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学者姓名：刘艳玲
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Abstract ：
Biofilms play a pivotal role in the survival and persistence of microorganisms, endowing them with heightened resistance to environmental stressors and antimicrobial agents. The EamB protein, which encodes an inner membrane transporter, acted as a negative regulator of biofilm formation, and the gene eamB deletion in the pathogen Aeromonas hydrophila LP-2 resulted in a significant increase in biofilm formation. Proteomic analysis revealed a total of 616 differentially abundant proteins between the Delta eamB and wild-type (WT) strains, with 308 downregulated and 308 upregulated. RT-qPCR was employed to verify the stability and accuracy of the proteomics data. Bioinformatic analysis indicated that EamB is involved in critical bacterial biological processes, including flagellar assembly, amino acid metabolism, and fatty acid degradation. Biofilm formation assays further revealed that supplementation with exogenous lysine significantly inhibited biofilm formation in the Delta eamB strain, conversely, exogenous cysteine and O-acetylserine obviously increased biofilm formation in the Delta eamB strain. These findings demonstrated that EamB may modulate bacterial biofilm formation in A. hydrophila through the regulation of amino acid metabolism. This finding provides novel insights into the regulatory mechanism underlying biofilm formation and highlights potential targets for the development of future antibacterial strategies. Significance statement: This study elucidates the critical role of the eamB gene in Aeromonas hydrophila, a significant aquatic pathogen, by demonstrating its impact on biofilm formation and physiological traits. Through comparative proteomic analysis, we identified 616 differentially abundant proteins in the Delta eamB mutant, revealing its involvement in key metabolic pathways such as amino acid metabolism, flagellar assembly, and fatty acid degradation. Notably, eamB deletion enhanced biofilm formation, while exogenous amino acids like cysteine and O-acetylserine obviously increased biofilm formation in the Delta eamB strain. These findings highlight EamB as a regulator of biofilm formation, offering novel molecular insights into bacterial pathogenicity. This research advances our understanding of biofilm-associated antibiotic resistance and provides potential targets for developing strategies to mitigate infections caused by A. hydrophila in aquaculture and public health.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila Amino acid transport Amino acid transport Biofilm formation Biofilm formation EamB EamB Proteomics Proteomics
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| GB/T 7714 | Xu, Qiaozhen , Tian, Feng , Wang, Xinyun et al. Proteomics reveals the role of the EamB transporter from Aeromonas hydrophila LP-2 in biofilm formation [J]. | JOURNAL OF PROTEOMICS , 2025 , 321 . |
| MLA | Xu, Qiaozhen et al. "Proteomics reveals the role of the EamB transporter from Aeromonas hydrophila LP-2 in biofilm formation" . | JOURNAL OF PROTEOMICS 321 (2025) . |
| APA | Xu, Qiaozhen , Tian, Feng , Wang, Xinyun , Lian, Juanqi , Zhang, Xiaowei , Lin, Xiangmin et al. Proteomics reveals the role of the EamB transporter from Aeromonas hydrophila LP-2 in biofilm formation . | JOURNAL OF PROTEOMICS , 2025 , 321 . |
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Post-translational modifications are crucial in regulating biological functions across both prokaryotes and eukaryotes. In Aeromonas hydrophila, CobQ, a recently identified novel deacetylase, plays a significant role in lysine deacetylation, influencing bacterial metabolism and stress responses. The present study utilized quantitative proteomics to investigate the impact of cobQ deletion on the global protein expression profile in A. hydrophila. Through data-independent acquisition mass spectrometry, we identified 233 upregulated and 41 downregulated proteins in the cobQ deletion mutant (Delta ahcobQ) strain compared to the wild-type (WT) strain. Key differentially expressed proteins were involved in oxidative phosphorylation, bacterial secretion, and ribosomal function. Additionally, phenotypic assays demonstrated that the Delta ahcobQ strain exhibited an increased resistance to oxidative phosphorylation inhibitors, suggesting a pivotal role for AhCobQ in energy metabolism. Outer membrane proteins and efflux pumps also showed altered expression, indicating potential implications for membrane permeability and antibiotic resistance. These results suggested that AhCobQ plays a vital regulatory role in maintaining metabolic homeostasis and responding to environmental stress, highlighting its potential as a target for therapeutic interventions against A. hydrophila infections.
