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学者姓名：赵超
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Abstract ：
Background: Protein glycosylation as a common post-translational modification that has significant impacts on protein folding, enzymatic activity, and interfering with receptor functioning. In recent years, with the rapid development of glycopeptide enrichment and analysis technology and the deepening of glycosylation research, glycosylation has gradually become a sign of disease occurrence and development. Multiple investigations suggest that protein glycosylation affect the advances of diabetes and aging. Purpose and Methods: This review was focused on the action mechanisms of glycosylated proteins production, permanent abnormalities in extracellular matrix component function, inflammatory and reactive oxygen species production, as well as the glycosylated characterizations of diabetes and aging. Further, advances in glycosylation analysis and detection methods are presented for the first time, highlighting for needed future developments. All literatures were gathered from PubMed and Google Scholar. Results: Herein, we review how protein glycosylation impacts the progression of diabetes and aging. Specifically, we focus on various types of glycosylation, including N-linked glycosylation, O-linked glycosylation, C-glycosylation, S-glycosylation, and glycophosphatidylinositol (GPI) anchors. N-linked glycosylation and O-linked glycosylation are commonly observed glycosylation forms, wherein O-GlcNAcylation plays a significant role in diabetes, while N-glycan could serve as biomarkers for identifying inflammation and aging. Conclusions: Protein glycosylation produces a vastly larger number of core glycan structures through utilizing at least 173 glycosyltransferases and repeated common scaffolds. Single protein may contain multiple glycosylation sites, and the structure and occupancy of glycan at each site may be different, resulting in the macro heterogeneity of protein glycosylation. This review will contribute to how protein glycosylation impacts the life progress of cells and its association with diseases.
Keyword ：
Aging Aging Diabetes mellitus Diabetes mellitus N-glycosylation N-glycosylation O-glycosylation O-glycosylation Phytochemicals Phytochemicals
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| GB/T 7714 | Chen, Yihan , Lu, Suyue , Shan, Shuo et al. New insights into phytochemicals via protein glycosylation focused on aging and diabetes [J]. | PHYTOMEDICINE , 2025 , 141 . |
| MLA | Chen, Yihan et al. "New insights into phytochemicals via protein glycosylation focused on aging and diabetes" . | PHYTOMEDICINE 141 (2025) . |
| APA | Chen, Yihan , Lu, Suyue , Shan, Shuo , Wu, Weihao , He, Xinxin , Farag, Mohamed A. et al. New insights into phytochemicals via protein glycosylation focused on aging and diabetes . | PHYTOMEDICINE , 2025 , 141 . |
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Marine polysaccharides, particularly those derived from red, brown, and green algae, have shown promising antiviral activity. Among them, sulfated polysaccharides are particularly notable due to their broad-spectrum antiviral properties. These include direct viral destruction, inhibition of virus adsorption, disruption of viral transcription and replication, and the stimulation of the host's antiviral immunity. With low toxicity, minimal drug resistance, and excellent biocompatibility, these polysaccharides represent promising candidates for the development of antiviral medications. For instance, carrageenan, a polysaccharide from red algae, and fucoidan, a polymer from brown algae, have both been proven to effectively inhibit viral infections. Sulfated polysaccharides from green algae, such as those found in Ulva species, also exhibit antiviral properties, including activity against the Japanese encephalitis virus. These polysaccharides function by blocking the attachment of viruses to host cells or interfering with various stages of the viral life cycle. Moreover, marine polysaccharides have been shown to enhance host immune responses, thereby aiding in viral clearance. Although these findings highlight the antiviral potential of marine polysaccharides, most studies have been conducted in vitro or in animal models. Further clinical trials are necessary to validate their effectiveness and safety for therapeutic use.
