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学者姓名：林晨昊
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Abstract ：
本发明提出了一种海带腥味的评价和预测方法，包括四个步骤：步骤一、对海带样品进行基于HS‑SPME的前处理，依次包括提取、富集、浓缩和解吸四个过程；步骤二、采集不同海带样品的GC‑MS谱图信息；步骤三、依据标准质谱图库（NIST\WEILY）对不同产区的海带样品GC‑MS图谱中成分进行检索定性和定量分析，提取不同来源样品组分的共有信息，计算共有化学成分的OAV值并进行相关气味描述；步骤四、筛选海带中关键腥味物质并采用主成分分析和熵值权分析评价确定海带腥味物质的贡献度，同时构建了基于随机森林机器学习算法预测模型。借此，本发明具有的对不同地区海带的挥发性风味物质进行深入分析，实现了对这些物质的定性和定量分析，成功鉴定出海带中的特征腥味成分优点。
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| GB/T 7714 | 陈继承 , 林晓娟 , 林晨昊 et al. 一种海带腥味的评价和预测方法 : CN202411767128.0[P]. | 2024-12-04 . |
| MLA | 陈继承 et al. "一种海带腥味的评价和预测方法" : CN202411767128.0. | 2024-12-04 . |
| APA | 陈继承 , 林晓娟 , 林晨昊 , 黄宝特 , 林健 . 一种海带腥味的评价和预测方法 : CN202411767128.0. | 2024-12-04 . |
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Abstract ：
BackgroundRemnant cholesterol (RC) has been implicated in cardiovascular diseases (CVDs) in populations of European ancestry, yet its causal role remains underexplored in populations of East Asian ancestry, which are underrepresented in genetic studies. We sought to investigate the causal association between circulating RC levels and CVD risk in East Asian populations.MethodsWe first conducted observational analyses of RC and multiple CVD outcomes in Chinese populations. We then conducted genome-wide association studies (GWAS) of RC in 14,939 Chinese individuals and assessed its causal associations with CVD risk using two-sample Mendelian randomization (MR) with Biobank Japan data. Replication analyses in European ancestry populations utilized summary statistics from the UK Biobank and FinnGen.ResultsCirculating RC levels were significantly associated with multiple CVD outcomes in Chinese individuals. Our GWAS identified seven significant loci associated with circulating RC levels in the Chinese population. In the MR analyses, we found that genetically predicted higher RC levels were significantly associated with increased risks of aortic aneurysm (odds ratio per standard deviation increase, 1.82; 95% CI, 1.53-2.17; P = 1.17 x 10-11) and ischemic heart diseases, such as myocardial infarction (1.22, 1.13-1.32; P = 1.81 x 10-7) and stable angina pectoris (1.17, 1.11-1.23; P = 1.18 x 10-8). Notably, these associations persisted after adjustment for total cholesterol, low-density and high-density lipoprotein cholesterols, Apolipoprotein A1 and Apolipoprotein B, respectively. Replication in European ancestry populations confirmed consistent causal effects for aortic aneurysm and ischemic heart diseases. A suggestive East Asian-specific association was identified between genetically predicted higher RC levels and an increased risk of peripheral artery disease, whereas a suggestive association with a higher risk of atrial flutter/fibrillation and ventricular arrhythmia was only observed in populations of European ancestry.ConclusionsOur findings establish RC as an independent causal CVD risk factor in East Asian ancestry individuals and highlight population-specific differences in CVD risk profiles, emphasizing the need for ethnicity-tailored prevention strategies.
Keyword ：
Cardiovascular diseases Cardiovascular diseases Genome-wide association study Genome-wide association study Mendelian randomization Mendelian randomization Remnant cholesterol Remnant cholesterol
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| GB/T 7714 | Lin, Chenhao , Wen, Haolong , Yu, Mengyao et al. The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians [J]. | BMC MEDICINE , 2025 , 23 (1) . |
| MLA | Lin, Chenhao et al. "The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians" . | BMC MEDICINE 23 . 1 (2025) . |
| APA | Lin, Chenhao , Wen, Haolong , Yu, Mengyao , Huang, Qingxia , Wang, Qi , Lin, Jinran et al. The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians . | BMC MEDICINE , 2025 , 23 (1) . |
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Differential susceptibilities to various diseases and corresponding metabolite variations have been documented across diverse ethnic populations, but the genetic determinants of these disparities remain unclear. Here, we performed large-scale genome-wide association studies of 171 directly quantifiable metabolites from a nuclear magnetic resonance-based metabolomics platform in 10,792 Han Chinese individuals. We identified 15 variant-metabolite associations, eight of which were successfully replicated in an independent Chinese population (n = 4,480). By cross-ancestry meta-analysis integrating 213,397 European individuals from the UK Biobank, we identified 228 additional variant-metabolite associations and improved fine-mapping precision. Moreover, two-sample Mendelian randomization analyses revealed evidence that genetically predicted levels of triglycerides in high-density lipoprotein were associated with a higher risk of coronary artery disease and that of glycine with a lower risk of heart failure in both ancestries. These findings enhance our understanding of the shared and specific genetic architecture of metabolites as well as their roles in complex diseases across populations.
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| GB/T 7714 | Lin, Chenhao , Xia, Mingfeng , Dai, Yuxiang et al. Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites [J]. | CELL GENOMICS , 2025 , 5 (4) . |
| MLA | Lin, Chenhao et al. "Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites" . | CELL GENOMICS 5 . 4 (2025) . |
| APA | Lin, Chenhao , Xia, Mingfeng , Dai, Yuxiang , Huang, Qingxia , Sun, Zhonghan , Zhang, Guoqing et al. Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites . | CELL GENOMICS , 2025 , 5 (4) . |
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