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学者姓名：林文津
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Abstract ：
Objectives: Alpinia japonica (A. japonica) is traditionally used for digestive disorders, but its hypolipidemic mechanisms remain unclear. This study investigated the lipid-lowering effects of its fruit (SJGS), rhizome (SJGJ), and leaf (SJY) extracts, exploring their bioactive constituents and organ-specific mechanisms. Methods: Sprague Dawley rats (n = 8/group) fed a high-fat diet received SJGS, SJGJ, or SJY (200 mg/kg/day) for 4 weeks. Serum lipids (TC, TG), liver enzymes (AST, ALT), and intestinal barrier markers (DAO) were measured. Gut microbiota (16S rDNA sequencing), hepatic histopathology, and ileal tight junction proteins were analyzed. Transcriptomics and qPCR assessed ileal gene expression. LC-MS identified chemical constituents, while network pharmacology predicted compound-target interactions. Results: All extracts significantly reduced serum TC (down arrow 27-33%), TG (down arrow 29-38%), AST/ALT (down arrow 22-30%), and DAO (down arrow 35-42%) versus controls (p < 0.05). They improved hepatic steatosis, enhanced intestinal barrier function, and modulated gut microbiota (up arrow alpha-diversity, down arrow Firmicutes/Bacteroidetes ratio). Transcriptomics revealed PPAR signaling as the core pathway: SJGS/SJGJ downregulated fatty acid oxidation genes (ACSL1, ACOX1, ACADM), while SJY upregulated APOA1 (2.3-fold). LC-MS identified 33-48 compounds/part, with seven shared constituents. Network analysis prioritized three flavonoids (pinocembrin, luteolin, galangin) targeting TNF, AKT1, and PPAR pathways. Conclusions: The findings suggest A. japonica extracts ameliorate hyperlipidemia through distinct mechanisms-SJGS/SJGJ may inhibit fatty acid oxidation, while SJY potentially enhances APOA1-mediated clearance. Shared flavonoids likely contribute to these effects via PPAR signaling, supporting its traditional use. This study provides a scientific basis for the sustainable utilization of A. japonica resources.
Keyword ：
Alpinia japonica Alpinia japonica hypolipidemic effects hypolipidemic effects LC-MS LC-MS network pharmacology network pharmacology PPAR pathway PPAR pathway transcriptomics transcriptomics
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| GB/T 7714 | Zhou, Liqing , Fang, Cong , Li, Hongwei et al. Hypolipidemic Effects of Alpinia japonica Extracts: Modulation of PPAR Signaling, Gut Microbiota, and Intestinal Barrier Function in Hyperlipidemic Rats [J]. | PHARMACEUTICALS , 2025 , 18 (9) . |
| MLA | Zhou, Liqing et al. "Hypolipidemic Effects of Alpinia japonica Extracts: Modulation of PPAR Signaling, Gut Microbiota, and Intestinal Barrier Function in Hyperlipidemic Rats" . | PHARMACEUTICALS 18 . 9 (2025) . |
| APA | Zhou, Liqing , Fang, Cong , Li, Hongwei , Lin, Yifan , Que, Huiqing , Liu, Hongxu et al. Hypolipidemic Effects of Alpinia japonica Extracts: Modulation of PPAR Signaling, Gut Microbiota, and Intestinal Barrier Function in Hyperlipidemic Rats . | PHARMACEUTICALS , 2025 , 18 (9) . |
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This study aimed to compare the therapeutic effects of fresh (CMF) and dried (CMD) Centipeda minima against allergic rhinitis (AR), elucidate their underlying molecular mechanisms, and identify the bioactive compounds responsible for their immunomodulatory actions. An ovalbumin-induced AR mouse model was treated with CMF or CMD extracts, followed by evaluation of nasal symptoms, serum biomarkers (IgE, histamine, cytokines), and nasal mucosa histopathology. Transcriptomics and widely targeted metabolomics were integrated with network pharmacology to identify differentially expressed genes and bioactive components, which were further validated in RAW264.7 and RBL-2H3 cells. CMF and CMD exhibited distinct anti-AR mechanisms: CMF predominantly suppressed Th2 responses (reducing IgE, IL-6, and histamine while elevating IL-10), whereas CMD enhanced Th1 activity (increasing IFN-gamma). Metabolomic analysis revealed CMF was rich in amino acids while CMD contained higher flavonoids, with neocnidilide and 6-gingerol identified as key bioactive compounds that modulated TNF-alpha, IL-6, and IL-10 via NF-kappa B and JAK-STAT pathways. These findings demonstrate that CMF and CMD exert complementary anti-inflammatory effects through Th2 inhibition and Th1 activation, respectively, providing a molecular basis for the traditional use of Centipeda minima and highlighting its bioactive compounds as potential therapeutics for inflammatory diseases.
