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学者姓名：王长康
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Abstract ：
Astaxanthin (AST), a keto carotenoid, is widely recognized for its antioxidant, anti-inflammatory, and apoptosisregulating properties, but its effects on intestinal health have not been elucidated. Therefore, this experiment aimed to investigate the effects of astaxanthin on intestinal morphology, barrier function, mucosal immunity, and cecal flora in yellow-feathered broilers, and to explore the potential mechanisms. A total of 288 male yellow- feathered broilers (1-day-old) were randomly allocated to four groups with six replicates of 12 birds each. The control group (CON) was fed a basal diet, the test groups were fed a basal diet added with 20 mg/kg, 40 mg/kg, and 80mg/kg of astaxanthin (AST20, AST40, and AST80), respectively. The results showed that compared with the CON group, the villus height and the villus-to-crypt ratio of broiler jejunum in the astaxanthin-added group increased, while the crypt depth decreased (P < 0.05). In addition, IL-1 beta content and gene expression in broiler jejunal mucosa decreased, IL-6 gene expression decreased, and IL-4 content and gene expression increased (P < 0.05). The tight junction protein ZO-1 expression level in the jejunum mucosa of broilers was up-regulated, and the content of serum D-lactic acid was decreased (P < 0.05). Besides, the alpha-diversity and beta-diversity analyses showed that astaxanthin regulated both the diversity and the structure of the intestinal flora of broilers. After multiple comparative analyses, the relative abundance of norank_f__Eubacterium_coprostanoligenes_group, Lachnospiraceae NC2004_group, and unclassified_p_Firmicutes increased in the AST20 group compared to the CON group, while that of Ruminococcus_torques_group in the AST80 group decreased (P < 0.05). Therefore, AST can regulate the immune function of broiler intestinal mucosa, improve intestinal morphology and structure, and then influence intestinal permeability. It also has a considerable regulatory effect on the diversity and structure of broiler intestinal flora and plays a multifaceted role in maintaining broiler intestinal health.
Keyword ：
Astaxanthin Astaxanthin Intestinal health Intestinal health Yellow-feathered broilers Yellow-feathered broilers
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| GB/T 7714 | Gao, Yu-Yun , Lin, Zhi-Xin , Zhang, Min et al. Health effects of astaxanthin in the intestinal tract of yellow-feathered broilers [J]. | POULTRY SCIENCE , 2025 , 104 (3) . |
| MLA | Gao, Yu-Yun et al. "Health effects of astaxanthin in the intestinal tract of yellow-feathered broilers" . | POULTRY SCIENCE 104 . 3 (2025) . |
| APA | Gao, Yu-Yun , Lin, Zhi-Xin , Zhang, Min , Yang, Rui , Guo, Ping-Ting , Zhang, Jing et al. Health effects of astaxanthin in the intestinal tract of yellow-feathered broilers . | POULTRY SCIENCE , 2025 , 104 (3) . |
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Antibiotics have been commonly added to poultry feed to promote growth and prevent diseases, but overuse raises concerns about human health and environmental safety. Finding safe alternatives is crucial for sustainable poultry production. Astaxanthin (AST) is a red, lipid-soluble carotenoid possessing antioxidant and anti-inflammatory properties. This study investigated the effects of different doses of astaxanthin (20, 40, and 80 mg/kg) on growth performance, meat quality, antioxidant capacity, immune function, and gut microbiota in yellow-feathered broilers. Results showed that dietary astaxanthin supplementation improved the meat quality (increased pH, a* and b* values, decreased L* value and drip loss), enhanced antioxidant capacity (reduced MDA, increased T-AOC and SOD levels) and immune function (decreased IL-1 beta and IL-6, increased IL-4 levels), and regulated gut microbiot (increased Faecalibacterium, norank_f__Ruminococcaceae, decreased Romboutsia and Turicibacter) (P < 0.05). Thus, astaxanthin may serve as a potential novel functional feed additive, beneficial for improving broiler health and meat quality.
