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学者姓名：吕旭聪
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Correction for 'Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats' by Lu Li et al., Food Funct., 2019, 10, 2560-2572, https://doi.org/10.1039/C9FO00075E.
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| GB/T 7714 | Li, Lu , Guo, Wei-Ling , Zhang, Wen et al. Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats (vol 10, pg 2560, 2019) [J]. | FOOD & FUNCTION , 2024 , 15 (20) : 10553-10553 . |
| MLA | Li, Lu et al. "Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats (vol 10, pg 2560, 2019)" . | FOOD & FUNCTION 15 . 20 (2024) : 10553-10553 . |
| APA | Li, Lu , Guo, Wei-Ling , Zhang, Wen , Xu, Jia-Xin , Qian, Min , Bai, Wei-Dong et al. Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats (vol 10, pg 2560, 2019) . | FOOD & FUNCTION , 2024 , 15 (20) , 10553-10553 . |
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本研究采用不同极性溶剂和复合蛋白酶酶解法依次浸提灵芝,获得灵芝不同活性部位。通过比较不同灵芝活性部位干预高脂饮食诱导的脂质代谢紊乱大鼠,筛选出灵芝95%乙醇提取物(GL95)具有较好改善脂质代谢作用,并对其改善脂质代谢紊乱可能作用机制进行分析。对GL95进行鉴定发现其富含灵芝酸A(GA),并验证其改善脂质代谢紊乱的可能作用机制,为GA在功能食品及降血脂药物的应用提供理论依据。主要研究结果如下:1.本研究以鹿角灵芝为原料,采用不同极性溶剂和复合蛋白酶依次浸提灵芝中不同活性部位并进行体内改善脂质代谢作用研究。结果表明:与其他实验组相比,GL95能显著抑制高脂饮食诱导的血清和肝脏中甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、游离脂肪酸(NEFA)水平的升高,和高密度脂蛋白胆固醇(HDL-C)水平的降低(P <0.01)。此外,HE染色显示GL95能有效抑制高脂饮食大鼠诱导的肝脏脂肪积累和组织病变。2.探究GL95对高脂饮食大鼠肠道菌群结构及其与脂质代谢相关生化指标的关系,并分析GL95对高脂饮食小鼠与脂质代谢相关基因表达的影响。与HFD组相比,口服GL95促进短链脂肪酸的合成和胆汁酸的排泄,并改变肠道微生物群的组成,尤其是调节与相关功能肠道菌群的相对丰度。网络图相关性分析显示:Alistipes、Defluviitalea、Peptococcaceae和Alloprevotella与血清和肝脏生化指标呈负相关。同时,口服GL95调控与脂质和胆固醇代谢相关基因的m RNA表达水平,以改善脂质代谢紊乱。通过超高效液相飞行质谱(UPLC-QTOFMS-MS)鉴定GL95,发现GL95含有12种物质,其中GA最为丰富。3.从GL95中分离纯化得到GA,并采用体内实验进一步验证其改善高脂饮食诱导的脂质代谢紊乱作用,结果表明:GA抑制高脂饮食小鼠体重和附睾脂肪的增长,显著降低血清中TC、TG和LDL-C,和降低肝组织中TC、TG和NEFA水平。组织病理学切片直观表现出GA能抑制肝组织脂质的积累和附睾脂肪细胞的增大。研究GA对高脂饮食小鼠粪便菌群结构及其与脂质代谢相关生化指标的关系,并分析GA对高脂饮食小鼠与脂质代谢相关基因表达的影响。研究发现:在种水平上,高脂饮食能有效改变粪便菌群结构,而灌胃GA干预具有改善高脂饮食小鼠粪便菌群结构。灌胃75 mg/kg day GA能显著性改变15 OTU丰富度,其中10...