Keyword ：
allergic rhinitis allergic rhinitis Centipeda minima Centipeda minima fresh and dried products fresh and dried products transcriptomics transcriptomics widely targeted metabolomics widely targeted metabolomics
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| GB/T 7714 | Zhang, Yamin , Lin, Jiajia , Xu, Xiaomei et al. Neocnidilide and 6-Gingerol as Key Bioactives in Fresh and Dried Centipeda minima: Distinct Th1/Th2 Modulation via NF-κB/JAK-STAT Pathways for Allergic Rhinitis Therapy [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2025 , 26 (17) . |
| MLA | Zhang, Yamin et al. "Neocnidilide and 6-Gingerol as Key Bioactives in Fresh and Dried Centipeda minima: Distinct Th1/Th2 Modulation via NF-κB/JAK-STAT Pathways for Allergic Rhinitis Therapy" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 26 . 17 (2025) . |
| APA | Zhang, Yamin , Lin, Jiajia , Xu, Xiaomei , Lu, Xuehua , Li, Lisha , Yang, Yuezhen et al. Neocnidilide and 6-Gingerol as Key Bioactives in Fresh and Dried Centipeda minima: Distinct Th1/Th2 Modulation via NF-κB/JAK-STAT Pathways for Allergic Rhinitis Therapy . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2025 , 26 (17) . |
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Abstract ：
目的 通过应用古今医案云平台去分析探究闽南青草药文化下的保生大帝药签组方用药规律及文化传承。方法 从保生大帝的个人事迹及其内科120首药签的签方组成数据整理校正、药物的药味数、用药频次、归经、功效，聚类分析等数据挖掘方法，分析其用药规律。结果 发现药签的三个特点分别是：配伍得当；药味少剂量轻中草药易得；以中草药治病为主，以药膳调补为辅的中医药。结论 闽南青草药在原中医药的基础上融入闽南独特的地气物候认知和民间养生治病的实践，形成具有闽南特色的青草药文化。先人的经验处方是我国中医药不可多得的宝贵财富，闽南地区青草药文化历史悠久，对当地人民健康影响深远。
Keyword ：
保生大帝 保生大帝 药签 药签 闽南青草药 闽南青草药
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| GB/T 7714 | 张超群 , 李紫婷 , 林文津 . 闽南青草药文化视野下的保生大帝药签 [J]. | 海峡药学 , 2025 , 37 (04) : 13-16 . |
| MLA | 张超群 et al. "闽南青草药文化视野下的保生大帝药签" . | 海峡药学 37 . 04 (2025) : 13-16 . |
| APA | 张超群 , 李紫婷 , 林文津 . 闽南青草药文化视野下的保生大帝药签 . | 海峡药学 , 2025 , 37 (04) , 13-16 . |
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Baphicacanthus cusia (Nees) Bremek (B. cusia) is an effective herb for the treatment of acute promyelocytic leukemia and psoriasis in traditional Chinese medicine. Methyl jasmonate (MeJA) is a well-known signaling phytohormone that triggers gene expression in secondary metabolism. Currently, MeJA-mediated biosynthesis of indigo and indirubin in B. cusia is not well understood. In this study, we analyzed the content of indigo and indirubin in leaf and root tissues of B. cusia with high-performance liquid chromatography and measured photosynthetic characteristics of leaves treated by MeJA using FluorCam6 Fluorometer and chlorophyll fluorescence using the portable photosynthesis system CIRAS-2. We performed de novo RNA-seq of B. cusia leaf and root transcriptional profiles to investigate differentially expressed genes (DEGs) in response to exogenous MeJA application. The amount of indigo in MeJA-treated leaves were higher than that in controled leaves (p = 0.004), and the amounts of indigo in treated roots was higher than that in controlled roots (p = 0.048); Chlorophyll fluorescence of leaves treated with MeJA were significantly decreased. Leaves treated with MeJA showed lower photosynthetic rate compared to the control in the absence of MeJA. Functional annotation of DEGs showed the DEGs related to growth and development processes were down-regulated in the treated leaves, while most of the unigenes involved in the defense response were up-regulated in treated roots. This coincided with the effects of MeJA on photosynthetic characteristics and chlorophyll fluorescence. The qRT-PCR results showed that MeJA appears to down-regulate the gene expression of tryptophan synthase beta-subunits (trpA-beta) in leaves but increased the gene expression of anthranilate synthase (trp 3) in roots responsible for increased indigo content. The results showed that MeJA suppressed leaf photosynthesis for B. cusia and this growth-defense trade-off may contribute to the improved adaptability of B. cusia in changing environments.
