Query：
学者姓名：赵超
Refining：
Year
Type
Indexed by
Source
Complex
Co-Author
Language
Clean All
Abstract ：
Moringa oleifera Lam., a perennial species of the Moringaceae family, is esteemed for its multifaceted nutritional, medicinal, and economic properties. M. oleifera leaves are abundant in bioactive compounds with potential health benefits, yet existing structural and functional studies of these bioactives remain insufficiently comprehensive. This study aimed to isolate the active compound from M. oleifera leaves and investigate its mechanism of inhibiting lipid absorption and its potential as a pancreatic lipase inhibitor. In the present study, octacosanol (OCT) was isolated and purified from M. oleifera leaves, demonstrating notable pancreatic lipase inhibitory activity with an IC50 of 7.87 +/- 0.72 mu g/mL, and effectively suppressing lipid uptake in HepG2 cells. Simulated digestion assays indicated that OCT retained 73.5% of its pancreatic lipase inhibitory activity, with a recorded inhibition rate of 63.62%. Molecular docking analyses revealed that OCT binds to pancreatic lipase with an affinity comparable to orlistat and stronger than that of 4-nitrophenyl palmitate. The binding of OCT to key active sites (Ser152, His263, and Asp176) likely disrupts the enzyme's conformation, decreasing its substrate affinity. Additionally, OCT significantly attenuated lipid absorption and the synthesis of total cholesterol and triglycerides. This study elucidates the lipid-lowering mechanism of OCT and provides a theoretical foundation for its potential application in food production and biomedicine.
Keyword ：
enzyme kinetics enzyme kinetics LC-MS LC-MS moleculardocking moleculardocking Moringa oleifera Moringa oleifera NMR NMR octacosanol octacosanol pancreatic lipase pancreatic lipase
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Dong, Xiaoying , Wen, Yuxi , Nie, Qing et al. Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (12) : 7202-7210 . |
| MLA | Dong, Xiaoying et al. "Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73 . 12 (2025) : 7202-7210 . |
| APA | Dong, Xiaoying , Wen, Yuxi , Nie, Qing , Shan, Shuo , Zhao, Runfan , El-Seedi, Hesham R. et al. Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2025 , 73 (12) , 7202-7210 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
The main goal of this study is to improve the bioactivity of citrus pomace by subjecting it to solid-state fermentation by Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus plantarum over varying periods of time. The viability of Lactobacillus, as well as the total phenolic content (TPC) and total antioxidant capacity (TAC) values of orange pomace (OP), varied depending on the Lactobacillus species and fermentation period. The incorporation of pomace into orange juice samples at a ratio of 5% considerably enhanced the viability of probiotics. The TPC and TAC of orange juice samples were reduced after fermentation. The addition of orange pomace to orange juice significantly increased prostaglandin H2 and improved antioxidant capacity with more pronounced effects at increased pomace concentrations. After postfermentation with L. plantarum, key bioactive compounds such as corynoxeine and phenolics were upregulated, while picroside III and allocryptopine levels were decreased. On the other hand, metabolomics analysis revealed significant changes after fermentation in amino acid, sphingolipid, and fatty acid metabolism and the synthesis of secondary metabolites improving the nutritional profile and bioactivity of fermented orange juice. These findings highlight the potential of pomace addition and fermentation to improve the health benefits and quality of orange juice products. Therefore, the combined use of fermentation and fortification with OP could be a promising approach to creating new functional foods and promoting the use of edible food waste and byproducts.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Dikmetas, Dilara Nur , Nemli, Elifsu , Karbancioglu-Guler, Funda et al. Lactic Acid Bacterial Culture Selection for Orange Pomace Fermentation and Its Potential Use in Functional Orange Juice [J]. | ACS OMEGA , 2025 , 10 (11) : 11038-11053 . |
| MLA | Dikmetas, Dilara Nur et al. "Lactic Acid Bacterial Culture Selection for Orange Pomace Fermentation and Its Potential Use in Functional Orange Juice" . | ACS OMEGA 10 . 11 (2025) : 11038-11053 . |
