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学者姓名：卢凯
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Abstract ：
The involvement of carboxylesterases (CarEs) in resistance to chlorpyrifos has been confirmed by the synergism analysis in Nilaparvata lugens. However, the function of specific CarE gene in chlorpyrifos resistance and the transcriptional regulatory mechanism are obscure. Herein, the expression patterns of 29 CarE genes in the susceptible and chlorpyrifos-resistant strains were analyzed. Among them, CarE3, CarE17 and CarE19 were overexpressed in the resistant strain, and knockdown of either CarE gene by RNA interference significantly increased the susceptibility to chlorpyrifos. Remarkably, knockdown of CarE17 reduced the enzymatic activity of CarE by 88.63 % and showed a much greater effect on increasing chlorpyrifos toxicity than silencing other two CarE genes. Overexpression of CarE17 in Drosophila melanogaster decreased the toxicity of chlorpyrifos to transgenic fruit flies. Furthermore, the region between - 205 to + 256 of CarE17 promoter sequence showed the highest promoter activity, and 16 transcription factors (TFs) were predicted from this region. Among these TFs, Lim1 beta and C15 were overexpressed in the resistant strain. Knockdown of either TF resulted in reduced CarE17 expression and a decrease in resistance of N. lugens to chlorpyrifos. These results indicate that the constitutive overexpression of Lim1 beta and C15 induces CarE17 expression thus conferring chlorpyrifos resistance in N. lugens.
Keyword ：
Brown planthopper Brown planthopper Homeobox Homeobox Insecticide resistance Insecticide resistance Metabolic detoxification Metabolic detoxification Regulatory mechanism Regulatory mechanism
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| GB/T 7714 | Lu, Kai , Li, Yimin , Xiao, Tianxiang et al. The metabolic resistance of Nilaparvata lugens to chlorpyrifos is mainly driven by the carboxylesterase CarE17 [J]. | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY , 2022 , 241 . |
| MLA | Lu, Kai et al. "The metabolic resistance of Nilaparvata lugens to chlorpyrifos is mainly driven by the carboxylesterase CarE17" . | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 241 (2022) . |
| APA | Lu, Kai , Li, Yimin , Xiao, Tianxiang , Sun, Zhongxiang . The metabolic resistance of Nilaparvata lugens to chlorpyrifos is mainly driven by the carboxylesterase CarE17 . | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY , 2022 , 241 . |
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Insect cytochrome P450 monooxygenases (P450s) are well known to be involved in metabolic detoxification of xenobiotics, such as phytochemicals, insecticides and environmental pollutants. Enhanced metabolic detoxification is closely associated with the constitutive overexpression and induction of P450s. In general, multiple insect P450s are co-responsible for xenobiotic detoxification. Considering the capacity of P450s to respond to a wide range of xenobiotics, synergistic interactions between natural and synthetic xenobiotics and P450-mediated cross-tolerance/resistance are ubiquitous. Recent studies have indicated that both transcription factors and signaling pathways are involved in the regulation of P450 genes in xenobiotic responses. This article reviews our current understanding of P450-mediated detoxification in insect adaptation to xenobiotics and highlights recent progress in the molecular basis of P450 regulation.
