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学者姓名：胡军
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Abstract ：
BackgroundMammalian intestine harbors a mass of phages that play important roles in maintaining gut microbial ecosystem and host health. Pig has become a common model for biomedical research and provides a large amount of meat for human consumption. However, the knowledge of gut phages in pigs is still limited.ResultsHere, we investigated the gut phageome in 112 pigs from seven pig breeds using PhaBOX strategy based on the metagenomic data. A total of 174,897 non-redundant gut phage genomes were assembled from 112 metagenomes. A total of 33,487 gut phage genomes were classified and these phages mainly belonged to phage families such as Ackermannviridae, Straboviridae, Peduoviridae, Zierdtviridae, Drexlerviridae, and Herelleviridae. The gut phages in seven pig breeds exhibited distinct communities and the gut phage communities changed with the age of pig. These gut phages were predicted to infect a broad range of 212 genera of prokaryotes, such as Candidatus Hamiltonella, Mycoplasma, Colwellia, and Lactobacillus. The data indicated that broad KEGG and CAZy functions were also enriched in gut phages of pigs. The gut phages also carried the antimicrobial resistance genes (ARGs) and the most abundant antimicrobial resistance genotype was diaminopyrimidine resistance.ConclusionsOur research delineates a landscape for gut phages in seven pig breeds and reveals that gut phages serve as a key reservoir of ARGs in pigs.53TvwP5ops6wwG1EthsGXZVideo AbstractConclusionsOur research delineates a landscape for gut phages in seven pig breeds and reveals that gut phages serve as a key reservoir of ARGs in pigs.53TvwP5ops6wwG1EthsGXZVideo Abstract
Keyword ：
Antimicrobial resistance genes Antimicrobial resistance genes Gut phageome Gut phageome Metagenomic Metagenomic PhaBOX PhaBOX Pig Pig
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| GB/T 7714 | Hu, Jun , Chen, Jianwei , Nie, Yangfan et al. Characterizing the gut phageome and phage-borne antimicrobial resistance genes in pigs [J]. | MICROBIOME , 2024 , 12 (1) . |
| MLA | Hu, Jun et al. "Characterizing the gut phageome and phage-borne antimicrobial resistance genes in pigs" . | MICROBIOME 12 . 1 (2024) . |
| APA | Hu, Jun , Chen, Jianwei , Nie, Yangfan , Zhou, Changhao , Hou, Qiliang , Yan, Xianghua . Characterizing the gut phageome and phage-borne antimicrobial resistance genes in pigs . | MICROBIOME , 2024 , 12 (1) . |
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| GB/T 7714 | Hu, J. , Liao, Y. , Chen, J. . Role of a novel long non-coding RNA in innate immune response to influenza virus infection. [J]. | MOLECULAR BIOLOGY OF THE CELL , 2018 , 29 (26) . |
| MLA | Hu, J. et al. "Role of a novel long non-coding RNA in innate immune response to influenza virus infection." . | MOLECULAR BIOLOGY OF THE CELL 29 . 26 (2018) . |
| APA | Hu, J. , Liao, Y. , Chen, J. . Role of a novel long non-coding RNA in innate immune response to influenza virus infection. . | MOLECULAR BIOLOGY OF THE CELL , 2018 , 29 (26) . |
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