Keyword ：
Aeromonashydrophila Aeromonashydrophila CobQ deacetylase CobQ deacetylase oxidativephosphorylation oxidativephosphorylation proteomics proteomics stress response stress response
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| GB/T 7714 | Wang, Guibin , Chen, Linxin , Lian, Juanqi et al. Proteomic Insights into the Regulatory Role of CobQ Deacetylase in Aeromonas hydrophila [J]. | JOURNAL OF PROTEOME RESEARCH , 2025 , 24 (1) : 333-343 . |
| MLA | Wang, Guibin et al. "Proteomic Insights into the Regulatory Role of CobQ Deacetylase in Aeromonas hydrophila" . | JOURNAL OF PROTEOME RESEARCH 24 . 1 (2025) : 333-343 . |
| APA | Wang, Guibin , Chen, Linxin , Lian, Juanqi , Gong, Lanqing , Tian, Feng , Wang, Yuqian et al. Proteomic Insights into the Regulatory Role of CobQ Deacetylase in Aeromonas hydrophila . | JOURNAL OF PROTEOME RESEARCH , 2025 , 24 (1) , 333-343 . |
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Aeromonas hydrophila is a pervasive opportunistic fish pathogen, often leading to severe infections. However, the combination of its extensive genetic variety and the complexity of its virulence factors has hindered our ability to fully comprehend its pathogenic mechanisms to date. In this study, the pathogenicity and potential virulence factors of strain LP-2, a representative member of the high virulent ST251 clones isolated from a diseased silver carp were investigated. LP-2 was identified through Rimler-Shotts medium and 16S rRNA sequencing as A. hydrophila. Genome sequencing and comparative genomics revealed that LP-2 was an ST251-type bacterium and exhibited a genetic closeness to other fish epidemic-causing ST251 clones. Pathogenicity assays showed LP2's robust virulence, marked by its significantly lower LD50 value (5.64 x 103 CFU) compared to the non-virulent strain ATCC 7966, as well as by its siderophore production, hemolysis, and protease activity. Moreover, using Virulence Factor Database, we identified diverse virulence genes in LP-2, with siderophore, polar flagella, and chemotaxis systems being the most prevalent. LP-2 also harbored aerolysin, enterotoxin and type IV pili (Flp and MSHA), which were commonly associated with the virulence profile of ST251. In addition, we generated 15 virulence gene deletion strains via gene recombination and assessed their impact on zebrafish survival. Notably, deleting orf00306 (enterobactin receptor) and orf03433 (ABC-type heme transporter) significantly reduced zebrafish mortality, highlighting their crucial role in LP-2 virulence. Overall, this study provides insights into the virulence characteristics of LP-2 strain, enhancing our understanding of A. hydrophila pathogenicity.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila Genome sequencing Genome sequencing Pathogenicity Pathogenicity Virulence factors Virulence factors Zebrafish survival Zebrafish survival
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| GB/T 7714 | Lian, Lingli , Sun, Lina , Zhao, Xinrui et al. Analysis of pathogenicity factors in the highly virulent Aeromonas hydrophila strain LP-2 [J]. | AQUACULTURE , 2025 , 598 . |
| MLA | Lian, Lingli et al. "Analysis of pathogenicity factors in the highly virulent Aeromonas hydrophila strain LP-2" . | AQUACULTURE 598 (2025) . |
| APA | Lian, Lingli , Sun, Lina , Zhao, Xinrui , Chen, Linxin , Zhang, Binghui , Liu, Yanling et al. Analysis of pathogenicity factors in the highly virulent Aeromonas hydrophila strain LP-2 . | AQUACULTURE , 2025 , 598 . |
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Introduction: Bacterial biofilm is a well-known characteristic that plays important roles in diverse physiological functions, whereas the current intrinsic regulatory mechanism of its formation is still largely unknown. Methods: In the present study, a label-free based quantitative proteomics technology was conducted to compare the differentially expressed proteins (DEPs) between Delta uidR and the wild-type strain in the biofilm state. Results: The results showed that the deletion of gene uidR encoding a TetR transcriptional regulator significantly increased the biofilm formation in Aeromonas