Keyword ：
mRNA表 mRNA表 三萜类 三萜类 灵芝 灵芝 脂质代谢 脂质代谢 菌群结构 菌群结构
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| GB/T 7714 | 郭伟灵 , 曾峰 , 吕旭聪 et al. 灵芝活性物质对肠道菌群及脂质代谢调控作用机制 [C] //第十二届药用真菌学术研讨会 . 2023 . |
| MLA | 郭伟灵 et al. "灵芝活性物质对肠道菌群及脂质代谢调控作用机制" 第十二届药用真菌学术研讨会 . (2023) . |
| APA | 郭伟灵 , 曾峰 , 吕旭聪 , 刘斌 . 灵芝活性物质对肠道菌群及脂质代谢调控作用机制 第十二届药用真菌学术研讨会 . (2023) . |
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Levilactobacillus brevis FZU0713, a potential probiotic previously isolated from the traditional brewing process of Hongqu rice wine, may have the beneficial effects on improving lipid metabolism. This study aimed to evaluate the in vivo protective effects and possible mechanism of L. brevis FZU0713 on the disturbance of lipid metabolism in hyperlipidemic rats fed a high-fat diet (HFD). Results showed that oral administration of L. brevis FZU0713 could significantly inhibit obesity, ameliorate the lipid metabolism disorder, including serum/liver biochemical parameters and hepatic oxidative stress in HFD-fed rats. Histopathological result also indicated that dietary intervention of L. brevis FZU0713 could reduce the accumulation of lipid droplets in liver induced by 8 weeks HFD feeding. Furthermore, L. brevis FZU0713 intervention significantly increased the fecal levels of short-chain fatty acids (SCFAs, including acetate, propionate, butyrate, isobutyrate, valerate and isovalerate) in HFD-fed rats, which may be closely related to the changes of intestinal microbial composition and metabolic function. Intestinal microbiota profiling by 16S rRNA gene sequencing revealed that L. brevis FZU0713 intervention significantly altered the relative abundance of Coprococcus, Butyricicoccus, Intestinimonas, Lachnospiraceae FCS020 group, Ruminococcaceae_NK4A214 group, Ruminococcaceae_UCG-005 and UCG-01 4 at genus levels. Based on Spearman's rank correlation coefficient, serum and liver lipid metabolism related biochemical parameters were positively correlated with genera Ruminococcus, Pediococcus and Lachnospiraceae, but negatively correlated with genera Pseudoflavonifractor, Butyricicoccus and Intestinimonas. Furthermore, liver metabolomics analysis demonstrated that L. brevis FZU0713 had a significant regulatory effect on the composition of liver metabolites in hyperlipidemic rats, especially the levels of some important biomarkers involved in the metabolic pathways of arachidonic acid metabolism, primary bile acid biosynthesis, amino sugar and nucleotide sugar metabolism, taurine and hypotaurine metabolism, biosynthesis of unsaturated fatty acid, fructose and mannose metabolism, tyrosine metabolism, etc. Additionally, oral administration of L. brevis FZU0713 significantly regulated the mRNA levels of liver genes (including Acat2, Acox1, Hmgcr, Cd36, Srebp-1c and Cyp7a1) involved in lipid metabolism and bile acid homeostasis. In conclusion, our findings provide the evidence that L. brevis FZU0713 has the potential to improve disturbance of lipid metabolism by regulating intestinal microflora and liver metabonomic profile. Therefore, L. brevis FZU0713 may be used as a potential probiotic strain to produce functional food to prevent hyperlipidemia.(c) 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keyword ：
Hyperlipidemia Hyperlipidemia Intestinal microbiota Intestinal microbiota Levilactobacillus brevis FZU0713 Levilactobacillus brevis FZU0713 Lipid metabolism Lipid metabolism Liver metabolomics Liver metabolomics mRNA expression mRNA expression
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| GB/T 7714 | Fan, Xiaoyun , Zhang, Qing , Guo, Weiling et al. The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats [J]. | FOOD SCIENCE AND HUMAN WELLNESS , 2023 , 12 (5) : 1646-1659 . |
| MLA | Fan, Xiaoyun et al. "The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats" . | FOOD SCIENCE AND HUMAN WELLNESS 12 . 5 (2023) : 1646-1659 . |
| APA | Fan, Xiaoyun , Zhang, Qing , Guo, Weiling , Wu, Qi , Hu, Jinpeng , Cheng, Wenjian et al. The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats . | FOOD SCIENCE AND HUMAN WELLNESS , 2023 , 12 (5) , 1646-1659 . |
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Type 2 diabetes mellitus (T2DM) may lead to abnormally elevated blood glucose, lipid metabolism disorder, and low-grade inflammation. Besides, the development of T2DM is always accompanied by gut microbiota dysbiosis and metabolic dysfunction. In this study, the T2DM mice model was established by feeding a high-fat/sucrose diet combined with injecting a low dose of streptozotocin. Additionally, the effects of oral administration of ethanol extract from Sanghuangporous vaninii (SVE) on T2DM and its complications (including hypoglycemia, hyperlipidemia, inflammation, and gut microbiota dysbiosis) were investigated. The results showed SVE could improve body weight, glycolipid metabolism, and inflammation-related parameters. Besides, SVE intervention effectively ameliorated the diabetes-induced pancreas and jejunum injury. Furthermore, SVE intervention significantly increased the relative abundances of Akkermansia, Dubosiella, Bacteroides, and Parabacteroides, and decreased the levels of Lactobacillus, Flavonifractor, Odoribacter, and Desulfovibrio compared to the model group (LDA > 3.0, p < 0.05). Metabolic function prediction of the intestinal microbiota by PICRUSt revealed that glycerolipid metabolism, insulin signaling pathway, PI3K-Akt signaling pathway, and fatty acid degradation were enriched in the diabetic mice treated with SVE. Moreover, the integrative analysis indicated that the key intestinal microbial phylotypes in response to SVE intervention were strongly correlated with glucose and lipid metabolism-associated biochemical parameters. These findings demonstrated that SVE has the potential to alleviate T2DM and its complications by modulating the gut microbiota imbalance.
