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学者姓名：黄志坚
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Abstract ：
本发明公开了一种肉桂醛的应用，其中肉桂醛能够调节雄激素睾酮的合成与分泌，可应用于调节雄激素睾酮的合成与分泌的相关产品中。且本发明通过试验探明了肉桂醛通过提高类固醇激素合成核受体启动子活性，上调类固醇激素合成酶的表达，增加了睾丸间质细胞雄激素的合成与分泌。
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| GB/T 7714 | 王磊 , 黄晓宇 , 黄志坚 et al. 肉桂醛的应用 : CN202510598873.5[P]. | 2025-05-09 . |
| MLA | 王磊 et al. "肉桂醛的应用" : CN202510598873.5. | 2025-05-09 . |
| APA | 王磊 , 黄晓宇 , 黄志坚 , 殷光文 , 孟庆蕊 , 王登峰 et al. 肉桂醛的应用 : CN202510598873.5. | 2025-05-09 . |
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Cinnamon (Cinnamomum cassia (L.) D. Don) is a commonly used drug in traditional Chinese medicine; it is especially useful for improving the reproductive performance in males and females. Cinnamaldehyde is the main component of cinnamon, which has bactericidal and disinfectant properties, promotes gastrointestinal motility and regulates testosterone secretion in the male. The present study aimed to investigate the mechanisms by which cinnamaldehyde regulates testosterone secretion in male animals. For this purpose, four-month-old male mice (n=25) were randomly divided into five groups (n=5 each) and treated with PBS, DMSO and three doses of cinnamaldehyde (25, 50 and 75mg/kg) by gavage for 2 weeks. Histological (IHC), ELISA and molecular analyses (WB, RTqPCR) were used to assess effects of cinnamaldehyde on murine liver, serum testosterone levels, and testicular enzymes associated with testosterone production. The mechanisms by which cinnamaldehyde affects testosterone secretion in testis Leydig cells were explored using ELISA, flow cytometry, WB, fluorescent quantitative PCR, and dual luciferase reporter systems. The results showed that cinnamaldehyde elevated murine body weight, serum testosterone, testicular interstitial cell density, and steroidogenic enzyme expression (StAR, CYP11A1, 3 beta- HSD) without altering hepatic tissue and testicular indices. Cinnamaldehyde treatment at 5x10-5M increased the expression of steroid hormone synthase in Leydig cells, increased the proportion of cells in the S phase, significantly increased the promoter activity of the steroid hormone synthesis nuclear receptor steroidogenic factor 1 (SF-1), and up-regulated the expression of the nuclear receptor SF-1. The present study showed that cinnamaldehyde can upregulate the expression of steroid hormone synthase by increasing the activity of the steroid hormone synthesis nuclear receptor promoter, which in turn increases the synthesis and secretion of testosterone from testicular interstitial cells.
Keyword ：
Cinnamaldehyde Cinnamaldehyde Leydig cells Leydig cells Nuclear receptors Nuclear receptors Steroidogenic-related genes Steroidogenic-related genes Testosterone Testosterone
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| GB/T 7714 | Meng, Qingrui , Huang, Xiaoyu , Cai, Congguang et al. The Effect and Mechanism of Cinnamaldehyde on Testosterone Secretion in Murine Model [J]. | PAKISTAN VETERINARY JOURNAL , 2025 , 45 (2) : 683-692 . |