| APA | Dikmetas, Dilara Nur , Nemli, Elifsu , Karbancioglu-Guler, Funda , Apak, Resat , Bener, Mustafa , Zhang, Wenbo et al. Lactic Acid Bacterial Culture Selection for Orange Pomace Fermentation and Its Potential Use in Functional Orange Juice . | ACS OMEGA , 2025 , 10 (11) , 11038-11053 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Introduction Prolonged hyperglycemia caused by type 2 diabetes mellitus (T2DM) can lead to liver injury and disrupt the community of the gut microbiota that pose significant risks to human health. As a food rich in a variety of active ingredients, Zingiber striolatum (Z. striolatum) exhibits hypoglycemic and hypolipidemic effects. However, the regulatory influence of Z. striolatum ethanol extract (ZSE) on the gut microbiota of T2DM mice or its potential relationship with T2DM pathology remains unexplored.Methods After a one-week acclimation period, 12 mice were randomly selected as the normal group. The remaining 48 mice were employed T2DM model, and then randomly assigned to four groups: the model group, a low-dose ZSE group (ZSE-L, 100 mg/kg/day), a high-dose ZSE group (ZSE-H, 300 mg/kg/day), and a positive control group treated with metformin hydrochloride (MET, 100 mg/kg/day).Results After a 4-week intervention, the results revealed that ZSE significantly ameliorated fasting blood glucose (FBG), area under the curve of oral glucose tolerance test (AUC of OGTT) and glycated serum protein (GSP) in T2DM mice. Moreover, the high-dose (ZSE-H) treatment increased the relative abundance of beneficial bacteria such as Faecalibaculum, while reducing harmful bacteria such as Bilophila, thereby alleviating insulin resistance. Additionally, ZSE-H demonstrated superior efficacy over low-dose (ZSE-L) in improving FBG, AUC of OGTT, and other hypoglycemic parameters. Predictive analysis of the correlation between gut microbiota and hypoglycemic parameters identified Dubosiella, Bacillus, and Mailhella as potential microbial biomarkers for further investigation into the pathogenesis of T2DM.Conclusion ZSE plays a pivotal role in mitigating hyperglycemia in T2DM mice through the modulation of intestinal microbiota communities.
Keyword ：
ethanol extract ethanol extract gut microbiota gut microbiota hyperglycemia hyperglycemia type 2 diabetes mellitus type 2 diabetes mellitus Zingiber striolatum Zingiber striolatum
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Liu, Tingting , Ge, Xiaodong , Song, Lu et al. Zingiber striolatum phytochemicals ameliorated hyperglycemia symptoms by modulating gut microbial communities in mice with type 2 diabetes mellitus [J]. | FRONTIERS IN NUTRITION , 2025 , 12 . |
| MLA | Liu, Tingting et al. "Zingiber striolatum phytochemicals ameliorated hyperglycemia symptoms by modulating gut microbial communities in mice with type 2 diabetes mellitus" . | FRONTIERS IN NUTRITION 12 (2025) . |
| APA | Liu, Tingting , Ge, Xiaodong , Song, Lu , Wu, Huanhuan , Qian, Xue , Jia, Bowen et al. Zingiber striolatum phytochemicals ameliorated hyperglycemia symptoms by modulating gut microbial communities in mice with type 2 diabetes mellitus . | FRONTIERS IN NUTRITION , 2025 , 12 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Breast cancer is the second leading cause of cancer-related mortality among women worldwide, with its progression closely tied to the tumor microenvironment. To address the limitations and adverse effects of conventional therapies, algal polysaccharides and their nanoparticle derivatives have emerged as promising and effective anti-breast cancer agents. These bioactive compounds, derived from algae, are distinguished by their natural origin, non-toxicity, and significant medical relevance. Notably, algal polysaccharide-based nanoparticles exhibit advantageous properties such as hydrophilicity, biodegradability, prolonged circulation, and selective accumulation in tumor tissues. This review explores the relationship between the structural attributes of algal polysaccharides and their therapeutic efficacy. It further highlights the advantages of algal polysaccharide-based nanoparticles as drug delivery systems, particularly their potential in tumor targeting and overcoming multidrug resistance, thereby providing a theoretical foundation for their application in breast cancer treatment.