Keyword ：
algae algae antiviral mechanisms antiviral mechanisms marine polysaccharides marine polysaccharides sulfated polysaccharides sulfated polysaccharides virus virus
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| GB/T 7714 | Dong, Xiaoying , Qiu, Yusong , Jia, Nan et al. Recent advances of edible marine algae-derived sulfated polysaccharides in antiviral treatments: challenges vs. opportunities [J]. | FRONTIERS IN NUTRITION , 2025 , 12 . |
| MLA | Dong, Xiaoying et al. "Recent advances of edible marine algae-derived sulfated polysaccharides in antiviral treatments: challenges vs. opportunities" . | FRONTIERS IN NUTRITION 12 (2025) . |
| APA | Dong, Xiaoying , Qiu, Yusong , Jia, Nan , Wu, Yinfeng , Nie, Qing , Wen, Jiahui et al. Recent advances of edible marine algae-derived sulfated polysaccharides in antiviral treatments: challenges vs. opportunities . | FRONTIERS IN NUTRITION , 2025 , 12 . |
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Fish is rich in protein and is an ideal raw material for the preparation of bioactive peptides. This study effectively identified 21 bioactive peptides from Larimichthys crocea protein using a combination of bioinformatics and in vitro evaluation. Molecular docking and molecular dynamics simulations (MD) showed that six of the peptides could strongly bind to the active center of thrombin through hydrogen bonding and hydrophobic interactions (binding energies are -7.2 to -8.5 kcal/mol), thereby displaying significant anticoagulant potential. These peptides were further demonstrated to have significant anticoagulant activity in vitro experiments with half-maximal inhibitory concentration (IC50) ranging from 0.47 +/- 0.14 to 9.33 +/- 0.12 mM. The activity may be closely related to the beta-sheet and random coil conformations they contains. Furthermore, molecular docking with coagulation factors also revealed that these peptides might precisely regulate the intrinsic coagulation pathway by prolonging the activated partial thromboplastin time (APTT) by 2-3 times (p < 0.05) through blocking Factor IXa (FIXa) activity. This work provides new strategies for the anticoagulant evaluation and inhibitory mechanism of food-derived bioactive peptides.
Keyword ：
Anticoagulant peptide Anticoagulant peptide Coagulation factor Coagulation factor Larimichthys crocea Larimichthys crocea Molecular docking Molecular docking Molecular dynamics Molecular dynamics Thrombin Thrombin
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| GB/T 7714 | Yang, Zhizhi , Xu, Hui , Wang, Changrong et al. Discovery and mechanism of novel anticoagulant peptides from Larimichthys crocea based on in silico, molecular docking, molecular dynamics, and in vitro analysis [J]. | FOOD RESEARCH INTERNATIONAL , 2025 , 213 . |
| MLA | Yang, Zhizhi et al. "Discovery and mechanism of novel anticoagulant peptides from Larimichthys crocea based on in silico, molecular docking, molecular dynamics, and in vitro analysis" . | FOOD RESEARCH INTERNATIONAL 213 (2025) . |
| APA | Yang, Zhizhi , Xu, Hui , Wang, Changrong , Liu, Zhiyu , Chen, Yihui , Zhao, Chao et al. Discovery and mechanism of novel anticoagulant peptides from Larimichthys crocea based on in silico, molecular docking, molecular dynamics, and in vitro analysis . | FOOD RESEARCH INTERNATIONAL , 2025 , 213 . |
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The main goal of this study is to improve the bioactivity of citrus pomace by subjecting it to solid-state fermentation by Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus plantarum over varying periods of time. The viability of Lactobacillus, as well as the total phenolic content (TPC) and total antioxidant capacity (TAC) values of orange pomace (OP), varied depending on the Lactobacillus species and fermentation period. The incorporation of pomace into orange juice samples at a ratio of 5% considerably enhanced the viability of probiotics. The TPC and TAC of orange juice samples were reduced after fermentation. The addition of orange pomace to orange juice significantly increased prostaglandin H2 and improved antioxidant capacity with more pronounced effects at increased pomace concentrations. After postfermentation with L. plantarum, key bioactive compounds such as corynoxeine and phenolics were upregulated, while picroside III and allocryptopine levels were decreased. On the other hand, metabolomics analysis revealed significant changes after fermentation in amino acid, sphingolipid, and fatty acid metabolism and the synthesis of secondary metabolites improving the nutritional profile and bioactivity of fermented orange juice. These findings highlight the potential of pomace addition and fermentation to improve the health benefits and quality of orange juice products. Therefore, the combined use of fermentation and fortification with OP could be a promising approach to creating new functional foods and promoting the use of edible food waste and byproducts.
