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学者姓名：何新新
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Abstract ：
Animal proteins are the primary global protein source, but their production is environmentally challenging and has low conversion efficiency. This highlights the need to diversify dietary protein sources. Algal proteins provide a sustainable alternative, outperforming traditional plant and animal proteins in protein content, quality, and digestibility. Furthermore, bioactive peptides (BAPs) derived from algal proteins exhibit significant health benefits, including antihypertensive, antioxidant, antimicrobial, anticancer, and antidiabetic activities. This review comprehensively explores the nutritional benefits of algal proteins and provides an innovative summary of the production techniques for algal bioactive peptides. It also highlights the synergistic application methods of these technologies. By integrating pretreatment methods such as ultrasound-assisted extraction, pulsed electric field, and high hydrostatic pressure with enzymatic-assisted extraction, these techniques demonstrate a synergistic effect in improving protein hydrolysis efficiency while also increasing the yield of BAPs. Meanwhile, database resources related to algal proteins are integrated and the application of computer technology in the development of algal proteins is analyzed. It aims to provide new insights to optimize the development and utilization of algal proteins to help them become a sustainable source of nutrition to meet the needs of a growing global population.
Keyword ：
Algal proteins Algal proteins Bioactive peptides Bioactive peptides Bioavailability Bioavailability Nutritional functions Nutritional functions Production techniques Production techniques
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| GB/T 7714 | Meng, Tianzeng , Wen, Jiahui , Liu, Hanqi et al. Algal proteins and bioactive peptides: Sustainable nutrition for human health [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 303 . |
| MLA | Meng, Tianzeng et al. "Algal proteins and bioactive peptides: Sustainable nutrition for human health" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 303 (2025) . |
| APA | Meng, Tianzeng , Wen, Jiahui , Liu, Hanqi , Guo, Yuxin , Tong, Aijun , Chu, Yaoyao et al. Algal proteins and bioactive peptides: Sustainable nutrition for human health . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 303 . |
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Algae, a crucial constituent of marine systems, serve an indispensable function as primary producers, supporting the marine food web, contributing to carbon sequestration, and providing habitats that sustain biodiversity. This review focuses on the bioactive constituents of algae, including polysaccharides, polyphenols, polypeptides, and terpenoid compounds, and discusses their potential applications in treating immune-related diseases, as well as the mechanisms through which they modulate immune responses. The bioactive substances derived from algae, including polyphenols, bioactive peptides, terpenes, polysaccharides and other compounds, may play a preventive role by modulating allergic responses and reducing the incidence of inflammation and cancer.
Keyword ：
Algal bioactive substances Algal bioactive substances allergy allergy cancer cancer immunomodulation immunomodulation inflammation inflammation
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| GB/T 7714 | Jia, Nan , Zhang, Shuangtao , Chen, Ruoxin et al. Immunomodulatory functions of algal bioactive compounds [J]. | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION , 2025 , 65 (30) : 7133-7150 . |
| MLA | Jia, Nan et al. "Immunomodulatory functions of algal bioactive compounds" . | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION 65 . 30 (2025) : 7133-7150 . |
| APA | Jia, Nan , Zhang, Shuangtao , Chen, Ruoxin , He, Xinxin , Dai, Congjie , El-Seedi, Hesham R. et al. Immunomodulatory functions of algal bioactive compounds . | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION , 2025 , 65 (30) , 7133-7150 . |
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With the increasing global demand for natural green foods and health-related products, there is an urgent need for the sustainable extraction of nutrient pigments from algae. Dunaliella, a widely studied model alga, serves as a significant source of natural vitamin A, particularly rich in the beta-carotene isomer, 9-cis beta-carotene (9CBC). 9CBC is recognized for its strong bioactive potential and is one of the most expensive pigments worldwide. It is extensively utilized in the food, pharmaceutical, cosmetic, and animal feed industries. Moreover, 9CBC has therapeutic applications in the treatment of Alzheimer's disease, retinal degenerative diseases, atherosclerosis, and other medical conditions. However, the natural occurrence of 9CBC is limited, and its synthesis is challenging and costly. This paper reviews the biosynthetic pathways of 9CBC in Dunaliella and investigates methods to enhance its yield. Furthermore, it briefly discusses the therapeutic potential of 9CBC for various diseases.