hydrophila. And there was a total of 220 DEPs, including 120 up-regulated proteins and 100 down-regulated proteins between Delta uidR and the wild-type strain based on the quantitative proteomics. Bioinformatics analysis suggested that uidR may affect bacterial biofilm formation by regulating some related proteins in glyoxylic acid and dicarboxylic acid pathway. The expressions of selected proteins involved in this pathway were further confirmed by q-PCR assay, and the results was in accordance with the quantitative proteomics data. Moreover, the deletion of four genes (AHA_3063, AHA_3062, AHA_4140 and aceB) related to the glyoxylic acid and dicarboxylic acid pathway lead to a significant decrease in the biofilm formation. Discussion: Thus, the results indicated that uidR involved in the regulatory of bacterial biofilm formation, and it may provide a potential target for the drug development and a new clue for the prevention of pathogenic A. hydrophila in the future.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila biofilm formation biofilm formation quantitative proteomics quantitative proteomics transcription regulator transcription regulator UidR UidR
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| GB/T 7714 | Li, Xiaoyan , Tian, Feng , Zhang, Binghui et al. Quantitative proteomics analysis reveals an important role of the transcriptional regulator UidR in the bacterial biofilm formation of Aeromonas hydrophila [J]. | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY , 2024 , 14 . |
| MLA | Li, Xiaoyan et al. "Quantitative proteomics analysis reveals an important role of the transcriptional regulator UidR in the bacterial biofilm formation of Aeromonas hydrophila" . | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 14 (2024) . |
| APA | Li, Xiaoyan , Tian, Feng , Zhang, Binghui , Zhang, Lishan , Chen, Xiaomeng , Lin, Xiaoke et al. Quantitative proteomics analysis reveals an important role of the transcriptional regulator UidR in the bacterial biofilm formation of Aeromonas hydrophila . | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY , 2024 , 14 . |
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The transcriptional regulators of the MarR family play an important role in diverse bacterial physiologic functions, whereas their effect and intrinsic regulatory mechanism on the aquatic pathogenic bacterium Aeromonas hydrophila are, clearly, still unknown. In this study, we firstly constructed a deletion strain of AHA_2124 (Delta AHA_2124) of a MarR family transcriptional regulator in Aeromonas hydrophila ATCC 7966 (wild type), and found that the deletion of AHA_2124 caused significantly enhanced hemolytic activity, extracellular protease activity, and motility when compared with the wild type. The differentially abundant proteins (DAPs) were compared by using data-independent acquisition (DIA), based on a quantitative proteomics technology, between the Delta AHA_2124 strain and wild type, and there were 178 DAPs including 80 proteins up-regulated and 98 proteins down-regulated. The bioinformatics analysis showed that the deletion of gene AHA_2124 led to some changes in the abundance of proteins related to multiple biological processes, such as translation, peptide transport, and oxidation and reduction. These results provided a theoretical basis for better exploring the regulatory mechanism of the MarR family transcriptional regulators of Aeromonas hydrophila on bacterial physiological functions.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila biological function biological function MarR family transcriptional regulator MarR family transcriptional regulator
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| GB/T 7714 | Li, Zhen , Li, Wanxin , Lu, Jinlian et al. Quantitative Proteomics Analysis Reveals the Effect of a MarR Family Transcriptional Regulator AHA_2124 on Aeromonas hydrophila [J]. | BIOLOGY-BASEL , 2023 , 12 (12) . |
| MLA | Li, Zhen et al. "Quantitative Proteomics Analysis Reveals the Effect of a MarR Family Transcriptional Regulator AHA_2124 on Aeromonas hydrophila" . | BIOLOGY-BASEL 12 . 12 (2023) . |
