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学者姓名：饶义剑
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Abstract ：
Conventional chemical or biological synthetic methods often encounter challenges in conveniently preparing chiral natural and unnatural products with the same skeleton at a scalable level, due to their complexity with numerous chiral centers or uncharacterized enzymes. Herein, a simplified modular chemoenzymatic platform is designed featuring a streamlined four-enzyme cascade coupled with a chemical module that involves one or two chemical steps. This platform enables the divergent synthesis of structurally diverse natural and unnatural benzylisoquinoline alkaloids (BIAs), including 1-benzylisoquinoline, protoberberine, morphinan, and aporphine alkaloids. Moreover, the enantioselectivity of the chiral BIAs is up to 99% ee. The titer of papaverine reaches an impressive 2.83 g L-1, demonstrating substantial industrial potential. Overall, this work establishes a paradigm for constructing modular chemoenzymatic platforms that simplify the production of structurally diverse natural and unnatural products for drug development.
Keyword ：
artificial platform artificial platform benzylisoquinoline alkaloids benzylisoquinoline alkaloids chemoenzymatic cascade chemoenzymatic cascade papaverine papaverine (S)-glaucine (S)-glaucine
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| GB/T 7714 | Liu, Huiling , Yuan, Zhenbo , Gao, Yue et al. A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids [J]. | ADVANCED SCIENCE , 2025 . |
| MLA | Liu, Huiling et al. "A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids" . | ADVANCED SCIENCE (2025) . |
| APA | Liu, Huiling , Yuan, Zhenbo , Gao, Yue , Li, Fei , Deng, Zhiwei , Zhang, Yan et al. A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids . | ADVANCED SCIENCE , 2025 . |
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