Query：
学者姓名：冯跃
Refining：
Year
Type
Indexed by
Source
Complex
Co-Author
Language
Clean All
Abstract ：
This study aims to investigate the effects of dietary supplementation with different concentrations of oligofructose (FOS) on growth performance, antioxidant capacity, immunity, and intestinal microbial composition in growing rabbits. One hundred female Dehua black rabbits (34 d of age) were randomly assigned to four groups (CON, FOS-1, FOS-2, and FOS-3), with twenty-five rabbits in each group. The CON group received only a basal diet, while the FOS-1/FOS-2/FOS-3 group received the diet supplemented with 0.3%/0.6%/0.9% FOS, respectively. The trial period lasted for 72 days. Our results revealed that FOS supplementation could improve the growing performance of rabbits and decrease the feed/gain ratio. FOS significantly enhanced serum antioxidant enzyme (SOD) and total antioxidant capacity (T-AOC) while reducing malondialdehyde (MDA). The levels of plasmic immunoglobulin (IgG, IgA, and IgM) and intestinal immune factors (IL-1 alpha, IL-2, and sIgA) were significantly improved with the FOS supplement. Additionally, FOS can improve intestinal morphology and enhance the activity of intestinal enzymes, including cellulase, lipase, and protease. Furthermore, FOS supplementation influenced the composition of intestinal microflora by increasing the abundance of Lachnospiraceae_NK4A136_group (barrier-enhancing) and Monoglobus (fiber-degrading). In conclusion, the addition of FOS has a positive impact on the growth performance, antioxidant capacity, immunity, and intestinal health of growing rabbits. The optimal dietary addition for rabbits was identified as 0.6% oligofructose.
Keyword ：
antioxidant capacity antioxidant capacity immunity immunity intestinal health intestinal health oligofructose oligofructose rabbits rabbits
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Qin, Liwen , Xiao, Chunlong , Shi, Menglei et al. Effects of Oligofructose Supplementation on Growth Performance, Antioxidant Capacity, Immunity, and Intestinal Health in Growing Rabbits [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2025 , 26 (17) . |
| MLA | Qin, Liwen et al. "Effects of Oligofructose Supplementation on Growth Performance, Antioxidant Capacity, Immunity, and Intestinal Health in Growing Rabbits" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 26 . 17 (2025) . |
| APA | Qin, Liwen , Xiao, Chunlong , Shi, Menglei , He, Lu , Du, Yifei , Lin, Lifan et al. Effects of Oligofructose Supplementation on Growth Performance, Antioxidant Capacity, Immunity, and Intestinal Health in Growing Rabbits . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2025 , 26 (17) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Antimicrobial resistance caused by overuse of antibiotics has promoted the demand for effective antibacterial materials. However, the development of existing antibacterial strategies mostly focuses on direct sterilization, which may lead to flora imbalance and drug resistance. Here, a series of peptide-based aggregation-induced emssion nanomaterials (PBANs) with multiple structural domains were designed by mimicking the self-assembly of human alpha-defensin 6. Specifically, PBANs self-assemble to form nanoparticles in physiological environments and in situ transform into nanofibers on bacterial surfaces through receptor-ligand interactions in infected microenvironments, resulting in enhanced fluorescence signal and activation of functions, while labeling and entrapping bacteria. Different from traditional antibacterial strategies that directly kill pathogenic microorganisms, PBANs can inhibit bacterial motility and invasion into the host system through physical barriers and affecting energy metabolism pathways. In addition, PBANs can further recruit macrophages to the infection site to engulf entrapped bacteria, thereby synergistically reducing the infection efficiency. In mouse and piglet systemic infection models, the PBANs showed favorable therapeutic efficacy, significantly reducing bacterial load and levels of inflammation factors. Overall, this study provides perspectives for developing biomimetic stimuli-responsive nanomaterials to combat bacterial infections.