| APA | Li, Zhen , Li, Wanxin , Lu, Jinlian , Liu, Ziqiu , Lin, Xiangmin , Liu, Yanling et al. Quantitative Proteomics Analysis Reveals the Effect of a MarR Family Transcriptional Regulator AHA_2124 on Aeromonas hydrophila . | BIOLOGY-BASEL , 2023 , 12 (12) . |
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Recently, the prevalence of Aeromonas hydrophila antibiotic-resistant strains has been reported in aquaculture, but its intrinsic antibiotic resistance mechanisms are largely unknown. In the present study, a label-free proteomics technology was used to compare the differential protein abundances in response to norfloxacin (NOR) stress in A. hydrophila. The results showed that there were 186 proteins decreasing and 220 proteins increasing abundances in response to NOR stress. Bioinformatics analysis showed that the differentially expressed proteins were enriched in several biological processes, such as sulfur metabolism and homologous recombination. Furthermore, the antibiotic sensitivity assays showed that the deletion of AHA_0904, cirA, and cysI significantly decreased the resistance against NOR, whereas AAHA_1239, AcysA, AcysD, and AcysN significantly increased the resistance against NOR. Our results provide insights into NOR resistance mechanisms and indicate that AHA_0904, cirA, AHA_1239, and sulfur metabolism may play important roles in NOR resistance in A. hydrophila.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila DNA repair DNA repair norfloxacin norfloxacin proteomics proteomics sulfur metabolism sulfur metabolism
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| GB/T 7714 | Liu, Ziqiu , Zhang, Lishan , Song, Qingli et al. Quantitative Proteomics Reveal the Inherent Antibiotic Resistance Mechanism against Norfloxacin Resistance in Aeromonas hydrophila [J]. | JOURNAL OF PROTEOME RESEARCH , 2023 , 22 (4) : 1193-1200 . |
| MLA | Liu, Ziqiu et al. "Quantitative Proteomics Reveal the Inherent Antibiotic Resistance Mechanism against Norfloxacin Resistance in Aeromonas hydrophila" . | JOURNAL OF PROTEOME RESEARCH 22 . 4 (2023) : 1193-1200 . |
| APA | Liu, Ziqiu , Zhang, Lishan , Song, Qingli , Song, Huanhuan , Xu, Yunqi , Lu, Jinlian et al. Quantitative Proteomics Reveal the Inherent Antibiotic Resistance Mechanism against Norfloxacin Resistance in Aeromonas hydrophila . | JOURNAL OF PROTEOME RESEARCH , 2023 , 22 (4) , 1193-1200 . |
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AimsTo understand the species composition, abundance and diversity of nitrogen-fixing bacteria in the Cenchrus fungigraminus rhizosphere and to screen nitrogen-fixing bacteria to study their potential role in plant growth promotion.MethodsSoil were collected from 4 depths (G1, G2, G3 and G4) of the C. fungigraminus rhizosphere, and their physical and chemical properties were determined. The diversity and abundance of nitrogen-fixing bacteria and the nifH gene was analysed. Nitrogen-fixing bacteria were screened and selected to promote growth of C. fungigraminus seedlings.ResultsThe highest diversity and abundance of nitrogen-fixing bacteria was observed in the G2 samples collected from the C. fungigraminus rhizosphere. These bacteria mainly included Proteobacteria (93.91%), Actinobacteria (0.42%), and Firmicutes (0.18%) and were significantly affected by total nitrogen, available nitrogen and soil depth. The nifH gene copy number was highest (1.56 +/- 0.17 x 10(7)copies/g) in G2. Rhizobium pusense No. 8 and No. 28 were isolated from G1 and G2, with nitrogenase activities of 145.06 +/- 4.10 and 199.78 +/- 7.50 U/L. The promotion experiment revealed that the plant height, root length, and leaf length of C. fungigraminus seedlings treated with both strains significantly increased by 56.79%, 76.99% and 55.71%, and the soil moisture and total nitrogen were significantly increased compared to the control (P < 0.05). The available nitrogen, organic matter and organic carbon in soil with strain No. 28 significantly increased compared to CK.ConclusionRhizobacteria in the C. fungigraminus rhizosphere play an important role as plant growth promoting rhizobacteria (PGPR). Two strains showed potential for the development of biological fertilizers.
