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学者姓名：谢联辉
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Author summaryEmerging and re-emerging dangerous viruses cause epidemics or pandemics to threaten human and economically important crops and animals. Some of the most dangerous human viruses have zoonotic origins from wild animals. Native plants may also host new endemic viruses that can spread to cause epidemics in cultivated rice, one of the most important staple plants in the world. In the research, we discovered Rice tiller inhibition virus (RTIV), a new insect-borne positive-strand RNA virus, from Asian wild rice plants through metagenomic sequencing, and demonstrated that RTIV could be transmitted by a wide-distributed specific species of aphids to cultivated rice and inhibited tillering, an important agronomic trait of rice plants. We further rescued RTIV by developing infectious clone and confirmed that it can be a dangerous aphid-transmitted viral pathogen of cultivated rice plants. Thus, not only a rare aphid-transmitted viral pathogen of rice plants was discovered in the research, our findings also indicate that novel pathogenic viruses could spread out from native plants to threaten important crop plants. A major threat to rice production is the disease epidemics caused by insect-borne viruses that emerge and re-emerge with undefined origins. It is well known that some human viruses have zoonotic origins from wild animals. However, it remains unknown whether native plants host uncharacterized endemic viruses with spillover potential to rice (Oryza sativa) as emerging pathogens. Here, we discovered rice tiller inhibition virus (RTIV), a novel RNA virus species, from colonies of Asian wild rice (O. rufipogon) in a genetic reserve by metagenomic sequencing. We identified the specific aphid vector that is able to transmit RTIV and found that RTIV would cause low-tillering disease in rice cultivar after transmission. We further demonstrated that an infectious molecular clone of RTIV initiated systemic infection and causes low-tillering disease in an elite rice variety after Agrobacterium-mediated inoculation or stable plant transformation, and RTIV can also be transmitted from transgenic rice plant through its aphid vector to cause disease. Finally, global transcriptome analysis indicated that RTIV may disturb defense and tillering pathway to cause low tillering disease in rice cultivar. Thus, our results show that new rice viral pathogens can emerge from native habitats, and RTIV, a rare aphid-transmitted rice viral pathogen from native wild rice, can threaten the production of rice cultivar after spillover.
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| GB/T 7714 | Yan, Wenkai , Zhu, Yu , Liu, Wencheng et al. Discovery of aphid-transmitted Rice tiller inhibition virus from native plants through metagenomic sequencing [J]. | PLOS PATHOGENS , 2023 , 19 (3) . |
| MLA | Yan, Wenkai et al. "Discovery of aphid-transmitted Rice tiller inhibition virus from native plants through metagenomic sequencing" . | PLOS PATHOGENS 19 . 3 (2023) . |
| APA | Yan, Wenkai , Zhu, Yu , Liu, Wencheng , Zou, Chengwu , Jia, Bei , Chen, Zhong-Qi et al. Discovery of aphid-transmitted Rice tiller inhibition virus from native plants through metagenomic sequencing . | PLOS PATHOGENS , 2023 , 19 (3) . |
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Paddy is an artificial ecosystem driven by human activities, such as adjustment of cropping systems, deployment of resistant varieties and pesticides use. Inappropriate human intervention aggravated the disruption of ecosystems, which resulted in rice viral disease epidemics characterized by fulminant, migrating and intermittent outbreaks. Rice stripe disease (RSD), lasting for over 10 years from 2000, was modeled for exploring better management strategies of plant viral disease transmitted by insect vectors. In eight counties of Jiangsu province, China, the biotic, abiotic and human factors between 2000 and 2012 were monitored to determine key factors of human activities related to RSD epidemics. RSD severity was significantly related to resistance, the interval of wheat harvest and rice sowing (WHRS) and inconsecutive interval of wheat sowing and rice harvest (WSRH). The relationship between human activities and the small brown planthopper (SBPH) showed that the resistance was more significantly associated with SBPH viruliferous rate in the preceding year than that of the current year but not correlated with SBPH density. Resistance could impact the SBPH viruliferous rate in the preceding year indirectly through transmission probability and, thereafter, the continuing disease epidemics. The insignificant interactive effects among resistance, WHRS and WSRH on disease severity meant that these three factors could be taken into consideration separately in agricultural practice according to rice chronological order. The quantitative field study conducted in Jiangsu province presented a good example of plant viral disease management, guided by which could not only avoid pointless actions but, most importantly, generate more efficient and economic returns. Therefore, in order to improve the management of RSD, it should focus on the adjustment of these human factors independently and sequentially in combination with the forecast of RSD.