Keyword ：
Antioxidant Antioxidant Astaxanthin Astaxanthin Gut microbiota Gut microbiota Immunity Immunity Meat quality Meat quality
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| GB/T 7714 | Gu, Xiao-Ming , Ye, Ding-Cheng , Cheng, Jun-Wei et al. Astaxanthin enhances broiler health via integrated regulation of antioxidant capacity, immune function, and gut microbiota [J]. | FOOD CHEMISTRY , 2025 , 496 . |
| MLA | Gu, Xiao-Ming et al. "Astaxanthin enhances broiler health via integrated regulation of antioxidant capacity, immune function, and gut microbiota" . | FOOD CHEMISTRY 496 (2025) . |
| APA | Gu, Xiao-Ming , Ye, Ding-Cheng , Cheng, Jun-Wei , Lin, Zhi-Xin , Lv, Hai-Xuan , Cai, Zai-Xing et al. Astaxanthin enhances broiler health via integrated regulation of antioxidant capacity, immune function, and gut microbiota . | FOOD CHEMISTRY , 2025 , 496 . |
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This experiment investigated the effects of dietary supplementation with nano-composites of copper and carbon (NCCC) on antioxidants, immune functions, and the cecum microbiota of weaned Ira white rabbits. A total of 240 weaned 35-day-old Ira white rabbits were randomly allocated to five dietary treatments (n = 6 per treatment, each replicate consisted of eight rabbits) that included the control group (CON) with a basal diet, the SAL group with 60 mg/kg salinomycin (SAL) in addition to the basal diet, and the NCCC I, II, III groups, which were supplemented with 50, 100, and 200 mg/kg NCCC, respectively, in addition to the basal diet. The test lasted for 28 d. The results showed that dietary NCCC supplementation increased the liver Cu/Zn-SOD content and up-regulated the gene expression of Cu/Zn-SOD (p < 0.05), while also reducing the content of MDA in the liver and enhancing the antioxidant capacity of Ira white rabbits. Moreover, the NCCC diet supplementation reduced the content of IL-6 and down-regulated the relative expression of IL-6 and IL-1 beta genes in the jejunum of Ira white rabbits (p < 0.05). In addition, the metagenomic analysis of 16 S rRNA showed significant differences in the cecal microbial structure of weaned Ira white rabbits in the NCCC III group compared with the CON, NCCC I, and NCCC II groups (p < 0.05). Firmicutes and Bacteroidetes were the dominant phyla of cecal microorganisms in weaned Ira rabbits in the NCCC diet groups. The dominant genera included unidentified Eubacteriaceae, unclassified Lachnospiraceae, Christensenellaceae, and Ruminococcus. Furthermore, the relative abundance of Ruminococcus in the NCCC I and II groups was lower than that in the CON group in the cecum of Ira white rabbits (p < 0.05). In summary, our results showed that diet supplementation with NCCC could enhance the antioxidant capacity in the liver, alleviate intestinal inflammation, and regulate the structure of intestinal flora, improving the health of Ira white rabbits.
Keyword ：
cecum microorganisms cecum microorganisms Ira white rabbit Ira white rabbit jejunal immunity jejunal immunity liver antioxidant liver antioxidant NCCC NCCC weaning stress weaning stress
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| GB/T 7714 | Zhou, Ying-Huan , Liu, Xiao-Ping , Gu, Xiao-Ming et al. Effects of Dietary Nano-Composite of Copper and Carbon on Antioxidant Capacity, Immunity, and Cecal Microbiota of Weaned Ira White Rabbits [J]. | ANIMALS , 2025 , 15 (2) . |