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| GB/T 7714 | Lu, Kai , Song, Yuanyuan , Zeng, Rensen . The role of cytochrome P450-mediated detoxification in insect adaptation to xenobiotics [J]. | CURRENT OPINION IN INSECT SCIENCE , 2021 , 43 : 103-107 . |
| MLA | Lu, Kai et al. "The role of cytochrome P450-mediated detoxification in insect adaptation to xenobiotics" . | CURRENT OPINION IN INSECT SCIENCE 43 (2021) : 103-107 . |
| APA | Lu, Kai , Song, Yuanyuan , Zeng, Rensen . The role of cytochrome P450-mediated detoxification in insect adaptation to xenobiotics . | CURRENT OPINION IN INSECT SCIENCE , 2021 , 43 , 103-107 . |
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Increasing evidence indicates that insect resistance to synthesized insecticides is regulated by the nuclear receptors. However, the underlying mechanisms of this regulation are not clear. Here, we demonstrate that inhibition of hepatocyte nuclear factor 4 (HNF4) confers imidacloprid resistance in the brown planthopper (BPH) Nilaparvata lugens by regulating cytochrome P450 and UDP-glycosyltransferase (UGT) genes. An imidacloprid-resistant strain (Res) exhibited a 251.69-fold resistance to imidacloprid in comparison to the susceptible counterpart (Sus) was obtained by successive selection with imidacloprid. The expression level of HNF4 in the Res strain was lower than that in Sus, and knockdown of HNF4 by RNA interference significantly enhanced the resistance of BPH to imidacloprid. Comparative transcriptomic analysis identified 1400 differentially expressed genes (DEGs) in the HNF4-silenced BPHs compared to controls. Functional enrichment analysis showed that cytochrome P450- and UGT-mediated metabolic detoxification pathways were enriched by the up-regulated DEGs after HNF4 knockdown. Among of them, UGT-1-7, UGT-2B10 and CYP6ER1 were found to be over-expressed in the Res strain, and knockdown of either gene significantly decreased the resistance of BPH to imidacloprid. This study increases our understanding of molecular mechanisms involved in the regulation of insecticide resistance and also provides potential targets for pest management. (C) 2020 Elsevier Ltd. All rights reserved.
Keyword ：
Cytochrome P450 Cytochrome P450 Imidacloprid resistance Imidacloprid resistance Nilaparvata lugens Nilaparvata lugens Transcriptome Transcriptome UGT UGT
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| GB/T 7714 | Cheng, Yibei , Li, Yimin , Li, Wenru et al. Inhibition of hepatocyte nuclear factor 4 confers imidacloprid resistance in Nilaparvata lugens via the activation of cytochrome P450 and UDP-glycosyltransferase genes [J]. | CHEMOSPHERE , 2021 , 263 . |
| MLA | Cheng, Yibei et al. "Inhibition of hepatocyte nuclear factor 4 confers imidacloprid resistance in Nilaparvata lugens via the activation of cytochrome P450 and UDP-glycosyltransferase genes" . | CHEMOSPHERE 263 (2021) . |
| APA | Cheng, Yibei , Li, Yimin , Li, Wenru , Song, Yuanyuan , Zeng, Rensen , Lu, Kai . Inhibition of hepatocyte nuclear factor 4 confers imidacloprid resistance in Nilaparvata lugens via the activation of cytochrome P450 and UDP-glycosyltransferase genes . | CHEMOSPHERE , 2021 , 263 . |
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Increased production of detoxification enzymes appears to be the primary route for insecticide resistance in many crop pests. However, the mechanisms employed by resistant insects for overexpression of detoxification genes involved in insecticide resistance remain obscure. We report here that the NR2E nuclear receptor HR83 plays a critical role in chlorpyrifos resistance by regulating the expression of detoxification genes in the brown planthopper (BPH), Nilaparvata lugens. HR83 was highly expressed in the fat body and ovary of adult females in chlorpyrifos-resistant BPHs. Knockdown of HR83 by RNA interference showed no effect on female fecundity, whereas caused a decrease of resistance to chlorpyrifos. This treatment also led to a dramatic reduction in the expression of multiple detoxification genes, including four UDP-glycosyltransferases (UGTs), three cytochrome P450 monooxygenases (P450s) and four carboxylesterases (CarEs). Among these HR83-regulated genes, UGT-13, UGT-2B10?, CYP6CW1, CYP4CE1, CarE and Esterase E4-1 were over-expressed both in the fat body and ovary of the resistant BPHs. Functional analyses revealed that UGT-2B10?, CYP4CE1, CarE and Esterase E4-1 are essential for the resistance of BPH to chlorpyrifos. Generally, this study implicates HR83 in the metabolic detoxification?mediated chlorpyrifos resistance and suggests that the regulation of detoxification genes may be an ancestral function of the NR2E nuclear receptor subfamily.