Keyword ：
human activity human activity integrated pest management integrated pest management resistance resistance rice stripe disease rice stripe disease small brown planthopper small brown planthopper viruliferous rate viruliferous rate
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| GB/T 7714 | Ma, Yan-Li , Lin, Wen-Wu , Guo, Si-Si et al. Human Activity Played a Key Role in Rice Stripe Disease Epidemics: From an Empirical Evaluation of over a 10-Year Period [J]. | AGRICULTURE-BASEL , 2022 , 12 (9) . |
| MLA | Ma, Yan-Li et al. "Human Activity Played a Key Role in Rice Stripe Disease Epidemics: From an Empirical Evaluation of over a 10-Year Period" . | AGRICULTURE-BASEL 12 . 9 (2022) . |
| APA | Ma, Yan-Li , Lin, Wen-Wu , Guo, Si-Si , Xie, Lian-Hui , He, Dun-Chun , Cheng, Zhao-Bang . Human Activity Played a Key Role in Rice Stripe Disease Epidemics: From an Empirical Evaluation of over a 10-Year Period . | AGRICULTURE-BASEL , 2022 , 12 (9) . |
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植物病害的流行,多是人为干预不当偶发或突发事件所致.针对我国半个多世纪以来农业生产中出现的新问题,本文指出了农业绿色生产的紧迫性,并提出其原则要求与战略思考,强调坚持农业绿色生产,有利于调控植物病害的发生、流行,强调顺其自然才能维护自然本真的本质原理.最后阐述了在农业绿色生产中,强化植物医学工作对植物生态调控的重要性,研究结果旨在促进农业生态平衡,确保植物群体健康.
Keyword ：
农业绿色生产 农业绿色生产 植物医学 植物医学 植物生命系统 植物生命系统 生态调控 生态调控 病害流行 病害流行
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| GB/T 7714 | 谢联辉 . 农业绿色生产与病害生态调控 [J]. | 植物医生 , 2022 , 1 (1) : 1-4 . |
| MLA | 谢联辉 . "农业绿色生产与病害生态调控" . | 植物医生 1 . 1 (2022) : 1-4 . |
| APA | 谢联辉 . 农业绿色生产与病害生态调控 . | 植物医生 , 2022 , 1 (1) , 1-4 . |
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植物病害的流行，多是人为干预不当偶发或突发事件所致.针对我国半个多世纪以来农业生产中出现的新问题，本文指出了农业绿色生产的紧迫性，并提出其原则要求与战略思考，强调坚持农业绿色生产，有利于调控植物病害的发生、流行，强调顺其自然才能维护自然本真的本质原理.最后阐述了在农业绿色生产中，强化植物医学工作对植物生态调控的重要性，研究结果旨在促进农业生态平衡，确保植物群体健康.
Keyword ：
农业绿色生产 农业绿色生产 植物医学 植物医学 植物生命系统 植物生命系统 生态调控 生态调控 病害流行 病害流行
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| GB/T 7714 | 谢联辉 . 农业绿色生产与病害生态调控 [J]. | 植物医学 , 2022 , 1 (01) : 1-4 . |
| MLA | 谢联辉 . "农业绿色生产与病害生态调控" . | 植物医学 1 . 01 (2022) : 1-4 . |
| APA | 谢联辉 . 农业绿色生产与病害生态调控 . | 植物医学 , 2022 , 1 (01) , 1-4 . |
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Plant disease management plays an important role in achieving the sustainable development goals of the United Nations (UN) such as food security, human health, socio-economic improvement, resource conservation and ecological resilience. However, technologies available are often limited due to different interests between producers and society and lacks of proper understanding of economic thresholds and the complex interactions among ecology, productivity and profitability. A comprehensive synergy and conflict evaluation of economic, sociological and ecological effects with technologies, productions and evolutionary principles as main components should be used to guide sustainable disease management that aims to mitigate crop and economic losses in the short term while maintaining functional farm ecosystem in the long term. Consequently, there should be an increased emphasis on technology development, public education and information exchange among governments, researchers, producers and consumers to broaden the options for disease management in the future.