Keyword ：
Cenchrus fungigraminus Cenchrus fungigraminus Nitrogen-fixing microorganisms Nitrogen-fixing microorganisms Plant growth-promoting rhizobacteria Plant growth-promoting rhizobacteria Rhizobium pusense Rhizobium pusense Rhizosphere Rhizosphere
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| GB/T 7714 | Li, Jing , Zhou, Bingxin , Li, Tingting et al. Isolation of rhizobacteria from the Cenchrus fungigraminus rhizosphere and characterization of their nitrogen-fixing performance and potential role in plant growth promotion [J]. | PLANT AND SOIL , 2023 , 489 (1-2) : 405-421 . |
| MLA | Li, Jing et al. "Isolation of rhizobacteria from the Cenchrus fungigraminus rhizosphere and characterization of their nitrogen-fixing performance and potential role in plant growth promotion" . | PLANT AND SOIL 489 . 1-2 (2023) : 405-421 . |
| APA | Li, Jing , Zhou, Bingxin , Li, Tingting , Lin, Hui , Lin, Zhanxi , Lu, Guodong et al. Isolation of rhizobacteria from the Cenchrus fungigraminus rhizosphere and characterization of their nitrogen-fixing performance and potential role in plant growth promotion . | PLANT AND SOIL , 2023 , 489 (1-2) , 405-421 . |
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Purpose: To investigate the effects of hot water extract of the spent mushroom substrate from Ganoderma lucidum (HWE) on the immune functions of immune-deficient mice in the presence or absence of cyclophosphamide. Methods: The C57BL/6 mice were treated with varying doses of HWE and cyclophosphamide, and the spleen transcriptome was evaluated by high-throughput sequencing. Pathway enrichment analysis was conducted to generate an overview of differentially-expressed genes (DEGs) functions and interactions. Results: Significant DEGs were observed among the control (CK), normal control (HWE), model (CY), and high-dose HWE (CY + HWEH) groups (p < 0.05). Compared with CK group, HWE and CY + HWEH groups showed upregulation of genes (Alas2, CCNE1, and CCNA2), whereas genes encoding major histocompatibility complex components, costimulatory factors, proinflammatory chemokines, and inflammatory chemokines were significantly downregulated (p < 0.05). Compared with CY group, multiple tumor suppressor and tumorigenesis genes, such as CDKN1A, CDKN1B, MAPK10, and TN-C, were downregulated in CK, HWE, and CY + HWEH groups. Conclusion: This study highlights changes in the spleen transcriptomic profiles of C57BL/6 mice treated with HWE and CY, indicating that HWE improves immunomodulation in a mouse model with immune deficiency. Hot water extract of the spent mushroom substrate from Ganoderma lucidum (HWE) has potentials as an immune enhancer in immunocompromised patients.
Keyword ：
Cyclophosphamide Cyclophosphamide Ganoderma lucidum Ganoderma lucidum High-throughput sequencing High-throughput sequencing Hot water extract Hot water extract Immunomodulation Immunomodulation Spleen transcriptome Spleen transcriptome
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| GB/T 7714 | Liu, Yanling , Meng, Tong , Wang, Tong et al. Hot water extract from spent mushroom substrate of Ganoderma lucidum improves immune function in immune-deficient mice [J]. | TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH , 2023 , 22 (1) : 143-150 . |
| MLA | Liu, Yanling et al. "Hot water extract from spent mushroom substrate of Ganoderma lucidum improves immune function in immune-deficient mice" . | TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 22 . 1 (2023) : 143-150 . |
| APA | Liu, Yanling , Meng, Tong , Wang, Tong , Li, Jing , Zhang, Wei , Chen, Jihui et al. Hot water extract from spent mushroom substrate of Ganoderma lucidum improves immune function in immune-deficient mice . | TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH , 2023 , 22 (1) , 143-150 . |
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对6个菌草品种种植前后的土壤养分、土壤酶活性进行检测，采用Illumina-MiSeq高通量测序技术对微生物多样性和微生物群落进行分析.结果表明，6个不同品种菌草土壤的有机碳、全氮、速效氮和速效磷的含量均显著高于未种植菌草的对照组(P<0.05),桂闽引象草土壤速效氮(27.88 mg·kg~(-1))、全氮(1.12 g·kg~(-1))和有机质含量(33.51 g·kg~(-1))最高，象草的土壤速效磷(8.49 mg·kg~(-1))含量最高.种植6种菌草后，除了过氧化氢酶，土壤酶活性均有显著提高(P<0.05),象草土壤磷酸酶活性(883.46μmol·g~(-1))、桂闽引象草土壤脲酶活性(18.77μg·g~(-1))和蔗糖酶活性(16.43 mg·g~(-1))最高.Pearson相关性分析结果表明：过氧化氢酶与速效氮、全氮和有机碳均呈显著负相关(P<0.01),酸性磷酸酶与速效磷呈显著正相关(P<0.01),脲酶与速效氮、速效磷、全氮和有机碳均呈显著正相关(P<0.05),蔗糖酶与有机碳呈显著正相关(P<0.01).种植不同品种菌草后，巨菌草、象草、热研4号王草、桂闽引象草土壤中细菌和真菌多样性指数ACE均显著高于对照组(P<0.05),桂牧1号真菌多样性指数CHAO显著高于对照组(P<0.05).Pearson相关性分析表明：土壤微生物中多数细菌和真菌优势菌属均与土壤养分有显著的相关性.总之，种植菌草对改良土壤、提高土壤酶活性和土壤微生物多样性具有积极作用.