Keyword ：
Algal polysaccharides Algal polysaccharides Breast cancer Breast cancer Drug delivery system Drug delivery system Nanoparticles Nanoparticles
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Cai, Jiaer , Liao, Wei , Wen, Jiahui et al. Algae-derived polysaccharides and polysaccharide-based nanoparticles: A natural frontier in breast cancer therapy [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 297 . |
| MLA | Cai, Jiaer et al. "Algae-derived polysaccharides and polysaccharide-based nanoparticles: A natural frontier in breast cancer therapy" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 297 (2025) . |
| APA | Cai, Jiaer , Liao, Wei , Wen, Jiahui , Ye, Fangting , Nie, Qing , Chen, Weichao et al. Algae-derived polysaccharides and polysaccharide-based nanoparticles: A natural frontier in breast cancer therapy . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 297 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Background: Polysaccharides from algae provide a range of biology and health benefits. Lately, there has been a significant interest in how algal polysaccharides affect the immune microenvironment around tumors. Purpose: To elucidate the subtle interactions between algal polysaccharides and the tumor immune microenvironment to further understand the medicinal potential of algal polysaccharides. Study design: To give a summary of the sources, bioactivities and characteristics of the tumor immune microenvironment of algal polysaccharides, and to analyze alteration of the immunological milieu surrounding tumors by algal polysaccharides and their potential as immunomodulators of chemotherapeutic agents. Methods: Search popular academic search engines using selected keywords for articles ending before September 2024 using selected keywords Google Scholar, PubMed, ScienceDirect, Scopus, Web of Science, Springer, and official websites. Results: Algal polysaccharides can fight tumors by changing how immune cells work and affecting inflammation in different ways. Moreover, algal polysaccharides have shown promise in mitigating the adverse effects associated with conventional cancer treatments, such as chemotherapy. Algal polysaccharides, through their immunomodulatory effects, can alleviate some of these side effects, leading to an enhanced overall treatment outcome. Conclusion: As research continues to uncover the underlying mechanisms of their antitumor effects, algal polysaccharides are poised to become a vital component in the development of novel cancer treatments, providing new hope for patients and advancing the field of oncology.
Keyword ：
Algal polysaccharides Algal polysaccharides Immune cells Immune cells Inflammatory responses Inflammatory responses Tumor immune microenvironment Tumor immune microenvironment
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wu, Yinfeng , Jia, Nan , Sun, Jingyu et al. The roles of algal polysaccharides in modulating tumor immune microenvironment [J]. | PHYTOMEDICINE , 2025 , 140 . |
| MLA | Wu, Yinfeng et al. "The roles of algal polysaccharides in modulating tumor immune microenvironment" . | PHYTOMEDICINE 140 (2025) . |
| APA | Wu, Yinfeng , Jia, Nan , Sun, Jingyu , Liao, Wei , Xu, Jingxiang , Chen, Weichao et al. The roles of algal polysaccharides in modulating tumor immune microenvironment . | PHYTOMEDICINE , 2025 , 140 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Animal proteins are the primary global protein source, but their production is environmentally challenging and has low conversion efficiency. This highlights the need to diversify dietary protein sources. Algal proteins provide a sustainable alternative, outperforming traditional plant and animal proteins in protein content, quality, and digestibility. Furthermore, bioactive peptides (BAPs) derived from algal proteins exhibit significant health benefits, including antihypertensive, antioxidant, antimicrobial, anticancer, and antidiabetic activities. This review comprehensively explores the nutritional benefits of algal proteins and provides an innovative summary of the production techniques for algal bioactive peptides. It also highlights the synergistic application methods of these technologies. By integrating pretreatment methods such as ultrasound-assisted extraction, pulsed electric field, and high hydrostatic pressure with enzymatic-assisted extraction, these techniques demonstrate a synergistic effect in improving protein hydrolysis efficiency while also increasing the yield of BAPs. Meanwhile, database resources related to algal proteins are integrated and the application of computer technology in the development of algal proteins is analyzed. It aims to provide new insights to optimize the development and utilization of algal proteins to help them become a sustainable source of nutrition to meet the needs of a growing global population.
Keyword ：
Algal proteins Algal proteins Bioactive peptides Bioactive peptides Bioavailability Bioavailability Nutritional functions Nutritional functions Production techniques Production techniques
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Meng, Tianzeng , Wen, Jiahui , Liu, Hanqi et al. Algal proteins and bioactive peptides: Sustainable nutrition for human health [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 303 . |
| MLA | Meng, Tianzeng et al. "Algal proteins and bioactive peptides: Sustainable nutrition for human health" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 303 (2025) . |
| APA | Meng, Tianzeng , Wen, Jiahui , Liu, Hanqi , Guo, Yuxin , Tong, Aijun , Chu, Yaoyao et al. Algal proteins and bioactive peptides: Sustainable nutrition for human health . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 303 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Algae, a crucial constituent of marine systems, serve an indispensable function as primary producers, supporting the marine food web, contributing to carbon sequestration, and providing habitats that sustain biodiversity. This review focuses on the bioactive constituents of algae, including polysaccharides, polyphenols, polypeptides, and terpenoid compounds, and discusses their potential applications in treating immune-related diseases, as well as the mechanisms through which they modulate immune responses. The bioactive substances derived from algae, including polyphenols, bioactive peptides, terpenes, polysaccharides and other compounds, may play a preventive role by modulating allergic responses and reducing the incidence of inflammation and cancer.