Keyword ：
agricultural sustainability agricultural sustainability disease economics disease economics food security food security plant disease management plant disease management resource conservation resource conservation
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| GB/T 7714 | He, Dun-chun , Burdon, Jeremy J. , Xie, Lian-hui et al. Triple bottom-line consideration of sustainable plant disease management: From economic, sociological and ecological perspectives [J]. | JOURNAL OF INTEGRATIVE AGRICULTURE , 2021 , 20 (10) : 2581-2591 . |
| MLA | He, Dun-chun et al. "Triple bottom-line consideration of sustainable plant disease management: From economic, sociological and ecological perspectives" . | JOURNAL OF INTEGRATIVE AGRICULTURE 20 . 10 (2021) : 2581-2591 . |
| APA | He, Dun-chun , Burdon, Jeremy J. , Xie, Lian-hui , Zhan, Jiasui . Triple bottom-line consideration of sustainable plant disease management: From economic, sociological and ecological perspectives . | JOURNAL OF INTEGRATIVE AGRICULTURE , 2021 , 20 (10) , 2581-2591 . |
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茶叶是中国重要的经济作物,品质安全附加值大,病虫防控是保障茶叶品质安全的关键环节。传统病虫防控的负外部性明显,生态调控是未来发展的方向,弄清茶农采纳生态调控技术的影响因素及其内在关系是重要的科学命题。为此,随机选取福建省五大茶区的517位茶农进行调查,对获取的数据采用Logistic回归模型分析茶农采纳生态调控技术的显著性影响因素,进而运用解释结构模型(Interpretative structural modeling,ISM)分析这些显著性因素间的层次结构,从茶农特征、技术认知和环境特征3个方面探讨因素间的内在逻辑。结果表明,在茶农采纳生态调控技术的显著性影响因素层次结构中,表层直接因素有茶叶年收益、销售模式、培训次数、政府抽检频率、往年病虫情况,中间因素有新技术成本和收益变化的认知、是否合作社成员、茶园面积,根源因素有文化教育程度、年龄,各层次因素沿根源层、中间层、表层、目标层逐级向上影响。据此,本文从合作、培训、监管、示范等方面提出了对茶树病虫生态调控技术推广进行宏观管理的建议。
Keyword ：
Logistic-ISM模型 Logistic-ISM模型 层次结构 层次结构 影响因素 影响因素 病虫生态调控 病虫生态调控
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| GB/T 7714 | 郑蓉蓉 , 刘路星 , 马妍丽 et al. 基于Logistic-ISM模型的茶农采纳病虫生态调控技术的影响因素及层次结构分析 [J]. | 茶叶科学 , 2020 , 40 (05) : 696-706 . |
| MLA | 郑蓉蓉 et al. "基于Logistic-ISM模型的茶农采纳病虫生态调控技术的影响因素及层次结构分析" . | 茶叶科学 40 . 05 (2020) : 696-706 . |
| APA | 郑蓉蓉 , 刘路星 , 马妍丽 , 王自帅 , 陈少游 , 何敦春 et al. 基于Logistic-ISM模型的茶农采纳病虫生态调控技术的影响因素及层次结构分析 . | 茶叶科学 , 2020 , 40 (05) , 696-706 . |
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Banana bunchy top virus (BBTV) poses a serious danger to banana crops worldwide. BBTV-encoded protein B4 is a determinant of pathogenicity. However, the relevant molecular mechanisms underlying its effects remain unknown. In this study, we found that a functional peptide could be liberated from protein B4, likely via proteolytic processing. Site-directed mutagenesis indicated that the functional processing of protein B4 is required for its pathogenic effects, including dwarfism and sterility, in plants. The released protein fragment targets host proteins, such as the large subunit of RuBisCO (RbcL) and elongation factor 2 (EF2), involved in protein synthesis. Therefore, the peptide released from B4 (also a precursor) may act as a non-canonical modifier to influence host-pathogen interactions involving BBTV and plants.