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| GB/T 7714 | Dikmetas, Dilara Nur , Nemli, Elifsu , Karbancioglu-Guler, Funda et al. Lactic Acid Bacterial Culture Selection for Orange Pomace Fermentation and Its Potential Use in Functional Orange Juice [J]. | ACS OMEGA , 2025 , 10 (11) : 11038-11053 . |
| MLA | Dikmetas, Dilara Nur et al. "Lactic Acid Bacterial Culture Selection for Orange Pomace Fermentation and Its Potential Use in Functional Orange Juice" . | ACS OMEGA 10 . 11 (2025) : 11038-11053 . |
| APA | Dikmetas, Dilara Nur , Nemli, Elifsu , Karbancioglu-Guler, Funda , Apak, Resat , Bener, Mustafa , Zhang, Wenbo et al. Lactic Acid Bacterial Culture Selection for Orange Pomace Fermentation and Its Potential Use in Functional Orange Juice . | ACS OMEGA , 2025 , 10 (11) , 11038-11053 . |
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Ocean acidification (OA) and seawater salinity are two major environmental factors that influence the growth and distribution of macroalgae in coastal ecosystems. To investigate the effects of OA and salinity on the invasive macroalga Codium fragile, the growth, Chlorophyll a fluorescence, and biochemical compositions (pigment and soluble carbohydrate contents, the superoxide dismutase (SOD) activity, and malondialdehyde (MDA) contents) were studied after exposure to two pCO2 levels (400 ppmv, LC; and 1000 ppmv, HC) and four salinity regimes (high salinity, 40 psu; control salinity, 30 psu; medium salinity, 20 psu; low salinity, 10 psu). The results showed that, except for SOD activity at 20 psu, the growth, maximum and effective quantum yield of PSII, and maximum relative electron transport, pigment and soluble carbohydrate contents, SOD activity, and the MDA content were adversely impacted by both hypo- and hypersaline under LC conditions. Similarly, under HC conditions, the growth, photosynthetic physiology and biochemistry were negatively impacted by low salinity, while high salinity enhanced pigment contents and chlorophyll fluorescence parameters but inhibited SOD activity and MDA contents. Furthermore, higher pCO2 significantly promoted growth, pigment contents, and photosynthetic performance at 20 and 40 psu, while it amplified the depression in growth at 10 psu. These findings suggest that OA may enhance the potential invasive ability and salinity tolerance of C. fragile under medium hyposaline and hypersaline conditions by alleviating the negative effects of salinity stress on growth, photosynthesis, and pigments synthesis. However, it may also synergistically reduce algal growth at further reduced salinity. These data collected herein are valuable for understanding C. fragile cultivation and predicting its future distribution in response to changing ocean conditions.
Keyword ：
Codium fragile Codium fragile Growth Growth Invasive macroalgae Invasive macroalgae Ocean acidification Ocean acidification Photosynthetic physiology Photosynthetic physiology Salinity Salinity
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| GB/T 7714 | Chu, Yaoyao , Shi, Yunyun , Xue, Yuning et al. Salinity-dependent effects of seawater acidification on growth, photosynthetic physiology and biochemistry of the invasive macroalga Codium fragile [J]. | ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS , 2025 , 88 . |
| MLA | Chu, Yaoyao et al. "Salinity-dependent effects of seawater acidification on growth, photosynthetic physiology and biochemistry of the invasive macroalga Codium fragile" . | ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 88 (2025) . |
| APA | Chu, Yaoyao , Shi, Yunyun , Xue, Yuning , He, Lianghua , Li, Xiaodong , Shi, Xiangzhu et al. Salinity-dependent effects of seawater acidification on growth, photosynthetic physiology and biochemistry of the invasive macroalga Codium fragile . | ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS , 2025 , 88 . |
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Moringa oleifera Lam., a perennial species of the Moringaceae family, is esteemed for its multifaceted nutritional, medicinal, and economic properties. M. oleifera leaves are abundant in bioactive compounds with potential health benefits, yet existing structural and functional studies of these bioactives remain insufficiently comprehensive. This study aimed to isolate the active compound from M. oleifera leaves and investigate its mechanism of inhibiting lipid absorption and its potential as a pancreatic lipase inhibitor. In the present study, octacosanol (OCT) was isolated and purified from M. oleifera leaves, demonstrating notable pancreatic lipase inhibitory activity with an IC50 of 7.87 +/- 0.72 mu g/mL, and effectively suppressing lipid uptake in HepG2 cells. Simulated digestion assays indicated that OCT retained 73.5% of its pancreatic lipase inhibitory activity, with a recorded inhibition rate of 63.62%. Molecular docking analyses revealed that OCT binds to pancreatic lipase with an affinity comparable to orlistat and stronger than that of 4-nitrophenyl palmitate. The binding of OCT to key active sites (Ser152, His263, and Asp176) likely disrupts the enzyme's conformation, decreasing its substrate affinity. Additionally, OCT significantly attenuated lipid absorption and the synthesis of total cholesterol and triglycerides. This study elucidates the lipid-lowering mechanism of OCT and provides a theoretical foundation for its potential application in food production and biomedicine.