| MLA | Zhou, Ying-Huan et al. "Effects of Dietary Nano-Composite of Copper and Carbon on Antioxidant Capacity, Immunity, and Cecal Microbiota of Weaned Ira White Rabbits" . | ANIMALS 15 . 2 (2025) . |
| APA | Zhou, Ying-Huan , Liu, Xiao-Ping , Gu, Xiao-Ming , Lv, Hai-Xuan , Yang, Yun , Cai, Zai-Xing et al. Effects of Dietary Nano-Composite of Copper and Carbon on Antioxidant Capacity, Immunity, and Cecal Microbiota of Weaned Ira White Rabbits . | ANIMALS , 2025 , 15 (2) . |
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Lutein, a naturally occurring xanthophyll carotenoid abundant in leafy green vegetables, is known for its antioxidative and anti-inflammatory effects. This research assessed how lutein modulates intestinal inflammation triggered by lipopolysaccharide (LPS) exposure in vivo and in vitro. In vivo trials involved 240 male yellowfeathered broilers (1-day-old) divided into four groups: control (basal diet), lutein-supplemented (40 mg/kg), LPS-challenged (1 mg/kg), and lutein+LPS. Growth parameters, inflammatory cytokines, and TLR4/MyD88 pathway components were analyzed. In vitro, chicken intestinal epithelial cells were exposed to LPS (20 mu g/mL) with or without lutein pretreatment. Results indicated that lutein mitigated LPS-induced growth suppression (ADG: P = 0.09; BWG: P = 0.10) and reduced pro-inflammatory cytokines (IL-1(3, IL-6) and the inflammatory signaling pathway transduction molecules TLR4, MyD88 expression (P < 0.05). In vitro, 80 mol/L lutein optimally attenuated inflammatory markers. In conclusion, lutein prevented the LPS-induced decline in growth performance, attenuated the inflammatory response, and inhibited the TLR4/MyD88 signaling pathway, thereby exerting a protective effect on the intestinal tract of broilers. These findings highlight lutein's potential to counteract LPS-induced inflammation via TLR4/MyD88 modulation, offering a strategy for poultry health management.
Keyword ：
Broiler Broiler Lipopolysaccharide Lipopolysaccharide Lutein Lutein
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| GB/T 7714 | Jin, Ling , Lin, Zhi-Xin , He, Jia-Yi et al. In vivo and in vitro protective effect of lutein against inflammatory response in lipopolysaccharide-induced broilers [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 320 . |
| MLA | Jin, Ling et al. "In vivo and in vitro protective effect of lutein against inflammatory response in lipopolysaccharide-induced broilers" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 320 (2025) . |
| APA | Jin, Ling , Lin, Zhi-Xin , He, Jia-Yi , Yang, Guo-Feng , Di, Bin , Guo, Ping-Ting et al. In vivo and in vitro protective effect of lutein against inflammatory response in lipopolysaccharide-induced broilers . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 320 . |
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本研究旨在探究纳米铜碳复合物（NCCC）对1～21日龄黄羽肉鸡生长性能、抗氧化能力及肠道屏障功能的影响，并寻求可达到最大生产效益且无明显不良影响的NCCC最低添加剂量。试验共选取240只1日龄黄羽肉鸡公雏，随机分至4个试验组，每组5个重复，每个重复12只，对照组饲喂玉米-豆粕型基础饲粮,其余3组则在基础饲粮中分别添加50、100 mg/kg和200 mg/kg NCCC。其中，对照组和50 mg/kg NCCC组为铜安全剂量组，100、200 mg/kg NCCC组为铜高剂量添加组。试验期为21 d。结果表明：与对照组相比，饲粮中添加不同水平的NCCC对黄羽肉鸡生长性能和免疫器官指数均无显著影响（P>0.05）。就抗氧化功能而言，与对照组相比，50 mg/kg和200 mg/kg NCCC组的肉鸡空肠黏膜还原型谷胱甘肽（GSH）与氧化型谷胱甘肽（GSSG）比值提高了6.14%和8.57%，过氧化氢酶（CAT）含量也提高了28.38%和24.92%，但同时会导致丙二醛（MDA）的含量增加19.27%和13.39%(P<0.05)。就肠道屏障功能而言，与对照组相比，50 mg/kg和200 mg/kg NCCC添加组肉鸡空肠黏膜分泌型免疫球蛋白A(sIgA)含量升高了32.04%和29.80%,β-防御素9(β-DF9)含量升高了38.38%和25.41%(P<0.05)，但50、100、200 mg/kg NCCC处理组屏障蛋白基因CLDN-1、CLDN-3、CLDN-1的表达水平降低了28.00%、10.00%和52.00%(P<0.05)。综上所述，1～21日龄黄羽肉鸡饲粮中添加NCCC对其生长性能和免疫器官发育无显著影响，对抗氧化功能和肠道屏障功能的影响有利有弊，因此，NCCC应用于肉鸡生产时，需要慎重考虑。