Keyword ：
anti-diabetic effect anti-diabetic effect gut microbiota gut microbiota hyperglycemia hyperglycemia hyperlipidemia hyperlipidemia Sanghuangporous vaninii Sanghuangporous vaninii
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| GB/T 7714 | Huang, Zi-Rui , Zhao, Li-Yuan , Zhu, Fu-Rong et al. Anti-Diabetic Effects of Ethanol Extract from Sanghuangporous vaninii in High-Fat/Sucrose Diet and Streptozotocin-Induced Diabetic Mice by Modulating Gut Microbiota [J]. | FOODS , 2022 , 11 (7) . |
| MLA | Huang, Zi-Rui et al. "Anti-Diabetic Effects of Ethanol Extract from Sanghuangporous vaninii in High-Fat/Sucrose Diet and Streptozotocin-Induced Diabetic Mice by Modulating Gut Microbiota" . | FOODS 11 . 7 (2022) . |
| APA | Huang, Zi-Rui , Zhao, Li-Yuan , Zhu, Fu-Rong , Liu, Yun , Xiao, Jian-Yong , Chen, Zhi-Chao et al. Anti-Diabetic Effects of Ethanol Extract from Sanghuangporous vaninii in High-Fat/Sucrose Diet and Streptozotocin-Induced Diabetic Mice by Modulating Gut Microbiota . | FOODS , 2022 , 11 (7) . |
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This study aimed to investigate effect of Hong Qu on flavor and quality of Hakka yellow rice wine (Hakka Huangjiu). Volatile components of three kinds of Hakka Huangjiu with or without adding Hong Qu were analyzed by solid phase microextraction-gas chromatography-mass spectrometry. Their non-volatile components were also detected by liquid chromatography quadrupole Orbitrap mass spectrometry (LC-Q-Orbitrap-MS). Re-sults indicated that there were great differences in flavor components among three wines. Among them, the main difference components between traditional Hakka Huangjiu and Hakka Huangjiu without adding Hong Qu were isoamyl alcohol, phenylethanol, isobutyl acetate, isobutyl alcohol, ethyl palmitate and ethyl decanoate. In Hakka Huangjiu, esters were the most volatile components, followed by alcohols, while acids were less. Under NEG and POS modes of LC-Q-Orbitrap-MS, a total of 765 and 1244 components were detected in three kinds of Hakka Huangjiu, respectively. Among 217 kinds of polypeptides detected, the content of 160 kinds of polypeptides in Hakka Huangjiu adding only with Hong Qu was higher than that of traditional Hakka Huangjiu and Hakka Huangjiu without adding Hong Qu. Amino acids and polypeptides contents in Hakka Huangjiu brewed only with Hong Qu and traditional Hakka Huangjiu co-fermented with Hong Qu were relatively high.