Keyword ：
Brown planthopper Brown planthopper Carboxylesterase Carboxylesterase Chlorpyrifos resistance Chlorpyrifos resistance Cytochrome P450 Cytochrome P450 UDP-glycosyltransferase UDP-glycosyltransferase
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| GB/T 7714 | Lu, Kai , Li, Yimin , Cheng, Yibei et al. Activation of the NR2E nuclear receptor HR83 leads to metabolic detoxification-mediated chlorpyrifos resistance in Nilaparvata lugens [J]. | PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY , 2021 , 173 . |
| MLA | Lu, Kai et al. "Activation of the NR2E nuclear receptor HR83 leads to metabolic detoxification-mediated chlorpyrifos resistance in Nilaparvata lugens" . | PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 173 (2021) . |
| APA | Lu, Kai , Li, Yimin , Cheng, Yibei , Li, Wenru , Song, Yuanyuan , Zeng, Rensen et al. Activation of the NR2E nuclear receptor HR83 leads to metabolic detoxification-mediated chlorpyrifos resistance in Nilaparvata lugens . | PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY , 2021 , 173 . |
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Insecticide resistance is one of the major obstacles for controlling agricultural pests. There have been a lot of studies on insecticides stimulating the development of insect resistance. Herbicides account for the largest sector in the agrochemical market and are often co-applied with insecticides to control insect pests and weeds in the same cropland ecosystem. However, whether and how herbicides exposure will affect insecticide resistance in insect pests is largely unexplored. Here we reported that after exposure to herbicide butachlor, the lepidopteran Spodoptera litura larvae reduced susceptibility to the insecticide chlorpyrifos. Docking simulation studies suggested that general odorant-binding protein 2 (GOBP2) could bind to butachlor with high binding affinity, and silencing SlGOBP2 by RNA interference (RNAi) decreased larval tolerance to chlorpyrifos. Butachlor exposure induced ecdysone biosynthesis, whose function on increasing chlorpyrifos tolerance was supported in synergism experiments and confirmed by silencing the key gene (SlCYP307A1) for ecdysone synthesis. Butachlor exposure also activated the expression of detoxification enzyme genes. Silencing the genes with the highest herbicideinduced expression among the three detoxification enzyme genes led to increased larval susceptibility to chlorpyrifos. Collectively, we proposed a new mechanism that olfactory recognition of herbicides by GOBP2 triggers insect hormone biosynthesis and leads to high metabolic tolerance against insecticides. These findings provide valuable information for the dissection of mechanisms of herbicide-induced resistance to insecticides and also supplements the development of reduced-risk strategies for pest control.
Keyword ：
Detoxification enzyme Detoxification enzyme Ecdysone biosynthesis Ecdysone biosynthesis Herbicides Herbicides Insecticides Insecticides Olfactory perception Olfactory perception Spodoptera litura Spodoptera litura
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| GB/T 7714 | Sun, Zhongxiang , Wang, Rumeng , Du, Yifei et al. Olfactory perception of herbicide butachlor by GOBP2 elicits ecdysone biosynthesis and detoxification enzyme responsible for chlorpyrifos tolerance in Spodoptera litura [J]. | ENVIRONMENTAL POLLUTION , 2021 , 285 . |
| MLA | Sun, Zhongxiang et al. "Olfactory perception of herbicide butachlor by GOBP2 elicits ecdysone biosynthesis and detoxification enzyme responsible for chlorpyrifos tolerance in Spodoptera litura" . | ENVIRONMENTAL POLLUTION 285 (2021) . |
| APA | Sun, Zhongxiang , Wang, Rumeng , Du, Yifei , Gao, Binyuan , Gui, Furong , Lu, Kai . Olfactory perception of herbicide butachlor by GOBP2 elicits ecdysone biosynthesis and detoxification enzyme responsible for chlorpyrifos tolerance in Spodoptera litura . | ENVIRONMENTAL POLLUTION , 2021 , 285 . |
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Tolerance to chemical insecticides can be driven by the necessity of herbivorous insects to defend against host plant-produced phytochemicals. However, how the phytochemicals are sensed and further transduced into a defense response associated with insecticide tolerance is poorly understood. Herein, we show that pre-exposure to flavone, a flavonoid phytochemical, effectively enhanced larval tolerance to multiple synthetic insecticides and elevated detoxification enzyme activities in Spodoptera litura. RNASeq analysis revealed that flavone induced a spectrum of genes spanning phase I and II detoxification enzyme families, as well as two transcription factors Cap "n" collar isoform C (CncC) and its partner small muscle aponeurosis fibromatosis (MafK). Knocking down of CncC by RNA interference suppressed flavone-induced detoxification gene expression and rendered the larvae more sensitive to the insecticides. Flavone exposure elicited a reactive oxygen species (ROS) burst, while scavenging of ROS inhibited CncC-mediated detoxification gene expression and suppressed flavone-induced detoxification enzyme activation. Metabolome analysis showed that the ingested flavone was mainly converted into three flavonoid metabolites, and only 3-hydroxyflavone was found to affect the ROS/CncC pathway-mediated metabolic detoxification. These results indicate that the ROS/CncC pathway is an important route driving detoxification gene expression responsible for insecticide tolerance after exposure to the phytochemical flavone.