Keyword ：
9-cis beta-carotene 9-cis beta-carotene Biological activity Biological activity Biosynthesis Biosynthesis Dunaliella Dunaliella
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| GB/T 7714 | Wu, Shuyang , Wu, Xue , Wen, Jiahui et al. Biosynthesis and biological activities of 9-cis beta-carotene from green microalga Dunaliella [J]. | ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS , 2025 , 91 . |
| MLA | Wu, Shuyang et al. "Biosynthesis and biological activities of 9-cis beta-carotene from green microalga Dunaliella" . | ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 91 (2025) . |
| APA | Wu, Shuyang , Wu, Xue , Wen, Jiahui , Chen, Zhengxin , Yang, Xinyue , He, Xinxin et al. Biosynthesis and biological activities of 9-cis beta-carotene from green microalga Dunaliella . | ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS , 2025 , 91 . |
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Cancer is a formidable adversary, accounting for the second highest number of fatalities worldwide. A multitude of studies have indicated that naturally sourced small-molecule compounds, owing to their low toxicity and multi-target capabilities, significantly aid in the fight against tumorigenesis. However, natural small molecules have certain limitations, such as poor water solubility and permeability. These limitations curtail their clinical potency and result in lower bioavailability within the human body. To address these limitations, nano-encapsulation techniques have emerged as a promising strategy to enhance the solubility, stability, and delivery of these natural compounds. For instance, in several preclinical studies, encapsulating resveratrol in liposomal nanocarriers increased its solubility by up to 50-fold and enhanced its bioavailability by three to five times. This work is based on the reports published from 1999 to 2024 in PubMed and ISI Web of Science databases. This review examines the anticancer mechanisms of key natural small molecules, including polyphenols, alkaloids, and terpenes, and discusses how their incorporation into nanocarrier systems improves their efficacy. Additionally, this analysis provides a comprehensive overview of how nanotechnology can overcome the pharmacokinetic and bioavailability limitations of natural compounds, offering a foundation for future advancements in cancer treatment. © 2025 The Author(s). Food Frontiers published by John Wiley & Sons Australia, Ltd and Nanchang University, Northwest University, Jiangsu University, Zhejiang University, Fujian Agriculture and Forestry University.
Keyword ：
Diseases Diseases Encapsulation Encapsulation
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| GB/T 7714 | Ye, Fangting , Zheng, Shaojie , Shan, Shuo et al. Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment [J]. | Food Frontiers , 2025 , 6 (3) : 1303-1322 . |
| MLA | Ye, Fangting et al. "Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment" . | Food Frontiers 6 . 3 (2025) : 1303-1322 . |
| APA | Ye, Fangting , Zheng, Shaojie , Shan, Shuo , Cai, Jiaer , Liu, Yufan , Chen, Weichao et al. Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment . | Food Frontiers , 2025 , 6 (3) , 1303-1322 . |
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Background: Protein glycosylation as a common post-translational modification that has significant impacts on protein folding, enzymatic activity, and interfering with receptor functioning. In recent years, with the rapid development of glycopeptide enrichment and analysis technology and the deepening of glycosylation research, glycosylation has gradually become a sign of disease occurrence and development. Multiple investigations suggest that protein glycosylation affect the advances of diabetes and aging. Purpose and Methods: This review was focused on the action mechanisms of glycosylated proteins production, permanent abnormalities in extracellular matrix component function, inflammatory and reactive oxygen species production, as well as the glycosylated characterizations of diabetes and aging. Further, advances in glycosylation analysis and detection methods are presented for the first time, highlighting for needed future developments. All literatures were gathered from PubMed and Google Scholar. Results: Herein, we review how protein glycosylation impacts the progression of diabetes and aging. Specifically, we focus on various types of glycosylation, including N-linked glycosylation, O-linked glycosylation, C-glycosylation, S-glycosylation, and glycophosphatidylinositol (GPI) anchors. N-linked glycosylation and O-linked glycosylation are commonly observed glycosylation forms, wherein O-GlcNAcylation plays a significant role in diabetes, while N-glycan could serve as biomarkers for identifying inflammation and aging. Conclusions: Protein glycosylation produces a vastly larger number of core glycan structures through utilizing at least 173 glycosyltransferases and repeated common scaffolds. Single protein may contain multiple glycosylation sites, and the structure and occupancy of glycan at each site may be different, resulting in the macro heterogeneity of protein glycosylation. This review will contribute to how protein glycosylation impacts the life progress of cells and its association with diseases.