Keyword ：
土壤养分 土壤养分 土壤微生物多样性 土壤微生物多样性 土壤酶活性 土壤酶活性 菌草 菌草
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| GB/T 7714 | 崔绾彤 , 孟彤 , 齐彬 et al. 不同品种菌草对土壤酶活性及土壤微生物多样性的影响 [J]. | 福建农林大学学报(自然科学版) , 2023 , 52 (01) : 48-58 . |
| MLA | 崔绾彤 et al. "不同品种菌草对土壤酶活性及土壤微生物多样性的影响" . | 福建农林大学学报(自然科学版) 52 . 01 (2023) : 48-58 . |
| APA | 崔绾彤 , 孟彤 , 齐彬 , 张威 , 张兆荣 , 林冬梅 et al. 不同品种菌草对土壤酶活性及土壤微生物多样性的影响 . | 福建农林大学学报(自然科学版) , 2023 , 52 (01) , 48-58 . |
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Aeromonas hydrophila is a widespread opportunistic pathogen of aquatic fishes in freshwater habitats. The current emergence of antimicrobial-resistant A. hydrophila has been reported in the world while the bacterial antibiotics adaptive mechanism remains poorly explored. In this study, using quantitative proteomics technology, the behavior of A. hydrophila was investigated by comparing the differentially expression proteins between with and without kanamycin (KAN) treatment. A total of 374 altered proteins including 184 increasing and 190 proteins decreasing abundances were quantified when responding to KAN stress. The bioinformatics analysis showed that stress related proteins were hub proteins that significantly increased to reduce the pressure from the misreading of mRNA caused by KAN. Moreover, several metallic pathways, such as oxidative phosphorylation and TCA cycle pathways may affect KAN resistance. Finally, eight selected genes were deleted and their antibiotics susceptibilities to kanamycin were valued, respectively. Results showed that OmpA II family protein A0KI26, and twocomponent system protein AtoC may involve in the KAN resistance in this study. In general, our results provide an insight into the behaviors of bacterial responding to KAN stress, and demonstrate the intrinsic antibiotics adaptive mechanism of A. hydrophila. Biological significance: In this study, the differentially expressed proteins (DEPs) of A. hydrophila strain between with and without kanamycin (KAN) were compared by using a data-independent acquisition (DIA) - based quantitative proteomics method. Bioinformatics analysis showed that stress - related proteins are hub proteins that significantly increased under KAN stress. Moreover, several metallic pathways, such as oxidative phosphorylation and citrate cycle (TCA cycle) pathways, can affect KAN resistance. Finally, our antibiotics susceptibility assay showed that the protein A0KI26 of the OmpA II family, and the AtoC of the two-component system may involve in KAN resistance in this study. These results provide insights into the antibiotics adaptation mechanism of A. hydrophila when responding to KAN stress.
Keyword ：
Aeromonas hydrophila Aeromonas hydrophila AtoC AtoC Kanamycin resistance mechanism Kanamycin resistance mechanism LC MS LC MS MS MS OmpA II OmpA II
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| GB/T 7714 | Zhang, Lishan , Chen, Xiaomeng , Wang, Guibin et al. Quantitative proteomics reveals the antibiotics adaptation mechanism of Aeromonas hydrophila under kanamycin stress [J]. | JOURNAL OF PROTEOMICS , 2022 , 264 . |
| MLA | Zhang, Lishan et al. "Quantitative proteomics reveals the antibiotics adaptation mechanism of Aeromonas hydrophila under kanamycin stress" . | JOURNAL OF PROTEOMICS 264 (2022) . |
| APA | Zhang, Lishan , Chen, Xiaomeng , Wang, Guibin , Yao, Jindong , Wei, Jin , Liu, Zhu et al. Quantitative proteomics reveals the antibiotics adaptation mechanism of Aeromonas hydrophila under kanamycin stress . | JOURNAL OF PROTEOMICS , 2022 , 264 . |
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