Keyword ：
detoxification enzyme detoxification enzyme insecticide tolerance insecticide tolerance phytochemical phytochemical Spodoptera litura Spodoptera litura transcriptional regulation transcriptional regulation
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| GB/T 7714 | Lu, Kai , Cheng, Yibei , Li, Yimin et al. Phytochemical Flavone Confers Broad-Spectrum Tolerance to Insecticides in Spodoptera litura by Activating ROS/CncC-Mediated Xenobiotic Detoxification Pathways [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2021 , 69 (26) : 7429-7445 . |
| MLA | Lu, Kai et al. "Phytochemical Flavone Confers Broad-Spectrum Tolerance to Insecticides in Spodoptera litura by Activating ROS/CncC-Mediated Xenobiotic Detoxification Pathways" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 69 . 26 (2021) : 7429-7445 . |
| APA | Lu, Kai , Cheng, Yibei , Li, Yimin , Li, Wenru , Zeng, Rensen , Song, Yuanyuan . Phytochemical Flavone Confers Broad-Spectrum Tolerance to Insecticides in Spodoptera litura by Activating ROS/CncC-Mediated Xenobiotic Detoxification Pathways . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2021 , 69 (26) , 7429-7445 . |
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Adaptation to phytochemicals in herbivorous insects can influence tolerance to insecticides. However, it is unclear how insects use phytochemicals as cues to activate their metabolic detoxification systems. In this study, we found that dietary exposure to xanthotoxin enhanced tolerance of Spodoptera litura larvae to lambda-cyhalothrin. Xanthotoxin ingestion significantly elevated the mRNA levels of 35 detoxification genes as well as the transcription factors Cap 'n' collar isoform-C (CncC) and its binding factor small muscle aponeurosis fibromatosis isoform-K (MafK). Additionally, xanthotoxin exposure increased the levels of reactive oxygen species (ROS), while ROS inhibitor N-acetylcysteine (NAC) treatment blocked xanthotoxin-induced expression of CncC, MafK, and detoxification genes and also prevented xanthotoxin-enhanced larval tolerance to lambda-cyhalothrin. The 20-hydroxyecdysone (20E) signaling pathway was effectively activated by xanthotoxin, while blocking of 20E signaling transduction prevented xanthotoxin-enhanced larval tolerance to lambda-cyhalothrin. Application of 20E induced the expression of multiple xanthotoxin-induced detoxification genes and enhanced lambda-cyhalothrin tolerance in S. litura. NAC treatment blocked xanthotoxin-induced 20E synthesis, while the CncC agonist curcumin activated the 20E signaling pathway. These results indicate that the ROS/CncC pathway controls the induction of metabolic detoxification upon exposure to xanthotoxin, at least in part, through its regulation of the 20E signaling pathway.