Keyword ：
抗氧化能力 抗氧化能力 生长性能 生长性能 纳米铜碳复合物 纳米铜碳复合物 肠道屏障 肠道屏障 黄羽肉鸡 黄羽肉鸡
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| GB/T 7714 | 林青杰 , 吴淑琴 , 林诗颖 et al. 纳米铜碳复合物对1～21日龄黄羽肉鸡生长性能、抗氧化和肠道屏障功能的影响 [J]. | 中国饲料 , 2024 , 9 (11) : 90-98 . |
| MLA | 林青杰 et al. "纳米铜碳复合物对1～21日龄黄羽肉鸡生长性能、抗氧化和肠道屏障功能的影响" . | 中国饲料 9 . 11 (2024) : 90-98 . |
| APA | 林青杰 , 吴淑琴 , 林诗颖 , 王长康 , 郭娉婷 . 纳米铜碳复合物对1～21日龄黄羽肉鸡生长性能、抗氧化和肠道屏障功能的影响 . | 中国饲料 , 2024 , 9 (11) , 90-98 . |
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Simple Summary: Juncao-substrate Ganoderma lucidum Residue (HWE-JGLR) is a dark brown powder. It is obtained by cultivating G. lucidum using mycorrhizae as culture material and extracting it from the remaining culture substrate after G. lucidum harvesting. The application of HWE-JGLR in animal feeds not only reduces the waste of resources but also promotes the reuse of agricultural resources and sustainable development. In our study, HWE-JGLR not only optimised the growth performance of broilers but also enhanced their immune responses. Specifically, dietary supplementation with HWE-JGLR was associated with increased production and gene expression of the immunomodulatory cytokine interleukin-4 (IL-4) and IL-10. Meanwhile, levels and gene expression of the pro-inflammatory cytokine IL-1 beta were significantly reduced. In addition, HWE-JGLR enhanced the intestinal barrier aspect in poultry. The addition of HWE-JGLR upregulated the gene expression of the broiler jejunal mucosal tight junction proteins Claudin-1 and ZO-1. The purpose of this experiment was to investigate the effects of Hot Water Extract of Juncao-substrate Ganoderma lucidum Residue (HWE-JGLR) on the immune function and intestinal health of yellow-feather broilers. In an animal feeding experiment, 288 male yellow-feather broilers (1 day old) were randomly allocated to four treatment groups with six replicates of 12 birds each. The control (CON) group was fed a basal diet. HJ-1, HJ-2, and HJ-3 were fed a basal diet supplemented with 0.25%, 0.50%, and 1.00% HWE-JGLR, respectively. The feeding trial lasted for 63 d. The results showed increased ADFI (p = 0.033) and ADG (p = 0.045) of broilers in HJ-3, compared with the CON group. Moreover, higher contents of serum IL-4 and IL-10 and gene expression of IL-4 and IL-10 in jejunum mucosa and lower contents of serum IL-1 beta and gene expression of IL-1 beta in jejunum mucosa in HJ-3 were observed (p < 0.05). Additionally, the jejunal mucosal gene expression of Claudin-1 and ZO-1 in HJ-2 and HJ-3 was higher than that in the CON group (p < 0.05). As for the microbial community, compared with the CON group, the ACE index, Shannon index, and Shannoneven index of cecal microorganisms in HJ-2 and HJ-3 were elevated (p < 0.05). PCoA analysis showed that the cecal microbial structure of broilers in HJ-2 and HJ-3 was different from the CON group (p < 0.05). In contrast with the CON group, the broilers in HJ-2 and HJ-3 possessed more abundant Desulfobacterota at the phylum level and unclassified Lachnospiraceae, norank Clostridia vadinBB60 group and Blautia spp. at the genus level, while Turicibacter spp. and Romboutsia spp. were less (p < 0.05). In conclusion, dietary supplementation with HWE-JGLR can improve growth performance, enhance body immunity and intestinal development, and maintain the cecum microflora balance of yellow-feather broilers.
