 , 140 . |
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Moringa oleifera Lam., a perennial species of the Moringaceae family, is esteemed for its multifaceted nutritional, medicinal, and economic properties. M. oleifera leaves are abundant in bioactive compounds with potential health benefits, yet existing structural and functional studies of these bioactives remain insufficiently comprehensive. This study aimed to isolate the active compound from M. oleifera leaves and investigate its mechanism of inhibiting lipid absorption and its potential as a pancreatic lipase inhibitor. In the present study, octacosanol (OCT) was isolated and purified from M. oleifera leaves, demonstrating notable pancreatic lipase inhibitory activity with an IC50 of 7.87 +/- 0.72 mu g/mL, and effectively suppressing lipid uptake in HepG2 cells. Simulated digestion assays indicated that OCT retained 73.5% of its pancreatic lipase inhibitory activity, with a recorded inhibition rate of 63.62%. Molecular docking analyses revealed that OCT binds to pancreatic lipase with an affinity comparable to orlistat and stronger than that of 4-nitrophenyl palmitate. The binding of OCT to key active sites (Ser152, His263, and Asp176) likely disrupts the enzyme's conformation, decreasing its substrate affinity. Additionally, OCT significantly attenuated lipid absorption and the synthesis of total cholesterol and triglycerides. This study elucidates the lipid-lowering mechanism of OCT and provides a theoretical foundation for its potential application in food production and biomedicine.
Keyword ：
enzyme kinetics enzyme kinetics LC-MS LC-MS moleculardocking moleculardocking Moringa oleifera Moringa oleifera NMR NMR octacosanol octacosanol pancreatic lipase pancreatic lipase
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| GB/T 7714 | Dong, Xiaoying , Wen, Yuxi , Nie, Qing et al. Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (12) : 7202-7210 . |
| MLA | Dong, Xiaoying et al. "Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73 . 12 (2025) : 7202-7210 . |
| APA | Dong, Xiaoying , Wen, Yuxi , Nie, Qing , Shan, Shuo , Zhao, Runfan , El-Seedi, Hesham R. et al. Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (12) , 7202-7210 . |
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Animal proteins are the primary global protein source, but their production is environmentally challenging and has low conversion efficiency. This highlights the need to diversify dietary protein sources. Algal proteins provide a sustainable alternative, outperforming traditional plant and animal proteins in protein content, quality, and digestibility. Furthermore, bioactive peptides (BAPs) derived from algal proteins exhibit significant health benefits, including antihypertensive, antioxidant, antimicrobial, anticancer, and antidiabetic activities. This review comprehensively explores the nutritional benefits of algal proteins and provides an innovative summary of the production techniques for algal bioactive peptides. It also highlights the synergistic application methods of these technologies. By integrating pretreatment methods such as ultrasound-assisted extraction, pulsed electric field, and high hydrostatic pressure with enzymatic-assisted extraction, these techniques demonstrate a synergistic effect in improving protein hydrolysis efficiency while also increasing the yield of BAPs. Meanwhile, database resources related to algal proteins are integrated and the application of computer technology in the development of algal proteins is analyzed. It aims to provide new insights to optimize the development and utilization of algal proteins to help them become a sustainable source of nutrition to meet the needs of a growing global population.
Keyword ：
Algal proteins Algal proteins Bioactive peptides Bioactive peptides Bioavailability Bioavailability Nutritional functions Nutritional functions Production techniques Production techniques
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| GB/T 7714 | Meng, Tianzeng , Wen, Jiahui , Liu, Hanqi et al. Algal proteins and bioactive peptides: Sustainable nutrition for human health [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 303 . |
| MLA | Meng, Tianzeng et al. "Algal proteins and bioactive peptides: Sustainable nutrition for human health" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 303 (2025) . |
| APA | Meng, Tianzeng , Wen, Jiahui , Liu, Hanqi , Guo, Yuxin , Tong, Aijun , Chu, Yaoyao et al. Algal proteins and bioactive peptides: Sustainable nutrition for human health . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 303 . |
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Glycinin, a major anti-nutrient in soybean meal, may trigger enteritis and oxidative stress in fish with overconsumption. However, its impact on intestinal inflammation and underlying signaling mechanisms in Larimichthys crocea remains unclear. The purpose of this study was to assess the effects of glycinin on growth, antioxidant function, inflammatory response, and gut microbiota. Four isonitrogenous and isolipidic experimental feeds were prepared, supplemented with 0%(G0), 3%(G3), 6%(G6), and 12%(G12) glycinin, respectively, and fed to juvenile L. crocea for 10 weeks. The findings indicated that dietary glycinin markedly decreased the growth, feed utilization, and survival rate of L. crocea. In addition, L. crocea fed with G6 and G12 diets showed lower trypsin activity compared with those fed with G0 and G3 diets. Similarly, fish fed with G6 and G12 diets showed higher malondialdehyde content and lower superoxide dismutase activity in the liver compared with those fed with G0 and G3 diets, suggesting that glycinin induced oxidative stress and led to the imbalance of the antioxidant system. Dietary glycinin significantly increased the mRNA expression levels of toll-like receptors in the gut. Moreover, dietary glycinin resulted in a heightened expression of both C-rel and p65 proteins, while also elevating the phosphorylation levels of JNK and ERK proteins, indicating that glycinin activated the MAPK/NF-κB signaling route. In addition, dietary glycinin increased the abundance of pathogenic bacteria in the gut, including Bacteroides and Streptococcus, and reduced the Bifidobacterium abundance. The findings suggested that L. crocea is highly sensitive to glycinin, and a 3% level can cause growth decline and enteritis. © 2024 The Author(s). Food Frontiers published by Nanchang University, Northwest University, Jiangsu University, Fujian Agriculture and Forestry University, International Association of Dietetic Nutrition and Safety and John Wiley & Sons Australia, Ltd.