Keyword ：
enzyme kinetics enzyme kinetics LC-MS LC-MS moleculardocking moleculardocking Moringa oleifera Moringa oleifera NMR NMR octacosanol octacosanol pancreatic lipase pancreatic lipase
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| GB/T 7714 | Dong, Xiaoying , Wen, Yuxi , Nie, Qing et al. Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (12) : 7202-7210 . |
| MLA | Dong, Xiaoying et al. "Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73 . 12 (2025) : 7202-7210 . |
| APA | Dong, Xiaoying , Wen, Yuxi , Nie, Qing , Shan, Shuo , Zhao, Runfan , El-Seedi, Hesham R. et al. Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (12) , 7202-7210 . |
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Algae, a crucial constituent of marine systems, serve an indispensable function as primary producers, supporting the marine food web, contributing to carbon sequestration, and providing habitats that sustain biodiversity. This review focuses on the bioactive constituents of algae, including polysaccharides, polyphenols, polypeptides, and terpenoid compounds, and discusses their potential applications in treating immune-related diseases, as well as the mechanisms through which they modulate immune responses. The bioactive substances derived from algae, including polyphenols, bioactive peptides, terpenes, polysaccharides and other compounds, may play a preventive role by modulating allergic responses and reducing the incidence of inflammation and cancer.
Keyword ：
Algal bioactive substances Algal bioactive substances allergy allergy cancer cancer immunomodulation immunomodulation inflammation inflammation
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| GB/T 7714 | Jia, Nan , Zhang, Shuangtao , Chen, Ruoxin et al. Immunomodulatory functions of algal bioactive compounds [J]. | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION , 2025 , 65 (30) : 7133-7150 . |
| MLA | Jia, Nan et al. "Immunomodulatory functions of algal bioactive compounds" . | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION 65 . 30 (2025) : 7133-7150 . |
| APA | Jia, Nan , Zhang, Shuangtao , Chen, Ruoxin , He, Xinxin , Dai, Congjie , El-Seedi, Hesham R. et al. Immunomodulatory functions of algal bioactive compounds . | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION , 2025 , 65 (30) , 7133-7150 . |
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Parkinson's disease is a complex neurodegenerative disorder characterized by neuroinflammation, mitochondrial dysfunction, and the accumulation of misfolded proteins such as alpha-synuclein. This review explores the therapeutic potential of tannins, particularly proanthocyanidins and hydrolyzable tannins from grape seeds, in alleviating Parkinson's disease pathology. Condensed tannins exhibit significant antioxidant properties, can cross the blood-brain barrier, reduce oxidative stress, upregulate antioxidant proteins, and prevent neuronal apoptosis. Hydrolyzable tannins, through their unique chemical structure, further help reduce neuroinflammation and improve mitochondrial function. Both types of tannins can modulate inflammatory responses and enhance mitochondrial integrity, addressing key aspects of Parkinson's disease pathogenesis. Tannins possess excellent neuroprotective effects, representing a promising therapeutic approach. However, due to their chemical nature and structural characteristics, the bioavailability of tannins in the human body remains low. Current methods to enhance their bioavailability are limited. Further exploration is needed to improve their bioavailability and strengthen their potential clinical applications. Based on this, new Parkinson's disease treatment strategies can be developed, warranting in-depth research and clinical validation.