Keyword ：
feed additives feed additives Ganoderma lucidum polysaccharide Ganoderma lucidum polysaccharide immune effect immune effect intestinal barrier intestinal barrier yellow-feather broilers yellow-feather broilers
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| GB/T 7714 | Gao, Yu-Yun , Liu, Xiao-Ping , Zhou, Ying-Huan et al. The Addition of Hot Water Extract of Juncao-Substrate Ganoderma lucidum Residue to Diets Enhances Growth Performance, Immune Function, and Intestinal Health in Broilers [J]. | ANIMALS , 2024 , 14 (20) . |
| MLA | Gao, Yu-Yun et al. "The Addition of Hot Water Extract of Juncao-Substrate Ganoderma lucidum Residue to Diets Enhances Growth Performance, Immune Function, and Intestinal Health in Broilers" . | ANIMALS 14 . 20 (2024) . |
| APA | Gao, Yu-Yun , Liu, Xiao-Ping , Zhou, Ying-Huan , He, Jia-Yi , Di, Bin , Zheng, Xian-Yue et al. The Addition of Hot Water Extract of Juncao-Substrate Ganoderma lucidum Residue to Diets Enhances Growth Performance, Immune Function, and Intestinal Health in Broilers . | ANIMALS , 2024 , 14 (20) . |
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Ganoderma lucidum polysaccharides (GLP) are the primary bioactive macromolecular compounds of Ganoderma lucidum, possessing antioxidant and immunomodulatory effects. Hot water extract of Juncao-substrate Ganoderma Lucidum residue (HWE-JGLR) is abundant in GLP. There are few research reports on the application of HWE-JGLR in animal husbandry. Therefore, this study aims to investigate the effects of HWE-JGLR supplementation on growth performance, serum biochemistry, the antioxidant function of serum and liver, and the intestinal microbiota of yellow-feathered broilers. The control group was fed a corn-soybean meal basal diet, while the HJ I, II, and III groups received diets supplemented with 0.25 %, 0.5 %, and 1 % of HWE-JGLR, respectively. Results showed that HWE-JGLR increased the serum HDL-C content and decreased the TG content in broilers. Moreover, HWE-JGLR enhanced the antioxidant function by the Keap1-Nrf2/ARE signaling pathway and the antioxidative enzyme in broilers. In addition, the cecum of the metagenomic analysis of 16S rRNA showed that the relative abundance of no-rank Ruminococcacea was increased in the HJ I group. Our findings indicate that HWE-JGLR has strong potential for development as a green feed additive based on its functions of lipid-lowering, antioxidation, and the modulation of gut microbiota composition.
Keyword ：
Antioxidant Antioxidant GLP GLP HWE-JGLR HWE-JGLR Intestinal microbiota Intestinal microbiota Lipid lowering Lipid lowering
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| GB/T 7714 | Gao, Yu-Yun , Zhou, Ying-Huan , Liu, Xiao-Ping et al. Ganoderma lucidum polysaccharide promotes broiler health by regulating lipid metabolism, antioxidants, and intestinal microflora [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 280 . |
| MLA | Gao, Yu-Yun et al. "Ganoderma lucidum polysaccharide promotes broiler health by regulating lipid metabolism, antioxidants, and intestinal microflora" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 280 (2024) . |
| APA | Gao, Yu-Yun , Zhou, Ying-Huan , Liu, Xiao-Ping , Di, Bin , He, Jia-Yi , Wang, Ya-Ting et al. Ganoderma lucidum polysaccharide promotes broiler health by regulating lipid metabolism, antioxidants, and intestinal microflora . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 280 . |
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Potassium diformate (KDF) is a kind of formate, which possesses the advantages of antimicrobial activity, growth promotion and preventing diarrhea in weaned piglets. However, the researches of KDF in animal production mostly focused on apparent indexes such as growth performance and the mechanisms of KDF on intestinal health have not been reported. Thus, porcine small intestinal epithelial cells (IPEC-J2) infected with Enterohemorrhagic Escherichia coli (EHEC) was used to investigate the role of KDF on alleviating intestinal inflammation in this study. The 0.125 mg/mL KDF treated IPEC-J2 cells for 6 h and IPEC-J2 cells challenged with 5 x 107 CFU/mL EHEC