Keyword ：
Aging Aging Diabetes mellitus Diabetes mellitus N-glycosylation N-glycosylation O-glycosylation O-glycosylation Phytochemicals Phytochemicals
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| GB/T 7714 | Chen, Yihan , Lu, Suyue , Shan, Shuo et al. New insights into phytochemicals via protein glycosylation focused on aging and diabetes [J]. | PHYTOMEDICINE , 2025 , 141 . |
| MLA | Chen, Yihan et al. "New insights into phytochemicals via protein glycosylation focused on aging and diabetes" . | PHYTOMEDICINE 141 (2025) . |
| APA | Chen, Yihan , Lu, Suyue , Shan, Shuo , Wu, Weihao , He, Xinxin , Farag, Mohamed A. et al. New insights into phytochemicals via protein glycosylation focused on aging and diabetes . | PHYTOMEDICINE , 2025 , 141 . |
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Abstract ：
Cancer is a formidable adversary, accounting for the second highest number of fatalities worldwide. A multitude of studies have indicated that naturally sourced small‐molecule compounds, owing to their low toxicity and multi‐target capabilities, significantly aid in the fight against tumorigenesis. However, natural small molecules have certain limitations, such as poor water solubility and permeability. These limitations curtail their clinical potency and result in lower bioavailability within the human body. To address these limitations, nano‐encapsulation techniques have emerged as a promising strategy to enhance the solubility, stability, and delivery of these natural compounds. For instance, in several preclinical studies, encapsulating resveratrol in liposomal nanocarriers increased its solubility by up to 50‐fold and enhanced its bioavailability by three to five times. This work is based on the reports published from 1999 to 2024 in PubMed and ISI Web of Science databases. This review examines the anticancer mechanisms of key natural small molecules, including polyphenols, alkaloids, and terpenes, and discusses how their incorporation into nanocarrier systems improves their efficacy. Additionally, this analysis provides a comprehensive overview of how nanotechnology can overcome the pharmacokinetic and bioavailability limitations of natural compounds, offering a foundation for future advancements in cancer treatment.