| MLA | Meng, Qingrui et al. "The Effect and Mechanism of Cinnamaldehyde on Testosterone Secretion in Murine Model" . | PAKISTAN VETERINARY JOURNAL 45 . 2 (2025) : 683-692 . |
| APA | Meng, Qingrui , Huang, Xiaoyu , Cai, Congguang , Guo, Yuxin , Yang, Yang , Huang, Zhijian et al. The Effect and Mechanism of Cinnamaldehyde on Testosterone Secretion in Murine Model . | PAKISTAN VETERINARY JOURNAL , 2025 , 45 (2) , 683-692 . |
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Abstract ：
试验旨在探究海藻酶解产物对大黄鱼生长、消化吸收及免疫指标的影响。选取315尾健康状况良好、体重（109.30±2.94） g的大黄鱼幼鱼，随机分为3组，每组3个重复，每个重复35尾大黄鱼。A组在基础饲料中添加0.5%的复合海藻酶解产物，B组在基础饲料中添加0.5%的海带酶解产物，对照组（C组）饲喂基础饲料。试验期56 d。结果显示：A组和B组大黄鱼末重、存活率（SR）、平均增重（AWG）、增重率（WGR）显著高于C组（P<0.05）。A组肌肉中粗蛋白含量显著高于C组（P<0.05），水分和灰分含量显著低于C组（P<0.05）。A组和B组大黄鱼肠道绒毛高度（VH）和隐窝深度（CD）均显著大于C组（P<0.05）。C组大黄鱼血清补体C3水平显著高于A组和B组（P<0.05），补体C4水平显著高于B组（P<0.05）。研究表明，在饲料中添加0.5%海藻酶解产物或0.5%海带酶解产物可提升大黄鱼生长性能及SR，改善肌肉营养成分，促进肠道营养物质的吸收，增加抗病力，以0.5%复合海藻酶解产物添加效果较好。
Keyword ：
大黄鱼 大黄鱼 抗病力 抗病力 海藻酶解产物 海藻酶解产物 肌肉营养成分 肌肉营养成分 肠道功能 肠道功能
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| GB/T 7714 | 熊宇明 , 曾企辉 , 梁萍 et al. 海藻酶解产物对大黄鱼生长、消化吸收及免疫指标的影响 [J]. | 饲料研究 , 2025 , 48 (03) : 56-60 . |
| MLA | 熊宇明 et al. "海藻酶解产物对大黄鱼生长、消化吸收及免疫指标的影响" . | 饲料研究 48 . 03 (2025) : 56-60 . |
| APA | 熊宇明 , 曾企辉 , 梁萍 , 陈度煌 , 黄志坚 , 殷光文 et al. 海藻酶解产物对大黄鱼生长、消化吸收及免疫指标的影响 . | 饲料研究 , 2025 , 48 (03) , 56-60 . |
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为明确海藻酶解物饲喂大黄鱼的应用效果及对肠道菌群的影响，2022年11—12月在福建宁德海域使用添加0.5%复合海藻酶解物和0.5%海带酶解物的自配饲料饲养网箱养殖的大黄鱼8周，测定大黄鱼的存活率和平均增重，并采用NovaSeq PE250方案对肠道内容物进行16S rDNA扩增子测序，分析肠道菌群组成和特定菌群的相对丰度。结果显示：0.5%的复合海藻酶解物或0.5%的海带酶解物均可显著提高大黄鱼的存活率和平均增重（P<0.05）；肠道菌群分析显示0.5%复合海藻酶解物组大黄鱼肠道中扩增子序列变体（ASVs）达1 353种，以厚壁菌门（Firmicutes）、变形菌门（Proteobacteria）、拟杆菌门（Bacteroidota）、梭杆菌门（Fusobacteriota）和放线菌门（Actinobacteriota）为主，而0.5%海带酶解物组大黄鱼肠道中ASVs仅242种，各样本中以厚壁菌门和脱硫杆菌门（Desulfobacterota）为主，变形菌门相对丰度较低，均与对照组（749个ASVs，各样本中菌门相对丰度无规律）有较大差异；基于KEGG的肠道菌群功能分析显示在淀粉和蔗糖代谢、谷胱甘肽代谢、磷酸转移酶系统、氰基氨基酸代谢、亨廷顿病和其他糖降解上3组存在显著差异（P<0.05）；进一步分析发现，0.5%复合海藻酶解物增加了大黄鱼肠道菌群α多样性并提高了拟杆菌属及丁酸合成相关细菌的相对丰度，而0.5%海带酶解物则降低了大黄鱼肠道菌群α多样性，但可抑制肠道中假单胞菌属细菌的生长，且体外培养试验证实褐藻寡糖可极显著抑制变形假单胞菌生长（P<0.01）。综上可知，本试验制备的2种海藻酶解物可调节大黄鱼形成不同的肠道菌群结构，并均可促进大黄鱼的健康和生长，该结果可为大黄鱼海藻类饲料添加剂的开发和通过调整大黄鱼肠道菌群改善大黄鱼健康和生长的饲料添加剂研发提供数据参考。
Keyword ：
健康 健康 大黄鱼 大黄鱼 海藻酶解物 海藻酶解物 生长 生长 肠道菌群 肠道菌群
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| GB/T 7714 | 张露 , 熊宇明 , 董黎黎 et al. 海藻酶解物对大黄鱼生长和肠道菌群结构的影响 [J]. | 动物营养学报 , 2024 , 36 (03) : 1819-1833 . |
| MLA | 张露 et al. "海藻酶解物对大黄鱼生长和肠道菌群结构的影响" . | 动物营养学报 36 . 03 (2024) : 1819-1833 . |
| APA | 张露 , 熊宇明 , 董黎黎 , 梁萍 , 秦志清 , 王磊 et al. 海藻酶解物对大黄鱼生长和肠道菌群结构的影响 . | 动物营养学报 , 2024 , 36 (03) , 1819-1833 . |
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Abstract ：
马属动物胎儿颈部及四肢较长，易发生胎向异位难产。中国矮马是稀特马种资源，目前我国矮马的剖腹产手术成功率较低。该文报道了一例矮马剖腹产手术，总结分析了矮马难产、术后死亡的原因及剖腹产注意事项，以期为提高矮马剖腹产手术成功率提供参考和借鉴。
Keyword ：
剖腹产 剖腹产 外科手术 外科手术 矮马 矮马 胎向异位 胎向异位 难产 难产
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| GB/T 7714 | 李淑萍 , 胡崇伟 , 黄志坚 et al. 一例矮马剖腹产手术报告 [J]. | 福建畜牧兽医 , 2024 , 46 (03) : 60-62 . |
| MLA | 李淑萍 et al. "一例矮马剖腹产手术报告" . | 福建畜牧兽医 46 . 03 (2024) : 60-62 . |