for 4 h were confirmed as the optimum concentration and time for the following experiment. The subsequent experiment was divided into four groups: control group (CON), EHEC group, KDF group, KDF+EHEC group. The results showed that KDF increased the cell viability and the gene expression levels of SGLT3 and TGF beta, while decreased the content of IL-1 beta compared with the CON group. The cell viability and the gene expressions of SGLT1, SGLT3, GLUT2, Claudin-1, Occludin and TGF-beta, and the protein expression of ZO-1 in EHEC group were lower than those in CON group, whereas the gene expressions of IL-1 beta, TNF, IL-8 and TLR4, and the level of phosphorylation NF-kB protein were increased. Pretreatment with KDF reduced the content of IgM and IL-1 beta, the gene expressions of IL-1 beta, TNF, IL-8 and TLR4 and the level of phosphorylation NF-kB protein, and increased the gene expression of TGF-beta and the protein expression of Occludin in IPEC-J2 cells infected EHEC. In conclusion, 0.125 mg/mL KDF on IPEC-J2 cells for 6 h had the beneficial effects on ameliorating the intestinal inflammation because of reduced pro-inflammatory cytokines and enhanced anti-inflammatory cytokines through regulating NF-kB signaling pathway under the EHEC challenge.
Keyword ：
Intestinal inflammation Intestinal inflammation Porcine small intestinal epithelial cells Porcine small intestinal epithelial cells Potassium diformate Potassium diformate
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| GB/T 7714 | Lin, Ying , Zhai, Jun-Lei , Wang, Ya-Ting et al. Potassium diformate alleviated inflammation of IPEC-J2 cells infected with EHEC [J]. | VETERINARY MICROBIOLOGY , 2024 , 291 . |
| MLA | Lin, Ying et al. "Potassium diformate alleviated inflammation of IPEC-J2 cells infected with EHEC" . | VETERINARY MICROBIOLOGY 291 (2024) . |
| APA | Lin, Ying , Zhai, Jun-Lei , Wang, Ya-Ting , Guo, Ping-Ting , Zhang, Jing , Wang, Chang-Kang et al. Potassium diformate alleviated inflammation of IPEC-J2 cells infected with EHEC . | VETERINARY MICROBIOLOGY , 2024 , 291 . |
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The present study was undertaken to evaluate the impacts of nano-composites of copper and carbon (NCCC) on the intestinal luminal micro-ecosystem and mucosal homeostasis of yellow-feather broilers. A total of two-hundred and forty 1-day-old male yellow-feather broilers were randomly allocated into four groups, each with five replications of twelve birds. The control (CON) group received a corn-soybean basal diet, while the N50, N100, and N200 groups were supplemented with 50, 100, and 200 mg/kg of NCCC in basal diets, respectively. The trial duration was 63 days. The findings demonstrated that there were slight impacts of NCCC addition on the intestinal luminal micro-ecosystem of broilers, with the fecal moisture content in the N100 group being slightly higher on Day 3 in the starter phase (p < 0.05). The cecal microbiota structure also did not obviously change (p > 0.05), in spite of the fall in the relative abundance of the Ruminococcus torques group in the N50 group and norank Clostridia UCG-014 in N200 group (p < 0.05). But for intestinal mucosal homeostasis, NCCC played a crucial part in jejunal morphology, tight junction, immunologic status, and antioxidant capacity. There was linear growth in villus height and a quadratic increase in villus height, crypt depth and their ratio with the increase in NCCC dosage (p < 0.05), and 100 mg/kg NCCC supplementation could intensify the expression of CLDN-3 genes (p < 0.05). In addition, IL-4 and IL-10 linearly increased after NCCC treatment (p < 0.05), along with some irregular changes in sIgA (p < 0.05). In addition, higher jejunal mucosal total antioxidant capacities in N50 and N200 groups were also observed (p < 0.05). Overall, NCCC treatment optimized the intestinal mucosa function of broilers in terms of physical barrier and immune and antioxidant capacities, but exerted subtle influence in the luminal environment of yellow-feather broilers. More precisely, dietary supplementation with 50 mg/kg NCCC is recommended for intestinal homeostasis of broilers.