Keyword ：
aggregation-induced emission aggregation-induced emission bacterial infection bacterial infection intelligent-responsive intelligent-responsive peptide-based nanomaterials peptide-based nanomaterials structural transformation structural transformation
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Zhou, Chenlong , Tang, Qi , Tan, Peng et al. Bacteria-responsive transformable peptide-based nanomaterials inspired by human α-defensin 6 for labeling and entrapping pathogenic bacteria [J]. | RESPONSIVE MATERIALS , 2025 , 3 (2) . |
| MLA | Zhou, Chenlong et al. "Bacteria-responsive transformable peptide-based nanomaterials inspired by human α-defensin 6 for labeling and entrapping pathogenic bacteria" . | RESPONSIVE MATERIALS 3 . 2 (2025) . |
| APA | Zhou, Chenlong , Tang, Qi , Tan, Peng , Wang, Tao , Zhang, Yucheng , Yang, Shuaikang et al. Bacteria-responsive transformable peptide-based nanomaterials inspired by human α-defensin 6 for labeling and entrapping pathogenic bacteria . | RESPONSIVE MATERIALS , 2025 , 3 (2) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Deoxynivalenol (DON) is a prevalent mycotoxin in animal feed that particularly impacts weaned piglets, causing liver damage, growth retardation, and posing significant public health risks. However, the precise mechanisms underlying DON-induced liver damage and optimal treatment approaches remain unclear. The pregnane X receptor (PXR) holds a pivotal position in hepatic xenobiotic elimination and drug metabolism. This research aimed to explore the involvement of PXR in DON-induced liver injury and evaluate the potential of the PXR agonist, 3-indolepropionic acid (IPA), to alleviate liver damage and associated diarrhea in weaned piglets under practical farming conditions. The results demonstrated that DON initiates p53-mediated hepatocyte apoptosis in weaned piglets. RNA-seq and hepatocyte-specific PXR knockout (PXR-HKO) mice revealed PXR's regulatory role in DON-induced hepatocyte apoptosis. IPA reduces DON-induced hepatocyte apoptosis in piglets, mice, and hepatocyte cell lines by enhancing PXR expression and facilitating nuclear translocation. Furthermore, AlphaFold3 predictions and Co-IP assays demonstrate that DON diminishes PXR-p53 binding, thereby amplifying p53-mediated apoptotic transactivation. In conclusion, this study elucidates a novel mechanism by which PXR decreases its binding to p53 upon DON exposure, thereby promoting hepatocyte apoptosis. Additionally, it validates the positive impact of IPA in mitigating liver damage and diarrhea caused by DON in weaned piglets.
Keyword ：
deoxynivalenol deoxynivalenol hepatocyte apoptosis hepatocyte apoptosis IPA IPA PXR PXR weaned piglets weaned piglets
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Feng, Yue , Lin, Zishen , Wang, Haoran et al. 3-Indolepropionic acid confers PXR-p53 binding to mitigate deoxynivalenol-induced hepatocyte apoptosis [J]. | SCIENCE CHINA-LIFE SCIENCES , 2025 , 68 (9) : 2707-2722 . |
| MLA | Feng, Yue et al. "3-Indolepropionic acid confers PXR-p53 binding to mitigate deoxynivalenol-induced hepatocyte apoptosis" . | SCIENCE CHINA-LIFE SCIENCES 68 . 9 (2025) : 2707-2722 . |
| APA | Feng, Yue , Lin, Zishen , Wang, Haoran , Men, Zhaoyue , Shen, Jiakun , Ma, Xi . 3-Indolepropionic acid confers PXR-p53 binding to mitigate deoxynivalenol-induced hepatocyte apoptosis . | SCIENCE CHINA-LIFE SCIENCES , 2025 , 68 (9) , 2707-2722 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Probiotics are promising alternatives to antibiotics for the treatment of intestinal infections, but the effects of probiotics alone are often insufficient. Here we uncovered synergism between antibacterial iron-sulfur nanozymes (nFeS) and tryptophan derivatives that protects mice and pigs against bacterial gut infections. nFeS selectively inhibited potential intestinal pathogens while sparing commensal Lactobacillus vaginalis, whose presence enhanced the protective activity of nFeS against Salmonella enterica subsp. enterica serovar Typhimurium in vivo. Metabolomics and mutational analysis revealed that L. vaginalis synthesized 2-indolecarboxylic acid from a tryptophan derivative, indole-3-carboxaldehyde, a reaction that was catalysed by nFeS. The cytoplasmic pH of L. vaginalis (pH 7.5) allowed 2-indolecarboxylic acid to chelate free ferrous ions released by nFeS, thereby protecting it from antibacterial effects, whereas pathogens such as S. Typhimurium with a lower cytoplasmic pH were susceptible (pH 6.5). Pretreatment of pigs and mice with L. vaginalis and nFeS protected them against Salmonella infection. Our findings provide a foundation for improving probiotic bacteria-based therapies against intestinal infections.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Lin, Zishen , Feng, Yue , Chen, Lei et al. Nanozymes modulate probiotic tryptophan metabolism to prevent Salmonella infection in mammalian models [J]. | NATURE MICROBIOLOGY , 2025 . |
| MLA | Lin, Zishen et al. "Nanozymes modulate probiotic tryptophan metabolism to prevent Salmonella infection in mammalian models" . | NATURE MICROBIOLOGY (2025) . |
| APA | Lin, Zishen , Feng, Yue , Chen, Lei , Wang, Jinping , Wang, Qian , Cao, Haolin et al. Nanozymes modulate probiotic tryptophan metabolism to prevent Salmonella infection in mammalian models . | NATURE MICROBIOLOGY , 2025 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