Keyword ：
Algal bioactive substances Algal bioactive substances allergy allergy cancer cancer immunomodulation immunomodulation inflammation inflammation
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Jia, Nan , Zhang, Shuangtao , Chen, Ruoxin et al. Immunomodulatory functions of algal bioactive compounds [J]. | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION , 2025 , 65 (30) : 7133-7150 . |
| MLA | Jia, Nan et al. "Immunomodulatory functions of algal bioactive compounds" . | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION 65 . 30 (2025) : 7133-7150 . |
| APA | Jia, Nan , Zhang, Shuangtao , Chen, Ruoxin , He, Xinxin , Dai, Congjie , El-Seedi, Hesham R. et al. Immunomodulatory functions of algal bioactive compounds . | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION , 2025 , 65 (30) , 7133-7150 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Phycoerythrin (PE) is a naturally occurring plant protein of algal origin. The colour, bioactivity and stability of PE are inextricably linked to its structure. PE has powerful antioxidant properties that effectively prevent oxidative stress and cellular damage, for which the chromophore structure plays a key role. However, the relationship between the chromophore and thermal stability is unclear in PE. The environmental factors affecting the thermal stability of PE are mainly light, high temperature and extreme pH. PE stability can be enhanced through various techniques, including the incorporation of additives, cross-linking processes, and the formation of complexes. Improving the stability of PE is of significant importance for its applications within the food industry. This paper outlines the structural characteristics of PE, discusses the relationship between its structure and antioxidant activity, and focuses on the application of PE in the food industry, as well as the factors affecting its stability and strategies for its improvement.
Keyword ：
Antioxidants Antioxidants Chromophore Chromophore Food application Food application Phycoerythrin Phycoerythrin Structure stability Structure stability
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wen, Yuxi , Shan, Shuo , Ye, Fangting et al. Prospects of phycoerythrin: Structural features, antioxidation and in food [J]. | FOOD CHEMISTRY , 2025 , 463 . |
| MLA | Wen, Yuxi et al. "Prospects of phycoerythrin: Structural features, antioxidation and in food" . | FOOD CHEMISTRY 463 (2025) . |
| APA | Wen, Yuxi , Shan, Shuo , Ye, Fangting , Liao, Wei , Wu, Xue , Chen, Weichao et al. Prospects of phycoerythrin: Structural features, antioxidation and in food . | FOOD CHEMISTRY , 2025 , 463 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
本发明提供了一种ATP5F1A及其同源基因作为调控糖代谢治疗靶点及浒苔寡糖的应用。本发明提出以ATP5F1A蛋白或其编码基因或转录产物作为高糖高脂饮食导致的2型糖尿病的生物标记物及治疗靶点，通过调控ATP5F1A蛋白的表达水平和/或巴豆酰化修饰水平，可起到缓解糖尿病作用。针对该靶点，本发明还开发了一种浒苔寡糖药物，可以针对性地提高ATP5F1A蛋白的表达量及其巴豆酰化修饰水平，并改善糖代谢，为2型糖尿病及其相关代谢疾病提供了一种新的治疗策略。
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 赵超 , 张丽珠 , 文愉熙 et al. ATP5F1A及其同源基因作为调控糖代谢治疗靶点及浒苔寡糖的应用 : CN202510572562.1[P]. | 2025-05-06 . |
| MLA | 赵超 et al. "ATP5F1A及其同源基因作为调控糖代谢治疗靶点及浒苔寡糖的应用" : CN202510572562.1. | 2025-05-06 . |
| APA | 赵超 , 张丽珠 , 文愉熙 , 吴雪 , 姚井月 , 郭俞辛 . ATP5F1A及其同源基因作为调控糖代谢治疗靶点及浒苔寡糖的应用 : CN202510572562.1. | 2025-05-06 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | El-Garawani, Islam M. , Abd El-Gaber, Amira S. , Algamdi, Noura A. et al. RETRACTION: In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract [J]. | METABOLITES , 2025 , 15 (8) . |
| MLA | El-Garawani, Islam M. et al. "RETRACTION: In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract" . | METABOLITES 15 . 8 (2025) . |
| APA | El-Garawani, Islam M. , Abd El-Gaber, Amira S. , Algamdi, Noura A. , Saeed, Aamer , Zhao, Chao , Khattab, Omar M. et al. RETRACTION: In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract . | METABOLITES , 2025 , 15 (8) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