Keyword ：
bacterial community bacterial community chicken chicken Cu-C nano-composites Cu-C nano-composites immunity immunity mechanical barrier mechanical barrier
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| GB/T 7714 | Wang, Xianglin , Xiao, Chunlong , Wu, Shuqing et al. Impacts of Nano-Composite of Copper and Carbon on Intestinal Luminal Micro-Ecosystem and Mucosal Homeostasis of Yellow-Feather Broilers [J]. | MICROORGANISMS , 2024 , 12 (11) . |
| MLA | Wang, Xianglin et al. "Impacts of Nano-Composite of Copper and Carbon on Intestinal Luminal Micro-Ecosystem and Mucosal Homeostasis of Yellow-Feather Broilers" . | MICROORGANISMS 12 . 11 (2024) . |
| APA | Wang, Xianglin , Xiao, Chunlong , Wu, Shuqing , Lin, Qingjie , Lin, Shiying , Liu, Jing et al. Impacts of Nano-Composite of Copper and Carbon on Intestinal Luminal Micro-Ecosystem and Mucosal Homeostasis of Yellow-Feather Broilers . | MICROORGANISMS , 2024 , 12 (11) . |
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The aim of this study was to investigate the effects of mixed organic acids (MOAs) on growth performance, immunity, antioxidants, intestinal digestion, and barrier function in Ira rabbits. A total of 192 weaned male Ira rabbits at 35 days of age were randomly assigned to four groups with six replicates of eight rabbits each. The rabbits in the control group (CON) were fed a basal diet, and the antibiotic group (SAL) was fed a basal diet supplemented with 60 mg/kg salinomycin. The test groups were fed a basal diet supplemented with 1000 mg/kg and 2000 mg/kg MOAs (MOA1 and MOA2, respectively). The experiment lasted for 55 days. The results showed that the ADG of Ira rabbits in the SAL group and MOA1 group was higher than that in the CON group (p < 0.05). The serum IL-6 and liver MDA levels of Ira rabbits in the SAL group, MOA1 group, and MOA2 group were lower than those in the CON group (p < 0.05). In addition, sIgA levels in the jejunal mucosa of Ira rabbits in the SAL group and MOA1 group were increased compared with those in the CON group (p < 0.05). Compared with the CON group, the gene expression of IL-6 was decreased (p < 0.05) in the jejunal mucosa of Ira rabbits in the SAL, MOA1, and MOA2 groups, while the gene expression of IL-1 beta tended to decrease (p = 0.077) and the IL-10 content tended to increase (p = 0.062). Moreover, the gene expression of ZO-1 in the jejunal mucosa of Ira rabbits was elevated in the MOA1 group compared with the CON group (p < 0.05). In conclusion, dietary supplementation with MOAs can improve growth performance, enhance immune function and antioxidant capacity, and maintain the intestinal barrier in weaned Ira rabbits.
Keyword ：
antioxidant antioxidant growth performance growth performance immunity immunity intestinal function intestinal function Ira rabbit Ira rabbit mixed organic acids mixed organic acids
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| GB/T 7714 | Lin, Zhixin , Yang, Guofeng , Zhang, Min et al. Dietary Supplementation of Mixed Organic Acids Improves Growth Performance, Immunity, and Antioxidant Capacity and Maintains the Intestinal Barrier of Ira Rabbits [J]. | ANIMALS , 2023 , 13 (19) . |
| MLA | Lin, Zhixin et al. "Dietary Supplementation of Mixed Organic Acids Improves Growth Performance, Immunity, and Antioxidant Capacity and Maintains the Intestinal Barrier of Ira Rabbits" . | ANIMALS 13 . 19 (2023) . |
| APA | Lin, Zhixin , Yang, Guofeng , Zhang, Min , Yang, Rui , Wang, Yating , Guo, Pingting et al. Dietary Supplementation of Mixed Organic Acids Improves Growth Performance, Immunity, and Antioxidant Capacity and Maintains the Intestinal Barrier of Ira Rabbits . | ANIMALS , 2023 , 13 (19) . |
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