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| GB/T 7714 | Lin, Wenjin , Huang, Wei , Ning, Shuju et al. Comparative transcriptome analyses revealed differential strategies of roots and leaves from methyl jasmonate treatment Baphicacanthus cusia (Nees) Bremek and differentially expressed genes involved in tryptophan biosynthesis [J]. | PLOS ONE , 2019 , 14 (3) . |
| MLA | Lin, Wenjin et al. "Comparative transcriptome analyses revealed differential strategies of roots and leaves from methyl jasmonate treatment Baphicacanthus cusia (Nees) Bremek and differentially expressed genes involved in tryptophan biosynthesis" . | PLOS ONE 14 . 3 (2019) . |
| APA | Lin, Wenjin , Huang, Wei , Ning, Shuju , Gong, Xiaogui , Ye, Qi , Wei, Daozhi . Comparative transcriptome analyses revealed differential strategies of roots and leaves from methyl jasmonate treatment Baphicacanthus cusia (Nees) Bremek and differentially expressed genes involved in tryptophan biosynthesis . | PLOS ONE , 2019 , 14 (3) . |
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Baphicacanthus cusia (Nees) Bremek is an herb widely used for the clinical treatment of colds, fever, and influenza in Traditional Chinese Medicine. The roots, stems and leaves can be used as natural medicine, in which indigo and indirubin are two main active ingredients. In this study, quantification of indigo, indirubin, indican and adenosine among various tissues of B. cusia was conducted using HPLC-DAD. Leaves have significantly higher contents than stems and roots (380.66, 315.15, 20,978.26, 4323.15 mu g/g in leaves, 306.36, 71.71, 3,056.78, 139.45 mu g/g in stems, and 9.31, 7.82, 170.45, 197.48 mu g/g in roots, respectively). De novo transcriptome sequencing of B. cusia was performed for the first time. The sequencing yielded 137,216,248, 122,837,394 and 140,240,688 clean reads from leaves, stems and roots respectively, which were assembled into 51,381 unique sequences. A total of 33,317 unigenes could be annotated using the databases of Nr, Swiss-Prot, KEGG and KOG. These analyses provided a detailed view of the enzymes involved in indican backbone biosynthesis, such as cytochrome P450, UDP-glycosyltransferase, glucosidase and tryptophan synthase. Analysis results showed that tryptophan synthase was the candidate gene involved in the tissue-specific biosynthesis of indican. We also detected sixteen types of simple sequence repeats in RNA-Seq data for use in future molecular mark assisted breeding studies. The results will be helpful in further analysis of B. cusia functional genomics, especially in increasing biosynthesis of indican through biotechnological approaches and metabolic regulation.
