Query：
学者姓名：陈润芝
Refining：
Year
Type
Indexed by
Source
Complex
Co-Author
Language
Clean All
Abstract ：
Unveiling a metabolic mystery, this article explores how 3-Oacylated bile acids, specifically 3-O-succinylated cholic acid (3sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen, Runzhi , Chen, Xinhua , Gao, Jiangtao . Forum 3-O-acylated bile acids: disrupters or harmonizers of metabolism? [J]. | TRENDS IN MOLECULAR MEDICINE , 2025 , 31 (2) : 103-105 . |
| MLA | Chen, Runzhi 等. "Forum 3-O-acylated bile acids: disrupters or harmonizers of metabolism?" . | TRENDS IN MOLECULAR MEDICINE 31 . 2 (2025) : 103-105 . |
| APA | Chen, Runzhi , Chen, Xinhua , Gao, Jiangtao . Forum 3-O-acylated bile acids: disrupters or harmonizers of metabolism? . | TRENDS IN MOLECULAR MEDICINE , 2025 , 31 (2) , 103-105 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
This review critically examines the emerging role of hyodeoxycholic acid (HDCA) in metabolic and inflammatory disorders. We analyze the current understanding of HDCA biosynthesis, highlighting species-specific differences and challenges in identifying HDCA-producing bacteria. The study evaluated the signaling mechanism by which HDCA simultaneously activates intestinal G protein-coupled bile acid receptor 1 (TGR5) and farnesoid X receptor (FXR), challenging the traditional paradigm of bile acid (BA)signaling. We assess HDCA's immunomodulatory effects, particularly its Toll-like receptor 4 (TLR4) inhibition, and discuss potential therapeutic applications in metabolic diseases and sepsis. The review addresses challenges in translating rodent studies to human applications and explores future directions, including the development of HDCA derivatives and integration with microbiome modulation strategies. Ethical and regulatory considerations for microbiome-derived therapeutics are also discussed. We propose that HDCA research may catalyze paradigm shifts in understanding hostmicrobiome-BA interactions, calling for interdisciplinary approaches to harness its potential fully.
Keyword ：
Bile acid signaling pathways Bile acid signaling pathways Hyodeoxycholic acid Hyodeoxycholic acid Immunomodulatory effects Immunomodulatory effects Metabolic and inflammatory disorders Metabolic and inflammatory disorders Microbiome-derived therapeutics Microbiome-derived therapeutics Therapeutic applications in sepsis Therapeutic applications in sepsis
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Zhan, Zhikun , Chen, Runzhi , Deng, Zixin et al. Burgeoning momentum: the present and future of hyodeoxycholic acid in host microbiome dynamics [J]. | BIOCHEMICAL PHARMACOLOGY , 2025 , 240 . |
| MLA | Zhan, Zhikun et al. "Burgeoning momentum: the present and future of hyodeoxycholic acid in host microbiome dynamics" . | BIOCHEMICAL PHARMACOLOGY 240 (2025) . |
| APA | Zhan, Zhikun , Chen, Runzhi , Deng, Zixin , Gao, Jiangtao . Burgeoning momentum: the present and future of hyodeoxycholic acid in host microbiome dynamics . | BIOCHEMICAL PHARMACOLOGY , 2025 , 240 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