Keyword ：
Flavor Flavor GC-MS GC-MS Orbitrap Orbitrap Polypeptide Polypeptide Yellow rice wine Yellow rice wine
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| GB/T 7714 | Zhao, Wenhong , Qian, Min , Dong, Hao et al. Effect of Hong Qu on the flavor and quality of Hakka yellow rice wine (Huangjiu) produced in Southern China [J]. | LWT-FOOD SCIENCE AND TECHNOLOGY , 2022 , 160 . |
| MLA | Zhao, Wenhong et al. "Effect of Hong Qu on the flavor and quality of Hakka yellow rice wine (Huangjiu) produced in Southern China" . | LWT-FOOD SCIENCE AND TECHNOLOGY 160 (2022) . |
| APA | Zhao, Wenhong , Qian, Min , Dong, Hao , Liu, Xiaoyan , Bai, Weidong , Liu, Gongliang et al. Effect of Hong Qu on the flavor and quality of Hakka yellow rice wine (Huangjiu) produced in Southern China . | LWT-FOOD SCIENCE AND TECHNOLOGY , 2022 , 160 . |
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This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake. Results showed GA supplement significantly inhibited the abnormal elevation of the liver index, serum lipid parameters, aspartate aminotransferase and alanine aminotransferase in mice exposed to alcohol intake, and also significantly protected the excessive lipid accumulation and pathological changes. Alcohol-induced oxidative stress in the liver was significantly ameliorated by GA intervention through reducing the levels of maleic dialdehyde and lactate dehydrogenase and increasing the levels of glutathione, catalase, superoxide dismutase and alcohol dehydrogenase. Intestinal microbiota profiling demonstrated GA intervention modulated the composition of intestinal microflora by increasing the levels of Lactobacillus, Faecalibaculum, Romboutsia, Bifidobacterium and decreasing the Helicobacter level. Furthermore, liver metabolomic profiling suggested GA intervention had a remarkable regulatory effect on liver metabolism with excessive alcohol consumption. Moreover, GA intervention regulated mRNA levels of alcohol metabolism, fatty lipid metabolism, oxidative stress, bile acid biosynthesis and metabolism-related genes in the liver. Conclusively, these findings demonstrate GA intervention can significantly relieve alcoholic liver injury and it is hopeful to become a new functional food ingredient for the prevention of alcoholic liver injury.
Keyword ：
ganoderic acids ganoderic acids Ganoderma lucidum Ganoderma lucidum intestinal flora intestinal flora liver injury liver injury liver metabolism liver metabolism
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| GB/T 7714 | Cao, Ying-Jia , Huang, Zi-Rui , You, Shi-Ze et al. The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake [J]. | FOODS , 2022 , 11 (7) . |
| MLA | Cao, Ying-Jia et al. "The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake" . | FOODS 11 . 7 (2022) . |
| APA | Cao, Ying-Jia , Huang, Zi-Rui , You, Shi-Ze , Guo, Wei-Ling , Zhang, Fang , Liu, Bin et al. The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake . | FOODS , 2022 , 11 (7) . |
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This study aimed to evaluate the possibility that Spirulina platensis crude polysaccharides may ameliorate the lipid and carbohydrate metabolism disorder, including obesity, hyperlipidemia, hyperglycemia, hepatic steatosis, and gut dysbiosis. The results showed Spirulina platensis crude polysaccharides could improve body weight, serum/liver lipid and carbohydrate indexes, and liver antioxidant parameters in high-sucrose and high-fat diet (HFD)-fed rats, which were accompanied by regulated liver mRNA expressions involved in lipid and carbohydrate metabolism disorder. In addition, SPLP intervention significantly decreased cecal level of propionic acid in HFD-fed rats. Notably, the SPLP could alter the relative abundance of Firmicutes, Bacteroides, Proteobacteria, and Actinobacteria at phylum levels. Based on Spearman's rank correlation coefficient, serum/liver lipid and carbohydrate profiles were found significantly positively correlated with genera Romboutsia, Allobaculum, Blautia, Phascolarctobacterium, Bifidobacterium, Coprococcus, Turicibacter, Erysipelotrichaceae_unclassified, Olsenella, Escherichia/Shigella, Coprobacillus, Lachnospiracea incertae, and Lactobacillus, but strongly negatively correlated with genera Atopostipes, Flavonifractor, Porphyromonadaceae_unclassified, Barnesiella, Oscillibacter, Paraprevotella, Jeotgalicoccus, Corynebacterium, Alloprevotella and Bacteroides. It was concluded that oral administration of SPLP could remarkably ameliorate the lipid and carbohydrate metabolism disorder and significantly modulate the intestinal microbiota in HFD-fed rats.