Keyword ：
Banana bunchy top virus (BBTV) Banana bunchy top virus (BBTV) Functional peptide Functional peptide Movement protein B4 Movement protein B4 Pathogenicity Pathogenicity
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| GB/T 7714 | Zhuang, Jun , Lin, Wenwu , Coates, Christopher J. et al. Cleavage of the Babuvirus Movement Protein B4 into Functional Peptides Capable of Host Factor Conjugation is Required for Virulence [J]. | VIROLOGICA SINICA , 2019 , 34 (3) : 295-305 . |
| MLA | Zhuang, Jun et al. "Cleavage of the Babuvirus Movement Protein B4 into Functional Peptides Capable of Host Factor Conjugation is Required for Virulence" . | VIROLOGICA SINICA 34 . 3 (2019) : 295-305 . |
| APA | Zhuang, Jun , Lin, Wenwu , Coates, Christopher J. , Shang, Pengxiang , Wei, Taiyun , Wu, Zujian et al. Cleavage of the Babuvirus Movement Protein B4 into Functional Peptides Capable of Host Factor Conjugation is Required for Virulence . | VIROLOGICA SINICA , 2019 , 34 (3) , 295-305 . |
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Viral infections universally rely on numerous hijacked host factors to be successful. It is therefore possible to control viral infections by manipulating host factors that are critical for viral replication. Given that host genes may play essential roles in certain cellular processes, any successful manipulations for virus control should cause no or mild effects on host fitness. We previously showed that a group of positive-strand RNA viruses enrich phosphatidylcholine (PC) at the sites of viral replication. Specifically, brome mosaic virus (BMV) replication protein 1a interacts with and recruits a PC synthesis enzyme, phosphatidylethanolamine methyltransferase, Cho2p, to the viral replication sites that are assembled on the perinuclear endoplasmic reticulum (ER) membrane. Deletion of the CHO2 gene inhibited BMV replication by 5-fold; however, it slowed down host cell growth as well. Here, we show that an engineered Cho2p mutant supports general PC synthesis and normal cell growth but blocks BMV replication. This mutant interacts and colocalizes with BMV 1a but prevents BMV 1a from localizing to the perinuclear ER membrane. The mislocalized BMV 1a fails to induce the formation of viral replication complexes. Our study demonstrates an effective antiviral strategy in which a host lipid synthesis gene is engineered to control viral replication without comprising host growth.
Keyword ：
metabolic engineering metabolic engineering phosphatidylcholine phosphatidylcholine phosphatidylethanolamine methyltransferase phosphatidylethanolamine methyltransferase plus-stranded RNA virus plus-stranded RNA virus protein targeting protein targeting viral replication viral replication viral replication complex viral replication complex virus control virus control
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| GB/T 7714 | He, Guijuan , Zhang, Zhenlu , Sathanantham, Preethi et al. An engineered mutant of a host phospholipid synthesis gene inhibits viral replication without compromising host fitness [J]. | JOURNAL OF BIOLOGICAL CHEMISTRY , 2019 , 294 (38) : 13973-13982 . |
| MLA | He, Guijuan et al. "An engineered mutant of a host phospholipid synthesis gene inhibits viral replication without compromising host fitness" . | JOURNAL OF BIOLOGICAL CHEMISTRY 294 . 38 (2019) : 13973-13982 . |
| APA | He, Guijuan , Zhang, Zhenlu , Sathanantham, Preethi , Zhang, Xin , Wu, Zujian , Xie, Lianhui et al. An engineered mutant of a host phospholipid synthesis gene inhibits viral replication without compromising host fitness . | JOURNAL OF BIOLOGICAL CHEMISTRY , 2019 , 294 (38) , 13973-13982 . |
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Scientific assessment related to the externalities of the tea ecological pest management (TEPM) system that can affect socio-economic development and ecological benefits is important to the sustainable development of the tea industry. This paper used the contingent valuation method to evaluate the externalities associated with TEPM and the factors affecting its adoption by farmers through survey data collected from Anxi county, Fujian province, China. The results showed that the positive externalities, which were not internalized (embodied in price), affected the willingness of tea farmers to adopt TEPM. The willingness to accept a subsidy for adopting the TEPM system was significantly affected by the individual tea farmer's age, education level, income, size of plantation, knowledge of human health and risk preference. The compensation threshold of externalities for TEPM was 5668.80 yuan per hectare per year. It is suggested that the government should adopt this threshold as a minimum subsidy to mitigate information asymmetry in two markets, namely ecological management technology and trading between suppliers and buyers of tea products. Finally, production stability and improved price for high quality tea resulting from healthy ecology in TEPM could enhance positive externalities. This coupled with other benefits, such as a reduction in the amount of resources spent on pesticides, could result in governmental subsidies for TEPM being gradually reduced over time.