Keyword ：
Fish Fish Medicinal chemistry Medicinal chemistry Pathology Pathology Superoxide dismutase Superoxide dismutase
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| GB/T 7714 | Shao, Jianchun , Li, Zhangqi , You, Haokun et al. Soybean Glycinin Reduced Growth Performance and Antioxidant Capacity and Caused Intestinal Inflammation and Microbiome Changes in Large Yellow Croaker (Larimichthys crocea) [J]. | Food Frontiers , 2025 , 6 (1) : 248-258 . |
| MLA | Shao, Jianchun et al. "Soybean Glycinin Reduced Growth Performance and Antioxidant Capacity and Caused Intestinal Inflammation and Microbiome Changes in Large Yellow Croaker (Larimichthys crocea)" . | Food Frontiers 6 . 1 (2025) : 248-258 . |
| APA | Shao, Jianchun , Li, Zhangqi , You, Haokun , Wang, Dejuan , Zhang, Jiaonan , Wang, Lei et al. Soybean Glycinin Reduced Growth Performance and Antioxidant Capacity and Caused Intestinal Inflammation and Microbiome Changes in Large Yellow Croaker (Larimichthys crocea) . | Food Frontiers , 2025 , 6 (1) , 248-258 . |
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LED visible light irradiation demonstrates significant potential for suppressing postharvest pathogens, yet the antifungal efficacy and underlying mechanisms of white light spectrum remain poorly understood. This study systematically evaluated the inhibitory effects of two white LED irradiation intensities (40 and 120 mu mol m_ 2 s_ 1) against Penicillium expansum through in vitro and in vivo trials, with darkness as the control, while elucidating the mechanistic basis via transcriptomic profiling. In vitro experiments revealed that white LED irradiation effectively suppressed fungal growth and induced substantial disruption of cell membrane integrity. In vivo applications demonstrated that 120 mu mol m_ 2 s_ 1 irradiation significantly attenuated P. expansum pathogenicity on apple fruits while maintaining optimal fruit quality parameters. Transcriptomic analysis identified irradiation-induced dysregulation of key metabolic pathways, including carbohydrate and lipid metabolism, coupled with impaired cell membrane functionality of P. expansum. We propose a tripartite inhibitory mechanism involving the suppression of energy supply, structural destabilization of cellular membranes, and reduction of virulence factor secretion in P. expansum exposed to 120 mu mol m_ 2 s_ 1 white LED irradiation. These findings elucidated the effect and mechanism of white light irradiation in inhibiting the growth of P. expansum, demonstrating white LED's potential as an eco-friendly, cost-effective preservation strategy for postharvest apple management.
Keyword ：
Antifungal efficacy Antifungal efficacy Apple postharvest blue mold Apple postharvest blue mold Penicillium expansum Penicillium expansum Physical approach Physical approach Transcriptome sequencing Transcriptome sequencing White LED light White LED light
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| GB/T 7714 | Cai, Yiliang , Shan, Jingjing , Mao, Xinyu et al. Transcriptomic investigation reveals a potential mechanism of white LED irradiation inhibiting the growth and pathogenicity of the blue mold pathogen Penicillium expansum [J]. | FOOD MICROBIOLOGY , 2025 , 132 . |
| MLA | Cai, Yiliang et al. "Transcriptomic investigation reveals a potential mechanism of white LED irradiation inhibiting the growth and pathogenicity of the blue mold pathogen Penicillium expansum" . | FOOD MICROBIOLOGY 132 (2025) . |
| APA | Cai, Yiliang , Shan, Jingjing , Mao, Xinyu , Zhang, Zihan , Hong, Wei , Wang, Weilun et al. Transcriptomic investigation reveals a potential mechanism of white LED irradiation inhibiting the growth and pathogenicity of the blue mold pathogen Penicillium expansum . | FOOD MICROBIOLOGY , 2025 , 132 . |
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