Keyword ：
Intestinal microbiota Intestinal microbiota Lipid and carbohydrate metabolism disorder Lipid and carbohydrate metabolism disorder mRNA expression mRNA expression Short-chain fatty acid Short-chain fatty acid Spirulina platensis polysaccharides Spirulina platensis polysaccharides
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| GB/T 7714 | Li, Tian-Tian , Huang, Zi-Rui , Jia, Rui-Bo et al. Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota [J]. | FOOD RESEARCH INTERNATIONAL , 2021 , 147 . |
| MLA | Li, Tian-Tian et al. "Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota" . | FOOD RESEARCH INTERNATIONAL 147 (2021) . |
| APA | Li, Tian-Tian , Huang, Zi-Rui , Jia, Rui-Bo , Lv, Xu-Cong , Zhao, Chao , Liu, Bin . Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota . | FOOD RESEARCH INTERNATIONAL , 2021 , 147 . |
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Chinese rice wine (Huangjiu), a typical representative of traditional fermented foods in China, is distinguished for its unique flavor. Microorganisms play the most important role in the formation of the unique flavor of Huangjiu. The complex flavor components in Huangjiu are closely related to the metabolism of various microorganisms during the traditional brewing. Therefore, understanding the influence of microbiota on the formation of flavor components in Huangjiu is conducive to the production of Huangjiu with high-quality flavor. In recent years, many scholars have conducted a large number of studies on the microbial community and flavor metabolites during the traditional brewing process of Huangjiu, with the help of high-throughput sequencing (HTS) and mass spectrometry-based metabolomics. This review mainly summarized the current study progress of the microbial diversity of fermentation starters (Qu) and brewing process of Huangjiu, and explored the potential relationship between the microbial community and the characteristic flavor formation of Huangjiu. Through the comparative analysis of literatures, we found that Huangjiu has strong regional characteristics due to the differences in raw materials, Qu and traditional brewing techniques. Dynamics of microbial composition during the traditional brewing of Huangjiu in different regions of China are quite different, making Huangjiu in each region have their own flavor characteristics. Therefore, revealing the relationship between brewing microorganisms and flavor characteristics of Huangjiu is helpful to the directional regulation of flavor quality. According to the current research status, it is proposed that in the future, emerging technologies such as multi-omics, artificial intelligence, and machine learning should be applied to further improve the accuracy of the analysis of microbial flora and flavor components in Huangjiu, so as to accurately reveal the relationship between the microbial community and the formation of characteristic flavor of Huangjiu. Afterwards, high-throughput screening of excellent functional strains from the traditional brewing system should be applied to the industrial production of Huangjiu, so as to improve the overall flavor quality and commercial value.
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| GB/T 7714 | Chen, Gui-Mei , Huang, Zi-Rui , Wu, Li et al. Microbial diversity and flavor of Chinese rice wine (Huangjiu): an overview of current research and future prospects [J]. | CURRENT OPINION IN FOOD SCIENCE , 2021 , 42 : 37-50 . |
| MLA | Chen, Gui-Mei et al. "Microbial diversity and flavor of Chinese rice wine (Huangjiu): an overview of current research and future prospects" . | CURRENT OPINION IN FOOD SCIENCE 42 (2021) : 37-50 . |
| APA | Chen, Gui-Mei , Huang, Zi-Rui , Wu, Li , Wu, Qi , Guo, Wei-Ling , Zhao, Wen-Hong et al. Microbial diversity and flavor of Chinese rice wine (Huangjiu): an overview of current research and future prospects . | CURRENT OPINION IN FOOD SCIENCE , 2021 , 42 , 37-50 . |
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This study aimed to investigate the beneficial effects of the oral administration of Lactobacillus brevis FZU0713-fermented Laminaria japonica (FLJ) on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed with a high-fat diet (HFD). The results demonstrated that the oral administration of FLJ significantly inhibited obesity and improved the serum and hepatic biochemical parameters in HFD-fed rats. Histopathological results also indicated that FLJ intervention could significantly reduce the accumulation of lipid droplets in the liver induced by HFD feeding. Furthermore, FLJ intervention up-regulated the fecal short-chain fatty acid (SCFA) levels (mainly acetate, propionate and isobutyrate) in HFD-fed rats. Intestinal microbiota profiling by 16S rRNA gene sequencing revealed that FLJ intervention increased the relative abundance of Akkermansia, Collinsella, Ruminococcaceae_UCG-013, Defluviitaleaceae_UCG-011, Intestinimonas, Actinomyces and Tyzzerella, but decreased the abundance of Flavonifractor, Collinsella, Sporosarcina and Lacticigenium. Based on Spearman's correlation, the fecal levels of TC, TG, acetic acid and butyric acid were positively correlated with the relative abundance of Akkermansia and Ruminococcaceae_NK4A214, but negatively correlated with the relative amount of Flavonifractor and Collinsella. The metabolic function of intestinal microbiota predicted by PICRUSt analysis of 16S rRNA gene sequences demonstrated that primary and secondary bile acid biosyntheses, fatty acid biosynthesis, taurine and hypotaurine metabolism, arachidonic acid metabolism, glycolysis/gluconeogenesis, etc. were significantly down-regulated after 8 weeks of FLJ intervention. Additionally, FLJ intervention significantly regulated the hepatic mRNA levels (including BSEP, CYP7A1, LDLR, HMGCR, CD36 and SREBP1-C) involved in lipid metabolism and bile acid homeostasis. In conclusion, these findings support the possibility that Laminaria japonica fermented with probiotic Lactobacillus has the potential to reduce the disturbance of lipid metabolism by regulating intestinal microflora and liver gene expression profiles, so it can be employed as a potential functional food to prevent hyperlipidemia.