Keyword ：
anticancer | bioavailability | nanocarriers | natural small molecules anticancer | bioavailability | nanocarriers | natural small molecules
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| GB/T 7714 | Fangting Ye , Shaojie Zheng , Shuo Shan et al. Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment [J]. | Food frontiers , 2025 , (3) : 1303-1322 . |
| MLA | Fangting Ye et al. "Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment" . | Food frontiers 3 (2025) : 1303-1322 . |
| APA | Fangting Ye , Shaojie Zheng , Shuo Shan , Jiaer Cai , Yufan Liu , Weichao Chen et al. Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment . | Food frontiers , 2025 , (3) , 1303-1322 . |
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为了减少环境污染和资源浪费,利用浓香型白酒丢糟作为原料生产还原糖用于培养苏云菌芽胞杆菌(Bt)。采用不同浓度、温度、氢氧化钙和氢氧化钠前处理浓香型白酒丢糟,HPLC测定前处理液还原糖产量,并利用前处理液培养Bt。结果表明,用0.75%Na OH在100℃下处理1 h后,还原糖产量最高(81 g/kg)。而芽胞产量最高的前处理条件为1%Ca(OH)_2在50℃下处理1 h,芽胞产量高达4.6×10~7CFU/m L。利用白酒丢糟前处理液培养Bt,既能有效的减少资源浪费和环境污染,又能实现Bt制剂商业化。
Keyword ：
生物质 生物质 白酒丢糟 白酒丢糟 碱前处理 碱前处理 苏云金芽胞杆菌 苏云金芽胞杆菌
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| GB/T 7714 | 沈小娟 , 何新新 , 王毅斌 et al. 碱前处理白酒丢糟生物质转化苏云金芽胞杆菌培养基 [J]. | 生物技术进展 , 2016 , 6 (05) : 357-360 . |
| MLA | 沈小娟 et al. "碱前处理白酒丢糟生物质转化苏云金芽胞杆菌培养基" . | 生物技术进展 6 . 05 (2016) : 357-360 . |
| APA | 沈小娟 , 何新新 , 王毅斌 , 丁海龙 , 关雄 , 邓波 . 碱前处理白酒丢糟生物质转化苏云金芽胞杆菌培养基 . | 生物技术进展 , 2016 , 6 (05) , 357-360 . |
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To minimize environmental contamination and waste of resources, distillers' grain (DG) from the Chinese liquor industry was used to produce reducing sugars for Bacillus thuringiensis cultivation. Four different pretreatments, using sodium hydroxide (0.5-2% w/v, 50-121 degrees C, 1 h), calcium hydroxide (0.2-4% w/v, 50-121 degrees C, 1 h), dilute sulfuric acid (0.5-2% w/v, 50-121 degrees C, 1 h), and hot water (50-121 degrees C, 1 h), were investigated in order to determine the optimal method for degrading cellulose in DG to produce monomeric sugars. Enzymatic hydrolysis and fermentation followed each pretreatment method. The results showed that the highest yield of monomeric sugars was obtained by using 2% dilute sulfuric acid treatment at 121 degrees C for 1 h (giving 313 g/kg DG), which was significantly higher (p < 0.001) than the yields obtained using other pretreatment methods. The highest spore count was achieved using this pretreatment with the addition of supplements. The utilization of DG in this study provides a plentiful carbon source that is effective not only for cultivating microorganisms but also for reducing industrial waste.
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| GB/T 7714 | Zheng, Qi , Lin, Bairong , Zhang, Qiuping et al. Treating Distillers' Grain from the Luzhou Aroma/Flavor Industry To Degrade Fiber [J]. | ENERGY & FUELS , 2015 , 29 (7) : 4305-4310 . |
| MLA | Zheng, Qi et al. "Treating Distillers' Grain from the Luzhou Aroma/Flavor Industry To Degrade Fiber" . | ENERGY & FUELS 29 . 7 (2015) : 4305-4310 . |
| APA | Zheng, Qi , Lin, Bairong , Zhang, Qiuping , Wu, Songqing , Wang, Songtao , He, Xinxin et al. Treating Distillers' Grain from the Luzhou Aroma/Flavor Industry To Degrade Fiber . | ENERGY & FUELS , 2015 , 29 (7) , 4305-4310 . |
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Luzhou-flavor liquor is fermented based on the metabolism of special microbial communities in pit. In this study, total proteins and DNAs of microbes from 30- and 300-year pit muds were firstly extracted. Meanwhile, an efficient approach for protein extraction with increased protein content was optimized. iTRAQ-based proteomic was then applied to investigate the aroma-forming functional protein expression of microbes from the samples. Furthermore, high-throughput sequencing of 16S rDNA was employed to reveal microbial diversity. We comparatively identified 63 proteins of aroma-forming functional microbes in these samples, and found that 59 of these proteins were highly expressed in the 300-year pit mud. Those aroma-forming functional proteins were found to be involved in methanogenesis, as well as the formation of caproic acid and butyric acid during the liquor fermentation. High-throughput sequencing revealed that the microbes most commonly found in both samples were members of phylum Firmicutes (by 97% sequence similarity), both of which, along with another common Methanobacterium, were important components of aroma-forming functional colonies in the pit muds for the brewing of Chinese liquor. The findings in this study afford us new insight into the different protein expression levels and microbial communities in two pit muds. (C) 2015 Elsevier Ltd. All rights reserved.