Keyword ：
contingent valuation method (CVM) contingent valuation method (CVM) externalities externalities impact factors impact factors risk preference risk preference tea ecological pest management (TEPM) tea ecological pest management (TEPM)
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| GB/T 7714 | Zheng, Rongrong , Zhan, Jiasui , Liu, Luxing et al. Factors and Minimal Subsidy Associated with Tea Farmers' Willingness to Adopt Ecological Pest Management [J]. | SUSTAINABILITY , 2019 , 11 (22) . |
| MLA | Zheng, Rongrong et al. "Factors and Minimal Subsidy Associated with Tea Farmers' Willingness to Adopt Ecological Pest Management" . | SUSTAINABILITY 11 . 22 (2019) . |
| APA | Zheng, Rongrong , Zhan, Jiasui , Liu, Luxing , Ma, Yanli , Wang, Zishuai , Xie, Lianhui et al. Factors and Minimal Subsidy Associated with Tea Farmers' Willingness to Adopt Ecological Pest Management . | SUSTAINABILITY , 2019 , 11 (22) . |
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The viral replication proteins of plus-stranded RNA viruses orchestrate the biogenesis of the large viral replication compartments, including the numerous viral replicase complexes, which represent the sites of viral RNA replication. The formation and operation of these virus-driven structures require subversion of numerous cellular proteins, membrane deformation, membrane proliferation, changes in lipid composition of the hijacked cellular membranes and intensive viral RNA synthesis. These virus-driven processes require plentiful ATP and molecular building blocks produced at the sites of replication or delivered there. To obtain the necessary resources from the infected cells, tomato bushy stunt virus (TBSV) rewires cellular metabolic pathways by co-opting aerobic glycolytic enzymes to produce ATP molecules within the replication compartment and enhance virus production. However, aerobic glycolysis requires the replenishing of the NAD(+) pool. In this paper, we demonstrate the efficient recruitment of pyruvate decarboxylase (Pdc1) and alcohol dehydrogenase (Adh1) fermentation enzymes into the viral replication compartment. Depletion of Pdc1 in combination with deletion of the homologous PDC5 in yeast or knockdown of Pdc1 and Adh1 in plants reduced the efficiency of tombusvirus replication. Complementation approach revealed that the enzymatically functional Pdc1 is required to support tombusvirus replication. Measurements with an ATP biosensor revealed that both Pdc1 and Adh1 enzymes are required for efficient generation of ATP within the viral replication compartment. In vitro reconstitution experiments with the viral replicase show the pro-viral function of Pdc1 during the assembly of the viral replicase and the activation of the viral p92 RdRp, both of which require the co-opted ATP-driven Hsp70 protein chaperone. We propose that compartmentalization of the co-opted fermentation pathway in the tombusviral replication compartment benefits the virus by allowing for the rapid production of ATP locally, including replenishing of the regulatory NAD(+) pool by the fermentation pathway. The compartmentalized production of NAD(+) and ATP facilitates their efficient use by the co-opted ATP-dependent host factors to support robust tombusvirus replication. We propose that compartmentalization of the fermentation pathway gives an evolutionary advantage for tombusviruses to replicate rapidly to speed ahead of antiviral responses of the hosts and to outcompete other pathogenic viruses. We also show the dependence of turnip crinkle virus, bamboo mosaic virus, tobacco mosaic virus and the insect-infecting Flock House virus on the fermentation pathway, suggesting that a broad range of viruses might induce this pathway to support rapid replication. Author summary Replication of positive-strand RNA viruses, which infect plants and animals, depends on many cellular resources. These viruses subvert cellular membranes and co-opt host proteins to build replication compartments that produce the viral progeny. The viral replication process also requires cellular metabolites and energy in the form of ATP. Using plant host as well as the model host yeast, the authors discovered that tomato bushy stunt tombusvirus (TBSV) co-opts the fermentation pathway to facilitate the local generation of ATP within the replication compartments. TBSV replication induces high expression of pyruvate decarboxylase (Pdc1) and alcohol dehydrogenase (Adh1) fermentation enzymes. With the help of the viral replication protein, TBSV recruits Pdc1 and Adh1 into the viral replication compartment. The authors propose that compartmentalization of the fermentation pathway gives an evolutionary advantage for tombusviruses by facilitating rapid and efficient replication in the infected hosts. The authors also showed that the replication of five other plant viruses depends on the fermentation pathway in plants.
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| GB/T 7714 | Lin, Wenwu , Liu, Yuyan , Molho, Melissa et al. Co-opting the fermentation pathway for tombusvirus replication: Compartmentalization of cellular metabolic pathways for rapid ATP generation [J]. | PLOS PATHOGENS , 2019 , 15 (10) . |
| MLA | Lin, Wenwu et al. "Co-opting the fermentation pathway for tombusvirus replication: Compartmentalization of cellular metabolic pathways for rapid ATP generation" . | PLOS PATHOGENS 15 . 10 (2019) . |
| APA | Lin, Wenwu , Liu, Yuyan , Molho, Melissa , Zhang, Shengjie , Wang, Longshen , Xie, Lianhui et al. Co-opting the fermentation pathway for tombusvirus replication: Compartmentalization of cellular metabolic pathways for rapid ATP generation . | PLOS PATHOGENS , 2019 , 15 (10) . |
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