Keyword ：
ecdysone ecdysone insecticide tolerance insecticide tolerance phytochemical phytochemical reactive oxygen species reactive oxygen species Spodoptera litura Spodoptera litura
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| GB/T 7714 | Lu, Kai , Li, Yimin , Cheng, Yibei et al. Activation of the ROS/CncC and 20-Hydroxyecdysone Signaling Pathways Is Associated with Xanthotoxin-Induced Tolerance to λ-Cyhalothrin in Spodoptera litura [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2021 , 69 (45) : 13425-13435 . |
| MLA | Lu, Kai et al. "Activation of the ROS/CncC and 20-Hydroxyecdysone Signaling Pathways Is Associated with Xanthotoxin-Induced Tolerance to λ-Cyhalothrin in Spodoptera litura" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 69 . 45 (2021) : 13425-13435 . |
| APA | Lu, Kai , Li, Yimin , Cheng, Yibei , Li, Wenru , Zeng, Bixue , Gu, Chengzhen et al. Activation of the ROS/CncC and 20-Hydroxyecdysone Signaling Pathways Is Associated with Xanthotoxin-Induced Tolerance to λ-Cyhalothrin in Spodoptera litura . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2021 , 69 (45) , 13425-13435 . |
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Vitellin (Vn) homeostasis is central to the fecundity of oviparous insects.Most studies have focused on the synthesis and transportation of Vn as a building block for developing eggs during vitellogenesis;however,less is known about how the utilization of this nutrient reserve affects embryonic development.Here,we show that the single or-tholog of the knirps and knirps-like nuclear receptors,KNRL,negatively regulates Vn breakdown by suppressing the expression of hydrolase genes in the brown planthopper,Nilaparvata lugens.KNRL was highly expressed in the ovary of adult females,and knock-down of KNRL by RNA interference resulted in the acceleration of Vn breakdown and the inhibition of embryonic development.Transcriptome sequencing analysis revealed that numerous hydrolase genes,including cathepsins and trypsins were up-regulated af-ter KNRL knockdown.At least eight of the nine significantly enriched Gene Ontology terms for the up-regulated genes were in proteolysis-related categories.The expression levels of five selected trypsin genes and the enzymatic activities of trypsin in the em-bryos were significantly increased after KNRL knockdown.Moreover,trypsin injection prolonged egg duration,delayed embryonic development,accelerated Vn breakdown and severely reduced egg hatchability,a pattem similar to that observed in KNRL-silenced N.lugens.These observations suggest that KNRL controls Vn breakdown in embryos via the transcriptional inhibition of hydrolases.Generally,this study provides a founda-tion for understanding how embryo nutrient reserves are mobilized during embryogen-esis and identifies several genes and pathways that may prove valuable targets for pest control.
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| GB/T 7714 | Kai Lu , Yi-Bei Cheng , Yi-Min Li et al. The KNRL nuclear receptor controls hydrolase-mediated vitellin breakdown during embryogenesis in the brown planthopper,Nilaparvata lugens [J]. | 中国昆虫科学（英文版） , 2021 , 28 (6) : 1633-1650 . |
| MLA | Kai Lu et al. "The KNRL nuclear receptor controls hydrolase-mediated vitellin breakdown during embryogenesis in the brown planthopper,Nilaparvata lugens" . | 中国昆虫科学（英文版） 28 . 6 (2021) : 1633-1650 . |
| APA | Kai Lu , Yi-Bei Cheng , Yi-Min Li , Wen-Ru Li , Yuan-Yuan Song , Ren-Sen Zeng et al. The KNRL nuclear receptor controls hydrolase-mediated vitellin breakdown during embryogenesis in the brown planthopper,Nilaparvata lugens . | 中国昆虫科学（英文版） , 2021 , 28 (6) , 1633-1650 . |
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Abstract ：
Vitellin (Vn) homeostasis is central to the fecundity of oviparous insects. Most studies have focused on the synthesis and transportation of Vn as a building block for developing eggs during vitellogenesis; however, less is known about how the utilization of this nutrient reserve affects embryonic development. Here, we show that the single ortholog of the knirps and knirps-like nuclear receptors, KNRL, negatively regulates Vn breakdown by suppressing the expression of hydrolase genes in the brown planthopper, Nilaparvata lugens. KNRL was highly expressed in the ovary of adult females, and knockdown of KNRL by RNA interference resulted in the acceleration of Vn breakdown and the inhibition of embryonic development. Transcriptome sequencing analysis revealed that numerous hydrolase genes, including cathepsins and trypsins were up-regulated after KNRL knockdown. At least eight of the nine significantly enriched Gene Ontology terms for the up-regulated genes were in proteolysis-related categories. The expression levels of five selected trypsin genes and the enzymatic activities of trypsin in the embryos were significantly increased after KNRL knockdown. Moreover, trypsin injection prolonged egg duration, delayed embryonic development, accelerated Vn breakdown and severely reduced egg hatchability, a pattern similar to that observed in KNRL-silenced N. lugens. These observations suggest that KNRL controls Vn breakdown in embryos via the transcriptional inhibition of hydrolases. Generally, this study provides a foundation for understanding how embryo nutrient reserves are mobilized during embryogenesis and identifies several genes and pathways that may prove valuable targets for pest control.