| APA | 李淑萍 , 胡崇伟 , 黄志坚 , 唐耀 . 一例矮马剖腹产手术报告 . | 福建畜牧兽医 , 2024 , 46 (03) , 60-62 . |
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本发明公开了一种降低LmrS外排活性的靶点、方法及LmrS活性抑制剂和应用，多药外排泵LmrS的N29和Q30是影响其外排活性的关键氨基酸，本发明以LmrS的TM1的第29位N和/或第30位氨基酸Q为靶点，通过单个或联合突变N29和Q30为非极性氨基酸，可降低LmrS对抗生素的外排活性。此外，本发明还提供了靶向LmrS的N29或Q30靶点的中药植物源化合物抑制剂，其能够降低LmrS对抗生素的外排活性，该抑制剂可作为抗生素的佐剂提高金葡菌对相应抗生素的药物敏感性，进而提高金葡菌感染的治愈率，适宜进一步推广应用。
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| GB/T 7714 | 王登峰 , 曾企辉 , 殷光文 et al. 一种降低LmrS外排活性的靶点、方法及LmrS活性抑制剂和应用 : CN202411297221.X[P]. | 2024-09-18 . |
| MLA | 王登峰 et al. "一种降低LmrS外排活性的靶点、方法及LmrS活性抑制剂和应用" : CN202411297221.X. | 2024-09-18 . |
| APA | 王登峰 , 曾企辉 , 殷光文 , 王磊 , 郭盼盼 , 黄志坚 . 一种降低LmrS外排活性的靶点、方法及LmrS活性抑制剂和应用 : CN202411297221.X. | 2024-09-18 . |
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3岁雄性萨摩耶犬，临床表现为呕吐、食欲不佳、精神萎靡，根据一般检查、实验室检查、影像学检查等确诊为饲养管理不当引起的犬肠道异物梗阻，在手术治疗中发现患犬继发肠套叠，套叠处肠管仍有活性，遂予以整复保留。术后经镇痛消炎、加强饲养管理等措施，预后良好，康复出院。
Keyword ：
治疗 治疗 犬 犬 肠套叠 肠套叠 肠梗阻 肠梗阻 诊断 诊断
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| GB/T 7714 | 李淑萍 , 周伟红 , 黄志坚 . 犬异物性肠梗阻继发肠套叠的诊治与分析 [J]. | 福建畜牧兽医 , 2024 , 46 (06) : 100-102 . |
| MLA | 李淑萍 et al. "犬异物性肠梗阻继发肠套叠的诊治与分析" . | 福建畜牧兽医 46 . 06 (2024) : 100-102 . |
| APA | 李淑萍 , 周伟红 , 黄志坚 . 犬异物性肠梗阻继发肠套叠的诊治与分析 . | 福建畜牧兽医 , 2024 , 46 (06) , 100-102 . |
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本发明属于饲料和中兽药领域，具体涉及一种药食同源组合物及其制备方法和应用。本发明提供一种药食同源组合物，由甘草、金荞麦、牛蒡子制成。本发明药食同源组合物中金荞麦、甘草和牛蒡子能够达到协同增效的作用，能够取得提高猪的生长性能、降低料肉比、改善猪应激性、改善猪肝脏性能、提高猪免疫力、改善猪肠道菌群等效果。
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| GB/T 7714 | 王登峰 , 曾金哲 , 徐骏 et al. 一种药食同源组合物及其制备方法和应用 : CN202410110046.2[P]. | 2024-01-26 . |
| MLA | 王登峰 et al. "一种药食同源组合物及其制备方法和应用" : CN202410110046.2. | 2024-01-26 . |
| APA | 王登峰 , 曾金哲 , 徐骏 , 黄志坚 , 邓莉萍 , 胡宇豪 et al. 一种药食同源组合物及其制备方法和应用 : CN202410110046.2. | 2024-01-26 . |
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我国教育部高度重视慕课建设，提出了课程建设的“双万计划”。慕课建设和应用是实现我国高等教育公平，提高教育质量的关键一招。笔者以福建省精品慕课“兽医产科学”为例，介绍兽医类慕课建设和应用，为高校教师进行慕课建设、开展混合式教学提供参考。
Keyword ：
兽医产科学 兽医产科学 慕课 慕课 课程应用 课程应用 课程建设 课程建设
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| GB/T 7714 | 王磊 , 殷光文 , 王登峰 et al. “兽医产科学”精品慕课的建设与应用 [J]. | 当代畜牧 , 2023 , 2 (09) : 64-65 . |
| MLA | 王磊 et al. "“兽医产科学”精品慕课的建设与应用" . | 当代畜牧 2 . 09 (2023) : 64-65 . |
| APA | 王磊 , 殷光文 , 王登峰 , 江和基 , 黄志坚 . “兽医产科学”精品慕课的建设与应用 . | 当代畜牧 , 2023 , 2 (09) , 64-65 . |
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Long non-coding RNAs (lncRNAs) are crucial modulators in a variety of biological processes, such as gene expression, development, and immune defense. However, little is known about the function of lncRNAs in the development of Asian honey bee (Apis cerana) larval guts. Here, on the basis of our previously obtained deep-sequencing data from the 4-, 5-, and 6-day-old larval guts of A. cerana workers (Ac4, Ac5, and Ac6 groups), an in-depth transcriptome-wide investigation was conducted to decipher the expression pattern, regulatory manners, and potential roles of lncRNAs during the developmental process of A. cerana worker larval guts, followed by the verification of