Keyword ：
165 rDNA 165 rDNA iTRAQ iTRAQ Luzhou-flavor Chinese liquor Luzhou-flavor Chinese liquor Microbial diversities Microbial diversities Proteomics Proteomics
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| GB/T 7714 | Zheng, Qi , Lin, Bairong , Wang, Yibin et al. Proteomic and high-throughput analysis of protein expression and microbial diversity of microbes from 30-and 300-year pit muds of Chinese Luzhou-flavor liquor [J]. | FOOD RESEARCH INTERNATIONAL , 2015 , 75 : 305-314 . |
| MLA | Zheng, Qi et al. "Proteomic and high-throughput analysis of protein expression and microbial diversity of microbes from 30-and 300-year pit muds of Chinese Luzhou-flavor liquor" . | FOOD RESEARCH INTERNATIONAL 75 (2015) : 305-314 . |
| APA | Zheng, Qi , Lin, Bairong , Wang, Yibin , Zhang, Qiuping , He, Xinxin , Yang, Ping et al. Proteomic and high-throughput analysis of protein expression and microbial diversity of microbes from 30-and 300-year pit muds of Chinese Luzhou-flavor liquor . | FOOD RESEARCH INTERNATIONAL , 2015 , 75 , 305-314 . |
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浓香型白酒的生产是以窖池为基础,窖池窖泥中栖息着庞大的微生物群系,微生物间相互作用形成浓香型白酒的独特风味,尤其以芽胞杆菌为主。本研究从泸州老窖酒厂300年窖池窖泥中分离出23株好氧芽胞杆菌属(Bacilli),经光学显微镜和菌落形态观察,23株好氧芽胞杆菌形态差异不显著。通过16S rDNA基因扩增,NCBI基因比对,构建系统发育树,结果表明,23株好氧芽胞杆菌主要为苏云金芽胞杆菌(Bacillus thuringiensis,Bt)、蜡样芽胞杆菌(B.cereus,Bc)和炭疽芽胞杆菌(B.anthrax),菌种间亲缘关系存在差异;窖泥中分离出的23株好氧芽胞杆菌亲缘关系近,遗传多样性较低。本研结果为了解白酒发酵过程中老窖泥周围环境的变化、提高白酒品质提供基础资料。
Keyword ：
16S rDNA 16S rDNA 窖泥 窖泥 系统发育树 系统发育树 芽胞杆菌 芽胞杆菌
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| GB/T 7714 | 郑琦 , 章秋萍 , 何新新 et al. 浓香型白酒老窖泥中好氧芽胞杆菌的分离及系统发育树的初步构建 [J]. | 农业生物技术学报 , 2014 , 22 (11) : 1411-1417 . |
| MLA | 郑琦 et al. "浓香型白酒老窖泥中好氧芽胞杆菌的分离及系统发育树的初步构建" . | 农业生物技术学报 22 . 11 (2014) : 1411-1417 . |
| APA | 郑琦 , 章秋萍 , 何新新 , 胡杰 , 黄小红 . 浓香型白酒老窖泥中好氧芽胞杆菌的分离及系统发育树的初步构建 . | 农业生物技术学报 , 2014 , 22 (11) , 1411-1417 . |
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