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| GB/T 7714 | Zhang, Qing , Fan, Xiao-Yun , Cao, Ying-Jia et al. The beneficial effects of Lactobacillus brevis FZU0713-fermented Laminaria japonica on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed with a high-fat diet [J]. | FOOD & FUNCTION , 2021 , 12 (16) : 7145-7160 . |
| MLA | Zhang, Qing et al. "The beneficial effects of Lactobacillus brevis FZU0713-fermented Laminaria japonica on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed with a high-fat diet" . | FOOD & FUNCTION 12 . 16 (2021) : 7145-7160 . |
| APA | Zhang, Qing , Fan, Xiao-Yun , Cao, Ying-Jia , Zheng, Ting-Ting , Cheng, Wen-Jian , Chen, Li-Jiao et al. The beneficial effects of Lactobacillus brevis FZU0713-fermented Laminaria japonica on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed with a high-fat diet . | FOOD & FUNCTION , 2021 , 12 (16) , 7145-7160 . |
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The present study investigated the composition of water extract of Grifola frondosa (GFWE) and its regulatory effects on glycolipid metabolism and gut microbiota in rats. Structural characteristics of GFWE were detected by high performance liquid chromatography and ultra-high-performance liquid chromatography with mass spectrometry. The hypoglycemic and hypolipidemic activities of GFWE were obtained by inhibition of weight gain, recovery of serumglucose and lipid, and reverse of liver tissue damage. GFWEhas up-regulated the relative mRNA and protein expression levels of adenine monophosphate activated protein kinase-alpha, peroxisome proliferator-activated receptors-alpha, and glucokinase, while down-regulated sterol regulatory element-binding transcription factor-1c and acetyl CoA carboxylase. Moreover, GFWE increased the abundances of caecal bacteria Oscillibacter and Barnesiella, which showed a significant negative correlationwith serumglucose and lipid parameters. And GFWE enhanced the levels of total bile acids and short-chain fatty acids in the cecum. These results indicated that GFWE could be provided as a potential candidate to regulate glycolipid metabolism and gut microbiota. (C) 2019 Elsevier B.V. All rights reserved.
Keyword ：
Glycolipid metabolism Glycolipid metabolism Grifola frondosa Grifola frondosa Gut microbiota Gut microbiota Signaling pathway Signaling pathway
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| GB/T 7714 | Pan, Yuyang , Wan, Xuzhi , Zeng, Feng et al. Regulatory effect of Grifola frondosa extract rich in polysaccharides and organic acids on glycolipid metabolism and gut microbiota in rats [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2020 , 155 : 1030-1039 . |
| MLA | Pan, Yuyang et al. "Regulatory effect of Grifola frondosa extract rich in polysaccharides and organic acids on glycolipid metabolism and gut microbiota in rats" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 155 (2020) : 1030-1039 . |
| APA | Pan, Yuyang , Wan, Xuzhi , Zeng, Feng , Zhong, Ruting , Guo, Weiling , Lv, Xu-Cong et al. Regulatory effect of Grifola frondosa extract rich in polysaccharides and organic acids on glycolipid metabolism and gut microbiota in rats . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2020 , 155 , 1030-1039 . |
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