Keyword ：
Absorption Absorption Bioavailability Bioavailability Parkinson's disease Parkinson's disease Tannins Tannins Therapeutics Therapeutics
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| GB/T 7714 | Zhao, Runfan , Jia, Nan , Wu, Shuyang et al. Therapeutic potential and limitation of condensed and hydrolyzed tannins in Parkinson's disease [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 307 . |
| MLA | Zhao, Runfan et al. "Therapeutic potential and limitation of condensed and hydrolyzed tannins in Parkinson's disease" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 307 (2025) . |
| APA | Zhao, Runfan , Jia, Nan , Wu, Shuyang , Wen, Jiahui , Huang, Yajun , Zhao, Chao et al. Therapeutic potential and limitation of condensed and hydrolyzed tannins in Parkinson's disease . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 307 . |
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Food-derived peptides with angiotensin-I-converting enzyme inhibitory (ACEI) activity have garnered significant research attention. This study focused on examining ACEI peptides from Porphyra haitanensis and investigating their potential inhibitory mechanisms through a combination of in silico and in vitro methods. Five novel potential ACEI peptides (ASF: Ala-Ser-Phe, EIIL: Glu-Ile-Ile-Leu, LCVPR: Leu-Cys-Val-Pro-Arg, LDVVN: Leu-Asp-Val-ValAsn, and LSPSW: Leu-Ser-Pro-Ser-Trp) were identified through a combination of peptidomics and in silico bioinformatics analysis, of which LSPSW showed the highest activity (IC50: 5.27 +/- 0.53 mu M). After simulated gastrointestinal digestion (SGD), the activities of LCVPR and LSPSW remained almost unchanged. The results from inhibition kinetics and molecular docking demonstrated that ACEI peptides with differing inhibition mechanisms could successfully bind to ACE through hydrogen bonds. Based on network pharmacology analysis and cellular experiments, LSPSW exerted antihypertensive effects by regulating the expression levels of peroxisome proliferator activated receptor gamma (PPARG), prostaglandin-endoperoxide synthase 2 (PTGS2), and renin (REN). This research provided a novel theoretical foundation for the high-value application of P. haitanensis.
Keyword ：
ACE inhibitory peptides ACE inhibitory peptides Inhibition mechanism Inhibition mechanism Molecular docking Molecular docking Network pharmacology Network pharmacology Porphyra haitanensis Porphyra haitanensis QSAR model QSAR model
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| GB/T 7714 | Ye, Xianjiang , Yang, Ran , Yang, Zhizhi et al. Novel angiotensin-I-converting enzyme (ACE) inhibitory peptides from Porphyra haitanensis: Screening, digestion stability, and mechanistic insights [J]. | FOOD BIOSCIENCE , 2025 , 68 . |
| MLA | Ye, Xianjiang et al. "Novel angiotensin-I-converting enzyme (ACE) inhibitory peptides from Porphyra haitanensis: Screening, digestion stability, and mechanistic insights" . | FOOD BIOSCIENCE 68 (2025) . |
| APA | Ye, Xianjiang , Yang, Ran , Yang, Zhizhi , Huang, Baote , Riaz, Talha , Zhao, Chao et al. Novel angiotensin-I-converting enzyme (ACE) inhibitory peptides from Porphyra haitanensis: Screening, digestion stability, and mechanistic insights . | FOOD BIOSCIENCE , 2025 , 68 . |
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Phycoerythrin (PE) is a naturally occurring plant protein of algal origin. The colour, bioactivity and stability of PE are inextricably linked to its structure. PE has powerful antioxidant properties that effectively prevent oxidative stress and cellular damage, for which the chromophore structure plays a key role. However, the relationship between the chromophore and thermal stability is unclear in PE. The environmental factors affecting the thermal stability of PE are mainly light, high temperature and extreme pH. PE stability can be enhanced through various techniques, including the incorporation of additives, cross-linking processes, and the formation of complexes. Improving the stability of PE is of significant importance for its applications within the food industry. This paper outlines the structural characteristics of PE, discusses the relationship between its structure and antioxidant activity, and focuses on the application of PE in the food industry, as well as the factors affecting its stability and strategies for its improvement.
Keyword ：
Antioxidants Antioxidants Chromophore Chromophore Food application Food application Phycoerythrin Phycoerythrin Structure stability Structure stability
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| GB/T 7714 | Wen, Yuxi , Shan, Shuo , Ye, Fangting et al. Prospects of phycoerythrin: Structural features, antioxidation and in food [J]. | FOOD CHEMISTRY , 2025 , 463 . |
| MLA | Wen, Yuxi et al. "Prospects of phycoerythrin: Structural features, antioxidation and in food" . | FOOD CHEMISTRY 463 (2025) . |
| APA | Wen, Yuxi , Shan, Shuo , Ye, Fangting , Liao, Wei , Wu, Xue , Chen, Weichao et al. Prospects of phycoerythrin: Structural features, antioxidation and in food . | FOOD CHEMISTRY , 2025 , 463 . |
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