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| GB/T 7714 | Lin, Wenjin , Huang, Wei , Ning, Shuju et al. De novo characterization of the Baphicacanthus cusia(Nees) Bremek transcriptome and analysis of candidate genes involved in indican biosynthesis and metabolism [J]. | PLOS ONE , 2018 , 13 (7) . |
| MLA | Lin, Wenjin et al. "De novo characterization of the Baphicacanthus cusia(Nees) Bremek transcriptome and analysis of candidate genes involved in indican biosynthesis and metabolism" . | PLOS ONE 13 . 7 (2018) . |
| APA | Lin, Wenjin , Huang, Wei , Ning, Shuju , Wang, Xiaohua , Ye, Qi , Wei, Daozhi . De novo characterization of the Baphicacanthus cusia(Nees) Bremek transcriptome and analysis of candidate genes involved in indican biosynthesis and metabolism . | PLOS ONE , 2018 , 13 (7) . |
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Abstract ：
桔梗是药食两用的大宗药材之一,近年来作为药材、食材生产及研究发展很快,但仍有一些有待进一步研究、解决的问题,在综合近年来多方面研究的基础上,提出了在资源研究及品质评价、生殖生物学及种子质量、药效学扩展及有效成分组、化学成分与次生代谢、有效成分测定取材和药材质量标准、生产规模控制及连作障碍6个方面存在问题,以期作为进一步促进桔梗生产及深入研究的参考。
Keyword ：
关键性问题 关键性问题 桔梗 桔梗 生产 生产 研究 研究
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| GB/T 7714 | 宁书菊 , 林文津 , 韩娜 et al. 目前桔梗生产及研究需要关注的几个关键性问题 [J]. | 中国种业 , 2017 , (08) : 23-25 . |
| MLA | 宁书菊 et al. "目前桔梗生产及研究需要关注的几个关键性问题" . | 中国种业 08 (2017) : 23-25 . |
| APA | 宁书菊 , 林文津 , 韩娜 , 魏道智 . 目前桔梗生产及研究需要关注的几个关键性问题 . | 中国种业 , 2017 , (08) , 23-25 . |
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为探讨密度对桔梗生长生理特性的影响,设计5个密度栽培试验,测定了不同密度处理桔梗植株茎高、根长、根粗,叶片的光合色素含量和光合特性,桔梗植株对氮磷钾的吸收和体内分布情况以及根中桔梗总皂苷含量。结果表明,密度处理显著影响单株桔梗茎高、根长、根粗、单株干重、光合色素含量、净光合速率、水分蒸腾速率、气孔导度和胞间CO_2浓度以及总皂苷含量。高密度条件下,单株发育较差,生长生理指标显著下降;低密度条件下,单株发育良好,生长生理指标及总皂苷含量较高,但单位面积生物产量较低。植株对氮、磷的吸收趋势一致,生育前、中期吸收逐渐增加,中期达到吸收高峰,后期逐渐降低,前期主要分布在叶片、茎中,中期分布在花果比例较大,后期转移至根部,密度与单株氮、磷吸收量成反比。相比氮、磷吸收,桔梗对于钾的吸收量较小,前后生育期在体内分布趋势相似,中期分布均衡,密度对钾的吸收、分布无显著性影响。综合生物产量和药用部位产量及药效成分含量考虑,闽北、中部地区南桔梗的种植密度在M3左右(约49.5万~45.0万株/hm~2)为宜。
Keyword ：
栽培密度 栽培密度 桔梗 桔梗 生长生理特性 生长生理特性
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| GB/T 7714 | 宁书菊 , 韩娜 , 林文津 et al. 栽培密度对亳州桔梗生长生理特性的影响 [J]. | 中国农学通报 , 2017 , 33 (28) : 13-18 . |
| MLA | 宁书菊 et al. "栽培密度对亳州桔梗生长生理特性的影响" . | 中国农学通报 33 . 28 (2017) : 13-18 . |
| APA | 宁书菊 , 韩娜 , 林文津 , 魏道智 . 栽培密度对亳州桔梗生长生理特性的影响 . | 中国农学通报 , 2017 , 33 (28) , 13-18 . |