the relative expression of differentially expressed lncRNAs (DElncRNAs) and the targeting relationships within a competing endogenous RNA (ceRNA) axis. In the Ac4 vs. Ac5 and Ac5 vs. Ac6 comparison groups, 527 and 498 DElncRNAs were identified, respectively, which is suggestive of the dynamic expression of lncRNAs during the developmental process of larval guts. A cis-acting analysis showed that 330 and 393 neighboring genes of the aforementioned DElncRNAs were respectively involved in 29 and 32 functional terms, such as cellular processes and metabolic processes; these neighboring genes were also respectively engaged in 246 and 246 pathways such as the Hedgehog signaling pathway and the Wnt signaling pathway. Additionally, it was found that 79 and 76 DElncRNAs as potential antisense lncRNAs may, respectively, interact with 72 and 60 sense-strand mRNAs. An investigation of competing endogenous RNA (ceRNA) networks suggested that 75 (155) DElncRNAs in the Ac4 vs. Ac5 (Ac5 vs. Ac6) comparison group could target 7 (5) DEmiRNAs and further bind to 334 (248) DEmRNAs, which can be annotated to 33 (29) functional terms and 186 (210) pathways, including 12 (16) cellular- and humoral-immune pathways (lysosome pathway, necroptosis, MAPK signaling pathway, etc.) and 11 (10) development-associated signaling pathways (Wnt, Hippo, AMPK, etc.). The RT-qPCR detection of five randomly selected DElncRNAs confirmed the reliability of the used sequencing data. Moreover, the results of a dual-luciferase reporter assay were indicative of the binding relationship between MSTRG.11294.1 and miR-6001-y and between miR-6001-y and ncbi_107992440. These results demonstrate that DElncRNAs are likely to modulate the developmental process of larval guts via the regulation of the source genes' transcription, interaction with mRNAs, and ceRNA networks. Our findings not only yield new insights into the developmental mechanism underlying A. cerana larval guts, but also provide a candidate ceRNA axis for further functional dissection.
Keyword ：
Apis cerana cerana Apis cerana cerana development development gut gut honey bee honey bee lncRNA lncRNA non-coding RNA non-coding RNA regulation regulation
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| GB/T 7714 | Fan, Xiaoxue , Gao, Xuze , Zang, He et al. Diverse Regulatory Manners and Potential Roles of lncRNAs in the Developmental Process of Asian Honey Bee (Apis cerana) Larval Guts [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (20) . |
| MLA | Fan, Xiaoxue et al. "Diverse Regulatory Manners and Potential Roles of lncRNAs in the Developmental Process of Asian Honey Bee (Apis cerana) Larval Guts" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 . 20 (2023) . |
| APA | Fan, Xiaoxue , Gao, Xuze , Zang, He , Guo, Sijia , Jing, Xin , Zhang, Yiqiong et al. Diverse Regulatory Manners and Potential Roles of lncRNAs in the Developmental Process of Asian Honey Bee (Apis cerana) Larval Guts . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (20) . |
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