Keyword ：
cathepsin cathepsin embryonic development embryonic development KNRL KNRL Nilaparvata lugens Nilaparvata lugens RNA‐ RNA‐ Seq Seq trypsin trypsin
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| GB/T 7714 | Lu, Kai , Cheng, Yi-Bei , Li, Yi-Min et al. The KNRL nuclear receptor controls hydrolase-mediated vitellin breakdown during embryogenesis in the brown planthopper, Nilaparvata lugens [J]. | INSECT SCIENCE , 2020 , 28 (6) : 1633-1650 . |
| MLA | Lu, Kai et al. "The KNRL nuclear receptor controls hydrolase-mediated vitellin breakdown during embryogenesis in the brown planthopper, Nilaparvata lugens" . | INSECT SCIENCE 28 . 6 (2020) : 1633-1650 . |
| APA | Lu, Kai , Cheng, Yi-Bei , Li, Yi-Min , Li, Wen-Ru , Song, Yuan-Yuan , Zeng, Ren-Sen et al. The KNRL nuclear receptor controls hydrolase-mediated vitellin breakdown during embryogenesis in the brown planthopper, Nilaparvata lugens . | INSECT SCIENCE , 2020 , 28 (6) , 1633-1650 . |
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Frequent insecticide use poses an environmental hazard and also selects for insecticide tolerance. Increased metabolic detoxification by cytochrome P450 monooxygenases (P450s) is the most common mechanism of insecticide tolerance. However, the underlying regulatory mechanisms remain unknown. We studied the midgut-specific P450 gene, CYP6AB12, associated with lambda-cyhalothrin tolerance. Its regulatory pathway was investigated in the tobacco cutworm, Spodoptera litura (Fabricius). P450 activities and CYP6AB12 transcript levels increased after lambda-cyhalothrin exposure. Inhibiting P450 activities with piperonyl butoxide and silencing CYP6AB12 by double-stranded RNA (dsRNA) injection decreased larval tolerance to lambda-cyhalothrin. lambda-Cyhalothrin exposure induced the expression of the cap 'n' collar isoform C (CncC) and muscle aponeurosis fibromatosis (Maf), increased hydrogen peroxide (H2O2) contents and elevated antioxidant enzyme activities. CncC knockdown by dsRNA feeding suppressed CYP6AB12 expression and decreased larval tolerance to lambda-cyhalothrin. In contrast, application of the CncC agonist curcumin induced CYP6AB12 expression and enhanced insecticide tolerance. Ingestion of the reactive oxygen species (ROS) scavenger N-acetylcysteine reduced H2O2 accumulation, suppressed the expression of CncC, Maf and CYP6AB12 and led to increased larval susceptibility to lambda-cyhalothrin. The results demonstrate that in S. litura, lambda-cyhalothrin induces cytochrome P450 CYP6AB12 via elicitation of the ROS burst and activation of the CncC pathway.
Keyword ：
CncC pathway CncC pathway Insecticide tolerance Insecticide tolerance Oxidative burst Oxidative burst P450 P450 Spodoptera litura Spodoptera litura
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| GB/T 7714 | Lu, Kai , Cheng, Yibei , Li, Wenru et al. Activation of CncC pathway by ROS burst regulates cytochrome P450 CYP6AB12 responsible for λ-cyhalothrin tolerance in Spodoptera litura [J]. | JOURNAL OF HAZARDOUS MATERIALS , 2020 , 387 . |
| MLA | Lu, Kai et al. "Activation of CncC pathway by ROS burst regulates cytochrome P450 CYP6AB12 responsible for λ-cyhalothrin tolerance in Spodoptera litura" . | JOURNAL OF HAZARDOUS MATERIALS 387 (2020) . |
| APA | Lu, Kai , Cheng, Yibei , Li, Wenru , Li, Yimin , Zeng, Rensen , Song, Yuanyuan . Activation of CncC pathway by ROS burst regulates cytochrome P450 CYP6AB12 responsible for λ-cyhalothrin tolerance in Spodoptera litura . | JOURNAL OF HAZARDOUS MATERIALS , 2020 , 387 . |
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