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桔梗是一味药食同源的大宗药材,福建是南桔梗适栽的区域之一。为了探讨密度对其生长生理特性的影响,设计了5个密度栽培实验,考察了茎高、根长、根粗等生长指标、光合色素和光合特性、氮磷钾吸收分布情况和有效成分桔梗总皂苷含量。结果表明密度处理显著影响单株桔梗茎高、根长、根粗发育,单株干重、光合色素含量、净光合速率、水分蒸腾速率、气孔导度和胞间CO_2浓度以及桔梗总皂苷含量。高密度条件下,单株发育较差,其生长生理指标显著下降,低密度条件下,单株发育良好,生长生理指标及总皂苷含量较高,但单位面积生物产量较低;植株对氮、磷的吸收趋势一致,生育前、中期吸收逐渐增加,中期达到吸收高峰,后期逐渐降低,前期主要分布在叶片、茎中,中期分布在花果比例较大,后期转移至根部,密度与单株吸收量成反比;相比氮、磷吸收,桔梗对于钾的吸收量较小,前后生育期在体内分布趋势相似,中期分布均衡,密度对钾的吸收、分布无显著性影响。综合生物产量和药用部位产量及药效成分含量考虑,闽北、中部地区南桔梗的种植密度在49.5-45.0万株/hm~2左右为宜。
Keyword ：
栽培密度 栽培密度 桔梗 桔梗 生长生理特性 生长生理特性
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| GB/T 7714 | 宁书菊 , 韩娜 , 林文津 et al. 不同栽培密度处理对亳州桔梗生长生理特性的影响 [C] //中国作物学会作物种子专业委员会2017年学术年会论文摘要集 . 2017 . |
| MLA | 宁书菊 et al. "不同栽培密度处理对亳州桔梗生长生理特性的影响" 中国作物学会作物种子专业委员会2017年学术年会论文摘要集 . (2017) . |
| APA | 宁书菊 , 韩娜 , 林文津 , 魏道智 . 不同栽培密度处理对亳州桔梗生长生理特性的影响 中国作物学会作物种子专业委员会2017年学术年会论文摘要集 . (2017) . |
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将同一批桔梗种子经过不同时间的超干处理,然后经过回湿处理、老化处理,测定种子的发芽率、发芽势、发芽指数、丙二醛含量、过氧化物酶活力以及种子浸出液电导率,研究超干处理对种子生理生化特性的影响。结果表明随着超干处理时间的增加,桔梗种子含水量逐渐降低,与自然含水量对照种子相比,经老化处理后超干种子的各项生理指标保持了较高水平,发芽势、发芽指数分别高于对照3-5%、9.6-21.4%,回湿后种子浸出液电导率降低7.3-28.2%,膜系统完好程度高于对照,丙二醛含量低于对照10.3-66.1%,过氧化物酶活性高于对照10.5-40.7%,耐贮性显著提高。结论:南桔梗种子超干贮藏最适合水分应在3.06%左右。
Keyword ：
桔梗种子 桔梗种子 生理生化特性 生理生化特性 超干处理 超干处理
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| GB/T 7714 | 宁书菊 , 郑嘉汉 , 林文津 et al. 超干处理对桔梗种子生理生化特性的影响 [C] //中国作物学会作物种子专业委员会2017年学术年会论文摘要集 . 2017 . |
| MLA | 宁书菊 et al. "超干处理对桔梗种子生理生化特性的影响" 中国作物学会作物种子专业委员会2017年学术年会论文摘要集 . (2017) . |
| APA | 宁书菊 , 郑嘉汉 , 林文津 , 韩娜 , 魏道智 . 超干处理对桔梗种子生理生化特性的影响 中国作物学会作物种子专业委员会2017年学术年会论文摘要集 . (2017) . |
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为了解决南桔梗种子贮藏期间生活力不断下降的问题,将同一批南桔梗种子经过不同时间的超干处理,再经过回湿处理、老化处理,测定种子的发芽率、发芽势、发芽指数、丙二醛含量、过氧化物酶活力以及种子浸出液电导率,研究超干处理对种子生理生化特性的影响。结果表明,随着超干处理时间的增加,桔梗种子含水量逐渐降低,与自然含水量对照种子相比,经老化处理后超干种子的各项生理指标保持了较高水平,发芽势、发芽指数分别高于对照3%~5%、9.6%~21.4%,回湿后种子浸出液电导率降低7.3%~28.2%,膜系统完好程度高于对照,丙二醛含量低于对照10.3%~66.1%,过氧化物酶活性高于对照10.5%~40.7%,耐贮性显著提高。研究认为,南桔梗种子超干贮藏最适合水分应在3.06%左右。
Keyword ：
桔梗种子 桔梗种子 生理生化特性 生理生化特性 超干处理 超干处理
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| GB/T 7714 | 宁书菊 , 郑嘉汉 , 林文津 et al. 超干处理对南桔梗种子生理特性的影响 [J]. | 中国农学通报 , 2016 , 32 (34) : 103-107 . |
| MLA | 宁书菊 et al. "超干处理对南桔梗种子生理特性的影响" . | 中国农学通报 32 . 34 (2016) : 103-107 . |
| APA | 宁书菊 , 郑嘉汉 , 林文津 , 韩娜 , 魏道智 . 超干处理对南桔梗种子生理特性的影响 . | 中国农学通报 , 2016 , 32 (34) , 103-107 . |
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